Within the university-industry ecosystem, improvement and innovation of technology transfer involve implementing appropriate dynamic capabilities. To answer the question-What are the ...micro-foundations of dynamic capabilities in university technology transfer?-this study investigates in-depth organizational-level dynamic capabilities in transferring university-based knowledge to business and society. Two qualitative case studies were deployed at organizational entities at Vrije Universiteit Amsterdam: the Industry Alliance Office, and the Demonstrator Lab. These two organizations stimulate science- and business-oriented university technology transfer. In this context, the micro-foundations of the dynamic capabilities "sensing", "seizing" and "reconfiguring" are identified and discussed. For "sensing", which is the university's ability to explore the opportunities in the ecosystem, the micro-foundations are "selecting internal competency" and "sensing external partners". For "seizing", which supports universities in managing complementarity with industry and society, micro-foundations include "resource co-allocation" and "collaborative business model". The micro-foundations of "reconfiguring", through which universities maintain evolutionary fitness in the innovation ecosystem, are "strategic renewal", "establishing a university technology transfer-friendly environment", and "asset orchestration". This study provides researchers with a better understanding of how dynamic capabilities facilitate university technology transfer. Industrial practitioners and policymakers can consider the suggestions of the present study when pursuing collaboration with universities.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Scholars acknowledge the critical role of employee innovative work behavior (IWB) in facilitating organizational innovation in high-tech industries. However, the current knowledge is far from ...complete to paint a clear picture of how to evoke employee IWB in the Chinese high-tech industry. Many Chinese high-tech firms face a challenge moving from hierarchy-based leadership toward more employee-centered leadership styles, as the styles have different effects on employees' IWB. This perspective may complement and sharpen the incomplete picture. Drawing on a dynamic componential model of creativity and innovation, this study proposes and tests a moderated mediation model that examines the hypothesized positive influence of servant leadership on employee IWB via meaningful work as well as the moderating role of job autonomy in this process. We collected data (
= 288) from three Chinese high-tech firms and found that employees' perceptions of meaningful work mediate the relationship between servant leaders and IWB. We also found that this mediating relationship is conditional on the moderating role of job autonomy in the path from servant leadership to meaningful work. The results further show that the indirect effect of servant leadership on employee IWB via meaningful work exists only when job autonomy is high.
Tuberculosis control relies on the identification and preventive treatment of individuals who are latently infected with Mycobacterium tuberculosis. However, direct identification of latent ...tuberculosis infection is not possible. The diagnostic tests used to identify individuals latently infected with M. tuberculosis, the in vivo tuberculin skin test and the ex vivo interferon-gamma release assays (IGRAs), are designed to identify an adaptive immune response against, but not necessarily a latent infection with, M. tuberculosis. The proportion of individuals who truly remain infected with M. tuberculosis after tuberculin skin test or IGRA conversion is unknown. It is also uncertain how long adaptive immune responses towards mycobacterial antigens persist in the absence of live mycobacteria. Clinical management and public healthcare policies for preventive chemotherapy against tuberculosis could be improved, if we were to gain a better understanding on M. tuberculosis latency and reactivation. This statement by the TBNET summarises knowledge and limitations of the currently available tests used in adults and children for the diagnosis of latent tuberculosis infection. In summary, the main issue regarding testing is to restrict it to those who are known to be at higher risk of developing tuberculosis and who are willing to accept preventive chemotherapy.
