Context.
Until recently, the 3D shape, and therefore density (when combining the volume estimate with available mass estimates), and surface topography of the vast majority of the largest (
D
≥ 100 ...km) main-belt asteroids have remained poorly constrained. The improved capabilities of the SPHERE/ZIMPOL instrument have opened new doors into ground-based asteroid exploration.
Aims.
To constrain the formation and evolution of a representative sample of large asteroids, we conducted a high-angular-resolution imaging survey of 42 large main-belt asteroids with VLT/SPHERE/ZIMPOL. Our asteroid sample comprises 39 bodies with
D
≥ 100 km and in particular most
D
≥ 200 km main-belt asteroids (20/23). Furthermore, it nicely reflects the compositional diversity present in the main belt as the sampled bodies belong to the following taxonomic classes: A, B, C, Ch/Cgh, E/M/X, K, P/T, S, and V.
Methods.
The SPHERE/ZIMPOL images were first used to reconstruct the 3D shape of all targets with both the ADAM and MPCD reconstruction methods. We subsequently performed a detailed shape analysis and constrained the density of each target using available mass estimates including our own mass estimates in the case of multiple systems.
Results.
The analysis of the reconstructed shapes allowed us to identify two families of objects as a function of their diameters, namely “spherical” and “elongated” bodies. A difference in rotation period appears to be the main origin of this bimodality. In addition, all but one object (216 Kleopatra) are located along the Maclaurin sequence with large volatile-rich bodies being the closest to the latter. Our results further reveal that the primaries of most multiple systems possess a rotation period of shorter than 6 h and an elongated shape (
c
∕
a
≤ 0.65). Densities in our sample range from ~1.3 g cm
−3
(87 Sylvia) to ~4.3 g cm
−3
(22 Kalliope). Furthermore, the density distribution appears to be strongly bimodal with volatile-poor (
ρ
≥ 2.7 g cm
−3
) and volatile-rich (
ρ
≤ 2.2 g cm
−3
) bodies. Finally, our survey along with previous observations provides evidence in support of the possibility that some C-complex bodies could be intrinsically related to IDP-like P- and D-type asteroids, representing different layers of a same body (C: core; P/D: outer shell). We therefore propose that P/ D-types and some C-types may have the same origin in the primordial trans-Neptunian disk.
Background Checkpoint blockade immunotherapy has improved metastatic cancer patient survival, but response rates remain low. There is an unmet need to identify mechanisms and tools to circumvent ...resistance. In human patients, responses to checkpoint blockade therapy correlate with tumor mutation load, and intrinsic resistance associates with pre-treatment signatures of epithelial mesenchymal transition (EMT), immunosuppression, macrophage chemotaxis and TGFbeta signaling. Methods To facilitate studies on mechanisms of squamous cell carcinoma (SCC) evasion of checkpoint blockade immunotherapy, we sought to develop a novel panel of murine syngeneic SCC lines reflecting the heterogeneity of human cancer and its responses to immunotherapy. We characterized six Kras-driven cutaneous SCC lines with a range of mutation loads. Following implantation into syngeneic FVB mice, we examined multiple tumor responses to alpha-PD-1, alpha-TGFbeta or combinatorial therapy, including tumor growth rate and regression, tumor immune cell composition, acquired tumor immunity, and the role of cytotoxic T cells and Tregs in immunotherapy responses. Results We show that alpha-PD-1 therapy is ineffective in establishing complete regression (CR) of tumors in all six SCC lines, but causes partial tumor growth inhibition of two lines with the highest mutations loads, CCK168 and CCK169. alpha-TGFbeta monotherapy results in 20% CR and 10% CR of established CCK168 and CCK169 tumors respectively, together with acquisition of long-term anti-tumor immunity. alpha-PD-1 synergizes with alpha-TGFbeta, increasing CR rates to 60% (CCK168) and 20% (CCK169). alpha-PD-1 therapy enhances CD4 + Treg/CD4 + Th ratios and increases tumor cell pSmad3 expression in CCK168 SCCs, whereas alpha-TGFbeta antibody administration attenuates these effects. We show that alpha-TGFbeta acts in part through suppressing immunosuppressive Tregs induced by alpha-PD-1, that limit the anti-tumor activity of alpha-PD-1 monotherapy. Additionally, in vitro and in