GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, ...schizophrenia, and autism. Work in cultured neurons has shown that ankyrin-G plays a key role in the regulation of GABAergic synapses on the axon initial segment and somatodendritic domain of pyramidal neurons, where it interacts directly with the GABA
receptor-associated protein (GABARAP) to stabilize cell surface GABA
receptors. Here, we generated a knock-in mouse model expressing a mutation that abolishes the ankyrin-G/GABARAP interaction (Ank3 W1989R) to understand how ankyrin-G and GABARAP regulate GABAergic circuitry in vivo. We found that Ank3 W1989R mice exhibit a striking reduction in forebrain GABAergic synapses resulting in pyramidal cell hyperexcitability and disruptions in network synchronization. In addition, we identified changes in pyramidal cell dendritic spines and axon initial segments consistent with compensation for hyperexcitability. Finally, we identified the ANK3 W1989R variant in a family with bipolar disorder, suggesting a potential role of this variant in disease. Our results highlight the importance of ankyrin-G in regulating forebrain circuitry and provide novel insights into how ANK3 loss-of-function variants may contribute to human disease.
The PSRIX backend is the primary pulsar timing instrument of the Effelsberg 100 m radio telescope since early 2011. This new ROACH-based system enables bandwidths up to 500 MHz to be recorded, ...significantly more than what was possible with its predecessor, the Effelsberg–Berkeley Pulsar Processor (EBPP). We review the first four years of PSRIX timing data for 33 pulsars collected as part of the monthly European Pulsar Timing Array (EPTA) observations. We describe the automated data analysis pipeline, coastguard, that we developed to reduce these observations. We also introduce toaster, the EPTA timing data base, used to store timing results, processing information and observation metadata. Using these new tools, we measure the phase-averaged flux densities at 1.4 GHz of all 33 pulsars. For seven of these pulsars, our flux density measurements are the first values ever reported. For the other 26 pulsars, we compare our flux density measurements with previously published values. By comparing PSRIX data with EBPP data, we find an improvement of ∼2–5 times in signal-to-noise ratio, which translates to an increase of ∼2–5 times in pulse time-of-arrival (TOA) precision. We show that such an improvement in TOA precision will improve the sensitivity to the stochastic gravitational wave background. Finally, we showcase the flexibility of the new PSRIX backend by observing several millisecond-period pulsars (MSPs) at 5 and 9 GHz. Motivated by our detections, we discuss the potential for complementing existing pulsar timing array data sets with MSP monitoring campaigns at these higher frequencies.
We introduce a Hubble Space Telescope (HST)/Space Telescope Imaging Spectrograph (STIS) stellar census of R136a, the central ionizing star cluster of 30 Doradus. We present low resolution ...far-ultraviolet STIS spectroscopy of R136 using 17 contiguous 52 arcsec × 0.2 arcsec slits which together provide complete coverage of the central 0.85 parsec (3.4 arcsec). We provide spectral types of 90 per cent of the 57 sources brighter than m
F555W = 16.0 mag within a radius of 0.5 parsec of R136a1, plus 8 additional nearby sources including R136b (O4 If/WN8). We measure wind velocities for 52 early-type stars from C ivλλ1548–51, including 16 O2–3 stars. For the first time, we spectroscopically classify all Weigelt and Baier members of R136a, which comprise three WN5 stars (a1–a3), two O supergiants (a5–a6) and three early O dwarfs (a4, a7, a8). A complete Hertzsprung–Russell diagram for the most massive O stars in R136 is provided, from which we obtain a cluster age of 1.5
$^{+0.3}_{-0.7}$
Myr. In addition, we discuss the integrated ultraviolet spectrum of R136, and highlight the central role played by the most luminous stars in producing the prominent He ii λ1640 emission line. This emission is totally dominated by very massive stars with initial masses above ∼100 M⊙. The presence of strong He ii λ1640 emission in the integrated light of very young star clusters (e.g. A1 in NGC 3125) favours an initial mass function extending well beyond a conventional upper limit of 100 M⊙. We include montages of ultraviolet spectroscopy for Large Magellanic Cloud O stars in the appendix. Future studies in this series will focus on optical STIS medium resolution observations.
A glitch in the millisecond pulsar J0613−0200 McKee, J. W; Janssen, G. H; Stappers, B. W ...
