A 34‐year‐old female presented with several weeks of fever, fatigue, weight loss, abdominal pain and hemoptysis. PE revealed moderate pallor, RUQ pain, mild dyspnea, conjunctival injection and ...hepatomegaly. The CBC showed anemia, mild leukocytosis, hypoalbuminemia, hypertransaminasemia, presence of nucleated red blood cells. Microsporidium was found in BMA.
Systemic infectious diseases can be confused with malignant hematological diseases, because they tend to invade the bloodstream and even bone marrow. Bone marrow aspiration can help full out the differential diagnoses.
Water deficit, especially during summer, is currently one of the most important stress factors that influence olive oil production in olive orchards. A precision irrigation strategy, based on daily ...trunk growth, was assessed and compared with one continuous deficit, one full irrigation, and two different regulated deficit irrigation strategies. All of them were tested in a super high-density olive orchard located in northeast Spain, in which oil production, main oil production components, applied irrigation water, and water productivity were assessed. For this purpose, the crop was monitored from budding to harvesting, mainly during the summer months in which the Precision strategy only applied water after two days of negative daily trunk growth. Maximum monthly water savings for the Precision strategy reached 91.8%, compared with full irrigation, while major annual mean water savings reached 50% for the continuous deficit strategy and 31.2% for the Precision strategy, which also reduced irrigation events by up to 19.7%, compared with the full irrigation strategy. Oil production and oil production components varied depending on the irrigation strategies providing the Control, one of the regulated deficit irrigations, and Precision higher values than the other strategies; oil yield results differ, nonetheless. The Precision strategy showed an overall better performance. Despite this, it did not achieve the highest water saving, it achieved higher water productivity.
Two complementary methods, namely Multi-Trait Meta-Analysis and Versatile Gene-Based Test for Genome-wide Association Studies (VEGAS), were used to identify putative pleiotropic genes affecting ...carcass traits in Bos indicus (Nellore) cattle. The genotypic data comprised over 777,000 single-nucleotide polymorphism markers scored in 995 bulls, and the phenotypic data included deregressed breeding values (dEBV) for weight measurements at birth, weaning and yearling, as well visual scores taken at weaning and yearling for carcass finishing precocity, conformation and muscling. Both analyses pointed to the pleomorphic adenoma gene 1 (PLAG1) as a major pleiotropic gene. VEGAS analysis revealed 224 additional candidates. From these, 57 participated, together with PLAG1, in a network involved in the modulation of the function and expression of IGF1 (insulin like growth factor 1), IGF2 (insulin like growth factor 2), GH1 (growth hormone 1), IGF1R (insulin like growth factor 1 receptor) and GHR (growth hormone receptor), suggesting that those pleiotropic genes operate as satellite regulators of the growth pathway.
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Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The purpose of this work is to study the evolution, over three selected harvests, of phenolic compounds and colour stability of red wines produced in the north of Portugal by means of two wine-making ...processes (conventional maceration/fermentation and fermentation after initial carbonic maceration), with and without the use of four different fining agents (polyvinylpolypyrrolidine, gelatine, egg albumin, and casein). In general, it was observed that wines obtained by conventional maceration/fermentation (PO) present the highest colour intensity and polyphenolic content (total and monomeric anthocyanins, flavan-3-ol monomers and polymers), and the lowest orange–red hue, immediately following vinification. Nevertheless, carbonic maceration (CM) afforded wines with most stability in colour density, for 26 months’ storage. Different evolutions of anthocyanins and of flavan-3-ol monomers (catechins) and polymers (procyanidins) in PO and CM protocols during storage were observed. Decrease of anthocyanins and flavan-3-ol dimmers were, in general, more remarkable in PO wines. Monomers and trimers underwent a rise, especially in CM wines. Wines treated with fining agents tended to have somewhat lower anthocyanins levels, and especially in the case of PVPP, less intense colouration than untreated wines. Principal component analysis (PCA) revealed that catechins and some procyanidins are mainly responsible for the separation and evolution of wines during storage according polyphenolic composition. Partial least squares (PLS) regression models confirm that colour density in wines from PO and CM protocols explains a high proportion of the variance in hue, chemical age, IFC and anthocyanins and a prediction model has been built.