vivo, alpha-TGFbeta acts directly on the tumor cell to attenuate EMT, to activate a program of gene expression that stimulates immuno-surveillance, including up regulation of genes encoding the tumor cell antigen presentation machinery. Conclusions We show that alpha-PD-1 not only initiates a tumor rejection program, but can induce a competing TGFbeta-driven immuno-suppressive program. We identify new opportunities for alpha-PD-1/alpha-TGFbeta combinatorial treatment of SCCs especially those with a high mutation load, high CD4+ T cell content and pSmad3 signaling. Our data form the basis for clinical trial of alpha-TGFbeta/alpha-PD-1 combination therapy (NCT02947165). Keywords: Checkpoint blockade, Squamous cell carcinoma, Tumor mutation load, alpha-TGFbeta /alpha-PD-1 combinatorial immunotherapy, Tregs, pSmad signaling, Epithelial mesenchymal transition (EMT)
ABSTRACT
We report the discovery with the Transiting Exoplanet Survey Satellite (TESS) of a third set of eclipses from V994 Herculis (V994 Her, TIC 424508303), previously only known as a doubly ...eclipsing system. The key implication of this discovery and our analyses is that V994 Her is the second fully characterized (2+2) + 2 sextuple system, in which all three binaries eclipse. In this work, we use a combination of ground-based observations and TESS data to analyse the eclipses of binaries A and B in order to update the parameters of the inner quadruple’s orbit (with a derived period of 1062 ± 2 d). The eclipses of binary C that were detected in the TESS data were also found in older ground-based observations, as well as in more recently obtained observations. The eclipse timing variations of all three pairs were studied in order to detect the mutual perturbations of their constituent stars, as well as those of the inner pairs in the (2 + 2) core. At the longest periods they arise from apsidal motion, which may help constraining parameters of the component stars’ internal structure. We also discuss the relative proximity of the periods of binaries A and B to a 3:2 mean motion resonance. This work represents a step forward in the development of techniques to better understand and characterize multiple star systems, especially those with multiple eclipsing components.
Context.
The recent estimates of the 3D shape of the M/Xe-type triple asteroid system (216) Kleopatra indicated a density of ~5 g cm
−3
, which is by far the highest for a small Solar System body. ...Such a high density implies a high metal content as well as a low porosity which is not easy to reconcile with its peculiar “dumbbell” shape.
Aims.
Given the unprecedented angular resolution of the VLT/SPHERE/ZIMPOL camera, here, we aim to constrain the mass (via the characterization of the orbits of the moons) and the shape of (216) Kleopatra with high accuracy, hence its density.
Methods.
We combined our new VLT/SPHERE observations of (216) Kleopatra recorded during two apparitions in 2017 and 2018 with archival data from the W. M. Keck Observatory, as well as lightcurve, occultation, and delay-Doppler images, to derive a model of its 3D shape using two different algorithms (ADAM, MPCD). Furthermore, an
N
-body dynamical model allowed us to retrieve the orbital elements of the two moons as explained in the accompanying paper.
Results.
The shape of (216) Kleopatra is very close to an equilibrium dumbbell figure with two lobes and a thick neck. Its volume equivalent diameter (118.75 ± 1.40) km and mass (2.97 ± 0.32) × 10
18
kg (i.e., 56% lower than previously reported) imply a bulk density of (3.38 ± 0.50) g cm
−3
. Such a low density for a supposedly metal-rich body indicates a substantial porosity within the primary. This porous structure along with its near equilibrium shape is compatible with a formation scenario including a giant impact followed by reaccumulation. (216) Kleopatra’s current rotation period and dumbbell shape imply that it is in a critically rotating state. The low effective gravity along the equator of the body, together with the equatorial orbits of the moons and possibly rubble-pile structure, opens the possibility that the moons formed via mass shedding.
Conclusions.
(216) Kleopatra is a puzzling multiple system due to the unique characteristics of the primary. This system certainly deserves particular attention in the future, with the Extremely Large Telescopes and possibly a dedicated space mission, to decipher its entire formation history.
