•Standardization of health outcomes can improve the quality of healthcare.•The present RRMS standard set of variables can help to optimize its management.•The study provided an opportunity to pool ...different stakeholders' perspectives.
Standardizing health outcomes is challenging in clinical management, but it also holds the potential for creating a healthcare system that is both more effective and efficient. The aim of the present study is to define a standardized set of health outcomes for managing Relapsing-Remitting Multiple Sclerosis (RRMS).
The project was led and coordinated by a multidisciplinary scientific committee (SC), which included a literature review, a patient-focused group, three nominal group meetings, and two SC meetings.
36 outcome variables were included in the standard set: 24 clinical (including weight, smoking habit, comorbidities, disability, mobility, diagnosis of secondary progressive multiple sclerosis, relapsed-related variables, radiological variables, cognitive status and disease-related symptoms), nine treatment-related (pharmacological and non-pharmacological information), and 3 related to the impact of RRMS on the patient's life (quality of life, pregnancy desire, work-related difficulties). In addition, experts also agreed to collect 10 case-mix variables that may affect but cannot be controlled as part of the management of the condition: 4 sociodemographic (age, sex, race, and employment status) and 6 clinical (height, date of diagnosis and first episode, serological status, early symptoms, and number of relapses pre-diagnosis).
The information provided through the present standard set of outcome variables can improve the management of RRMS and promote patient-centred quality care.
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Despite the immense literature related to diverse human electroencephalographic (EEG) parameters, very few studies have focused on the reliability of these measures. Some of the most studied ...components (i.e., P3 or MMN) have received more attention regarding the stability of their main parameters, such as latency, amplitude or topography. However, spectral modulations have not been as extensively evaluated considering that different analysis methods are available. The main aim of the present study is to assess the reliability of the latency, amplitude and topography of event-related desynchronization (ERD) for the alpha band (10-14 Hz) observed in a cognitive task (visual oddball). Topography reliability was analysed at different levels (for the group, within-subjects individually and between-subjects individually).
The latency for alpha ERD showed stable behaviour between two sessions, and the amplitude exhibited an increment (more negative) in the second session. Alpha ERD topography exhibited a high correlation score between sessions at the group level (r = 0.903, p<0.001). The mean value for within-subject correlations was 0.750 (with a range from 0.391 to 0.954). Regarding between-subject topography comparisons, some subjects showed a highly specific topography, whereas other subjects showed topographies that were more similar to those of other subjects.
ERD was mainly stable between the two sessions with the exception of amplitude, which exhibited an increment in the second session. Topography exhibits excellent reliability at the group level; however, it exhibits highly heterogeneous behaviour at the individual level. Considering that the P3 was previously evaluated for this group of subjects, a direct comparison of the correlation scores was possible, and it showed that the ERD component is less reliable in individual topography than in the ERP component (P3).
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Mango is the fruit most exported by Brazil, with a significant increase in cultivated area in recent years. However, the orchards have been made up of seedlings produced by the grafting process, but ...without identifying the most suitable rootstock for each cultivar, which affects the competitiveness of mango farming, since the rootstock affects, among other factors, the growth and nutrient absorption from the canopy cultivar. The objective of this study was to evaluate the nutritional status and mineral nutrition of 'Palmer,' 'Tommy Atkins,' 'Kent' and 'Keitt' mango seedlings grafted onto the polyembryonic rootstocks Capucho, Coquinho and Espada. The experiment was carried out between October 2019 and May 2020 at the Fruit Growing Nursery of the Agricultural Sciences Campus of the Federal University of Vale do São Francisco (UNIVASF), in Petrolina-PE, in a 3 × 4 factorial scheme, corresponding to three polyembryonic rootstocks (Espada, Capucho and Coquinho) and four crown cultivars ('Palmer,' 'Keitt,' 'Kent' and 'Tommy Atkins'), with five replications of ten plants each. Leaf contents of macronutrients (N, P, K, Ca), micronutrients (Cu and Fe) and silicon depend on the scion (Tommy Atkins, Palmer, Keitt and Kent) x rootstock (Espada, Capucho and Conquinho) combination. The leaf contents of S, Mg, B, Mn and Mo in the scion are affected by the rootstock adopted for mango propagation In general, for macro and micronutrient absorption purposes, the sword rootstock and the 'Keitt' cultivar are the best combination for most of the variables analyzed in the research. The effect of rootstock on the nutritional status of scion cultivars (Tommy Atkins, Palmer, Keitt and Kent) must be taken into consideration when interpreting crop nutrition.