Potential tetradentate thiocarbamoylbenzamidine derivatives H
L have been synthesized from the corresponding benzimidoyl chlorides and triglycine. They are suitable chelating agents for the ...oxidotechnetium(v) and oxidorhenium(v) cores and form stable, neutral MO(HL) complexes with an equatorial SN
coordination sphere and an additional, uncoordinated carboxylic group, which can be used for bioconjugation. Representatives of the rhenium and
Tc products have been isolated and analyzed with spectroscopic methods and X-ray diffraction. Bioconjugates of these complexes with angiotensin-II have been synthesized and structurally characterized. Analogous
Tc complexes have been produced and tested in vitro and in vivo. The experiments confirm a considerable stability for the
Tc(HL) product as well as for its bioconjugate and recommend this class of compounds for further bioconjugation studies towards clinical applications.
This paper presents a theoretical analysis of the data on wave velocity measurements at small stresses presented in a companion paper describing the experimental results on a Martian regolith loose ...sandy simulant (Fontainebleau sand) of the soil at the InSight landing site on Mars (Elysium Planitia). Experimental data of wave velocities and Poisson's ratio are interpreted in the light of a granular contact mechanics theory and completed accounting for rugosity effects that are suspected to have stronger effects in sands under low stresses. The asperities of a grain of Fontainebleau sand were investigated through Atomic Force Microscopy, but larger asperities had to be adopted so as to better fit the model prediction with experimental data. A good agreement between the experimental data and the model predictions is obtained for stress above 10 kPa. Below 5 kPa, an area in which asperities are suspected to have a stronger influence, the model is not fully satisfactory, showing that further experimental and theoretical investigation is necessary in a stress zone particularly relevant to surface soils in planets, with probably enhanced effects of asperities on the intergrain contact mechanics.
Plain Language Summary
To better understand seismic wave propagation at the surface of the InSight landing site on Mars, this paper presents a theoretical interpretation of the seismic wave velocities at low stress measured in a sand sample used as a Martian regolith simulant and presented in a companion paper. The theory is based on both a theoretical elastic model of a pack of smooth spheres of same diameter and approach accounting for the effects of local rugosity at the contact between sand grains (rugosity is supposed to have a stronger influence at the low stresses resulting from the smaller gravity on Mars). The sphere pack model shows that some slippage between grains is necessary to properly account for the radial deformation of a cylindrical sample subjected to an increase in axial stress (as described by an elastic parameter called the Poisson ratio). Accounting for rugosity effects allows a better prediction of the changes in wave velocity with respect to stress. The decrease in velocity under decreased stress is confirmed, but the rugosity parameter measured using an Atomic Force Microscope was under‐estimated, probably due to the over‐simplistic hypothesis of considering spheres. A proper prediction was obtained by fitting this parameter at a twice larger value.
Key Points
A novel theory based on contact mechanics was proposed to calculate Vp and Vs of uniform granular materials
The theory considers the roughness of the particles, the stress, the porosity of the granular assembly, and the properties of the grains
Theoretical results agree with experimental measurements on loose samples of Fontainebleau sand used as a Mars regolith simulant
Next-generation sequencing has revealed recurring somatic mutations in Waldenström macroglobulinemia (WM). Common mutations include MYD88 (95%-97%), as well as CXCR4 (30%-40%), ARID1A (17%), and ...CD79B (8%-15%), which are typically found in MYD88-mutated patients. The genomic findings provide important insights into the pathogenesis, prognostication, and treatment outcome in WM. We discuss the genomic landscape of WM, and the impact of underlying genomics on disease presentation, transcriptional changes, treatment outcome, and overall survival impact.
Several health organizations, mainly in Western countries, have recently authorized the use of a booster dose of the COVID-19 vaccine for patients previously vaccinated with mRNA vaccines, with ...criteria that do not always coincide. The COVID Scientific Committee of the Illustrious College of Physicians of Madrid (ICOMEM) has received and asked several questions about this situation, to which the group has tried to give answers, after deliberation and consensus. The efficacy of the vaccines administered so far is beyond doubt and they have managed to reduce, fundamentally, the severe forms of the disease. The duration of this protection is not well known, is different in different individuals and for different variants of the virus and is not easily predictable with laboratory tests. Data on the real impact of a supplementary or "booster" dose in the scientific literature are scarce for the moment and its application in large populations such as those in the state of Israel may be associated with a decrease in the risk of new and severe episodes in the short observation period available. We also lack sufficient data on the safety and potential adverse effects of these supplementary doses and we do not know the ideal time to administer them in different situations. In this state of affairs, it seems prudent to administer supplemental doses to those exposed to a higher risk, such as immunocompromised individuals and the elderly. On the other hand, we consider that this is not the time to accelerate, on the spur of the moment, a massive administration of a third dose to other population groups that are less exposed and at lower risk, without waiting for adequate scientific information, which will undoubtedly arrive gradually. We do not believe that this position is incompatible with the practical and ethical warnings made by the World Health Organization in this respect.
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