The stigma associated with mental disorders is a global public health problem. Programs to combat it must be informed by the best available evidence. To this end, a meta‐analysis was undertaken to ...investigate the effectiveness of existing programs. A systematic search of PubMed, PsycINFO and Cochrane databases yielded 34 relevant papers, comprising 33 randomized controlled trials. Twenty‐seven papers (26 trials) contained data that could be incorporated into a quantitative analysis. Of these trials, 19 targeted personal stigma or social distance (6,318 participants), six addressed perceived stigma (3,042 participants) and three self‐stigma (238 participants). Interventions targeting personal stigma or social distance yielded small but significant reductions in stigma across all mental disorders combined (d=0.28, 95% CI: 0.17‐0.39, p<0.001) as well as for depression (d=0.36, 95% CI: 0.10‐0.60, p<0.01), psychosis (d=0.20, 95% CI: 0.06‐0.34, p<0.01) and generic mental illness (d=0.30, 95% CI: 0.10‐0.50, p<0.01). Educational interventions were effective in reducing personal stigma (d=0.33, 95% CI: 0.19‐0.42, p<0.001) as were interventions incorporating consumer contact (d=0.47, 95% CI: 0.17‐0.78, p<0.001), although there were insufficient studies to demonstrate an effect for consumer contact alone. Internet programs were at least as effective in reducing personal stigma as face‐to‐face delivery. There was no evidence that stigma interventions were effective in reducing perceived or self‐stigma. In conclusion, there is an evidence base to inform the roll out of programs for improving personal stigma among members of the community. However, there is a need to investigate methods for improving the effectiveness of these programs and to develop interventions that are effective in reducing perceived and internalized stigma.
Objective
Although muscle dysmorphia (MD) is a new addition to DSM‐5 as a specifier of body dysmorphic disorder (BDD), previous studies have treated MD as a stand‐alone diagnosis. We aimed to assess ...the validity of MD as a stand‐alone diagnosis via systematic and meta‐analytic review of MD literature using both Robins and Guze criteria and additional criteria from Kendler.
Method
We performed a systematic search of ProQuest, PsycInfo, and PubMed databases for the period of January 1993 to October 2019 resulting in 40 papers to examine Robins and Guze's criteria (clinical picture) as well as those added by Kendler (antecedent validators; concurrent validators; predictive validators).
Results
We identified two distinct symptomatic presentations of MD using cluster analysis, a behavioral type and cognitive/behavioral type. For examining the concurrent validators, quantitative meta‐analyses differentiated MD populations from controls; however, results were inconclusive in delineating MD from existing disorders. For assessing antecedent and predictive validators, the symptomatic profiles, treatment response, and familial links for MD were similar to those for BDD and for eating disorders.
Discussion
We found preliminary support for MD as a clinically valid presentation, but insufficient evidence to determine whether it is best categorized as a specifier of BDD or unique psychiatric condition.
Resumen
Objectivo
Aunque la dismorfia muscular (MD, por sus siglas en inglés) es una nueva adición al DSM‐5 como un especificador del trastorno dismórfico corporal (BDD, por sus siglas en inglés), los estudios previos han tratado la MD como un diagnóstico independiente. El objetivo fue evaluar la validez de la MD como un diagnóstico independiente a través de revisiones sistemáticas y metaanalíticas de la literatura de MD utilizando los criterios de Robin y Guze (1970) y los criterios adicionales de Kendler (1980).
Método
Realizamos una búsqueda sistemática de las bases de datos ProQuest, PsycInfo y PubMed para el período de enero de 1993 a octubre de 2019, lo que resultó en 40 documentos para examinar los criterios de Robins y Guze (cuadro clínico), así como los agregados por Kendler (validadores antecedentes; validadores concurrentes; validadores predictivos).
Resultados
identificamos dos presentaciones sintomáticas distintas de MD mediante análisis de conglomerados, una de tipo conductual y una de tipo cognitivo / conductual. Para examinar los validadores concurrentes, los metaanálisis cuantitativos diferenciaron las poblaciones de MD de los controles; sin embargo, los resultados no fueron concluyentes para delinear la MD de los trastornos existentes. Para evaluar los validadores antecedente y predictivo, los perfiles sintomáticos, la respuesta al tratamiento y los vínculos familiares para la MD fueron similares a los de la BDD y los trastornos de la conducta alimentaria.
