The design of books for teaching French turns out, for publishing houses, to be a process of pedagogical, didactic, editorial and commercial reflection resulting from market re- search. The language ...manual as an educational tool is subject to issues, constraints, expecta- tions, needs, modifications, improvements or obsolescence. Despite the intention of publish- ing houses to design methods with an action-oriented perspective, it would seem that a minor- ity of these textbooks offer communicative tasks that can be transposed into the daily life of a learner in a situation of immersion in France. This is why we are wondering about the needs and expectations that French (as a foreign language teachers) who are based in in France have regarding tasks anchored in the daily life of French people for A1 level of the CEFR. During this research, we were led to set up a needs analysis process in order to identify three types of needs (gaps, dysfunctions and expectations) and to try to translate them in the form of 'an explicit request detailed by orientations and avenues for the design of textbooks or FLE lan- guage methods at Éditions Maison des Langues. Among the main results, FLE teachers in France wish to promote the Action Perspective through the integration of communicative tasks making it possible to put the learner in the position of a social actor and to approach him / her in the daily life of French society.
The extensive use of antibiotics has led to the emergence of multi-resistant strains in some species of the genus
.
To investigate the molecular characteristics of multidrug-resistant of
strains ...isolated from 52 patients collected between March 2009 and July 2010 in medical intensive care units in Cali - Colombia.
The susceptibility to various classes of antibiotics was determined by disc diffusion method, and the determination of the genomic species was carried out using amplified ribosomal DNA restriction analysis (ARDRA) and by sequencing of the 16s rDNA gene. Also, the genes of beta-lactamases as well as, integrases IntI1 and IntI2 were analyzed by PCR method.
The phenotypic identification showed that the isolates belong mainly to
All of them were multi-resistant to almost the whole antibiotics except to tigecycline and sulperazon, and they were grouped into five (I to V) different antibiotypes, being the antibiotype I the most common (50.0%). The percent of beta-lactamases detected was: blaTEM (17.3%), blaCTX-M (9.6%), blaVIM (21.2%), blaIMP (7.7%), blaOXA-58 (21.2%), and blaOXA-51 (21.2%). The phylogenetic tree analysis showed that the isolates were clustering to
(74.1%),
(11.1%) and
(7.4 %). Besides, the integron class 1 and class 2 were detected in 23.1% and 17.3% respectively.
The isolates were identified to species
mainly, and they were multiresistant. The resistance to beta-lactams may be by for presence of beta-lactamases in the majority of the isolates.
Background
Inguinal lymph node dissection (ILND) plays a crucial role in the oncological management of patients with melanoma, penile, and vulvar cancer. This study aims to systematically evaluate ...perioperative adverse events (AEs) in patients undergoing ILND and its reporting.
Methods
A systematic review was conducted according to PRISMA. PubMed, MEDLINE, Scopus, and Embase were queried to identify studies discussing perioperative AEs in patients with melanoma, penile, and vulvar cancer following ILND.
Results
Our search generated 3.469 publications, with 296 studies meeting the inclusion criteria. Details of 14.421 patients were analyzed. Of these studies, 58 (19.5%) described intraoperative AEs (iAEs) as an outcome of interest. Overall, 68 (2.9%) patients reported at least one iAE. Postoperative AEs were reported in 278 studies, combining data on 10.898 patients. Overall, 5.748 (52.7%) patients documented ≥1 postoperative AEs. The most reported ILND-related AEs were lymphatic AEs, with a total of 4.055 (38.8%) events. The pooled meta-analysis confirmed that high BMI (RR 1.09;
p
= 0.006), ≥1 comorbidities (RR 1.79;
p
= 0.01), and diabetes (RR 1.81;
p
= < 0.00001) are independent predictors for any AEs after ILND. When assessing the quality of the AEs reporting, we found 25% of studies reported at least 50% of the required criteria.
Conclusion
ILND performed in melanoma, penile, and vulvar cancer patients is a morbid procedure. The quality of the AEs reporting is suboptimal. A more standardized AEs reporting system is needed to produce comparable data across studies for furthering the development of strategies to decrease AEs.
