The extraneural diffusion of malignant gliomas is not frequent and some authors have reported single or multiple bone metastases
from glioblastoma contemporary to the time of primary cerebral tumor ...or accompanying relapse on the brain. We report the case
of a man affected by a glioblastoma who had a lumbar spine metastases without any brain relapse after excision of cerebral
glioblastoma multiforme and brain radiotherapy.
The UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase catalyzes the first and committed step in the dolichol cycle, thus playing a fundamental role in the pathway for protein N -glycosylation. The ...structure of the GlcNAc-1-P transferase gene has been previously elucidated in mouse and hamster. Moreover, the human cDNA has been cloned. Using sequence database tools, we deduced the genomic structure of the human GlcNAc-1-P transferase gene, which was experimentally confirmed by sequence analysis. The gene is composed of 9 exons and spans 5.5 kb. All splice acceptor and donor sites conform to the canonical AG/GT rule. The 5'-end of the gene is different from previously reported, as, consequently, the N-terminal of the encoded protein, which is predicted to be 408 amino acids long. The transcription start site, determined by 5' RACE, occurs 180 nucleotides upstream of the translation initiation codon. Several potential transcription regulatory motifs, such as Sp-1, E4TF1 and ATF binding sites, were identified in the 5'-flanking region. A polyadenylation signal is located 466 bp downstream of the stop codon. The genomic organization of the gene is similar to that of the corresponding mouse and hamster genes, though extensive homology is restricted to the coding regions. Analysis of a panel of radiation hybrids led to the assignment of the GlcNAc-1-P transferase gene to chromosome 11, at 4.19 cR from NIB361, according to the location of the homologous sequences in the database at 11q23.
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Provider: - Institution: Internet Culturale / Biblioteca Casanatense - Roma - Data provided by Europeana Collections- A margine: Isola del Regno di Sardegna.- All metadata published by Europeana are ...available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
Provider: - Institution: - Data provided by Europeana Collections- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain ...Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
•The impact of CSR on CFP is U-shaped.•Stakeholders punish firms with low CSR levels, while reward high CSR-levels ones.•Only high results in CSR generate positive financial performance.•Firms that ...do not adopt ISO 9001 certification perform better than ones that do.
Hospitality firms are increasingly investing in corporate social responsibility (CSR) to generate strong relationships with stakeholders while aiming to benefit their own performance. However, CSR may bring both costs and benefits to the focal firm. We analyze how corporate financial performance (CFP) is affected by CSR, finding that the impact of CSR on CFP has a U-shaped form, where CSR is a cost that translates into higher benefits only when it generates solid relationships between firms and their stakeholders. Furthermore, we adopt a contingency approach, assessing the role of quality management (QM) on the CSR-CFP relationship. We find that the simultaneous implementation of CSR and QM is less beneficial to CFP than the isolated implementation of CSR due to the redundancy of different activities aimed at similar goals, i.e., stakeholders’ satisfaction. In doing so, we advance academic understanding of the impact of CSR and QM on CFP.
Histone deacetylases (HDACs) are a family of enzymes involved in the regulation of gene expression, DNA repair, and stress response. These processes often are altered in tumors, and HDAC inhibitors ...have had pronounced antitumor activity with promising results in clinical trials. Here, we report the crystal structure of human HDAC8 in complex with a hydroxamic acid inhibitor. Such a structure of a eukaryotic zinc-dependent HDAC has not be described previously. Similar to bacterial HDAC-like protein, HDAC8 folds in a single α/β domain. The inhibitor and the zinc-binding sites are similar in both proteins. However, significant differences are observed in the length and structure of the loops surrounding the active site, including the presence of two potassium ions in HDAC8 structure, one of which interacts with key catalytic residues. CD data suggest a direct role of potassium in the fold stabilization of HDAC8. Knockdown of HDAC8 by RNA interference inhibits growth of human lung, colon, and cervical cancer cell lines, highlighting the importance of this HDAC subtype for tumor cell proliferation. Our findings open the way for the design and development of selective inhibitors of HDAC8 as possible antitumor agents.
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