Interferon-γ release assays (IGRAs) are now established for the immunodiagnosis of latent infection with Mycobacterium tuberculosis in many countries. However, the role of IGRAs for the diagnosis of ...active tuberculosis (TB) remains unclear. Following preferred reporting items for systematic reviews and meta-analyses (PRISMA) and quality assessment of diagnostic accuracy studies (QUADAS) guidelines, we searched PubMed, EMBASE and Cochrane databases to identify studies published in January 2001-November 2009 that evaluated the evidence of using QuantiFERON-TB® Gold in-tube (QFT-G-IT) and T-SPOT.TB® directly on blood or extrasanguinous specimens for the diagnosis of active TB. The literature search yielded 844 studies and 27 met the inclusion criteria. In blood and extrasanguinous fluids, the pooled sensitivity for the diagnosis of active TB was 80% (95% CI 75-84%) and 48% (95% CI 39-58%) for QFT-G-IT, and 81% (95% CI 78-84%) and 88% (confirmed and unconfirmed cases) (95% CI 82-92%) for T-SPOT.TB®, respectively. In blood and extrasanguinous fluids, the pooled specificity was 79% (95% CI 75-82%) and 82% (95% CI 70-91%) for QFT-G-IT, and 59% (95% CI 56-62%) and 82% (95% CI 78-86%) for T-SPOT.TB®, respectively. Although the diagnostic sensitivities of both IGRAs were higher than that of tuberculin skin tests, it was still not high enough to use as a rule out test for TB. Positive evidence for the use of IGRAs in compartments other than blood will require more independent and carefully designed prospective studies.
Although the positive effect of psychological capital (PsyCap) on employee performance is well documented, the conditions under which PsyCap exerts the most influence on creativity warrant further ...research. Complementing and extending prior studies, we theorize and examine how two critical contextual factors (supervisor support for creativity SSC and job characteristics) effectively activate PsyCap associated with self‐reported employee creativity. Drawing on an interactional perspective, we use trait activation theory to examine the moderating effects of SSC and job characteristics on the relationship between PsyCap and self‐reported employee creativity. Through rigorous hypotheses testing (N = 356 individuals from multiple industries in Chinese firms), our results demonstrate that both SSC and job characteristics positively moderate the PsyCap–creativity relationship. Additional analyses reveal that PsyCap is most effective at enhancing creativity when both SSC and job characteristics are high. Implications of these findings for theory, future research and practice are discussed.
Anti-tumour necrosis factor (TNF) monoclonal antibodies or soluble TNF receptors have become an invaluable treatment against chronic inflammatory diseases, such as rheumatoid arthritis, inflammatory ...bowel disease and psoriasis. Individuals who are treated with TNF antagonists are at an increased risk of reactivating latent infections, especially tuberculosis (TB). Following TNF antagonist therapy, the relative risk for TB is increased up to 25 times, depending on the clinical setting and the TNF antagonist used. Interferon-γ release assays or, as an alternative in individuals without a history of bacille Calmette-Guérin vaccination, tuberculin skin testing is recommended to screen all adult candidates for TNF antagonist treatment for the presence of latent infection with Mycobacterium tuberculosis. Moreover, paediatric practice suggests concomitant use of both the tuberculin skin test and an interferon-γ release assay, as there are insufficient data in children to recommend one test over the other. Consequently, targeted preventive chemotherapy is highly recommended for all individuals with persistent M. tuberculosis-specific immune responses undergoing TNF antagonist therapy as it significantly reduces the risk of progression to TB. This TBNET consensus statement summarises current knowledge and expert opinions and provides evidence-based recommendations to reduce the TB risk among candidates for TNF antagonist therapy.
The demonstration project can be an effective organizational form to transform a clean technology prototype—for example, in the field of photovoltaics, carbon capture and storage, or wind power—into ...a marketable product. A question with regard to the clean technology demonstration project is how its effectiveness can be increased. This article answers this question by reviewing scientific literature on clean technology demonstration projects of the past 39 years. It distinguishes and analyzes three types of demonstration projects: the technical demonstration, organizational demonstration, and market demonstration. The article proposes that the effectiveness of demonstration projects increases when clean technology prototypes are tested, improved, and marketed successively. First, they should be tested in technical demonstrations, then improved in organizational demonstrations, and finally marketed in market demonstrations. The article also proposes five managerial factors that stimulate the effectiveness of the three consecutive demonstration types. The article concludes with an agenda for future research, concentrating on the diffusion of clean technological innovations through a coherent program of demonstration projects. It presents several theoretical approaches that can be applied to conduct future demonstration project research.
