Background Dietary polyphenol intake has been associated with a decreased risk of hyperuricemia, but most of this knowledge comes from preclinical studies. The aim of the present study was to assess ...the association of the intake of different classes of polyphenols with serum uric acid and hyperuricemia. Methods and Results This cross‐sectional analysis involved baseline data of 6332 participants. Food polyphenol content was estimated by a validated semiquantitative food frequency questionnaire and from the Phenol‐Explorer database. Multivariable‐adjusted linear regression models with serum uric acid (milligrams per deciliter) as the outcome and polyphenol intake (quintiles) as the main independent variable were fitted. Cox regression models with constant follow‐up time (t=1) were performed to estimate the prevalence ratios (PRs) of hyperuricemia (≥7 mg/dL in men and ≥6 mg/dL in women). An inverse association between the intake of the phenolic acid class (β coefficient, −0.17 mg/dL for quintile 5 versus quintile 1 95% CI, −0.27 to −0.06) and hydroxycinnamic acids (β coefficient, −0.19 95% CI, −0.3 to −0.09), alkylmethoxyphenols (β coefficient, −0.2 95% CI, −0.31 to −0.1), and methoxyphenols (β coefficient, −0.24 95% CI, −0.34 to −0.13) subclasses with serum uric acid levels and hyperuricemia (PR, 0.82 95% CI, 0.71–0.95; PR, 0.82 95% CI, 0.71–0.95; PR, 0.80 95% CI, 0.70–0.92; and PR, 0.79 95% CI, 0.69–0.91; respectively) was found. The intake of hydroxybenzoic acids was directly and significantly associated with mean serum uric acid levels (β coefficient, 0.14 for quintile 5 versus quintile 1 95% CI, 0.02–0.26) but not with hyperuricemia. Conclusions In individuals with metabolic syndrome, a higher intake of some polyphenol subclasses (hydroxycinnamic acids, alkylmethoxyphenol, and methoxyphenol) was inversely associated with serum uric acid levels and hyperuricemia. Nevertheless, our findings warrant further research.
Visceral adipose tissue (VAT) is a strong predictor of cardiometabolic health, and lifestyle factors may have a positive influence on VAT depot. This study aimed to assess the cross-sectional ...associations between baseline levels of physical activity (PA), sedentary behaviours (SB) and adherence to the Mediterranean diet (MedDiet) with VAT depot in older individuals with overweight/obesity and metabolic syndrome.
Baseline data of the PREDIMED-Plus study including a sample of 1,231 Caucasian men and women aged 55-75 years were used. Levels of leisure-time PA (total, light, and moderate-to-vigorous, in METs·min/day) and SB (total and TV-viewing, in h/day) were evaluated using validated questionnaires. Adherence to the MedDiet was evaluated using a 17-item energy-restricted MedDiet (erMedDiet) screener. The chair-stand test was used to estimate the muscle strength. VAT depot was assessed with DXA-CoreScan. Multivariable adjusted linear regression models were used to evaluate the association between lifestyle factors and VAT. For the statistics we had used multiadjusted linear regression models.
Total leisure-time PA (100 METs·min/day: β -24.3g, -36.7;-11.9g), moderate-to-vigorous PA (β -27.8g, 95% CI -40.8;-14.8g), chair-stand test (repeat: β -11.5g, 95% CI -20.1;-2.93g) were inversely associated, and total SB (h/day: β 38.2g, 95% CI 14.7;61.7) positively associated with VAT. Light PA, TV-viewing time and adherence to an erMedDiet were not significantly associated with VAT.
In older adults with overweigh/obesity and metabolic syndrome, greater PA, muscle strength, and lower total SB were associated with less VAT depot. In this study, adherence to an erMedDiet was not associated with lower VAT.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
La hipertensión arterial (HTA) es un importante problema de salud pública, por su elevada morbimortalidad cardiovascular y sus costes económicos y sociales.
Fundamento. Identificar la prevalencia de ...HTA detectada en atención primaria y su grado de control; conocer los tipos de tratamientos utilizados y factores asociados a su control.
Pacientes y métodos. Estudio transversal comparativo de dos años en el Centro de Salud de Villava. Se analizan los datos de la historia clínica informatizada en los años 2003 y 2006. Se estudian las variables: edad, género, pensión arterial sistólica y diastólica, colesterol total, HDL, LDL, triglicéridos, tabaquismo, índice de masa corporal en ambos años. Tratamiento hipotensor en el año 2006. Mediante regresión logística se identifican las variables del año 2006 asociadas a buen control.
Resultados. Prevalencia detectada de HTA en ³18 años: 2003: 11,6% (IC:10,9-12,3); 2006: 16,6% (IC:15,8-17,4) (p<0,001). En hipertensos con registro de presión arterial estaban controlados (PA:<140/90) en 2003: 45,1% (IC: 41,0-48,0) y en 2006: 40,4% (IC: 37,7-43,2) (p<0,05). Variables asociadas a buen control: ser varón OR 1,60 (IC: 1,26-2,03) tratamiento con ARA II OR 2,16 (IC: 1,50-3,09) y ser diabético OR 1,50 (IC: 1,10-2,03. Se asocian a mal control: presentar enfermedad vascular cerebral, vasculopatía periférica y el tratamiento con IECA.
Conclusiones. La prevalencia de HTA detectada es baja. El nivel de control es superior para la PAD que para la PAS. El tratamiento con ARA II, ser varón o ser diabético se asocia a mejor control. La vasculopatía periférica, la cardiopatía isquémica, la enfermedad vascular cerebral, el tratamiento con IECA y edad se asocian a peor control.
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