This article examines the convention in Anabaptist historiography that Menno Simons (1496–1561) and in his wake Dirk Philips (1504–1568) increasingly stabilized the Anabaptist movement and built an ...extensive Anabaptist network in the Habsburg Netherlands/Northern Germany, from Friesland and Groningen to Holland and Flanders in the west and to Westphalia and Schleswig-Holstein to Poland in the east and back. The focus is on the development of Anabaptism on the Lower Rhine, in particular on the de-centralized religious leadership of local, cross-border Anabaptist bishops. It challenges the consensus narrative in the historiography of an alleged central role of Menno and Dirk and demonstrates that during the formative years 1540–1550, Anabaptism on the Lower Rhine and in the Habsburg Netherlands/Northern Germany was polyphonic, represented by itinerant local bishops, each with their own – albeit overlapping – network.
Adam Pastor (ca. 1500–ca. 1565) Brok, Theo
Church history and religious culture,
07/2021, Letnik:
101, Številka:
2-3
Journal Article
Recenzirano
Odprti dostop
Abstract
Adam Pastor was an itinerant Anabaptist bishop in the Lower Rhine region. Ordained by Menno Simons around 1542, he is best known for the division that unfolded between Dirk Philips and Menno ...Simons, which led to the first schism in Mennonitism. Although sixteenth-century contemporaries described him as an important bishop alongside Menno, Mennonite historiography since then has largely ignored him. Pastor’s theological views are known primarily from his
Onderscheytboeck
Book of Distinctions
of ca. 1554. The recent discovery of an earlier and hitherto unknown version of this writing, however, demonstrates a more gradual development of Adam Pastor’s “spiritualism.” In 1547 Pastor opposed Menno’s Melchiorite doctrine of the incarnation. Several years later, he arrived at the inevitable conclusion and denied—at least implicitly—the Trinity. The result was his break with Menno and Dirk and a subsequent division between the bishops from the Northern Netherlands and those of the Lower Rhine.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Adam Pastor (ca. 1500-ca. 1565) Brok, Theo
Church history and religious culture,
07/2021, Letnik:
101, Številka:
2-3
Journal Article
Recenzirano
Odprti dostop
Abstract
Adam Pastor was an itinerant Anabaptist bishop in the Lower Rhine region. Ordained by Menno Simons around 1542, he is best known for the division that unfolded between Dirk Philips and Menno ...Simons, which led to the first schism in Mennonitism. Although sixteenth-century contemporaries described him as an important bishop alongside Menno, Mennonite historiography since then has largely ignored him. Pastor's theological views are known primarily from his Onderscheytboeck Book of Distinctions of ca. 1554. The recent discovery of an earlier and hitherto unknown version of this writing, however, demonstrates a more gradual development of Adam Pastor's "spiritualism." In 1547 Pastor opposed Menno's Melchiorite doctrine of the incarnation. Several years later, he arrived at the inevitable conclusion and denied-at least implicitly-the Trinity. The result was his break with Menno and Dirk and a subsequent division between the bishops from the Northern Netherlands and those of the Lower Rhine.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Structural Equation Modeling (SEM) is a statistical approach to testing hypothesis about the relationships among observed and latent variables. The use of SEM in research has increased in psychology, ...sociology, and economics in recent years. This book presents the collective works on concepts, methodologies and applications of SEM in educational research and practice. The anthology of current research described in this book will be a valuable resource for the next generation educational practitioners.
Tumor-destructing techniques, like radiofrequency ablation (RFA), allow eradication of large tumors. Potentially, in situ tumor destruction also can provide the immune system with an antigen source ...for the induction of antitumor immunity. Antigen-presenting cells could take up antigens in the periphery after which they induce specific immune responses. Recent data show that especially antigen-presenting dendritic cells are crucial for the induction of potent immune responses. However, virtually nothing is known regarding the induction of immune responses after in situ tumor destruction in mice or humans. We used the well-defined murine B16-OVA melanoma cell line to develop a novel tumor model to explore: (a). the immunologic consequences of in situ tumor destruction; and (b). the efficacy of a combination approach of tumor destruction and immunostimulation. Applying this model system we demonstrate that following RFA, a weak but detectable immune response develops, directed against OVA, but also against a broader range of B16 antigens. Adoptive transfer experiments further indicate that antitumor reactivity can be transferred to naïve mice by splenocytes. To augment the response observed, we administered a blocking monoclonal antibody against cytotoxic T-lymphocyte-associated antigen 4 at the time of tumor destruction. Interestingly, this strongly enhanced antitumor immunity, resulting in long-lasting tumor protection. These results illustrate that in situ tumor destruction can provide a useful antigen source for the induction of antitumor immunity, provided that additional immunostimulatory signals are coadministered.
Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumor antigen-loaded mature DC are currently exploited as ...cancer vaccines in clinical studies. However, antigen loading and maturation of DC directly in vivo would greatly facilitate the application of DC-based vaccines. We have previously shown that in situ tumor destruction by ablative treatments efficiently delivers antigens for the in vivo induction of antitumor immunity. In this article, we show that although 20% of the draining lymph node DCs acquire intratumorally injected model antigens after in situ cryoablation, only partial protection against a subsequent tumor rechallenge is observed. However, we also show that a combination treatment of cryoablation plus TLR9 stimulation via CpG-oligodeoxynucleotides is far more effective in the eradication of local and systemic tumors than either treatment modality alone. Analysis of the underlying mechanism revealed that in situ tumor ablation synergizes with TLR9 stimulation to induce DC maturation and efficient cross-presentation in tumor-bearing mice, leading to superior DC function in vivo. Therefore, in situ tumor destruction in combination with CpG-oligodeoxynucleotide administration creates a unique "in situ DC vaccine" that is readily applicable in the clinic.
The TLR9 agonist CpG is increasingly applied in preclinical and clinical studies as a therapeutic modality to enhance tumor immunity. The clinical application of CpG appears, however, less successful ...than would be predicted from animal studies. One reason might be the different administration routes applied in most mouse studies and clinical trials. We studied whether the efficacy of CpG as an adjuvant in cancer immunotherapy is dependent on the route of CpG administration, in particular when the tumor is destructed in situ.
In situ tumor destruction techniques are minimally invasive therapeutic alternatives for the treatment of (nonresectable) solid tumors. In contrast to surgical resection, tumor destruction leads to the induction of weak but tumor-specific immunity that can be enhanced by coapplication of CpG. As in situ tumor destruction by cryosurgery creates an instant local release of antigens, we applied this model to study the efficacy of CpG to enhance antitumor immunity when administrated via different routes: peritumoral, intravenous, and subcutaneous but distant from the tumor. We show that peritumoral administration is superior in the activation of dendritic cells, induction of tumor-specific CTL, and long-lasting tumor protection. Although the intravenous and subcutaneous (at distant site) exposures are commonly used in clinical trials, they only provided partial protection or even failed to enhance antitumor responses as induced by cryosurgery alone.
CpG administration greatly enhances the efficacy of in situ tumor destruction techniques, provided that CpG is administered in close proximity of the released antigens. Hence, this study helps to provide directions to fully benefit from CpG as immune stimulant in a clinical setting.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The differences in function, location, and migratory pattern of conventional dendritic cells (cDC) and plasmacytoid DCs (pDC) not only point to specialized roles in immune responses but also signify ...additive and interdependent relationships required to clear pathogens. We studied the in vivo requirement of cross-talk between cDCs and pDCs for eliciting antitumor immunity against in situ released tumor antigens in the absence or presence of the Toll-like receptor (TLR) 9 agonist CpG. Previous data indicated that CpG boosted tumor-specific T-cell responses after in vivo tumor destruction and increased survival after tumor rechallenges. The present study shows that cDCs are indispensable for cross-presentation of ablation-released tumor antigens and for the induction of long-term antitumor immunity. Depletion of pDCs or applying this model in type I IFN receptor-deficient mice abrogated CpG-mediated responses. CD8α(+) cDCs and the recently identified merocytic cDCs were dependent on pDCs for CpG-induced upregulation of CD80. Moreover, DC transfer studies revealed that merocytic cDCs and CD8α(+) cDCs were most susceptible to pDC help and subsequently promoted tumor-free survival in a therapeutic setting. By transferring wild-type pDCs into TLR9-deficient mice, we finally showed that TLR9 expression in pDCs is sufficient to benefit from CpG as an adjuvant. These studies indicate that the efficacy of CpG in cancer immunotherapy is dependent on cross-talk between pDCs and specific subsets of cDCs.
Based on a review of recent studies and reports, this research investigates attrition among beginning teachers in the Netherlands as well as reasons for teacher attrition, and compares the finding ...with studies on this topic conducted elsewhere in the world. The findings suggest that attrition among beginning teachers in the Netherlands with a percentage close to 15% is somewhat lower than in countries such as the United Kingdom, United States, and Australia. Yet, causes for attrition are comparable to those reported elsewhere. Interestingly, attrition seemed lower for teachers with a teaching degree, suggesting that teacher education may play a vital role in reducing attrition. In addition, it seems that high-quality coaching and supervision, reducing workload, and organizing a social network for beginning teachers may be important factors in reducing attrition. Finally, there is a need for better registration and monitoring of teacher attrition and for more comprehensive research on this topic.
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