Two-tier serology testing is most frequently used for the diagnosis of Lyme borreliosis (LB); however, a positive result is no proof of active disease. To establish a diagnosis of active LB, better ...diagnostics are needed. Tests investigating the cellular immune system are available, but studies evaluating the utility of these tests on well-defined patient populations are lacking. Therefore, we investigated the utility of an enzyme-linked immunosorbent spot (ELISpot) assay to diagnose active Lyme neuroborreliosis. Peripheral blood mononuclear cells (PBMCs) of various study groups were stimulated by using
strain B31 and various recombinant antigens, and subsequently, the number of
-specific interferon gamma (IFN-γ)-secreting T cells was measured. We included 33 active and 37 treated Lyme neuroborreliosis patients, 28 healthy individuals treated for an early manifestation of LB in the past, and 145 untreated healthy individuals. The median numbers of
B31-specific IFN-γ-secreting T cells/2.5 × 10
PBMCs did not differ between active Lyme neuroborreliosis patients (6.0; interquartile range IQR, 0.5 to 14.0), treated Lyme neuroborreliosis patients (4.5; IQR, 2.0 to 18.6), and treated healthy individuals (7.4; IQR, 2.3 to 14.9) (
= 1.000); however, the median number of
B31-specific IFN-γ-secreting T cells/2.5 × 10
PBMCs among untreated healthy individuals was lower (2.0; IQR, 0.5 to 3.9) (
≤ 0.016). We conclude that the
ELISpot assay, measuring the number of
B31-specific IFN-γ-secreting T cells/2.5 × 10
PBMCs, correlates with exposure to the
bacterium but cannot be used for the diagnosis of active Lyme neuroborreliosis.
The purpose of this study is to gain a better understanding of how entrepreneurial leadership relates to workplace creativity in organizations from the compatibility perspective. Drawing on social ...cognitive theory, we propose that individual creative selfefficacy and team creative efficacy beliefs mediate the relationships between entrepreneurial leadership and individual and team creativity. This study examines the relationship between entrepreneurial leadership and creativity through creative efficacy. Survey data were collected from multiple sources, including 43 leaders and 237 employees in eight Chinese companies. Cross-level relationships are tested by means of a hierarchical linear modeling analysis (HLM). The results reveal that entrepreneurial leadership is positively related to employee and team creativity, and these relationships are found to be mediated by both employee creative self-efficacy and team creative efficacy. Furthermore, team creative efficacy is found to exert a cross-level mediating influence on the entrepreneurial leadership-employee creativity relationship. This study suggests that employees and teams led by entrepreneurial leaders are likely to produce creative outcomes. The findings further confirm the important role of creative efficacy beliefs in explaining how entrepreneurial leadership relates to employee and team creativity, as such beliefs serve as a within-level and cross-level mediating mechanism in these relationships. Our study is among the first to empirically investigate the concept of entrepreneurial leadership in a broader organizational context. We examine how entrepreneurial leadership contributes to workplace creativity. Our study shows that creative efficacy beliefs exert both within-level and crosslevel mediating influences in the entrepreneurial leadership-creativity relation.
Recently, interferon-gamma release assays (IGRA) for specific diagnosis of Mycobacterium tuberculosis infection have become available. In recent UK tuberculosis (TB) guidelines, it has been advised ...to screen for latent M. tuberculosis infection using the tuberculin skin test (TST), followed by IGRA if the TST is positive. Since TST can boost immune responses to tuberculin, the present authors evaluated whether TST administration affects the result of QuantiFERON-TB Gold in-tube (QFT-GIT), a whole blood-based IGRA. QFT-GIT was performed on the day of TST administration and the day of reading in 15 TST-negative subjects, 46 TST-positive subjects with recent or remote exposure to M. tuberculosis and five cured TB patients. No systematic boosting of QFT-GIT responses from negative to positive was observed. Only in a few TST-positive persons did TST enhance pre-existing QFT-GIT responses. Screening for latent Mycobacterium tuberculosis infection using tuberculin skin testing followed by interferon-gamma release assays on the day of reading is a reliable approach, as the specificity of QuantiFERON-TB Gold in-tube is not affected by prior tuberculin skin test administration.
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