A considerable percentage of multiple sclerosis patients have attentional impairment, but understanding its neurophysiological basis remains a challenge. The Attention Network Test allows 3 ...attentional networks to be studied. Previous behavioural studies using this test have shown that the alerting network is impaired in multiple sclerosis. The aim of this study was to identify neurophysiological indexes of the attention impairment in relapsing-remitting multiple sclerosis patients using this test.
After general slowing had been removed in patients group to isolate the effects of each condition, some behavioral differences between them were obtained. About Contingent Negative Variation, a statistically significant decrement were found in the amplitude for Central and Spatial Cue Conditions for patient group (p<0.05). ANOVAs showed for the patient group a significant latency delay for P1 and N1 components (p<0.05) and a decrease of P3 amplitude for congruent and incongruent stimuli (p<0.01). With regard to correlation analysis, PASAT-3s and SDMT showed significant correlations with behavioral measures of the Attention Network Test (p<0.01) and an ERP parameter (CNV amplitude).
Behavioral data are highly correlated with the neuropsychological scores and show that the alerting and orienting mechanisms in the patient group were impaired. Reduced amplitude for the Contingent Negative Variation in the patient group suggests that this component could be a physiological marker related to the alerting and orienting impairment in relapsing-remitting multiple sclerosis. P1 and N1 delayed latencies are evidence of the demyelination process that causes impairment in the first steps of the visual sensory processing. Lastly, P3 amplitude shows a general decrease for the pathological group probably indexing a more central impairment. These results suggest that the Attention Network Test give evidence of multiple levels of attention impairment, which could help in the assessment and treatment of relapsing-remitting multiple sclerosis patients.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Multiple sclerosis (MS) causes sleep disturbances in up to 70 % of individuals. These problems are linked to fatigue, mood and cognitive performance, thereby affecting the quality of life in people ...with MS (PwMS). The frequent and debilitating side effects of sleep medications prompt the exploration of alternative therapies.
Physical activity has shown benefits in improving sleep, reducing fatigue, and enhancing quality of life. Combined with a controlled exercise program tailored for PwMS, the study aims to analyze the impact of moderate physical exercise on sleep quality, cognitive function, quality of life, mood, and fatigue.
A single-center prospective cohort study was designed to assess the impact of a 12-week physical exercise program on patients with relapsing-remitting multiple sclerosis. Changes in sleep and activity parameters are evaluated using an actigraph and cognitive, quality of life, fatigue and mood changes are assessed through specific questionnaires before, during, and after the exercise program application.
23 patients completed the study (women = 84.6 %) Mean age was 37.2 years (SD 7.5). The mean EDSS score was 1.9, and 80.8 % were diagnosed within the last six years.
Significant improvements were noted in sleep efficiency between baseline and final measurements (χ2 = 27.5; p.adj = 0.004), sleep latency (χ2 = 275; p.adj = 0.000), sleep duration (χ2 = 251; p.adj = 0.001) and in the number of awakenings (χ2 = 269.5; p.adj = 0.000), with a decreased in total time in bed from 8.5 h to 7.35 h post-intervention. Regarding activity variables, an increase in caloric expenditure and an increase in the time participants engaged in light activity were observed. We found significant improvements in fatigue, quality of life and mood. Concerning neuropsychological exploration results, improvements were observed in all studied parameters, with statistically significant improvement in Verbal SRT (χ2 = 43; p = 0.022).
Our study showed a positive impact of a 12-week physical exercise program on sleep performance, cognition and mood in PwMS. The observed improvements underscore the potential of tailored exercise interventions in promoting a more comprehensive and holistic care paradigm for PwMS.
•“ACTIVE-FIT improved sleep, cognition, mood in PwMS. Rigorous methods, large sample, diverse outcomes”.
