The didactic lecture is a well-established but contentious practice in higher education. It is an essentially mono-directional experience delivered in purposefully designed spaces that entrench modes ...of learning and expected behaviours by both staff and students. This paper will challenge the ongoing primacy of the didactic lecture in higher education and posit a dialogical alternative that supports students to interact and connect at scale through the creation of social spaces. A case study of a program at the University of Sydney Business School will interrogate the role of technology in simulating an immersive hyperreality for students in large-group teaching settings that blurs the boundaries of disciplinary knowledge and the abstractions and realties of their work, life, play and learning.
Entrepreneurial ventures need frequently to adapt. Yet their adaptive capacity is often limited by the legacies of imprinted founding characteristics. The question then arises whether it is possible ...to explain and manage the imprinting process so that the capacity to adapt is enhanced, rather than diminished. I address this question by developing a model of the microfoundations of imprinting based in collective memory. I argue that entrepreneurial founding teams naturally develop transactive autobiographical memory systems. By partially managing the design and imprinting of these memory systems, I argue that founders may improve their venture's long–term capacity to adapt.
Most, but not all cnidarian species in the class Hydrozoa have a life cycle in which a colonial, asexually reproducing hydroid phase alternates with a free-swimming, sexually reproducing medusa ...phase. They are not well known, in part because many of them are microscopic, at least in the medusa phase. Matching the two phases has previously required rearing of the organism from one phase to another, which has not often been possible. Here we show that DNA barcoding makes it possible to easily link life-cycle phases without the need for laboratory rearing. Hydrozoan medusae were collected by zooplankton tows in Newport Bay and the Pacific Ocean near Newport Beach, California, and hydroid colonies were collected from solid substrates in the same areas. Specimens were documented by videomicroscopy, preserved in ethanol, and sent to the Canadian Centre for DNA Barcoding at the University of Guelph, Ontario, Canada for sequencing of the COI DNA barcode. In the order Anthoathecata (athecate hydroids), DNA barcoding allowed for the discrimination between the medusae of eight putative species of Bougainvillia, and the hydroid stages were documented for two of these. The medusae of three putative species of Amphinema were identified, and the hydroid stages were identified for two of them. DNA barcodes were obtained from medusae of one species of Cladonema, one adult of the by-the wind Sailor, Velella velella, five putative species of Corymorpha with the matching hydroid phase for one; and Coryne eximia, Turritopsis dohrnii and Turritopsis nutricula with the corresponding hydroid phases. The actinula larvae and hydroid for the pink-hearted hydroid Ectopleura crocea were identified and linked by DNA barcoding. In the order Leptothecata (thecate hydroids) medusae were identified for Clytia elsaeoswaldae, Clytia gracilis and Clytia sp. 701 AC and matched with the hydroid phases for the latter two species. Medusae were matched with the hydroid phases for two species of Obelia (including O. dichotoma) and Eucheilota bakeri. Obelia geniculata was collected as a single hydroid. DNA barcodes were obtained for hydroids of Orthopyxis everta and three other species of Orthopyxis. One member of the family Solmarisidae, representing the order Narcomedusae, and one member (Liriope tetraphylla) of the order Trachymedusae were recognized as medusae. The results show the utility of DNA barcoding for matching life-cycle stages as well as for documenting the diversity of this class of organisms.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Over the last 10 years there have been increasing concerns raised of a potential skills gap in field of radiation protection. Noting these concerns in 2019 the Society for Radiological Protection, ...the UK's Chartered Professional Body, launched a study to determine the radiation protection demand in the UK going forward along with the capacity of the profession. The initial results show that over 50% of the SRP membership retires in the next 10 -15 years, coupled with an increase in radiation protection demand across the nuclear fuel cycle, medical sector and advancement of new technologies or applications requiring radiation protection advice. This provides strong evidence supporting the concerns of a future skills gap. This paper presents a framework highlighting 3 core objectives that need to be met to resolve the skills gap. A review of the existing initiatives being undertaken by the Society of Radiological Protection to meet these objectives is included identifying both areas of good practice and areas for further work or development. A key theme to tackling this challenge has been identified as the need to foster greater collaboration between RP professionals, and organisations both within the UK and abroad, such as IRPA, the National Societies, Employers, Academia and Industry. This brings the unique opportunity of directing efforts and resources to a common goal, and allowing the sharing of good practice, whilst reducing the strain and burden on any one organisation. Another key output of the review was the need to embrace new and innovative solutions to developing our profession and importantly inspiring and communicating to the future of the profession.
The authors report data from a longitudinal study that addresses the relations between working memory capacity and reading comprehension skills in children aged 8, 9, and 11 years. At each time ...point, the authors assessed children's reading ability, vocabulary and verbal skills, performance on 2 working memory assessments (sentence-span and digit working memory), and component skills of comprehension. At each time point, working memory and component skills of comprehension (inference making, comprehension monitoring, story structure knowledge) predicted unique variance in reading comprehension after word reading ability and vocabulary and verbal ability controls. Further analyses revealed that the relations between reading comprehension and both inference making and comprehension monitoring were not wholly mediated by working memory. Rather, these component skills explained their own unique variance in reading comprehension.
