The memory performance of hafnium oxide (HfO x )-based resistive memory containing a thin reactive Ti buffer layer can be greatly improved. Due to the excellent ability of Ti to absorb oxygen atoms ...from the HfO x film after post-metal annealing, a large amount of oxygen vacancies are left in the HfO x layer of the TiN/Ti/HfO x /TiN stacked layer. These oxygen vacancies are crucial to make a memory device with a stable bipolar resistive switching behavior. Aside from the benefits of low operation power and large on/off ratio (>100), this memory also exhibits reliable switching endurance (>10 6 cycles), robust resistance states (200°C), high device yield (~100%), and fast switching speed (<10 ns).
Primary pulmonary EWS/PNET(PPES) is extremely rare and is associated with a poor prognosis. Tumor angiogenesis plays an important role in tumor, so it has become a hot topic in molecular targeted ...therapy. Anlotinib is a new oral small molecular multi-targeted receptor tyrosine kinase (RTK) inhibitor. This report describes a 20 year-old man with PPES. After 4 neoadjuvant chemotherapy cycles (VACwith alternating IE) combined with anlotinib, the left total pneumonectomy was performed. Then maintenance anlotinib monotherapy was continued, no sign of recurrence to date as an outcome. To our knowledge, this is the first demonstration of anlotinib combined with neoadjuvant chemotherapy efficacy in PPES.
We use polarization- and temperature-dependent x-ray absorption spectroscopy, in combination with photoelectron microscopy, x-ray diffraction, and electronic transport measurements, to study the ...driving force behind the insulator-metal transition in VO_{2}. We show that both the collapse of the insulating gap and the concomitant change in crystal symmetry in homogeneously strained single-crystalline VO_{2} films are preceded by the purely electronic softening of Coulomb correlations within V-V singlet dimers. This process starts 7 K (±0.3 K) below the transition temperature, as conventionally defined by electronic transport and x-ray diffraction measurements, and sets the energy scale for driving the near-room-temperature insulator-metal transition in this technologically promising material.
•This paper proposes the vendor's stocking policy as either forward or backward.•It shows that the vendor's optimal stocking policy depends on the holding costs.•It demonstrates that the forward ...policy was misused in Zanoni and Jaber (2015).•It formulates the maximum inventory levels at different stocking points.•It also improves the replenishment policy in Sajadieh, Thorstenson, and Jokar (2010).
We consider a vendor-managed inventory with consignment stock agreement applied to the integrated vendor–buyer system, in which the vendor manufactures a single product in batches and delivers it in equal-sized transfer lots to the buyer. Some of the delivered items are presented to the end customers in the buyer's display area, while the rest of the items are kept in the buyer's backroom warehouse. Demand is assumed to be positively dependent on the amount of stock displayed. We propose a new joint economic lot sizing (JELS) model, taking into account the vendor's stocking policy, to maximize the total profit for the coordinated system. This paper first proves that, for any stock-dependent demand, a minimum restocking level at the buyer's sales floor is a more profitable strategy than the traditional run-out replenishment policy. It then shows that when the unit inventory holding cost decreases as stock moves downstream the supply chain, the vendor ought to adopt the forward stocking policy, in which product is pushed forward to the buyer's warehouse as soon as possible. Finally, it derives the analytical formulations for the maximum inventory levels at different stocking points, while the vendor adopts either forward or backward stocking policy. Numerical examples are also provided for illustration.
Randomized trials demonstrated a lower risk of cardiovascular (CV) events with sodium-glucose cotransporter-2 inhibitors (SGLT-2i) in patients with type 2 diabetes (T2D) at high CV risk. Prior ...real-world data suggested similar SGLT-2i effects in T2D patients with a broader risk profile, but these studies focused on heart failure and death and were limited to the United States and Europe.
The purpose of this study was to examine a broad range of CV outcomes in patients initiated on SGLT-2i versus other glucose-lowering drugs (oGLDs) across 6 countries in the Asia Pacific, the Middle East, and North American regions.
New users of SGLT-2i and oGLDs were identified via claims, medical records, and national registries in South Korea, Japan, Singapore, Israel, Australia, and Canada. Propensity scores for SGLT-2i initiation were developed in each country, with 1:1 matching. Hazard ratios (HRs) for death, hospitalization for heart failure (HHF), death or HHF, MI, and stroke were assessed by country and pooled using weighted meta-analysis.
