Migration and infectious diseases Castelli, F.; Sulis, G.
Clinical microbiology and infection,
20/May , Letnik:
23, Številka:
5
Journal Article
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Infectious diseases still represent an important cause of morbidity and mortality among foreign-born individuals. The rising migration flows towards Europe throughout the last few years are raising ...renewed concerns about management issues and the potential associated risk for the native population.
To discuss the health implications and challenges related to the four phases of migration, from first arrival to stable resettlement.
Scientific literature and relevant statistical reports.
Although infectious diseases are not a health priority at first arrival, a syndromic screening to identify the most common communicable conditions (pulmonary tuberculosis above all) should be promptly conducted. Reception centres where asylum seekers are gathered after arrival may be crowded, so favouring epidemic outbreaks, sometimes caused by incomplete vaccine coverage for preventable diseases. After resettlement, the prevalence of some chronic infections such as human immunodeficiency virus, viral hepatitis or tuberculosis largely reflects the epidemiological pattern in the country of origin, with poor living conditions being an additional driver. Once resettled, migrants usually travel back to their country of origin without seeking pre-travel advice, which results in a high incidence of malaria and other infections.
Although infectious diseases among migrants are known to have a negligible impact on European epidemiology, screening programmes need to be implemented and adapted to the different stages of the migratory process to better understand the trends and set priorities for action. Appropriate access to care regardless of the legal status is crucial to improve the health status and prevent the spread of contagious conditions.
Civil responders currently have limited information available to them to support flood incident planning. A new generation of tools are emerging that produce more detailed understanding of flood ...impacts on people and accessibility during floods. These are typically applied in isolation, proving only a partial assessment of impacts. This paper integrates analysis of flood hydraulics, transport accessibility and human safety to explore the impact of flooding on pedestrians and drivers, and its implications on emergency routes and service areas. A reference scenario, developed and used by the local Civil Protection Agency, is applied to Galluzzo in Florence (Italy). Results shows that 37% of inhabitants live close to roads where they can be swept away, and 78% live in locations where parked vehicles can be transported by floodwaters. Furthermore, at its worst 22.5% of road extension is inaccessible; and all hospitals, fire and police stations cannot be reached, highlighting the need to take preventative action from the outset of an event that is predicted to lead to substantial inundation. Integration of multiple indicators of flood impacts, especially those most relevant to human safety, is fundamental to civil responders if they are to successfully planning and implement emergency response operations in urban environments.
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•A flood risk analysis is developed to increase Civil Protection preparedness.•Detailed data and models, e.g. hydraulic and transport, provide operational tools.•Safety and accessibility issues are modelled to evaluate urban resilience.•Safety issues include risk for pedestrians, parked vehicles and drivers.•The reduction of service areas in accessing critical structures is evaluated.
We present a new grid of model photospheres for the SDSS-III/APOGEE survey of stellar populations of the Galaxy, calculated using the ATLAS9 and MARCS codes. New opacity distribution functions were ...generated to calculate ATLAS9 model photospheres. MARCS models were calculated based on opacity sampling techniques. The metallicity (M/H) spans from -5 to 1.5 for ATLAS and -2.5 to 0.5 for MARCS models. There are three main differences with respect to previous ATLAS9 model grids: a new corrected H2O line list, a wide range of carbon (C/M) and alpha element alpha /M variations, and solar reference abundances from Asplund et al. The added range of varying carbon and alpha -element abundances also extends the previously calculated MARCS model grids. Altogether, 1980 chemical compositions were used for the ATLAS9 grid and 175 for the MARCS grid. Over 808,000 ATLAS9 models were computed spanning temperatures from 3500 K to 30,000 K and log g from 0 to 5, where larger temperatures only have high gravities. The MARCS models span from 3500 K to 5500 K, and log g from 0 to 5. All model atmospheres are publicly available online.
Ten able adults with autism or Asperger syndrome and 10 normal volunteers were PET scanned while watching animated sequences. The animations depicted two triangles moving about on a screen in three ...different conditions: moving randomly, moving in a goal‐directed fashion (chasing, fighting), and moving interactively with implied intentions (coaxing, tricking). The last condition frequently elicited descriptions in terms of mental states that viewers attributed to the triangles (mentalizing). The autism group gave fewer and less accurate descriptions of these latter animations, but equally accurate descriptions of the other animations compared with controls. While viewing animations that elicited mentalizing, in contrast to randomly moving shapes, the normal group showed increased activation in a previously identified mentalizing network (medial prefrontal cortex, superior temporal sulcus at the temporo‐parietal junction and temporal poles). The autism group showed less activation than the normal group in all these regions. However, one additional region, extrastriate cortex, which was highly active when watching animations that elicited mentalizing, showed the same amount of increased activation in both groups. In the autism group this extrastriate region showed reduced functional connectivity with the superior temporal sulcus at the temporo‐parietal junction, an area associated with the processing of biological motion as well as with mentalizing. This finding suggests a physiological cause for the mentalizing dysfunction in autism: a bottleneck in the interaction between higher order and lower order perceptual processes.