Introduction: Glaucoma is a leading cause of irreversible blindness worldwide; several risk factors have been identified as major underlying causes for developing this condition. Optic disc ...hemorrhage has been identified as a risk factor for the development and progression of primary open-angle glaucoma, as well it has been related to playing an important role in normal-tension glaucoma. Material and methods: A cross-sectional study was conducted in Colombia among hypertensive and diabetic patients. This study included 2,067 subjects older than 50 years who were attended by a group of ophthalmologists in six cities in Colombia who conducted a complete medical and ophthalmological examination and applied standardized questionnaires and interviews aiming to evaluate participant’s health conditions and lifestyles. Results: We found a prevalence of Optic disc hemorrhage (ODH) of 0.4%. ODH presented an OR: 8.82 (95% CI 1.60 - 48.52) for the presence of Glaucoma. Patients diagnosed with systemic hypertension had an OR: 0.02 (95% CI 0.00 - 0.96); Patients with Retinal Nerve Fiber Layer Defect (RNFL) presented an OR: 509.40 (95% CI 8.60 - 30152.97) for the presence of ODH and 50% of patients with ODH did not have a diagnosis of glaucoma. Conclusions: Despite the low prevalence of ODH in our study (0.4%), its presence is a High-risk factor for the presence of Glaucoma. RNFL defect is also highly related to ODH and the presence of Glaucoma.
This article presents the results obtained in research made during a sustainable urban renewal design in the city of Buenaventura, Valle del Cauca, Colombia, as part of MINGA team's proposal for ...SDLAC 2019 (Solar Decathlon Latin America and Caribbean). This project was developed by a group of students and professors, as part of the undergraduate programs of architecture and civil engineering of the partner universities in the MINGA team. A project-based teaching-learning methodology was used, integrating the curricula in interdisciplinary project workshop-type courses. The main goal was to demonstrate the viability of a resilient urban planning project, conceived for the future climate in a coastal city in the hot-humid tropics. The results showed that a climate-resilient urbanism can be created, which guarantees the permanence of the original inhabitants of the coastal areas, mitigating flooding risks, and preserving the cultural roots of the inhabitants, even under sea-rise scenarios.
This article attempts to extend the debate on open innovation and public policies in developing countries. It presents the case of the public policy of Competitiveness, Science, Technology and ...Innovation CSTI in the department of Valle del Cauca, Colombia, analyzing the dynamics and network structure of the open innovation actors in the policy according to breadth and depth relations using a network methodology. The results showed that the relationship between the actors needs to be expanded from breadth to a depth relation. Consequently, the policy's network in the region holds important implications for the management of open innovation and public policies where heterogeneous actors interact.
Antibiotic resistance is one of the most important public health problem and one of the most critical steps in preventing resistance is the monitorization of the resistance. Local, regional and ...global monitoring enables the spread of antibiotic resistance to be understood more clearly. In this study, it was aimed to evaluate the results of the pilot study for the establishment of molecular-based carbapenem surveillance system in Escherichia coli and Klebsiella pneumoniae isolates and to investigate the carbapenemase epidemiology in Turkey. Hospitals (n= 28) from 26 different statistical level II regions from Turkey were included in the study. The hospitals participated in the study submitted ten carbapenem susceptible and ten carbapenem resistant E.coli and K.pneumoniae isolates to our laboratory that were isolated in two different periiods of six-month either between 1 March-31 August or 1 April-30 September 2019. A total of 509 isolates were collected from 26 of the 28 participating hospitals in the study. Isolates were identified by matrix assisted laser desorptionization-time of flight mass spectrophotometry (MALDI TOF MS) (Bruker Daltonics, Germany) method and antibiotic susceptibility tests for imipenem, meropenem and colistin were studied by broth microdilution. Moreover, susceptibilities to amikacin, amoxicillin-clavulanic acid, ampicillin, aztreonam, cefepime, cefotaxime, ceftazidime, ciprofloxacin, ertapenem, gentamicin, piperacillin-tazobactam, tobramycin and trimethoprim-sulfamethoxazole were determined by disc diffusion method. The resistance genes were investigated in isolates which were found to be phenotypically resistant to carbapenem and colistin, in house method was used to investigate carbapenemase genes and a commercial colistin resistant real-time PCR kit (Biospeedy, Turkey) was used for colistin resistance genes. In total, 493 of the 509 isolates collected from hospitals were identified as E.coli (25.7%, n= 127) and K.pneumoniae (74.3%, n= 366) and included in the study. It was determined that 31% of the isolates evaluated were from community-acquired infections and 69% were either from healthcare-associated infections or from colonization sites. Among the tested isolates, 248 (50.3%) were susceptible to carbapenems and 245 (49.7%) were resistant. The types of carbapenemases in carbapenemase-producing were OXA-48 (52.2%), KPC (16.1%), NDM-1 (15%), OXA-48 + NDM-1 (12.6%), KPC + NDM-1 (2.8%) and VIM (0.5%) and OXA-48+VIM (0.5%). Resistance to colistin was detected in 23.3% of the isolates but mcr1-8 genes were not detected. It was found that all colistin resistant isolates are resistant to at least one of the carbapenems. The importance of a molecular-based antimicrobial resistance surveillance system in our country was demonstrated with this pilot study. It is thought that continuous monitoring of these epidemiological features will contribute to the management of infections due to carbapenemase-producing organisms.
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