The aim of this study was to assess whether caries risk, nutritional status, access to dental care and socio-behavioral factors are associated to two caries experience outcome variables using the ...Epidemiologic International Caries Detection and Assessment System (ICDASepi), which includes initial enamel caries lesions: 1- The presence of ICDAS-epi caries experience (dmf-ICDASepi ≥ 1), and 2- Having an ICDAS-epi caries experience (dmft-ICDASepi) higher than national figures for the same age. The sample included 316 eight- to 71-month-old children from the municipality of Anapoima, Colombia. Assessments included: prevalence and mean of caries experience using the ICDASepi system without compressed air-drying of teeth surfaces (dmf-ICDASepi), caries risk and nutritional status. Caregivers completed an elevenitem questionnaire assessing oral health-related social determinants, practices and quality of life (OHRQoL), and children's access to dental care. Data were analysed using the Wilcoxon-rank-sum test, the test, the Fisher-exact test, and bivariate-linear and non-conditioned logistic-multivariate regression models. Prevalence and mean number of teeth with dmft-ICDASepi were 65. 2% and 3. 5±4. 13, respectively. Nutritional status outside the normal status, lower educational level of caregivers and age were significantly associated with dmf-ICDASepi≥ 1. OHRQoL, access barriers to miss and to attend dental care, operative-treatment or emergency being the reason to attend dental care, high caries risk, and age were significantly associated with a higher-than-national dmft-ICDASepi. The significant associations found between early childhood caries experience and other variables represent oral-health inequalities in early childhood in Anapoima, Colombia.
Antecedentes: El examen clínico es el método más utilizado para valorar los patrones oclusales. Tiene la limitante de ser realizado en vigilia, cuando una persona controla la expresión real de los ...contactos en sueño como consecuencia del bruxismo. El Bruxchecker® es un dispositivo novedoso que permite, por medio de inspección visual, analizar los contactos durante la dinámica mandibular en sueño sin alterar la actividad muscular y oclusal. De acuerdo con diferentes características clínicas, es de esperarse que la relación intermaxilar genere diferentes contactos y, en consecuencia, patrones oclusales individualizados. Por lo tanto, es necesario identificar los patrones de desgaste oclusal durante la dinámica del sueño para establecer su funcionalidad. Propósito: esta serie de casos describe el Bruxchecker® como una herramienta de fácil uso y eficaz en el diagnóstico del patrón oclusal en odontología. Background: Clinical examination is the most used method for the evaluation of occlusal patterns. However, that evaluation is usually carried out during wakefulness when a person can hide the real expression of occlusal contacts that occur during sleep as a consequence of bruxism. Bruxchecker® is a new device that allows, by visual inspection, analyzing contacts of mandibular dynamics during sleep without altering the muscular and occlusal activity. Based on clinical characteristics, it could be expected that the intermaxillary relation generates different contacts and, as a result, individualized occlusal patterns. Therefore, it is necessary to identify the wear occlusal patterns during sleep dynamics to establish their functionality. Purpose: This case series report describes the Bruxchecker® as a simple-to-use tool that is effective to diagnose occlusal patterns in dentistry.
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Class I phosphoinositide 3‐kinase (PI3K) is a family of enzymes that generate 3‐phosphorylated poly‐phosphoinositides at the cell membrane following stimulation of protein tyrosine ...(Tyr) kinase‐associated or G protein‐coupled receptors (GPCR). The class I PI3K are divided into two types, class I
A
p85/p110 heterodimers, which are activated by Tyr kinases, and the class I
B
p110γ isoform, which is activated by GPCR. Although the T cell receptor (TCR) is a protein Tyr kinase‐associated receptor, previous studies showed that p110γ deletion affects TCR‐induced T cell stimulation. We examined whether the TCR activates p110γ and the consequences of interfering with p110γ expression or function for T cell activation. We found that after TCR ligation, p110γ interacts with Gα
q/11
, lymphocyte‐specific tyrosine kinase, and zeta‐associated protein. TCR stimulation activates p110γ, which affects 3‐phosphorylated poly‐phosphoinositides levels at the immunological synapse. We show that TCR‐stimulated p110γ controls Rac1 activity, F‐actin polarization and the interaction between T cells and antigen‐presenting cells, illustrating a crucial role for p110γ in TCR‐induced T cell activation.
Background: Several studies describe the orthopedic treatment of patients with cleft lip and palate, diagnosed with class III malocclusion; however, there is no standardization in the orthopedic ...treatment planning in these patients. Objective: To determine the effectiveness of treatment with facemask and a fixed intra-oral appliance for patients with cleft lip and palate and Class III malocclusion. Methods: A literature search conducted in several databases and print journals produced 199 articles. Inclusion criteria were: randomized clinical or open trials, English and Spanish language, patients with cleft lip and palate, 5-12 years of age, Class III malocclusion and/or facemask and/or maxillary protraction, assessment with lateral radiographs, cephalometric analysis, and clinical observation. Results: The sample consisted of eight articles that underwent quality analysis. Results indicate that treatment with facemask and intraoral appliance was effective in patients with cleft lip and palate to achieve maxillary protraction, of which a combination of facemask and Hyrax showed better skeletal results. Conclusion: Treatment with facemask with the intraoral appliance Hyrax, at 8-10 years of age, with 450-500 g forces and a 10º-30º inclination below the occlusal plane, used at least 12 hours/day for 9.2 months in patients with cleft lip and palate cleft and class III malocclusion, showed major skeletal changes in the maxilla and mandible.
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