Abstract
Adipose tissue macrophages (ATM) adapt to changes in their energetic microenvironment. Caloric excess, in a range from transient to diet-induced obesity, could result in the transition of ...ATMs from highly oxidative and protective to highly inflammatory and metabolically deleterious. Here, we demonstrate that Interferon Regulatory Factor 5 (IRF5) is a key regulator of macrophage oxidative capacity in response to caloric excess. ATMs from mice with genetic-deficiency of
Irf5
are characterised by increased oxidative respiration and mitochondrial membrane potential. Transient inhibition of IRF5 activity leads to a similar respiratory phenotype as genomic deletion, and is reversible by reconstitution of IRF5 expression. We find that the highly oxidative nature of
Irf5
-deficient macrophages results from transcriptional de-repression of the mitochondrial matrix component Growth Hormone Inducible Transmembrane Protein (GHITM) gene. The
Irf5
-deficiency-associated high oxygen consumption could be alleviated by experimental suppression of
Ghitm
expression. ATMs and monocytes from patients with obesity or with type-2 diabetes retain the reciprocal regulatory relationship between
Irf5
and
Ghitm
. Thus, our study provides insights into the mechanism of how the inflammatory transcription factor IRF5 controls physiological adaptation to diet-induced obesity via regulating mitochondrial architecture in macrophages.
Hydrogeomorphic models allow parsimonious, fast and effective floodplain extent mapping using topographic data as the main input. Hydrogeomorphic approaches enforce the principle that floodplains are ...well-distinguished and unique landscape features within river corridors. We investigated the sensitivity of a hydrogeomorphic floodplain delineation algorithm, based on a hydrological power law, relating flow depth to contributing area, digital terrain model (DTM) resolution and river network hierarchy. In addition, we compared the results to other common floodplain mapping methods using standard flood-hazard maps as a reference. Taking the Arno River Basin, Italy, as a case study, our results show a dependency between the optimal power law parameters and DTM resolution, with larger parameter values required to reach optimal consistency with flood-hazard maps as DTM resolution increased. Floodplain mapping performance was also found to depend on stream order. We further tested the model consistency at a larger scale to evaluate its performance with respect to inundation maps in Hungary, Italy, Spain and the UK. Our study suggests that pre-defined power law parameters can be assumed, considering DTM resolution and stream order, supporting the use of the presented hydrogeomorphic model for large-scale floodplain mapping in ungauged basins where reference flood-hazard maps are not available.
Growing evidence suggests that the cerebellum is not only involved in motor functions, but it significantly contributes to sensory and cognitive processing as well. In particular, it has been ...hypothesized that the cerebellum identifies recurrent serial events and recognizes their violations. Here we used transcranial magnetic stimulation (TMS) to shed light on the role of the cerebellum in short-term memory of visual sequences. In two experiments, we found that TMS over the right cerebellar hemisphere impaired participants' ability to recognize the correct order of appearance of geometrical stimuli varying in shape and/or size. In turn, cerebellar TMS did not affect recognition of highly familiar short sequences of letters or numbers. Overall, our data suggest that the cerebellum is involved in memorizing the order in which (concatenated) stimuli appear, this process being important for sequence learning.
ABSTRACT The Sloan Digital Sky Survey-III (SDSS-III) Apache Point Observatory Galactic Evolution Experiment (APOGEE) has obtained high-resolution (R ∼ 22,500), high signal-to-noise ratio ( ) spectra ...in the H-band (∼1.5-1.7 m) for about 146,000 stars in the Milky Way galaxy. We have computed spectral libraries with effective temperature ( ) ranging from 3500 to 8000 K for the automated chemical analysis of the survey data. The libraries, used to derive stellar parameters and abundances from the APOGEE spectra in the SDSS-III data release 12 (DR12), are based on ATLAS9 model atmospheres and the ASSϵT spectral synthesis code. We present a second set of libraries based on MARCS model atmospheres and the spectral synthesis code Turbospectrum. The ATLAS9/ASSϵT ( = 3500-8000 K) and MARCS/Turbospectrum ( = 3500-5500 K) grids cover a wide range of metallicity (−2.5 M/H +0.5 dex), surface gravity (0 ≤ 5 dex), microturbulence (0.5 8 km s−1), carbon (−1 C/M +1 dex), nitrogen (−1 N/M +1 dex), and -element (−1 /M +1 dex) variations, having thus seven dimensions. We compare the ATLAS9/ASSϵT and MARCS/Turbospectrum libraries and apply both of them to the analysis of the observed H-band spectra of the Sun and the K2 giant Arcturus, as well as to a selected sample of well-known giant stars observed at very high resolution. The new APOGEE libraries are publicly available and can be employed for chemical studies in the H-band using other high-resolution spectrographs.
Hepatitis C virus (HCV), first recognized as a cause of transfusion-associated acute and chronic hepatitis in 1989, plays a major role as a cause of chronic liver injury, with potential for ...neoplastic degeneration. It is mainly transmitted by the parenteral route. However, although with lower efficiency, it may be also transmitted by sexual intercourses and by the mother-to-child route. Epidemiological evidence shows that a wave of infection occurred in the 1945-65 period (baby boomers) in western countries. After acute infection, as many as 50-85% of the patients fail to clear the virus resulting in chronic liver infection and/or disease. It is estimated that, on a global scale, about 170 million people are chronically infected with HCV, leading to about 350.000 deaths yearly. Among western countries southern Europe, and particularly Italy, is among the most affected areas. The impact on the public health systems is noteworthy, with high number of hospitalizations due to chronic liver disease, cirrhosis or hepatocellular carcinoma. While waiting for a safe and effective vaccine to be made available, new promising direct-acting antiviral (DAA) drugs offer a better therapeutic scenario than in the past even for the poor responder genotypes 1 and 4, provided that effective screening and care is offered. However, the long and aspecific prodromic period before clinical symptoms develop is a major obstacle to early detection and treatment. Effective screening strategies may target at-risk groups or age specific groups, as recently recommended by the CDC.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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