Background
Patients with atrial fibrillation (AF) and heart failure (HF) have a high risk of thromboembolism and other outcomes and anticoagulation is recommended.
Hypothesis
This study was aimed to ...explore the risk factors associated with HF worsening in patients with AF and HF taking rivaroxaban in Spain.
Methods
Multicenter, prospective, observational study that included adults with AF and chronic HF, receiving rivaroxaban ≥4 months before entering. HF worsening was defined as first hospitalization or emergency visit because of HF exacerbation.
Results
A total of 672 patients from 71 Spanish centers were recruited, of whom 658 (97.9%) were included in the safety analysis and 552 (82.1%) in the per protocol analysis. At baseline, mean age was 73.7 ± 10.9 years, 64.9% were male, CHA2DS2‐VASc was 4.1 ± 1.5, HAS‐BLED was 1.6 ± 0.9% and 51.3% had HF with preserved ejection fraction. After 24 months of follow‐up, 24.9% of patients developed HF worsening, 11.6% died, 2.9% had a thromboembolic event, 3.1% a major bleeding, 0.5% an intracranial bleeding and no patient had a fatal hemorrhage. Older age, the history of chronic obstructive pulmonary disease, the previous use of vitamin K antagonists, and restrictive or infiltrative cardiomyopathies, were independently associated with HF worsening. Only 6.9% of patients permanently discontinued rivaroxaban treatment.
Conclusions
Approximately one out of four patients with HF and AF treated with rivaroxaban developed a HF worsening episode after 2 years of follow‐up. The identification of those factors that increase the risk of HF worsening could be helpful in the comprehensive management of this population.
Multicenter, prospective, observational study that included 672 adults from 71 Spanish centers with AF and chronic HF, receiving rivaroxaban. At baseline, mean age was 73.7 ± 10.9 years, 64.9% were male, CHA2DS2‐VASc was 4.1 ± 1.5, HAS‐BLED was 1.6 ± 0.9% and 51.3% had HF with preserved ejection fraction. After 24 months of follow‐up, 24.9% of patients developed HF worsening, 11.6% died, 2.9% had a thromboembolic event, 3.1% a major bleeding, 0.5% an intracranial bleeding and no patient had a fatal hemorrhage. Older age, the history of chronic obstructive pulmonary disease, the previous use of vitamin K antagonists, and restrictive or infiltrative cardiomyopathies, were independently associated with HF worsening. Only 6.9% of patients permanently discontinued rivaroxaban treatment.
As a starting point, a new 3D porous framework with the {CoL·0.5DMF·H
O}
chemical formula (where L = 3-amino-4-hydroxybenzoate) is described. Its performance as a single molecule magnet was explored. ...The study of magnetic properties reveals that Co-MOF shows no frequency-fdependant alternating current (
) signals under zero direct current (
) magnetic field, whereas single-molecule magnet behaviour is achieved when Co
ions are diluted in a Zn
based matrix. Interestingly, this strategy renders a bifunctional Co
Zn
L
material that is also characterized by a strong photoluminescent emitting capacity.
This systematic review aimed to evaluate the effectiveness of the independent or combined use of nutritional ergogenic aids belonging to Group A of the ABCD classification by the Australian Institute ...of Sport (AIS) in the context of cycling (caffeine, creatine, sodium bicarbonate, beta-alanine, nitrates, and glycerol). A comprehensive search was carried out using three databases: PubMed, Scopus, and Web of Science. All the databases were searched for Randomized Controlled Trials or crossover design studies assessing the effects of supplementation on cycling performance in comparison with placebos in healthy adults. The methodological quality of each study was evaluated using the Physiotherapy Evidence Database scale. Thirty-six articles involving 701 participants were included in this review, examining supplementation with caffeine (n = 5), creatine (n = 2), sodium bicarbonate (n = 6), beta-alanine (n = 3), and nitrates (n = 8). Additionally, supplemental combinations of caffeine and creatine (n = 3), caffeine and sodium bicarbonate (n = 3), caffeine and nitrates (n = 1), creatine and sodium bicarbonate (n = 1), and sodium bicarbonate and beta-alanine (n = 4) were analyzed. A benefit for cyclists’ athletic performnce was found when consuming a caffeine supplement, and a potential positive effect was noted after the consumption of sodium bicarbonate, as well as after the combination of caffeine and creatine. However, no statistically significant effects were identified for the remaining supplements, whether administered individually or in combination.
Herein, we describe and study a new family of isostructural multifunctional metal–organic frameworks (MOFs) with the formula {Ln5L6(OH)3(DMF)3·5H2O} n (where (H2L) is 3-amino-4-hydroxybenzoic acid ...ligand) for magnetism and photoluminescence. Interestingly, three of the materials (Dy-, Er-, and Yb-based MOFs) present single-molecule magnet (SMM) behavior derived from the magnetic anisotropy of the lanthanide ions as a consequence of the adequate electronic distribution of the coordination environment. Additionally, photoluminescence properties of the ligand in combination with Eu and Tb counterparts were studied, including the heterometallic Eu–Tb mixed MOF that shows potential as ratiometric luminescent thermometers. Finally, the porous nature of the framework allowed showing the CO2 sorption capacity.
