The purpose of this article is to evaluate the diagnostic performance of transient elastography, real-time strain elastography, and aspartate-to-platelet ratio index in assessing fibrosis in patients ...with chronic hepatitis C by using histologic Metavir scores as reference standard.
Consecutive patients with chronic hepatitis C scheduled for liver biopsy were enrolled. Liver biopsy was performed on the same day as transient elastography and real-time strain elastography. Transient elastography and real-time strain elastography were performed in the same patient encounter by a single investigator using a medical device based on elastometry and an ultrasound machine, respectively. Diagnostic performance was assessed by using receiver operating characteristic curves and area under the receiver operating characteristic curve (AUC) analysis.
One hundred thirty patients (91 men and 39 women) were analyzed. The cutoff values for transient elastography, real-time strain elastography, and aspartate-to-platelet ratio index were 6.9 kPa, 1.82, and 0.37, respectively, for fibrosis score of 2 or higher; 7.3 kPa, 1.86, and 0.70, respectively, for fibrosis score of 3 or higher; and 9.3 kPa, 2.33, and 0.70, respectively, for fibrosis score of 4. AUC values of transient elastography, real-time strain elastography, aspartate-to-platelet ratio index were 0.88, 0.74, and 0.86, respectively, for fibrosis score of 2 or higher; 0.95, 0.80, and 0.89, respectively, for fibrosis score of 3 or higher; and 0.97, 0.80, and 0.84, respectively, for fibrosis score of 4. A combination of the three methods, when two of three were in agreement, showed AUC curves of 0.93, 0.95, and 0.95 for fibrosis scores of 2 or higher, 3 or higher, and 4, respectively.
Transient elastography, real-time strain elastography, and aspartate-to-platelet ratio index values were correlated with histologic stages of fibrosis. Transient elastography offered excellent diagnostic performance in assessing severe fibrosis and cirrhosis. Real-time elastography does not yet have the potential to substitute for transient elastography in the assessment of liver fibrosis.
To compare results of liver stiffness measurements by transient elastography (TE) obtained in our patients population with that used in a recently published meta-analysis.
This was a single center ...cross-sectional study. Consecutive patients with chronic viral hepatitis scheduled for liver biopsy at the outpatient ward of our Infectious Diseases Department were enrolled. TE was carried out by using FibroScan™ (Echosens, Paris, France). Liver biopsy was performed on the same day as TE, as day case procedure. Fibrosis was staged according to the Metavir scoring system. The diagnostic performance of TE was assessed by using receiver operating characteristic (ROC) curves and the area under the ROC curve analysis.
Two hundred and fifty-two patients met the inclusion criteria. Six (2%) patients were excluded due to unreliable TE measurements. Thus, 246 (171 men and 75 women) patients were analyzed. One hundred and ninety-five (79.3%) patients had chronic hepatitis C, 41 (16.7%) had chronic hepatitis B, and 10 (4.0%) were coinfected with human immunodeficiency virus. ROC curve analysis identified optimal cut-off value of TE as high as 6.9 kPa for F ≥ 2; 7.9 kPa for F ≥ 3; 9.6 kPa for F = 4 in all patients (n = 246), and as high as 6.9 kPa for F ≥ 2; 7.3 kPa for F ≥ 3; 9.3 kPa for F = 4 in patients with hepatitis C (n = 195). Cut-off values of TE obtained by maximizing only the specificity were as high as 6.9 kPa for F ≥ 2; 9.6 kPa for F ≥ 3; 12.2 kPa for F = 4 in all patients (n = 246), and as high as 7.0 kPa for F ≥ 2; 9.3 kPa for F ≥ 3; 12.3 kPa for F = 4 in patients with hepatitis C (n = 195).
The cut-off values of TE obtained in this single center study are comparable to that obtained in a recently published meta-analysis that included up to 40 studies.
Marmosa mexicana es un pequeño marsupial que se distribuye desde México hasta Panamá. En el estado de Tabasco, México, se ha registrado en vegetación secundaria, selva baja inundable, y selva alta y ...mediana perennifolia. En la presente nota se registra este mamífero en bosque mesófilo de montaña, un tipo de vegetación correspondiente al clima húmedo de altura, con presencia de neblinas frecuentes. El registro correspondió a una hembra con crías prendidas del abdomen, la cual fue avistada casualmente el 2 de junio de 2023 en un fragmento de bosque mesófilo de montaña localizado en el municipio de Humanguillo, Tabasco (17.362769, -93.627261, WGS84; 1000 msnm).
A growing need for lightweight, durable materials in industry and research have made titanium and its oxides specifically Titanium Dioxide (TiO sub(2)) popular. As machinery, electronics and ...semiconductor technology advance, the application of TiO sub(2) becomes more extensive. Scientific research conducted on TiO sub(2) as a semiconductor or as a catalyst for an experiment proved the need for such a material. This indicates that the iron, golden, silver and copper ages are over and the next era is the age of titanium.
