Abstract
In the present work, we study the Timepix2 pixels’ high energy response in the so-called adaptive gain mode. Therefore, Timepix2 with a 500 μm thick silicon sensor was irradiated with ...protons of energies in the range from 400 keV to 2 MeV and
α
-particles of 5.5 MeV from
241
Am. A novel method was developed to determine the energy deposit in single pixels of particle imprints, which are spread out over a set of neighbor pixels (cluster). We show that each pixel is capable of measuring the deposited energy from 4 keV up to ∼3.2 MeV. Reconstructing the full energy content of the clusters, we found relative energy resolutions (
σ
E
) better than 2.7% and better than 4% for proton and
α
-particle data, respectively. In a simple experiment with a 5.5 MeV
α
-particle source, we demonstrate that energy losses in thin (organic) specimen can be spatially resolved, mapping out sample thickness variations, with a resolution around 1–2 μm, across the sensor area. The inherent spatial resolution of the device was determined to be 350 nm in the best case.
Abstract
Fast, incremental evolution of physics instrumentation raises the question of efficient software abstraction and transferability of algorithms across similar technologies. This contribution ...aims to provide an answer by introducing Track Lab, a modern data acquisition program focusing on extensibility and high performance. Shipping with documented API and more than 20 standard modules, Track Lab allows complex analysis pipelines to be constructed from simple, reusable building blocks. Thanks to multi-threaded infrastructure, data can be clustered, filtered, aggregated and plotted concurrently in real-time. In addition, full hardware support for Timepix2, Timepix3 pixel detectors and embedded photomultiplier systems enables such analysis to be carried out online during data acquisition. Repetitive procedures can be automated with support for motorized stages and X-ray tubes. Freely distributed on 7 popular operating systems and 2 CPU architectures, Track Lab is a versatile tool for high energy physics research.
Abstract
The present manuscript describes a comprehensive characterization of a novel highly segmented 5 mm CZT sensor attached to Timepix3. First, the sensor’s IV curve was measured and basic sensor ...characterization was done with laboratory
γ
-radiation sources. The sensor resistivity was determined to be (0.155± 0.02) GOhm · cm. The sensor showed decent homogeneity, both for the per-pixel count rate and electron mobility-lifetime product
μ
e
τ
e
. The latter was measured to be
μ
e
τ
e
¯
= 1.3 × 10
−3
cm
2
/V with a standard deviation
σ
= 0.4 × 10
−3
cm
2
/V describing the dispersion of values for different pixels. The basic sensor characterization is complemented by measurements at grazing angle in a 120 GeV/
c
at the CERN’s Super Proton Synchrotron. The penetrating nature of these particles together with the pixelation of the sensor allows for a determination of the charge collection efficiency (CCE), as well as charge carrier drift properties (drift times, lateral charge cloud expansion) as a function of the interaction depths in the sensor. While CCE drops by 30%–40% towards the cathode side of the sensor, from the drift time dependency on interaction depth, the electron mobility
μ
e
was extracted to be (944.8 ± 1.3) cm
2
/V/s and
τ
e
= (1.38 ± 0.31)
μ
s. The spectroscopic performance was assessed in photon fields and extracted from energy loss spectra measured at different angles in the pion beam. While at photon energies below 120 keV incomplete charge collection leads to an underestimation of the photon energy when irradiated from the front-side, at higher energies the relative energy resolution was found to be ∼4.5%, while a relative energy resolution of ∼7.5% was found for the particle energy loss spectra. It is shown that the drift time information can be used to reconstruct particle interactions in the sensor in 3D, providing a spatial resolution of
σ
xyz
= 241
μ
m within the sensor volume and a particle trajectory measurement precision Δ
xyz
= 100
μ
m, at a distance of 1 m from the sensor. We demonstrate by measurement with a
22
Na source, that the energy resolution combined with the 3D reconstruction allows for detection of
γ
-ray source location and polarity using Compton scattering within the sensor (Compton camera and scatter polarimeter).
