Since increasing evidence suggests that upregulation of the cAMP-second messenger system may be implicated in Alzheimer's disease neurodegeneration, we have compared the cAMP and cGMP levels in ...cerebrospinal fluid (CSF) from patients with dementia of the Alzheimer type (DAT,
n=10) with those from nondemented age-matched controls (
n=10). Our results show that cAMP levels, but not cGMP, are significantly (
p<0.01) elevated in CSF from patients with DAT compared to those from nondemented controls. Moreover, a linear regression analysis demonstrated a significant correlation (
r=0.62;
p<0.01) between cAMP and tau protein levels in CSF when controls and patients with DAT were studied together. These results suggest that upregulation of cAMP-signaling pathway is implicated in Alzheimer's disease physiopathology.
Objective To analyze the relationship between regular physical activity, as assessed by accelerometer and 7-day physical activity recall (PAR), and plasma fibrinogen concentrations. Methods A ...cross-sectional study in a previously established cohort of healthy subjects was performed. This study analyzed 1284 subjects who were included in the EVIDENT study (mean age 55.0 plus or minus 13.6 years; 60.90% women). Fibrinogen concentrations were measured in blood plasma. Physical activity was assessed with a 7-day PAR (metabolic equivalents (METs)/hour/week) and GT3X ActiGraph accelerometer (counts/minute) for 7 days. Results Physical exercise, which was evaluated with both an accelerometer (Median: 237.28 counts/minute) and 7-day PAR (Median: 8 METs/hour/week). Physical activity was negatively correlated with plasma fibrinogen concentrations, which was evaluated by counts/min (r = -0.100; p<0.001) and METs/hour/week (r = -0.162; p<0.001). In a multiple linear regression analysis, fibrinogen concentrations of the subjects who performed more physical activity (third tertile of count/minute and METs/hour/week) respect to subjects who performed less (first tertile), maintained statistical significance after adjustments for age and others confounders ( beta = -0.03; p = 0.046 and beta = -0.06; p<0.001, respectively). Conclusions Physical activity, as assessed by accelerometer and 7-day PAR, was negatively associated with plasma fibrinogen concentrations. This relation is maintained in subjects who performed more exercise even after adjusting for age and other confounders.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Whole plants of
Narcissus tortuosus were found to contain tortuosine and lycorine. Tortuosine is reported for the first time and its structure was established by spectroscopic methods.
To find the factors related with the research activities of primary care (PC) doctors in Catalonia, especially their motivation and the obstacles to research perceived by the doctors themselves.
An ...observational, crossover study.
Primary care doctors in Catalonia.
The number of doctors (1,286) was divided into two: a) doctors who had published between 1989 and 1994 (n = 146), b) doctors who had not published.
A survey concerning personal and workplace variables was carried out by post.
The reply percentage was 49.5% (63.7% among those who had published and 44.85% among those who had not). The multivariant analysis showed a significant link between publishing and postgraduate residence training (MIR), the fact of working in a teaching centre and working in a centre with more than ten doctors.
Research is close related to postgraduate residence training (MIR), work in a teaching unit and PC centres with over ten doctors. Care load, lack of time and difficulty in getting financing were the main obstacles to research given by the doctors polled.
Introducción y objetivos Evaluar las diferencias pronósticas de las distintas formas de presentación de la enfermedad aterosclerosa en pacientes diabéticos. Métodos Estudio multicéntrico de cohortes ...prospectivas, en el que participaron 31 médicos de atención primaria que registraron las características de 1.423 pacientes diabéticos que acudieron de forma consecutiva a sus consultas y fueron seguidos durante 45 ± 10 meses. Resultados Pacientes (el 50%, varones) con mediade edad de 66 años, el 64% hipertensos, el 70% dislipémicos y el 26% con eventos cardiovasculares previos. Tras el período de seguimiento, fallecieron 81 (6,2%) pacientes, 40 (3%) por causa cardiaca, y reingresaron 393 (30%), 179 (14%) por causa cardiovascular. En el análisis multivariable, resultaron determinantes independientes de mortalidad: la edad (hazard ratio HR = 1,08; intervalo de confianza IC del 95%, 1,05-1,11), tener enfermedad cardiovascular (HR = 2,15; IC del 95%, 1,12- 4,14) y seguir tratamiento con diuréticos (HR = 3,40; IC del 95%, 1,76-6,56), mientras que la prescripción de inhibidores de la enzima de conversión de angiotensina y/o antagonistas de los receptores de angiotensina II resultó factor protector (HR = 0,48; IC del 95%, 0,25-0,93). En comparación con diabéticos sin evento cardiovascular previo, el riesgo de tener una complicación cardiovascular fue superior en los pacientes con antecedentes de cardiopatía isquémica (HR = 2,48; IC del 95%, 1,51-4,07), enfermedad cerebrovascular (HR = 2,51; IC del 95%, 1,28-4,92) y enfermedad vascular periférica (HR = 1,46; IC del 95%, 0,81-2,60). Conclusiones El incremento del riesgo de complicaciones cardiovasculares es semejante entre los diabéticos con cardiopatía isquémica y con enfermedad cerebrovascular y más del doble respecto a diabéticos sin afección cardiovascular evidente.
DC conductance measurements of a ferroelectric liquid crystal binary system have been performed. This technique has allowed us to characterize the mesomorphic phase transition sequence by means of ...the change of the conductivity values at the transition temperatures and the variation of the activation energies.
PDF