Discusión
Encontramos apoyo preliminar para la MD como una presentación clínicamente válida, pero evidencia insuficiente para determinar si se clasifica mejor como un especificador de BDD o una condición psiquiátrica única.
In ancient Rome, any citizen who had brought disgrace upon the state could be subject to a judgment believed to be worse than death:damnatio memoriae, condemnation of memory. The Senate would decree ...that every trace of the citizen's existence be removed from the city as if they had never existed in the first place. Once reserved for individuals,damnatio memoriae in different forms now extends to social classes, racial and ethnic groups, and even entire peoples. In modern times, the condemned go by different names-"enemies of the people;" the "missing," the "disappeared," "ghost" detainees in "black sites"-but they are subject to the same fate of political erasure. Arthur Bradley explores the power to render life unlived from ancient Rome through the War on Terror. He argues that sovereignty is the power to decide what counts as being alive and what does not: to make life "unbearable," unrecognized as having lived or died. In readings of Augustine, Shakespeare, Hobbes, Robespierre, Schmitt, and Benjamin, Bradley asks: What is the "life" of this unbearable life? How does it change and endure across sovereign time and space, from empires to republics, from kings to presidents? To what extent can it be resisted or lived otherwise? A profoundly interdisciplinary and ambitious work,Unbearable Life rethinks sovereignty, biopolitics, and political theology to find the radical potential of a life that neither lives or dies.
This review aims to disentangle cause and effect in the relationship between anisometropia and amblyopia. Specifically, we examine the literature for evidence to support different possible ...developmental sequences that could ultimately lead to the presentation of both conditions. The prevalence of anisometropia is around 20% for an inter-ocular difference of 0.5D or greater in spherical equivalent refraction, falling to 2–3%, for an inter-ocular difference of 3D or above. Anisometropia prevalence is relatively high in the weeks following birth, in the teenage years coinciding with the onset of myopia and, most notably, in older adults starting after the onset of presbyopia. It has about one-third the prevalence of bilateral refractive errors of the same magnitude. Importantly, the prevalence of anisometropia is higher in highly ametropic groups, suggesting that emmetropization failures underlying ametropia and anisometropia may be similar.
Amblyopia is present in 1–3% of humans and around one-half to two-thirds of amblyopes have anisometropia either alone or in combination with strabismus. The frequent co-existence of amblyopia and anisometropia at a child's first clinical examination promotes the belief that the anisometropia has caused the amblyopia, as has been demonstrated in animal models of the condition. In reviewing the human and monkey literature however it is clear that there are additional paths beyond this classic hypothesis to the co-occurrence of anisometropia and amblyopia. For example, after the emergence of amblyopia secondary to either deprivation or strabismus, anisometropia often follows. In cases of anisometropia with no apparent deprivation or strabismus, questions remain about the failure of the emmetropization mechanism that routinely eliminates infantile anisometropia. Also, the chronology of amblyopia development is poorly documented in cases of ‘pure’ anisometropic amblyopia. Although indirect, the therapeutic impact of refractive correction on anisometropic amblyopia provides strong support for the hypothesis that the anisometropia caused the amblyopia. Direct evidence for the aetiology of anisometropic amblyopia will require longitudinal tracking of at-risk infants, which poses numerous methodological and ethical challenges. However, if we are to prevent this condition, we must understand the factors that cause it to develop.
To evaluate the impact of target distance on polychromatic image quality in a virtual model eye implanted with hybrid refractive-diffractive intraocular lenses (IOLs).
School of Optometry, Indiana ...University, Bloomington, Indiana, USA.
Experimental study.
A pseudophakic model eye was constructed by incorporating a phase-delay map for a diffractive optical element into a reduced eye model incorporating ocular chromatic aberration, pupil apodization, and higher-order monochromatic aberrations. The diffractive element was a monofocal IOL with a +3.2 diopter (D) diffractive power or 2 types of bifocal IOLs (nonapodized or apodized) with a +2.92 D addition (add) power. Polychromatic point-spread functions and image quality for white and monochromatic light were quantified for a series of target vergences, wavelengths, and pupil diameters using modulation transfer functions and image-quality metrics.
Ocular longitudinal chromatic aberration was largely corrected by the monofocal design and by both bifocal designs for near targets. In the bifocal design, add power and the ratio of distance:near image quality changed significantly with wavelength and pupil size. Also, image quality for distance was better with the apodized design.
Achromatization by the diffractive IOL provided significant improvement in polychromatic retinal image quality. Along with apodization and higher-order aberrations, it can significantly affect the near-distance balance provided by a diffractive multifocal IOL.