Monthly notices of the Royal Astronomical Society,
09/2016, Letnik:
461, Številka:
3
Journal Article
Recenzirano
Odprti dostop
We present evidence for a small glitch in the spin evolution of the millisecond pulsar J0613−0200, using the EPTA Data Release 1.0, combined with Jodrell Bank analogue filterbank times of arrival ...(TOAs) recorded with the Lovell telescope and Effelsberg Pulsar Observing System TOAs. A spin frequency step of 0.82(3) nHz and frequency derivative step of −1.6(39) × 10−19 Hz s−1 are measured at the epoch of MJD 50888(30). After PSR B1821−24A, this is only the second glitch ever observed in a millisecond pulsar, with a fractional size in frequency of Δν/ν = 2.5(1) × 10−12, which is several times smaller than the previous smallest glitch. PSR J0613−0200 is used in gravitational wave searches with pulsar timing arrays, and is to date only the second such pulsar to have experienced a glitch in a combined 886 pulsar-years of observations. We find that accurately modelling the glitch does not impact the timing precision for pulsar timing array applications. We estimate that for the current set of millisecond pulsars included in the International Pulsar Timing Array, there is a probability of ∼50 per cent that another glitch will be observed in a timing array pulsar within 10 years.
Fast radio bursts (FRBs) are millisecond-duration radio transients
of unknown origin. Two possible mechanisms that could generate extremely coherent emission from FRBs invoke neutron star ...magnetospheres
or relativistic shocks far from the central energy source
. Detailed polarization observations may help us to understand the emission mechanism. However, the available FRB polarization data have been perplexing, because they show a host of polarimetric properties, including either a constant polarization angle during each burst for some repeaters
or variable polarization angles in some other apparently one-off events
. Here we report observations of 15 bursts from FRB 180301 and find various polarization angle swings in seven of them. The diversity of the polarization angle features of these bursts is consistent with a magnetospheric origin of the radio emission, and disfavours the radiation models invoking relativistic shocks.
We report on the high-precision timing of 42 radio millisecond pulsars (MSPs) observed by the European Pulsar Timing Array (EPTA). This EPTA Data Release 1.0 extends up to mid-2014 and baselines ...range from 7–18 yr. It forms the basis for the stochastic gravitational-wave background, anisotropic background, and continuous-wave limits recently presented by the EPTA elsewhere. The Bayesian timing analysis performed with temponest
yields the detection of several new parameters: seven parallaxes, nine proper motions and, in the case of six binary pulsars, an apparent change of the semimajor axis. We find the NE2001 Galactic electron density model to be a better match to our parallax distances (after correction from the Lutz–Kelker bias) than the M2 and M3 models by Schnitzeler. However, we measure an average uncertainty of 80 per cent (fractional) for NE2001, three times larger than what is typically assumed in the literature. We revisit the transverse velocity distribution for a set of 19 isolated and 57 binary MSPs and find no statistical difference between these two populations. We detect Shapiro delay in the timing residuals of PSRs J1600−3053 and J1918−0642, implying pulsar and companion masses
$m_{\rm p}=1.22_{-0.35}^{+0.5}\ {\rm M}_{{\odot }}$
,
$m_{\rm c} = 0.21_{-0.04}^{+0.06}\ {\rm M}_{{\odot } }$
and
$m_{\rm p}=1.25_{-0.4}^{+0.6}\ {\rm M}_{{\odot }}$
,
$m_{\rm c} = 0.23_{-0.05}^{+0.07}\ {\rm M}_{{\odot } }$
, respectively. Finally, we use the measurement of the orbital period derivative to set a stringent constraint on the distance to PSRs J1012+5307 and J1909−3744, and set limits on the longitude of ascending node through the search of the annual-orbital parallax for PSRs J1600−3053 and J1909−3744.
ABSTRACT
Pulsar timing arrays (PTAs) can be used to study the Solar system ephemeris (SSE), the errors of which can lead to correlated timing residuals and significantly contribute to the PTA noise ...budget. Most Solar system studies with PTAs assume the dominance of the term from the shift of the Solar system barycentre (SSB). However, it is unclear to which extent this approximation can be valid, since the perturbations on the planetary orbits may become important as data precision keeps increasing. To better understand the effects of SSE uncertainties on pulsar timing, we develop the linimoss dynamical model of the Solar system, based on the SSE of Guangyu Li. Using the same input parameters as DE435, the calculated planetary positions by linimoss are compatible with DE435 at centimetre level over a 20 yr timespan, which is sufficiently precise for pulsar-timing applications. We utilize linimoss to investigate the effects of SSE errors on pulsar timing in a fully dynamical way, by perturbing one SSE parameter per trial and examining the induced timing residuals. For the outer planets, the timing residuals are dominated by the SSB shift, as assumed in previous work. For the inner planets, the variations in the orbit of the Earth are more prominent, making previously adopted assumptions insufficient. The power spectra of the timing residuals have complex structures, which may introduce false signals in the search of gravitational waves. We also study how to infer the SSE parameters using PTAs, and calculate the accuracy of parameter estimation.
