•This ESO-ESMO ABC 5 Clinical Practice Guideline provides key recommendations for managing advanced breast cancer patients.•It provides updates on managing patients with all breast cancer subtypes, ...LABC, follow-up, palliative and supportive care.•Updated diagnostic and treatment algorithms are also provided.•All recommendations were compiled by a multidisciplinary group of international experts.•Recommendations are based on available clinical evidence and the collective expert opinion of the authors.
Water quality management will be a priority issue in the near future. Indeed, due to scarcity and/or contamination of the water, regulatory frameworks will be increasingly strict to reduce ...environmental impacts of wastewater and to allow water to be reused. Moreover, drinking water quality standards must be improved in order to account for the emerging pollutants that are being detected in tap water. These tasks can only be achieved if new improved and sustainable water treatment technologies are developed. Nanomaterials are improving the ongoing research on advanced oxidation processes (AOPs). This work reviews the most important AOPs, namely: persulfate, chlorine and NH2Cl based processes, UV/H2O2, Fenton processes, ozone, and heterogeneous photocatalytic processes. A critical review of the current coupling of nanomaterials to some of these AOPs is presented. Besides the active role of the nanomaterials in the degradation of water contaminants/pollutants in the AOPs, the relevance of their adsorbent/absorbent function in these processes is also discussed.
We introduce wavelet phase harmonics (WPH) statistics: interpretable low-dimensional statistics that describe 2D non-Gaussian fields. These statistics are built from WPH moments, which were recently ...introduced in the data science and machine learning community. We apply WPH statistics to projected 2D matter density fields from the Quijote N -body simulations of the large-scale structure of the Universe. By computing Fisher information matrices, we find that the WPH statistics place more stringent constraints on four of five cosmological parameters when compared to statistics based on the combination of the power spectrum and bispectrum. We also use the WPH statistics with a maximum entropy model to statistically generate new 2D density fields that accurately reproduce the probability density function, the mean and standard deviation of the power spectrum, the bispectrum, and Minkowski functionals of the input density fields. Although other methods are efficient for either parameter estimates or statistical syntheses of the large-scale structure, WPH statistics are the first statistics that achieve state-of-the-art results for both tasks as well as being interpretable.
A large-scale hydrodynamical cosmological simulation, Horizon-AGN, is used to investigate the alignment between the spin of galaxies and the cosmic filaments above redshift 1.2. The analysis of more ...than 150 000 galaxies per time step in the redshift range 1.2 < z < 1.8 with morphological diversity shows that the spin of low-mass blue galaxies is preferentially aligned with their neighbouring filaments, while high-mass red galaxies tend to have a perpendicular spin. The reorientation of the spin of massive galaxies is provided by galaxy mergers, which are significant in their mass build-up. We find that the stellar mass transition from alignment to misalignment happens around 3 × 1010 M⊙. Galaxies form in the vorticity-rich neighbourhood of filaments, and migrate towards the nodes of the cosmic web as they convert their orbital angular momentum into spin. The signature of this process can be traced to the properties of galaxies, as measured relative to the cosmic web. We argue that a strong source of feedback such as active galactic nuclei is mandatory to quench in situ star formation in massive galaxies and promote various morphologies. It allows mergers to play their key role by reducing post-merger gas inflows and, therefore, keeping spins misaligned with cosmic filaments.
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