We report on the formation of two novel multifunctional isomorphous (4,4) square-grid 2D coordination polymers based on 1H-indazole-5-carboxylic acid. To the best of our knowledge, these complexes ...are the first examples of 2D-coordination polymers constructed with this novel ligand. We have analysed in detail the structural, magnetic and anti-parasitic properties of the resulting materials. In addition, the capability of inhibiting nitric oxide production from macrophage cells has been measured and was used as an indirect measure of the anti-inflammatory response. Finally, the photocatalytic activity was measured with a model pollutant, i.e. vanillic acid (phenolic compound), with the aim of further increasing the functionalities and applicability of the compounds.
We report on the formation of two isomorphous (4,4) square-grid 2D coordination polymers based on 1H-indazole-5-carboxylic acid. These materials show interesting magnetic, anti-parasitic and anti-inflammatory properties. Display omitted
•New 2D coordination polymers based on 1H-indazole-5-carboxylic acid are reported.•Magnetic studies have been performed.•Compounds show interesting anti-parasitic properties.•Anti-inflammatory activities have been analysed.•Cytotoxicity in macrophages has been measured.
A new porous metal-organic framework (MOF) with the chemical formula Y
5
L
6
(OH)
3
(DMF)
3
·5H
2
O (
1
) (where L = 3-amino-4-hydroxybenzoate) has been prepared by a solvothermal procedure. The ...structural characterization reveals that this material consists of a robust three-dimensional metal-organic framework (MOF) grown with clusters formed by Y(
iii
) and hydroxide anions joined to one another by the ligand, giving rise to an open structure with interconnected microchannels with variable dimensions. This assembled set has shown to possess a fascinating catalytic activity for the cyanosilylation of a broad range of aldehydes and ketones with exceptional recyclability, a solvent-free medium, and one order of magnitude lower catalyst loading compared to all related lanthanide-based MOFs described so far in the literature.
A novel MOF has been synthesized, characterized, and applied in the cyanosilylation of aldehydes and ketones being the first example of an yttrium MOF able to catalyze this reaction.
This work reports on the synthesis and characterization of five enantiomeric pairs of isostructural 3D metal-organic frameworks (MOFs) with the general formula {Ln
2
(μ
4
-tar)
2
(μ-tar)(H
2
O)
2
·
x
...H
2
O}
n
where Ln(
iii
) = Tb (
Tb-L
and
Tb-D
), Dy (
Dy-L
and
Dy-D
), Ho (
Ho-L
and
Ho-D
), Er (
Er-L
and
Er-D
) and Tm (
Tm-L
and
Tm-D
); tar = tartrate (
d
- or
l
-) and
x
= 3 or 4 depending on the counterpart, which possess interesting luminescence and magnetic properties. These MOFs undergo progressive and reversible dehydration processes upon controlled heating yielding three crystalline phases (
Ln-L′
,
Ln-L′′
and
Ln-L′′′
). Alternating current magnetic measurements on Tb, Dy and Er-based compounds exhibit field induced single-molecule magnet behavior dominated by QTM, which is partially suppressed when diluted on a Y-based matrix. Tartrate ligands show poor room temperature sensitization of Tb and Dy centers that is enhanced at low temperature (10 K), even enabling weak Tm-based emission. More interestingly, the dehydration modulates both magnetic and photoluminescence properties on the basis of both the distortions occurring in the coordination shells and a decrease of water molecules acting as quenchers, respectively, endowing these materials with potential humidity sensing capacity. Remarkably, the Tb-based MOF shows circularly polarized luminescence (CPL), being one of the examples of this very scarce family of CPL emitters reported so far.
Chiral 3D microporous lanthanide and tartrate-based MOFs with thermally induced modulation of magnetic/luminescence properties and chiroptical activity.
In recent decades, there has been a very rapid increase in the prevalence of diabetes globally, with serious health and economic implications. Although today there are several therapeutic treatments ...for this disease, these do not address the causes of the disease and have serious side effects, so it is necessary to seek new treatments to replace or complement the existing ones. Among these complementary treatments, a strong link between the intestinal microbiota and diabetes has been demonstrated, which has focused attention on the use of biotherapy to regulate the function of the intestinal microbiota and, thus, treat diabetes. In this way, the main objective of this work is to provide a review of the latest scientific evidence on diabetes, gathering information about new trends in its management, and especially, the influence of the intestinal microbiota and microbiome on this pathology. It is possible to conclude that the relationship between the intestinal microbiota and diabetes is carried out through alterations in energy metabolism, the immune system, changes in intestinal permeability, and a state of low-intensity systemic inflammation. Although, currently, most of the experimental work, using probiotics for diabetes management, has been done on experimental animals, the results obtained are promising. Thus, the modification of the microbiota through biotherapy has shown to improve the symptoms and severity of diabetes through various mechanisms related to these alterations.
In this work a family of multidimensional (2‐(1H‐tetrazol‐5‐yl)ethyl) amino acid coordination compounds have been synthesized and thoroughly characterized. For this purpose, glycine, valine, ...phenylalanine and tyrosine have been selected as starting amino acids and Mn2+, Zn2+ and Cd2+ as metallic nodes. From one side, for Mn2+ based dimer magnetic resonance imaging studies have been conducted, prompted by the number and disposition of the coordinated water molecules and taking into consideration the promising future of manganese‐based coordination compounds as bio‐compatible substitutes to conventional Gd based contrast agents. From another side, d10 block metal‐based complexes allowed exploring photoluminescence properties derived by in situ synthesized ligands. Finally, amino acid preserved structural chirality allowed us to examine chiroptical properties, particularly focusing on circularly polarized luminescence.
A family of multidimensional coordination compounds have been synthesized based on glycine, valine, phenylalanine and tyrosine. Magnetic resonance imaging studies and chiroptical properties have been explored.