No author has a financial or proprietary interest in any material or method mentioned.
Treatment of myopic children with a dual-focus soft contact lens (DFCL; MiSight 1 day) produced sustained slowing of myopia progression over a 6-year period. Significant slowing was also observed in ...children switched from a single vision control to treatment lenses (3 years in each lens).
This study aimed to evaluate the effectiveness of DFCLs in sustaining slowed progression of juvenile-onset myopia over a 6-year treatment period and assess myopia progression in children who were switched to a DFCL at the end of year 3.
Part 1 was a 3-year clinical trial comparing DFCLs with a control contact lens (Proclear 1 day) at four investigational sites. In part 2, subjects completing part 1 were invited to continue for 3 additional years during which all children were treated with MiSight 1 day DFCLs (52 and 56 from the initially treated T6 and control T3 groups, respectively). Eighty-five subjects (45 T3 and 40 T6) completed part 2. Cyclopleged spherical equivalent refractive errors (SEREs) and axial lengths (ALs) were monitored, and a linear mixed model was used to compare their adjusted change annually.
Average ages at part 2 baseline were 13.2 ± 1.3 and 13.0 ± 1.5 years for the T6 and T3 groups, respectively. Slowed myopia progression in the T6 group observed during part 1 was sustained throughout part 2 (mean ± standard error of the mean: change from baseline SERE in diopters, -0.52 ± 0.076 vs. -0.51 ± 0.076; change in AL in millimeters, 0.28 ± 0.033 vs. 0.23 ± 0.033; both P > .05). Comparing progression rates in part 2 for the T6 and T3 groups, respectively, indicates that prior treatment does not influence efficacy (SERE, -0.51 ± 0.076 vs. -0.34 ± 0.077; AL, 0.23 ± 0.03 vs. 0.18 ± 0.03; both P > .05). Within-eye comparisons of AL growth revealed a 71% slowing for the T3 group (3 years older than part 1) and further revealed a small subset of eyes (10%) that did not respond to treatment.
Dual-focus soft contact lenses continue to slow the progression of myopia in children over a 6-year period revealing an accumulation of treatment effect. Eye growth of the initial control cohort with DFCL was slowed by 71% over the subsequent 3-year treatment period.
This article revisits a set of classic political, theological and economic scenes in the (early) modern debate on usury from Luther to Bentham. To summarize, I argue that this theory of usury – which ...polemically mobilizes counter-Aristotelian tropes of the breeding, reproduction and husbandry of money – might also be read as a theory of what Foucault famously calls pastoral power. If this debate nominally concerns the ‘repeal’ of the ancient prohibition against money-lending at interest, I argue that what is really at stake here is the pastoral production of a new theory of the subject as ‘human interest’: a self whose allegedly intrinsic self-interest expresses itself paradigmatically through financial interest. In conclusion, I situate this genealogy of human interest within the larger history of the self-interested, capitalist and indebted subject from Hirschman, through Foucault, to Lazzarato.
The purpose of this study was to test the association between tear film fluorescence changes during tear break-up (TBU) or thinning and the concurrent ocular sensory response.
Sixteen subjects kept ...one eye open as long as possible (MBI), indicated their discomfort level continuously, and rated ocular sensations of irritation, stinging, burning, pricking, and cooling using visual analog scales (VAS). Fluorescence of the tear film was quantified by a pixel-based analysis of the median pixel intensity (PI), TBU, and percentage of dark pixels (DarkPix) over time. A cutoff of 5% TBU was used to divide subjects into either break-up (BU) or minimal break-up (BUmin) groups.
Tear film fluorescence decreased (median PI) and the percentage of TBU and DarkPix increased in all trials, with the rate significantly greater in the BU than the BUmin group (Mann-Whitney U test, P < 0.05). The rate of increasing discomfort during trials was highly correlated with the rate of decrease in median PI and developing TBU (Spearman's, r ≥ 0.70). Significant correlations were found between corneal fluorescence, MBI, and sensory measures.
Concentration quenching of fluorescein dye with tear film thinning best explains decreasing tear film fluorescence during trials. This was highly correlated with increasing ocular discomfort, suggesting that both tear film thinning and TBU stimulate underlying corneal nerves, although TBU produced more rapid stimulation. Slow increases in tear film hyperosmolarity may cause the gradual increase in discomfort during slow tear film thinning, whereas the sharp increases in discomfort during TBU suggest a more complex stimulus.
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