Cardiovascular complications in COVID-19 Long, Brit; Brady, William J.; Koyfman, Alex ...
The American journal of emergency medicine,
07/2020, Letnik:
38, Številka:
7
Journal Article
Recenzirano
Odprti dostop
The coronavirus disease of 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). While systemic inflammation and pulmonary complications can result in ...significant morbidity and mortality, cardiovascular complications may also occur.
This brief report evaluates cardiovascular complications in the setting of COVID-19 infection.
The current COVID-19 pandemic has resulted in over one million infected worldwide and thousands of death. The virus binds and enters through angiotensin-converting enzyme 2 (ACE2). COVID-19 can result in systemic inflammation, multiorgan dysfunction, and critical illness. The cardiovascular system is also affected, with complications including myocardial injury, myocarditis, acute myocardial infarction, heart failure, dysrhythmias, and venous thromboembolic events. Current therapies for COVID-19 may interact with cardiovascular medications.
Emergency clinicians should be aware of these cardiovascular complications when evaluating and managing the patient with COVID-19.
With more than 3 billion users, online social networks represent an important venue for moral and political discourse and have been used to organize political revolutions, influence elections, and ...raise awareness of social issues. These examples rely on a common process to be effective: the ability to engage users and spread moralized content through online networks. Here, we review evidence that expressions of moral emotion play an important role in the spread of moralized content (a phenomenon we call moral contagion). Next, we propose a psychological model called the motivation, attention, and design (MAD) model to explain moral contagion. The MAD model posits that people have group-identity-based motivations to share moral-emotional content, that such content is especially likely to capture our attention, and that the design of social-media platforms amplifies our natural motivational and cognitive tendencies to spread such content. We review each component of the model (as well as interactions between components) and raise several novel, testable hypotheses that can spark progress on the scientific investigation of civic engagement and activism, political polarization, propaganda and disinformation, and other moralized behaviors in the digital age.
Political debate concerning moralized issues is increasingly common in online social networks. However, moral psychology has yet to incorporate the study of social networks to investigate processes ...by which some moral ideas spread more rapidly or broadly than others. Here, we show that the expression of moral emotion is key for the spread of moral and political ideas in online social networks, a process we call “moral contagion.” Using a large sample of social media communications about three polarizing moral/political issues (n = 563,312), we observed that the presence of moral-emotional words in messages increased their diffusion by a factor of 20% for each additional word. Furthermore, we found that moral contagion was bounded by group membership; moral-emotional language increased diffusion more strongly within liberal and conservative networks, and less between them. Our results highlight the importance of emotion in the social transmission of moral ideas and also demonstrate the utility of social network methods for studying morality. These findings offer insights into how people are exposed to moral and political ideas through social networks, thus expanding models of social influence and group polarization as people become increasingly immersed in social media networks.
Contextual sensitivity in scientific reproducibility Van Bavel, Jay J.; Mende-Siedlecki, Peter; Brady, William J. ...
Proceedings of the National Academy of Sciences - PNAS,
06/2016, Letnik:
113, Številka:
23
Journal Article
Recenzirano
Odprti dostop
In recent years, scientists have paid increasing attention to reproducibility. For example, the Reproducibility Project, a large-scale replication attempt of 100 studies published in top psychology ...journals found that only 39% could be unambiguously reproduced. There is a growing consensus among scientists that the lack of reproducibility in psychology and other fields stems from various methodological factors, including low statistical power, researcher’s degrees of freedom, and an emphasis on publishing surprising positive results. However, there is a contentious debate about the extent to which failures to reproduce certain results might also reflect contextual differences (often termed “hidden moderators”) between the original research and the replication attempt. Although psychologists have found extensive evidence that contextual factors alter behavior, some have argued that context is unlikely to influence the results of direct replications precisely because these studies use the same methods as those used in the original research. To help resolve this debate, we recoded the 100 original studies from the Reproducibility Project on the extent to which the research topic of each study was contextually sensitive. Results suggested that the contextual sensitivity of the research topic was associated with replication success, even after statistically adjusting for several methodological characteristics (e.g., statistical power, effect size). The association between contextual sensitivity and replication success did not differ across psychological subdisciplines. These results suggest that researchers, replicators, and consumers should be mindful of contextual factors that might influence a psychological process. We offer several guidelines for dealing with contextual sensitivity in reproducibility.
Numerous polls suggest that COVID-19 is a profoundly partisan issue in the United States. Using the geotracking data of 15 million smartphones per day, we found that US counties that voted for Donald ...Trump (Republican) over Hillary Clinton (Democrat) in the 2016 presidential election exhibited 14% less physical distancing between March and May 2020. Partisanship was more strongly associated with physical distancing than numerous other factors, including counties' COVID-19 cases, population density, median income, and racial and age demographics. Contrary to our predictions, the observed partisan gap strengthened over time and remained when stay-at-home orders were active. Additionally, county-level consumption of conservative media (Fox News) was related to reduced physical distancing. Finally, the observed partisan differences in distancing were associated with subsequently higher COVID-19 infection and fatality growth rates in pro-Trump counties. Taken together, these data suggest that US citizens' responses to COVID-19 are subject to a deep-and consequential-partisan divide.