There is a growing need for lightweight, durable materials in industry and research. The "classic" materials such as gold, copper, and steel can not fit this new need. Thus, new sets of materials are ...being used more frequently, and none more so than titanium and its oxides-more specifically, titanium dioxide (TiO/sub 2/). The author discusses the discovery of titanium dioxide and then describes its properties and applications. In particular the author discusses its use in high efficiency dye sensitised solar cells.< >
La tesis aborda como problema de investigación si existe relación entre la percepción de
Justicia de la Institución y el Compromiso Organizacional en los trabajadores administrativos de una ...Universidad Privada de Lima. Para responder a esta interrogante se ha efectuado una investigación aplicada con el método descriptivo correlacional y con diseño transversal.
Para la evaluación del Compromiso Organizacional se utilizó el Cuestionario de Compromiso
Organizacional de Allen y Meyer (1990), habiendo encontrado que las tres sub escalas y el cuestionario en su conjunto presentan un alto índice de confiabilidad en la aplicación de la fórmula de Kuder Richardson. La validez se obtuvo por juicio de expertos.
Para la evaluación de Justicia Organizacional se aplicó la Escala de Justicia Organizacional percibida de Moorman, 1991; Colquitt, 2001 Traducida por Castro y Fernández en el 2006y que cuenta con una confiabilidad de 0.90 para cada una de las dimensiones que considera: procedimental, interpersonal e informacional y con una validación de expertos.
La población de estudio estuvo conformada todos los 270 trabajadores de la Universidad privada con una muestra tipo censo abarcando a toda la población.
El estudio encontró que existe relación significativa entre la percepción de la Justicia y sus componentes distributivo, procedimental e interaccional y los tipos de Compromiso
Organizacional en los trabajadores administrativos de una universidad privada de Lima.
This study compares the feasibility of matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry with whole genome sequencing (WGS) for identifying bacteria in river ...surface water samples. We collected samples from four rivers in the Dominican Republic and used both techniques to characterize bacterial profiles. MALDI-TOF demonstrated high precision, with 86.2% similarity to WGS results, except for a few discordant cases due to database limitations. MALDI-TOF provided cost-effective and rapid identification, making it a promising alternative to WGS in resource-constrained regions. In particular, good effectiveness of MALDI-TOF in identifying bacteria with a high probability of being resistant to antibiotics was observed, which allows this technology to be used in the monitoring processes of this type of microorganism for their rapid, accurate, and low-cost identification. We found this technology to be advantageous for environmental bacterial profiling, with potential applications in understanding waterborne pathogenic bacteria. Our findings underline the relevance of MALDI-TOF in microbiology and its potential to expand its capabilities in bacterial identification and protein profiling.
Cutaneous Manifestations of Zika in Peru Ramos, Willy; Luna, Miguel; Alarcón, Tania ...
Journal of cutaneous medicine and surgery,
01/2020, Letnik:
24, Številka:
1
Journal Article
Recenzirano
Odprti dostop
This article aims to describe the cutaneous manifestations observed in the Zika epidemic in Peru during 2016 and 2017, as well as discuss the potential differential diagnoses. During the outbreak, ...the main reason for seeking medical advice was the development of a pruriginous maculopapular rash with a marked papular component, which started on the chest and later generalized to the rest of the body. Similar manifestations were noted in adults, children, and pregnant women. Other manifestations such as conjunctivitis, edema, or petechiae on the palate were rare. We suggest that in areas that are endemic for arboviral infections, in the differential diagnosis of a rash one must consider infections such as dengue, Zika, or chikungunya viruses. In nonendemic areas, the diagnosis is more difficult, as the rash may result from other viral infections not transmitted by arthropods and/or reactive or inflammatory diseases (urticaria, atopic dermatitis, systemic lupus erythematosus). We recommend that primary care health personnel are trained in the recognition of the mucocutaneous lesions caused by Zika virus infection, which could contribute to the identification of suspicious cases, particularly pregnant women.
ABSTRACT
HIP 9618 (HD 12572, TOI-1471, TIC 306263608) is a bright (G = 9.0 mag) solar analogue. TESS photometry revealed the star to have two candidate planets with radii of 3.9 ± 0.044 R⊕ (HIP 9618 ...b) and 3.343 ± 0.039 R⊕ (HIP 9618 c). While the 20.77291 d period of HIP 9618 b was measured unambiguously, HIP 9618 c showed only two transits separated by a 680-d gap in the time series, leaving many possibilities for the period. To solve this issue, CHEOPS performed targeted photometry of period aliases to attempt to recover the true period of planet c, and successfully determined the true period to be 52.56349 d. High-resolution spectroscopy with HARPS-N, SOPHIE, and CAFE revealed a mass of 10.0 ± 3.1M⊕ for HIP 9618 b, which, according to our interior structure models, corresponds to a $6.8\pm 1.4~{{\ \rm per\ cent}}$ gas fraction. HIP 9618 c appears to have a lower mass than HIP 9618 b, with a 3-sigma upper limit of <18M⊕. Follow-up and archival RV measurements also reveal a clear long-term trend which, when combined with imaging and astrometric information, reveal a low-mass companion ($0.08^{+0.12}_{-0.05} M_\odot$) orbiting at $26.0^{+19.0}_{-11.0}$ au. This detection makes HIP 9618 one of only five bright (K < 8 mag) transiting multiplanet systems known to host a planet with P > 50 d, opening the door for the atmospheric characterization of warm (Teq < 750 K) sub-Neptunes.
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