The Timepix3—the latest generation of hybrid particle pixel detectors of Medipix family—yields a lot of new possibilities, i.e. a high hit-rate, a time resolution of 1.56 ns, event data-driven ...readout mode, and the capability of measuring the Time-over-Threshold (ToT - energy) and the Time-of-Arrival (ToA) simultaneously. This paper introduces a newly developed readout device for the Timepix3, called "Katherine", featuring a Gigabit Ethernet interface. The primary benefit of the Katherine is the operation of Timepix3 at long distance (up to 100 m) from computer or server, which is advantageous for the installation at beam lines, where the access is difficult or where radiation levels are too high for human interventions. The maximal hit-rate is limited by the bandwidth of the Ethernet connection (peer-to-peer connection; up to 16 Mhit/s). Since the Katherine interface is equipped with a processor of high computational power (ARM Cortex-A9 dual-core processor), it permits the use as a stand-alone (autonomous) radiation detector. The key features of the device are described in detail. These are the implemented high voltage power supply offering both polarities of bias voltage (up to ±300 V), the automatic data sending to a sever via SSH, the automatic compensation of ToA values from columns with shifted matrix clock, etc. A dedicated control software was developed, which can be used for the detector preparation (sensor equalization, the DACs dependency scan, and the THL scan) and measurement control. Measured energy spectra from photon fields are shown.
Four hybrid pixel detectors of Timepix3 technology, installed in the ATLAS experiment, were continuously taking data from April 2018 until the end of the Run-2 data taking period (December 2019). ...These detectors are synchronized with each other and the LHC orbit clock. They are capable of resolving the bunch structure of the LHC beams due to their time resolution of ∼2ns. Thus, they allow the characterization of the radiation field inside and outside bunch-crossing periods. This is shown for Timepix3 detectors at the extended barrel (x=-3.58 m, y=0.97 m, z=2.83 m). We apply pattern recognition methods to decompose the radiation field and determine the directionality of the minimum ionizing particles (MIP) component of the radiation field.
The Timepix3 readout chip—the latest member of the Medipix family of hybrid pixel detectors—brought several new functionalities in comparison with the older Timepix, i.e. a high hit-rate, a time ...granularity of 1.5625 ns, a data-driven readout scheme (with a per pixel dead time of approximately 475 ns), and the capability of measuring Time-over-Threshold (ToT) and Time-of-Arrival (ToA) in each pixel at the same time. However, the high power consumption of the Timepix3 in the standard setting prevents its use in applications with limited power budget. Moreover, the high power consumption poses the risk of overheating the sensor so that proper cooling is crucial. The presented work investigates the effect of different settings in the analogue and a digital part of the Timepix3 detector on its power consumption. Measurements were performed with the Timepix3 chipboard. The firmware of the Katherine readout was modified so that the user can monitor the power consumptions of analogue and digital part “on-line” (directly in the control software). In standard settings, a power consumption of approximately 1.3 W was found. By changes of internal DACs, the consumption could be reduced to 650 mW. Further reduction was achieved by the change of the clock management in the digital part of the Timepix3. In result, a power consumption of 216 mA could be achieved. In these low power settings, the ToA clock was reduced to 10 MHz and thus the time binning was 100 ns. The energy resolution was not affected significantly. The pixel dead time is also negatively affected when the matrix clock is reduced. In the case of 10 MHz, the minimal per pixel dead time is 1.9 μs.