Nominal number in sign languages Carneiro, Bruno Gonçalves; Borges, Mônica Veloso; Aldrete, Miroslava Cruz
Revista de estudos da linguagem,
10/2022, Letnik:
30, Številka:
4
Journal Article
This study describes the manifestation of the category of number in sign languages, aiming to identify the values, the main forms and strategies available and some intramodal and intermodal ...manifestation patterns, considering the noun phrase. To this end, we worked with a sample of 10 sign languages, from different regions and historical groups. Based on secondary data, we identified that some sign languages have optional number marking, which presupposes the presence of the general number, and that other sign languages have obligatory number marking. In sign languages where number marking is optional, the general form is similar to the singular form, expressed by zero. The values of the category of number are singular, plural and dual, expressed by syntactic and morphological strategies, but preference is given for the former. This preference suggests that sign languages are isolating languages with regard to the category of number, differing typologically from spoken languages in this respect. Furthermore, the number system in sign languages appears to be phonologically driven. The supposed trial and quadral values can be expressed by using the iconic plural, in a process of repetition of the singular form in the sign space, with a distinctive and localized pause. Therefore, they were considered to be an instance of direct counting and would be outside the number category. This strategy could create values that go beyond the amount of expected values for the category, in a typological perspective. Also, when mentioned, these values can be substituted for the plural. From the descriptions, morphological strategies suggest an implicational hierarchy, with mouthing being a rarely used strategy and reduplication with displacement being the most prevalent strategy. Another intra-modal feature is the spatial arrangement of the referent, expressed in the category of number.
ABSTRACT Light is essential for providing energy for photosynthetic reactions and has a complex and not yet fully understood effect on heliconia growth and yield. Thus, the objective of this study ...was to evaluate the effect of light intensity on the growth and photosynthesis of heliconia under semi-arid conditions and to screen potential genotypes tolerant to high solar irradiation levels during the vegetative stage. The experiment was conducted in Petrolina, PE, Brazil, whose geographic coordinates are 09° 19’ 14” S, 40° 32’ 40” W, with an average altitude of 387 m. The experimental design used was in randomized blocks, arranged in a split-plot scheme, and the treatments were composed of two light intensities (full sun and 50% shading) and five genotypes (Heliconia psittacorum x H. spathocircinata cv. Golden Torch; H. psittacorum cv. Red Opal; H. bihai cv. Lobster Claw Two; H. rauliniana and H. rostrata). Growth and gas exchange assessments were conducted on the 100th day after the trial initiation. Light intensity (full sun and 50% shading) did not influence the rates of photosynthesis (A), stomatal conductance (gs), or transpiration (E) of plants. However, the isolated effect of the genotype revealed that plants of cv. Red Opal, H. bihai, H. rauliniana, and cv. Golden Torch had higher values of A, gs, and E. Overall, shading improved plant growth. We conclude that the genotypes H. psittacorum cv. Red Opal, and H. psittacorum cv. Golden Torch exhibited the greatest tolerances to high solar irradiance conditions.
RESUMO A luz é essencial por fornecer energia para as reações fotossintéticas e tem uma influência complexa e não totalmente compreendida no crescimento e produção de helicônias. Assim, objetivou-se avaliar o efeito da intensidade de luz sobre o crescimento e fotossíntese de helicônias em condições semiáridas e a triagem de genótipos potenciais tolerantes as condições de altos níveis de irradiação solar durante o estágio vegetativo. O experimento foi conduzido em Petrolina-PE, Brasil, cujas coordenadas geográficas são: 09° 19’ 14” S, 40° 32’ 40” O, com altitude média de 387 m. O delineamento experimental utilizado foi em blocos casualizados, arranjados em esquema de parcelas subdivididas, e os tratamentos foram compostos por duas intensidades de luz (pleno sol e sombreamento de 50%) e cinco genótipos (Heliconia psittacorum x H. spathocircinata cv. Golden Torch; H. psittacorum cv. Red Opal; H. bihai cv. Lobster Claw Two; H. rauliniana e H. rostrata). No 100° dia após o início do experimento foram realizadas avaliações de crescimento e trocas gasosas. As intensidades de luz (pleno sol e sombreamento 50%) não influenciaram a taxa fotossintética (A), condutância estomática (gs) e transpiração (E) das plantas. Porém, o efeito isolado do genótipo revela que plantas de cv. Red Opal, H. bihai, H. rauliniana e cv. Golden Torch apresentaram maiores valores de A, gs e E. Em geral, o sombreamento favoreceu maior incremento no crescimento das plantas. Conclui-se que os genótipos H. psittacorum cv. Red Opal e H. psittacorum cv. Golden Torch exibem maior tolerância às condições de elevada irradiância solar.