Coronavirus disease of 2019 (COVID-19) has resulted in millions of cases worldwide. As the pandemic has progressed, the understanding of this disease has evolved.
This first in a two-part series on ...COVID-19 updates provides a focused overview of the presentation and evaluation of COVID-19 for emergency clinicians.
COVID-19, caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), has resulted in significant morbidity and mortality worldwide. Several variants exist, including a variant of concern known as Delta (B.1.617.2 lineage) and the Omicron variant (B.1.1.529 lineage). The Delta variant is associated with higher infectivity and poor patient outcomes, and the Omicron variant has resulted in a significant increase in infections. While over 80% of patients experience mild symptoms, a significant proportion can be critically ill, including those who are older and those with comorbidities. Upper respiratory symptoms, fever, and changes in taste/smell remain the most common presenting symptoms. Extrapulmonary complications are numerous and may be severe, including the cardiovascular, neurologic, gastrointestinal, and dermatologic systems. Emergency department evaluation includes focused testing for COVID-19 and assessment of end-organ injury. Imaging may include chest radiography, computed tomography, or ultrasound. Several risk scores may assist in prognostication, including the 4C (Coronavirus Clinical Characterisation Consortium) score, quick COVID Severity Index (qCSI), NEWS2, and the PRIEST score, but these should only supplement and not replace clinical judgment.
This review provides a focused update of the presentation and evaluation of COVID-19 for emergency clinicians.
Our social media newsfeeds are filled with a variety of content all battling for our limited attention. Across 3 studies, we investigated whether moral and emotional content captures our attention ...more than other content and if this may help explain why this content is more likely to go viral online. Using a combination of controlled lab experiments and nearly 50,000 political tweets, we found that moral and emotional content are prioritized in early visual attention more than neutral content, and that such attentional capture is associated with increased retweets during political conversations online. Furthermore, we found that the differences in attentional capture among moral and emotional stimuli could not be fully explained by differences in arousal. These studies suggest that attentional capture is 1 basic psychological process that helps explain the increased diffusion of moral and emotional content during political discourse on social media, and shed light on ways in which political leaders, disinformation profiteers, marketers, and activist organizations can spread moralized content by capitalizing on natural tendencies of our perceptual systems.
Metastases are the main cause of cancer deaths, but the mechanisms underlying metastatic progression remain poorly understood. We isolated pure populations of cancer cells from primary tumors and ...metastases from a genetically engineered mouse model of human small cell lung cancer (SCLC) to investigate the mechanisms that drive the metastatic spread of this lethal cancer. Genome-wide characterization of chromatin accessibility revealed the opening of large numbers of distal regulatory elements across the genome during metastatic progression. These changes correlate with copy number amplification of the Nfib locus, and differentially accessible sites were highly enriched for Nfib transcription factor binding sites. Nfib is necessary and sufficient to increase chromatin accessibility at a large subset of the intergenic regions. Nfib promotes pro-metastatic neuronal gene expression programs and drives the metastatic ability of SCLC cells. The identification of widespread chromatin changes during SCLC progression reveals an unexpected global reprogramming during metastatic progression.
Display omitted
•SCLC metastases have profound chromatin changes compared to primary tumors•Nfib drives an increase of chromatin accessibility at distal regulatory elements•Nfib is necessary and sufficient for metastatic ability in vivo•Nfib co-opts pro-metastatic neuronal gene expression programs
Global chromatin alterations driven by a key transcriptional regulator promotes metastasis of small cell lung cancer.
How Effective Is Online Outrage? Brady, William J.; Crockett, M.J.
Trends in cognitive sciences,
February 2019, 2019-02-00, 20190201, Letnik:
23, Številka:
2
Journal Article
Online social networks constitute a major platform for the exchange of moral and political ideas, and political elites increasingly rely on social media platforms to communicate directly with the ...public. However, little is known about the processes that render some political elites more influential than others when it comes to online communication. Here, we gauge influence of political elites on social media by examining how message factors (characteristics of the communication) interact with source factors (characteristics of elites) to impact the diffusion of elites' messages through Twitter. We analyzed messages (N = 286,255) sent from federal politicians (presidential candidates, members of the Senate and House of Representatives) in the year leading up to the 2016 U.S. presidential election-a period in which Democrats and Republicans sought to maximize their influence over potential voters. Across all types of elites, we found a "moral contagion" effect: elites' use of moral-emotional language was robustly associated with increases in message diffusion. We also discovered an ideological asymmetry: conservative elites gained greater diffusion when using moral-emotional language compared to liberal elites, even when accounting for extremity of ideology and other source cues. Specific moral emotion expressions related to moral outrage-namely, moral anger and disgust-were impactful for elites across the political spectrum, whereas moral emotion expression related to religion and patriotism were more impactful for conservative elites. These findings help inform the scientific understanding of political propaganda in the digital age, and the antecedents of political polarization in American politics.
PDF