This paper introduces a readout system for the Timepix2. Firstly, this chip is described and the readout modes are discussed in detail. The new readout system presented is based on the Gigabit ...Ethernet interface and implements pre-processing, i.e. decoding of the raw pixel data, directly in the hardware. The device suppresses zero pixels, so that only useful data are sent to the computer/server. In a special independent mode, the readout can send completed data files to a remote server via SSH and does not need to use a control software. In island mode, the device stores measured data to a local storage (SD card). The process of calibration and its results are also discussed. An energy resolution of approximately 1.5 keV was achieved for 60 keV gamma-rays from an 241Am source. We present enhanced features of the readout system facilitating measurements and data evaluation, such as the HW support of clustering and Matrix Occupation Control. The former implements the pixel clustering directly in the hardware and sends energy calibrated results of the cluster finding algorithm to the computer. The latter automatically controls acquisition time of detector in order to reduce cluster overlapping. Measurements with Timepix2 are presented in iron and electron test beams. Results show that pixels of Timepix2 saturate at a per-pixel energy deposition of 1.9 MeV.
Abstract
Timepix3 pixel detectors have demonstrated great potential for tracking applications. With 256 × 256 pixels, 55 µm pitch and improved resolution in time (1.56 ns) and energy (2 keV at 60 ...keV), they have become powerful instruments for characterization of unknown radiation fields. A crucial pre-processing step for such analysis is the determination of particle trajectories in 3D space from individual tracks. This study presents a comprehensive comparison of regression methods that tackle this task under the assumption of track linearity. The proposed methods were first evaluated on a simulation and assessed by their accuracy and computational time. Selected methods were then validated with a real-world dataset, which was measured in a well-known radiation field. Finally, the presented methods were applied to experimental data from the Large Hadron Collider. The best-performing methods achieved a mean absolute error of 1.99° and 3.90° in incidence angle
θ
and azimuth
φ
, respectively. The fastest presented method required a mean computational time of 0.02 ps per track. For all experimental applications, we present angular maps and stopping power spectra.
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological ...activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones. Sporothrix schenckii, the causing agent of Sporotrichosis (most common subcutaneous mycosis in Latin America), is dimorphic fungus, of saprophytic life in soil or plants, infecting people and animals mainly through skin injuries and bruises. The main of this work was to evaluate the influence of garlic consuming on immune modulation of healthy and infected Swiss mice in induced way by S. schenckii, since these animals functioning of peritoneal macrophages as well as the nitric oxide and cytokines' production (IL-1β, IL-10 and IL-12) and to evaluate the antifungal potential of garlic with S. schenckii through minimum inhibitory concentration test and colony-forming units. The results showed that garlic offers antifungal potential with S. schenckii. The oral taking of garlic extracts influences the releasing of cytokines by macrophages, regular consuming shows anti-inflammatory effect, and its acute use may take to an inflammatory response. Mice that consumed garlic responded more effectively to fight against the infection.
Abstract
The response of a Timepix3 (256 × 256 pixels, pixel pitch 55 μm) detector with a 500 μm thick HR GaAs:Cr sensor was studied in proton beams of 125 MeV at the Danish Centre for Particle ...Therapy in Aarhus, Denmark and in a 120 GeV/
c
pion beam at the Super-Proton Synchrotron (SPS) at CERN. The sensor was biased at different voltages and irradiated at different angles. The readout chip was configured to operate in electron and hole collection modes. Measurements at grazing angles allowed to see elongated tracks with well-defined impact and exit points, so that charge carrier production depths could be determined in each pixel. We extracted the charge collection efficiencies and the charge carrier drift times as a function of the distance to the pixel plane. It was found that measured proton tracks are shorter in hole collection than in the case of electron collection, which is explained by the shorter lifetime of holes. At an angle of 60 degrees with respect to the sensor normal, the average track length in hole collection was ∼700 μm and 950 μm in electron collection mode. To understand the experimental findings, models describing the properties of HR GaAs:Cr were implemented into the Allpix
2
simulation framework. We added previously presented experimental results describing the dependence of the electron drift velocity on the electric field and validated the response by comparing measurement and simulation for various X- and gamma-ray sources in the energy range of 10–60 keV. By comparison of the experimental and the simulated results, the mobility
μ
h
and the lifetime of holes
τ
h
were estimated as
μ
h
= (320 ± 10) cm
2
/V/s and
τ
h
= (4.5 ± 0.5) ns.
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