After propensity-matching, there were 235,064 episodes of treatment initiation in each group; ∼27% had established CV disease. Patient characteristics were well-balanced between groups. Dapagliflozin, empagliflozin, ipragliflozin, canagliflozin, tofogliflozin, and luseogliflozin accounted for 75%, 9%, 8%, 4%, 3%, and 1% of exposure time in the SGLT-2i group, respectively. Use of SGLT-2i versus oGLDs was associated with a lower risk of death (HR: 0.51; 95% confidence interval CI: 0.37 to 0.70; p < 0.001), HHF (HR: 0.64; 95% CI: 0.50 to 0.82; p = 0.001), death or HHF (HR: 0.60; 95% CI: 0.47 to 0.76; p < 0.001), MI (HR: 0.81; 95% CI: 0.74 to 0.88; p < 0.001), and stroke (HR: 0.68; 95% CI: 0.55 to 0.84; p < 0.001). Results were directionally consistent across both countries and patient subgroups, including those with and without CV disease.
In this large, international study of patients with T2D from the Asia Pacific, the Middle East, and North America, initiation of SGLT-2i was associated with a lower risk of CV events across a broad range of outcomes and patient characteristics. (Comparative Effectiveness of Cardiovascular Outcomes in New Users of SGLT-2 Inhibitors CVD-REAL; NCT02993614).
Efficiency of hydrogen evolution via water electrolysis is mainly impeded by the kinetically sluggish oxygen evolution reaction (OER). Thus, it is of great significance to develop highly active and ...stable OER catalyst for alkaline water electrolysis or to substitute the more kinetically demanding acidic OER with a facile electron-donating reaction such that OER is no longer the bottleneck half-reaction for either acidic or alkaline water electrolysis. Herein, the hierarchical Fe–Ni phosphide shelled with ultrathin carbon networks on Ni foam (FeNiP@C) is reported and shows exceptional OER activity and enhanced chemical stability in 1 M KOH. This unique electrode provides large active sites, facile electron transport pathways, and rapid gas release, resulting in a remarkable OER activity that delivers a current density of 100 mA/cm2 at an overpotential of 182 mV with a Tafel slope of 56 mV/dec. Combining the hydrogen evolution reaction with organic pollutant (methylene blue) oxidation, a multifunctional electrolyzer for simultaneous cost-effective hydrogen generation and organic pollutant decomposition in acid wastewater is proposed. Our strategies in this work provide attractive opportunities in energy- and environment-related fields.
Engineers and scientists alike will find this book to be an excellent introduction to the topic of porous materials, in particular the three main groups of porous materials: porous metals, porous ...ceramics, and polymer foams. Beginning with a general introduction to porous materials, the next six chapters focus on the processing and applications of each of the three main materials groups. The book includes such new processes as gel-casting and freeze-drying for porous ceramics and self-propagating high temperature synthesis (SHS) for porous metals. The applications discussed are relevant to a wide number of fields and industries, including aerospace, energy, transportation, construction, electronics, biomedical and others. The book concludes with a chapter on characterization methods for some basic parameters of porous materials. Porous Materials: Processing and Applications is an excellent resource for academic and industrial researchers in porous materials, as well as for upper-level undergraduate and graduate students in materials science and engineering, physics, chemistry, mechanics, metallurgy, and related specialties. * A comprehensive overview of processing and applications of porous materials – provides younger researchers, engineers and students with the best introduction to this class of materials * Includes three full chapters on modern applications - one for each of the three main groups of porous materials * Introduces readers to several characterization methods for porous materials, including methods for characterizing pore size, thermal conductivity, electrical resistivity and specific surface area
MicroRNAs (miRNAs) are endogenous non-coding RNAs that are known to be involved in the pathogenesis of tumors. Gastric carcinoma (GC) is a common malignancy worldwide. The aim of this study was the ...identification of the expression signature and functional roles of aberrant miRNAs in GC. Initial screening established a profile of aberrantly expressed miRNAs in tumors. miR-370 was confirmed to be overexpressed in GC tissues. Higher expression of miR-370 in GC tissues was associated with more advanced nodal metastasis and a higher clinical stage compared with controls. In addition, significantly higher level of miR-370 was noted in the plasma of GC patients compared with controls. Patients having more invasive or advanced tumors also exhibited a higher plasma level of miR-370. In vitro assays indicated that exogenous miR-370 expression enhanced the oncogenic potential of GC cells. The AGS-GFPM2 cells with exogenous miR-370 expression also exhibited enhanced abdominal metastatic dissemination in nude mice. Reporter assays confirmed that miR-370 targeted predicted sites in 3'UTR of transforming growth factor-β receptor II (TGFβ-RII) gene. The exogenous miR-370 expression decreased TGFβ-RII expression and the phosphorylation of Smad3 elicited by TGFβ1. The TGFβ1-mediated repression in cell migration was reverted by exogenous miR-370 expression. A reverse correlation between miR-370 and TGFβ-RII expression was noted in GC tissues. This study concludes that miR-370 is a miRNA that is associated with GC progression by downregulating TGFβ-RII. The miRNA expression profile described in this study should contribute to future studies on the role of miRNAs in GC.
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