Abstract
The error in the Solar system ephemeris will lead to dipolar correlations in the residuals of pulsar timing array for widely separated pulsars. In this paper, we utilize such correlated ...signals, and construct a Bayesian data-analysis framework to detect the unknown mass in the Solar system
and to measure the orbital parameters. The algorithm is designed to calculate the waveform of the induced pulsar-timing residuals due to the unmodelled objects following the Keplerian orbits in the Solar system. The algorithm incorporates a Bayesian-analysis suit used to simultaneously analyse the pulsar-timing data of multiple pulsars to search for coherent waveforms, evaluate the detection significance of unknown objects, and to measure their parameters. When the object is not detectable, our algorithm can be used to place upper limits on the mass. The algorithm is verified using simulated data sets, and cross-checked with analytical calculations. We also investigate the capability of future pulsar-timing-array experiments in detecting the unknown objects. We expect that the future pulsar-timing data can limit the unknown massive objects in the Solar system to be lighter than 10−11–10−12 M⊙, or measure the mass of Jovian system to a fractional precision of 10−8–10−9.
ABSTRACT
We present an optical analysis of 55 members of R136, the central cluster in the Tarantula Nebula of the Large Magellanic Cloud. Our sample was observed with STIS aboard the Hubble Space ...Telescope, is complete down to about 40 M⊙, and includes seven very massive stars with masses over 100 M⊙. We performed a spectroscopic analysis to derive their physical properties. Using evolutionary models, we find that the initial mass function of massive stars in R136 is suggestive of being top-heavy with a power-law exponent γ ≈ 2 ± 0.3, but steeper exponents cannot be excluded. The age of R136 lies between 1 and 2 Myr with a median age of around 1.6 Myr. Stars more luminous than log L/L⊙ = 6.3 are helium enriched and their evolution is dominated by mass-loss, but rotational mixing or some other form of mixing could be still required to explain the helium composition at the surface. Stars more massive than 40 M⊙ have larger spectroscopic than evolutionary masses. The slope of the wind–luminosity relation assuming unclumped stellar winds is 2.41 ± 0.13 which is steeper than usually obtained (∼1.8). The ionizing ($\log Q_0\, {\rm ph/s} = 51.4$) and mechanical ($\log L_{\rm SW}\, {\rm erg/s} = 39.1$) output of R136 is dominated by the most massive stars ($\gt 100\, \mathrm{ M}_{\odot }$). R136 contributes around a quarter of the ionizing flux and around a fifth of the mechanical feedback to the overall budget of the Tarantula Nebula. For a census of massive stars of the Tarantula Nebula region, we combined our results with the VLT-FLAMES Tarantula Survey plus other spectroscopic studies. We observe a lack of evolved Wolf–Rayet stars and luminous blue and red supergiants.
We have searched for continuous gravitational wave (CGW) signals produced by individually resolvable, circular supermassive black hole binaries (SMBHBs) in the latest European Pulsar Timing Array ...(EPTA) data set, which consists of ultraprecise timing data on 41-ms pulsars. We develop frequentist and Bayesian detection algorithms to search both for monochromatic and frequency-evolving systems. None of the adopted algorithms show evidence for the presence of such a CGW signal, indicating that the data are best described by pulsar and radiometer noise only. Depending on the adopted detection algorithm, the 95 per cent upper limit on the sky-averaged strain amplitude lies in the range ... This limit varies by a factor of five, depending on the assumed source position and the most constraining limit is achieved towards the positions of the most sensitive pulsars in the timing array. The most robust upper limit - obtained via a full Bayesian analysis searching simultaneously over the signal and pulsar noise on the subset of ours six best pulsars -- is ... These limits, the most stringent to date at f < 10...nHz, exclude the presence of sub-centiparsec binaries with chirp mass ... out to a distance of about 25 Mpc, and with ... out to a distance of about 1Gpc (...). We show that state-of-the-art SMBHB population models predict <1 per cent probability of detecting a CGW with the current EPTA data set, consistent with the reported non-detection. We stress, however, that PTA limits on individual CGW have improved by almost an order of magnitude in the last five years. The continuing advances in pulsar timing data acquisition and analysis techniques will allow for strong astrophysical constraints on the population of nearby SMBHBs in the coming years. (ProQuest: ... denotes formulae/symbols omitted.)
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