Este artigo pretende analisar, através da observação, principalmente, das capas da Revista Veja,o sujeito empreendedor de si ou capital humano na sociedade de mercado determinada pelo processode ...precificação da vida, pressupondo, ainda, que vivemos um século que denominamos de biotécnico.Nossa premissa é de que há uma valorização da retórica da autoajuda com o surgimento de campeõesde venda de livros neste campo e um aumento considerado das matérias jornalísticas, além da contaminaçãodesta retórica em outras editorias de mídias informativas. Verificou-se, também, a presença dalinguagem de autoajuda em outras editorias e, na década de 2000, identificamos o surgimento da figurado líder-coach, com dois perfis que nomeamos como o aconselhador e o treinador.
As tecnologias da memória se transformam através do uso de novos programas informáticos, destinados à reconstrução com imagens 3D de locais e artefatos danificados e inclusive extintos. A partir da ...virada do milênio, a preservação do patrimônio histórico e cultural passa da manipulação de suportes analógicos para o gerenciamento digital, com a administração de arquivos numéricos e bancos de dados. Transmitidas através de telas digitais e absorvidas no espaço virtual como um ato cotidiano, as imagens do passado podem gerar um tipo de percepção similar à conquistada no confronto com o objeto real. A contemplação e a reflexão sobre o conteúdo transcendem a materialidade da obra. Os museus seguem sendo instituições centrais da cultura, espaços depositários de valores culturais, mas competem agora com modelos de representação onde ocorrem conexões virtuais e multissensoriais entre o saber e a sociedade.
The aim of this study was to identify plant species among the diverse flora of the caatinga ecosystem that are used therapeutically. Research was undertaken in the municipalities of Piranhas and ...Delmiro Gouveia, in the Xingó region (state of Alagoas, NE Brazil). In order to identify the medicinal plants used in this region, semi-structured questionnaires were applied. The species cited were collected and sent to the Xingó Herbarium for taxonomic analysis. The relative importance (RI) of each species cited was calculated to verify their cultural importance. The therapeutic indications attributed to the species were classified under 16 body systems. A total of 187 medicinal species were cited, from 64 families and 128 genera. The main indications for medicinal plant use were against common colds, bronchitis, cardiovascular problems, kidney problems, inflammations in general, and as tranquilizers. Approximately 16% (30 plant species) were versatile in relation to their use, with an Relative Importance value over 1, having been indicated for up to nine body systems. The body systems that stood out the most were: the respiratory system, the gastrointestinal system, and infectious diseases. Most cited plant parts used for medicinal purposes were flowers, leaves, and inner stem bark.
Brazil is blessed with a great biodiversity, which constitutes one of the most important sources of biologically active compounds, even if it has been largely underexplored. As is the case of the ...Amazon and Atlantic rainforests, the Brazilian marine fauna remains practically unexplored in the search for new biologically active natural products. Considering that marine organisms have been shown to be one of the most promising sources of new bioactive compounds for the treatment of different human diseases, the 8000 km of the Brazilian coastline represents a great potential for finding new pharmacologically active secondary metabolites. This review presents the status of marine natural products chemistry in Brazil, including results reported by different research groups with emphasis on the isolation, structure elucidation, and evaluation of biological activities of natural products isolated from sponges, ascidians, octocorals, and Opistobranch mollusks. A brief overview of the first Brazilian program on the isolation of marine bacteria and fungi, directed toward the production of biologically active compounds, is also discussed. The current multidisciplinary collaborative program under development at the Universidade de São Paulo proposes to establish a new paradigm toward the management of the Brazilian marine biodiversity, integrating research on the species diversity, ecology, taxonomy, and biogeography of marine invertebrates and microorganisms. This program also includes a broad screening program of Brazilian marine bioresources, to search for active compounds that may be of interest for the development of new drug leads.
The Internet is by far the most intensely used communication tool of today and the main channel of interaction in the globalized world. This technology has opened up a whole new area for the ...interaction of knowledge: cyberspace, where information is always present and continuously changing. The interactivity that characterizes the virtual media together with the interactive modules developed by science centers and museums make the Internet a whole new space for the popularization of science. In order to stimulate dialog between science and society, Espaço Ciência Viva has decided to employ the Internet to divulge and to popularize scientific knowledge by bringing debates about the advances of science to the daily lives of people. To this end, its website was remodeled, which led to an increase of up to 600% in the number of visitors.
Over the last decade, there has been a dramatic increase in the prevalence and gravity of systemic fungal diseases. This study aimed therefore at evaluating the antifungal potential of ester ...derivatives of benzoic and cinnamic acids from three Candida species. The compounds were prepared via Fischer esterification, and the antifungal assay was performed by the microdilution method in 96-well microplates for determining the minimal inhibitory concentrations (MICs). The findings of the antifungal tests revealed that the analogue compound methyl ferulate, methyl o-coumarate, and methyl biphenyl-3-carboxylate displayed an interesting antifungal activity against all Candida strains tested, with MIC values of 31.25-62.5, 62.5-125, and 62.5 μg/ml, respectively. A preliminary Structure-Activity Relationship study of benzoic and cinnamic acid derivatives has led to the recognition of some important structural requirements for antifungal activity. The results of molecular docking indicate that the presence of the enoate moiety along with hydroxyl and one methoxy substitution in the phenyl ring has a positive effect on the bioactivity of compound 7 against Candida albicans. These observations further support the hypothesis that the antifungal activity of compound 7 could be due to its binding to multiple targets, specifically to QR, TS, and ST-PK. Additional experiments are required in the future to test this hypothesis and to propose novel compounds with improved antifungal activity.
To evaluate the antifungal activity of gallic acid (GA) against the strains of
spp. resistant to fluconazole and to determine its mechanism of action.
Antifungal activity was evaluated using the ...broth microdilution and flow cytometry techniques.
GA presented minimum inhibitory concentrations ranging from 16 to 72 μg/ml, causing alterations of the membrane integrity and mitochondrial transmembrane potential, production of reactive oxygen species and externalization of phosphatidylserine.
GA has potential antifungal activity against
spp.
This study aimed to evaluate the antibacterial effect of two new cationic surfactants based on phenylalanine-arginine (LPAM) and tryptophan-arginine (LTAM).
Antibacterial activity, mechanism of ...action and interactions with
enzymes were measured through microbiological, flow cytometry and molecular docking assays, respectively.
These compounds showed antibacterial activity in the range of 4.06-16.24 μg/ml against planktonic cells and no activity against mature biofilms, since they caused a loss of membrane integrity and increased DNA damage, as revealed by flow cytometry analysis.
assays revealed the existence of molecular bonds such as hydrogen bonds, mainly with DNA. Therefore, these compounds have promising pharmacological activity against MRSA strains.
This study was designed to evaluate the
antimicrobial activity of amlodipine against
strains.
The antimicrobial activity of amlodipine was evaluated by the broth microdilution method and its ...interaction with oxacillin was evaluated by checkerboard assay. The possible mechanism of action was evaluated by flow cytometry and molecular docking techniques.
Amlodipine showed activity against
between 64 and 128 μg/ml, in addition to showing synergism in approximately 58% of the strains used. Amlodipine also showed good activity against forming and mature biofilms. The possible mechanism of action may be attributed to its ability to lead to cell death.
Amlodipine has antibacterial activity against
.
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