Asteroid families are the byproducts of catastrophic collisions whose fragments form clusters in proper semimajor axis, eccentricity, and inclination space. Although many families have been observed ...in the main asteroid belt, only two very young families, Karin and Veritas, have well-determined ages. The ages of other families are needed, however, if we hope to infer information about their ejection velocity fields, space weathering processes, etc. In this paper, we developed a method that allows us to estimate the ages of moderately young asteroid families (approximately in between 0.1 and 1 Gyr). We apply it to four suitable cases—Erigone, Massalia, Merxia, and Astrid—and derive their likely ages and approximate ejection velocity fields. We find that Erigone and Merxia were produced by large catastrophic disruption events (i.e., parent body ⩾100 km) that occurred approximately 280 and 330 Myr ago, respectively. The Massalia family was likely produced by a cratering event on Asteroid (20) Massalia less than 200 Myr ago. Finally, the Astrid family, which was produced by the disruption of a 60–70 km asteroid, is 100–200 Myr old, though there is considerable uncertainty in this result. We estimate that the initial ejection velocities for these families were only a few tens of meters per second, consistent with numerical hydrocode models of asteroid impacts. Our results help to verify that asteroid families are constantly undergoing dynamical orbital evolution from thermal (Yarkovsky) forces and spin vector evolution from thermal (YORP) torques.
Aims.
Asteroid (31) Euphrosyne is one of the biggest objects in the asteroid main belt and it is also the largest member of its namesake family. The Euphrosyne family occupies a highly inclined ...region in the outer main belt and contains a remarkably large number of members, which is interpreted as an outcome of a disruptive cratering event.
Methods.
The goals of this adaptive-optics imaging study are threefold: to characterize the shape of Euphrosyne, to constrain its density, and to search for the large craters that may be associated with the family formation event.
Results.
We obtained disk-resolved images of Euphrosyne using SPHERE/ZIMPOL at the ESO 8.2 m VLT as part of our large program (ID: 199.C-0074, PI: Vernazza). We reconstructed its 3D shape via the
ADAM
shape modeling algorithm based on the SPHERE images and the available light curves of this asteroid. We analyzed the dynamics of the satellite with the
Genoid
meta-heuristic algorithm. Finally, we studied the shape of Euphrosyne using hydrostatic equilibrium models.
Conclusions.
Our SPHERE observations show that Euphrosyne has a nearly spherical shape with the sphericity index of 0.9888 and its surface lacks large impact craters. Euphrosyne’s diameter is 268 ± 6 km, making it one of the top ten largest main belt asteroids. We detected a satellite of Euphrosyne – S/2019 (31) 1 – that is about 4 km across, on a circular orbit. The mass determined from the orbit of the satellite together with the volume computed from the shape model imply a density of 1665 ± 242 kg m
−3
, suggesting that Euphrosyne probably contains a large fraction of water ice in its interior. We find that the spherical shape of Euphrosyne is a result of the reaccumulation process following the impact, as in the case of (10) Hygiea. However, our shape analysis reveals that, contrary to Hygiea, the axis ratios of Euphrosyne significantly differ from those suggested by fluid hydrostatic equilibrium following reaccumulation.
Aims.
To interpret adaptive-optics observations of (216) Kleopatra, we need to describe an evolution of multiple moons orbiting an extremely irregular body and include their mutual interactions. Such ...orbits are generally non-Keplerian and orbital elements are not constants.
Methods.
Consequently, we used a modified
N
-body integrator, which was significantly extended to include the multipole expansion of the gravitational field up to the order
ℓ
= 10. Its convergence was verified against the ‘brute-force’ algorithm. We computed the coefficients
C
ℓm
,
S
ℓm
for Kleopatra’s shape, assuming a constant bulk density. For Solar System applications, it was also necessary to implement a variable distance and geometry of observations. Our
χ
2
metric then accounts for the absolute astrometry, the relative astrometry (second moon with respect to the first), angular velocities, and silhouettes, constraining the pole orientation. This allowed us to derive the orbital elements of Kleopatra’s two moons.
Results.
Using both archival astrometric data and new VLT/SPHERE observations (ESO LP 199.C-0074), we were able to identify the true periods of the moons,
P
1
= (1.822359 ± 0.004156) d,
P
2
= (2.745820 ± 0.004820) d. They orbit very close to the 3:2 mean-motion resonance, but their osculating eccentricities are too small compared to other perturbations (multipole, mutual), meaning that regular librations of the critical argument are not present. The resulting mass of Kleopatra,
m
1
= (1.49 ± 0.16) × 10
−12
M
⊙
or 2.97 × 10
18
kg, is significantly lower than previously thought. An implication explained in the accompanying paper is that (216) Kleopatra is a critically rotating body.