Functional neuroanatomy of cognitive impairment in multiple sclerosis is currently still a challenge. During the progression of the disease, several cognitive mechanisms deteriorate thus diminishing ...the patient's quality of life. A primary objective in the cognitive assessment of multiple sclerosis (MS) patients is to find reliable measures utilizing diverse neuroimaging techniques. Moreover, especially relevant in the clinical environment is finding technical approaches that could be applied to individual participants and not only for group analysis. A 64-channel electroencephalographic recording (EEG) was made with thirty participants divided into three groups of equivalent size (N = 10) (healthy control, low-EDSS (1-2.5) and moderate-EDSS (4-6)). Correlation analysis was applied to multiple measures: behavior, neuropsychological tests (Paced Auditory Serial Addition Test, 3 seconds (PASAT-3s) and the Symbol Digit Modality Test (SDMT)), Expanded Disability Status Scale (EDSS), even-related potential (P3) and event-related desynchronization (ERD) parameters and the correlation scores between individual participant's P3/ERD maps and the healthy grand average P3/ERDmaps. Statistical analysis showed that diverse parameters exhibited significant correlations. A remarkable correlation was the moderate score found between SDMT and EDSS (r = -0.679, p = 0.0009). However, the strongest correlation was between the value of integrated measures (reaction time, P3 and ERD latency) and EDSS (r = 0.699, p = 0.0006). In regard to correlations for grand average maps between groups, the P3 component exhibited a lower score according to a more deteriorated condition (higher EDSS). In contrast, ERD maps remained stable with an increase of EDSS. Lastly, a Z-transformation of individual values of all variables included in the study exhibited heterogeneity in cognitive alterations in the multiple sclerosis participants.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Nitrate reductase is the enzyme that catalyzes the first reduction reaction in the nitrate assimilation process, an important nitrogen (N) source. This element is one of the macronutrients required ...in greater amounts by mango (Mangifera indica L.), exerting a great influence on the growth and development of the plants. In this context, this work aimed to evaluate nitrate reductase activity (NRa) throughout the day and characterize it in leaves of 1st and 2nd vegetative flushes and young roots of ‘Palmer’ mango cultivated in the Brazilian semiarid. For each phenophase, leaves and roots were randomly collected from six plants in the orchard. A completely randomized design was employed, with four replications, and the NRa quantification was based on the in vivo evaluation method. The enzyme activity was maximum in the period of greatest solar radiation or from 10 a.m. to 11 a.m. The 2nd flush leaves and young the roots constitute the main nitrate assimilation sites in the mango crop in comparation with 1st flush leaves. Fertilization with nitrate or potassium sources in the different phenological phases benefit the NRa, which remains maximum during reproductive phase than vegetative phase.
Some controversy remains about the potential applicability of cognitive potentials for evaluating the cerebral activity associated with cognitive capacity. A fundamental requirement is that these ...neurophysiological parameters show a high level of stability over time. Previous studies have shown that the reliability of diverse parameters of the P3 component (latency and amplitude) ranges between moderate and high. However, few studies have paid attention to the retest reliability of the P3 topography in groups or individuals. Considering that changes in P3 topography have been related to different pathologies and healthy aging, the main objective of this article was to evaluate in a longitudinal study (two sessions) the reliability of P3 topography in a group and at the individual level.
The correlation between sessions for P3 topography in the grand average of groups was high (r = 0.977, p<0.001). The within-subject correlation values ranged from 0.626 to 0.981 (mean: 0.888). In the between-subjects topography comparisons, the correlation was always lower for comparisons between different subjects than for within-subjects correlations in the first session but not in the second session.
The present study shows that P3 topography is highly reliable for group analysis (comprising the same subjects) in different sessions. The results also confirmed that retest reliability for individual P3 maps is suitable for follow-up studies for a particular subject. Moreover, P3 topography appears to be a specific marker considering that the between-subjects correlations were lower than the within-subject correlations. However, P3 topography appears more similar between subjects in the second session, demonstrating that is modulated by experience. Possible clinical applications of all these results are discussed.
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DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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