The life cycles and biodiversity of Pacific coast gastropods were analyzed by videomicroscopy and DNA barcoding of individuals collected from tide pools and in plankton nets from a variety of shore ...stations. In many species (Families Calyptraeidae, Cerithiopsidae, Strombidae, Vermetidae, Columbellidae, Nassariidae, Olivellidae, Hermaeidae, Onchidorididae, Gastropteridae, Haminoeidae), the free-swimming veligers were recovered from plankton collections; in Roperia poulsoni (family Muricidae) veligers were usually recovered from egg sacs where they had been retained although some escapees were found in plankton collections; in Pteropurpura festiva (family Muricidae) free-living veligers were also found; and in Atlanta californiensis (family Atlantidae) both veligers and adults were obtained from plankton collections making this a holoplanktonic species. The results confirm that DNA barcoding based on COI gene sequencing is a useful strategy to match life-cycle stages within species as well as to identify species and to document the level of biodiversity within the gastropods.
This open access book will examine the implications of digitalization for the understanding of humanity, conceived as a community of intelligent agency. It addresses important topics across a range ...of social and behavioral theories and identifies a range of novel mechanisms and their social behavioral effects. Across the book, the author highlights the expansion of intelligent processing capability brought about by digitalization and the challenges this exposes for integrating artificial and human capabilities. It includes the altered effects of bounded rationality in problem solving and decision making; related changes in the perception of rationality, plus novel myopias and biases. It also seeks to address cognitive intersubjectivity, learning from performance and agentic self-generation; and the novel methods and patterns of reasoned thought which emerge in a digitalized world; and how these mechanisms will combine in making and remaking the world of human experience and understanding. This book examines the problematics and prospects for digitally augmented humanity. In doing so, it maps the terrain for a future science of augmented agency. It will have cross-disciplinary appeal to students and scholars of applied psychology, cognitive and behavioral science, organizational psychology and management, business, finance, and digital cultures and humanities.
Drosophila imaginal disc growth factor 2 (IDGF2) is a member of chitinase-like protein family (CLPs) able to induce the proliferation of imaginal disc cells in vitro. In this study we characterized ...physiological concentrations and expression of IDGF2 in vivo as well as its impact on the viability and transcriptional profile of Drosophila cells in vitro. We show that IDGF2 is independent of insulin and protects cells from death caused by serum deprivation, toxicity of xenobiotics or high concentrations of extracellular adenosine (Ado) and deoxyadenosine (dAdo). Transcriptional profiling suggested that such cytoprotection is connected with the induction of genes involved in energy metabolism, detoxification and innate immunity. We also show that IDGF2 is an abundant haemolymph component, which is further induced by injury in larval stages. The highest IDGF2 accumulation was found at garland and pericardial nephrocytes supporting its role in organismal defence and detoxification. Our findings provide evidence that IDGF2 is an important trophic factor promoting cellular and organismal survival.
We recently discovered an inherited cancer syndrome caused by BRCA1-Associated Protein 1 (BAP1) germline mutations, with high incidence of mesothelioma, uveal melanoma and other cancers and very high ...penetrance by age 55. To identify families with the BAP1 cancer syndrome, we screened patients with family histories of multiple mesotheliomas and melanomas and/or multiple cancers. We identified four families that shared an identical BAP1 mutation: they lived across the US and did not appear to be related. By combining family histories, molecular genetics, and genealogical approaches, we uncovered a BAP1 cancer syndrome kindred of ~80,000 descendants with a core of 106 individuals, whose members descend from a couple born in Germany in the early 1700s who immigrated to North America. Their descendants spread throughout the country with mutation carriers affected by multiple malignancies. Our data show that, once a proband is identified, extended analyses of these kindreds, using genomic and genealogical studies to identify the most recent common ancestor, allow investigators to uncover additional branches of the family that may carry BAP1 mutations. Using this knowledge, we have identified new branches of this family carrying BAP1 mutations. We have also implemented early-detection strategies that help identify cancers at early-stage, when they can be cured (melanomas) or are more susceptible to therapy (MM and other malignancies).
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Across the world, we are seeing a resurgence in Nuclear New Build. In the UK alone, plans are under way for the construction of 10 new reactors, using 4 different reactor designs all of which are to ...be provided by foreign vendors, and operated by 3 newly formed licensees within the UK. As these new licensees embark on the task of establishing themselves and progressing the design and build of these reactors, there are challenges faced in integrating the Radiation Protection Requirements and Culture from the various Foreign Investors and Vendors into the UK 'Context'. The following paper identifies the origin of the Radiation Protection Requirements within the UK and foreign investor/vendor countries, in an attempt to integrate them into the UK licensing and approval process. Thus, allowing due credit to be taken for the regulatory regime of the foreign countries where these reactors originate.
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