Commentary: Open your mind to an open pylorus Bremner, Ross M.
The Journal of thoracic and cardiovascular surgery,
September 2022, 2022-09-00, 20220901, Letnik:
164, Številka:
3
Journal Article
Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) causes severe acute respiratory syndrome. mRNA vaccines directed at the SARS-CoV-2 spike protein resulted in development of Abs and ...protective immunity. To determine the mechanism, we analyzed the kinetics of induction of circulating exosomes with SARS-CoV-2 spike protein and Ab following vaccination of healthy individuals. Results demonstrated induction of circulating exosomes expressing spike protein on day 14 after vaccination followed by Abs 14 d after the second dose. Exosomes with spike protein, Abs to SARS-CoV-2 spike, and T cells secreting IFN-γ and TNF-α increased following the booster dose. Transmission electron microscopy of exosomes also demonstrated spike protein Ags on their surface. Exosomes with spike protein and Abs decreased in parallel after four months. These results demonstrate an important role of circulating exosomes with spike protein for effective immunization following mRNA-based vaccination. This is further documented by induction of humoral and cellular immune responses in mice immunized with exosomes carrying spike protein.
Commentary: Can a part be as good as the whole? Bremner, Ross M.
The Journal of thoracic and cardiovascular surgery,
January 2020, 2020-Jan, 2020-01-00, 20200101, Letnik:
159, Številka:
1
Journal Article
Commentary: Making more with less Bremner, Ross M.
The Journal of thoracic and cardiovascular surgery,
December 2019, 2019-12-00, 20191201, Letnik:
158, Številka:
6
Journal Article
Commentary: Less waste—More lives saved Bremner, Ross M.
The Journal of thoracic and cardiovascular surgery,
October 2019, 2019-10-00, 20191001, Letnik:
158, Številka:
4
Journal Article
Commentary: To see, you need the cee-tee Bremner, Ross M.
The Journal of thoracic and cardiovascular surgery,
April 2019, 2019-04-00, 20190401, Letnik:
157, Številka:
4
Journal Article
Commentary: No flow? Quick, re-sew Bremner, Ross M.
The Journal of thoracic and cardiovascular surgery,
June 2019, 2019-06-00, 20190601, Letnik:
157, Številka:
6
Journal Article
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