Two modules of the AD detector have been studied with the test beam at the T10 facility at CERN. The AD detector is made of scintillator pads read out by wave-length shifters (WLS) coupled to clean ...fibres that carry the produced light to photo-multiplier tubes (PMTs). In ALICE the AD is used to trigger and study the physics of diffractive and ultra-peripheral collisions as well as for a variety of technical tasks like beam-gas background monitoring or as a luminometer. \par The position dependence of the modules' efficiency has been measured and the effect of hits on the WLS or PMTs has been evaluated. The charge deposited by pions and protons has been measured at different momenta of the test beam. The time resolution is determined as a function of the deposited charge. These results are important ingredients to better understand the AD detector, to benchmark the corresponding simulations, and very importantly they served as a baseline for a similar device, the Forward Diffractive Detector (FDD), being currently built and that will be in operation in ALICE during the LHC Runs 3 and 4.
Context. Asteroid (7) Iris is an ideal target for disk-resolved imaging owing to its brightness (V ~ 7–8) and large angular size of 0.33′′ during its apparitions. Iris is believed to belong to the ...category of large unfragmented asteroids that avoided internal differentiation, implying that its current shape and topography may record the first few 100 Myr of the solar system’s collisional evolution. Aims. We recovered information about the shape and surface topography of Iris from disk-resolved VLT/SPHERE/ZIMPOL images acquired in the frame of our ESO large program. Methods. We used the All-Data Asteroid Modeling (ADAM) shape reconstruction algorithm to model the 3D shape of Iris, using optical disk-integrated data and disk-resolved images from SPHERE and earlier AO systems as inputs. We analyzed the SPHERE images and our model to infer the asteroid’s global shape and the morphology of its main craters. Results. We present the 3D shape, volume-equivalent diameter Deq = 214 ± 5 km, and bulk density ρ = 2.7 ± 0.3 g cm−3 of Iris. Its shape appears to be consistent with that of an oblate spheroid with a large equatorial excavation. We identified eight putative surface features 20–40 km in diameter detected at several epochs, which we interpret as impact craters, and several additional crater candidates. Craters on Iris have depth-to-diameter ratios that are similar to those of analogous 10 km craters on Vesta. Conclusions. The bulk density of Iris is consistent with that of its meteoritic analog based on spectroscopic observations, namely LL ordinary chondrites. Considering the absence of a collisional family related to Iris and the number of large craters on its surface, we suggest that its equatorial depression may be the remnant of an ancient (at least 3 Gyr) impact. Iris’s shape further opens the possibility that large planetesimals formed as almost perfect oblate spheroids. Finally, we attribute the difference in crater morphology between Iris and Vesta to their different surface gravities, and the absence of a substantial impact-induced regolith on Iris.
Context. The larger number of models of asteroid shapes and their rotational states derived by the lightcurve inversion give us better insight into both the nature of individual objects and the whole ...asteroid population. With a larger statistical sample we can study the physical properties of asteroid populations, such as main-belt asteroids or individual asteroid families, in more detail. Shape models can also be used in combination with other types of observational data (IR, adaptive optics images, stellar occultations), e.g., to determine sizes and thermal properties. Aims. We use all available photometric data of asteroids to derive their physical models by the lightcurve inversion method and compare the observed pole latitude distributions of all asteroids with known convex shape models with the simulated pole latitude distributions. Methods. We used classical dense photometric lightcurves from several sources (Uppsala Asteroid Photometric Catalogue, Palomar Transient Factory survey, and from individual observers) and sparse-in-time photometry from the U.S. Naval Observatory in Flagstaff, Catalina Sky Survey, and La Palma surveys (IAU codes 689, 703, 950) in the lightcurve inversion method to determine asteroid convex models and their rotational states. We also extended a simple dynamical model for the spin evolution of asteroids used in our previous paper. Results. We present 119 new asteroid models derived from combined dense and sparse-in-time photometry. We discuss the reliability of asteroid shape models derived only from Catalina Sky Survey data (IAU code 703) and present 20 such models. By using different values for a scaling parameter cYORP (corresponds to the magnitude of the YORP momentum) in the dynamical model for the spin evolution and by comparing synthetic and observed pole-latitude distributions, we were able to constrain the typical values of the cYORP parameter as between 0.05 and 0.6.
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