The dynamics of a quantum phase transition are explored using slow quenches from the polar to the broken-axisymmetry phases in a small spin-1 ferromagnetic Bose-Einstein condensate. Measurements of ...the evolution of the spin populations reveal a power-law scaling of the temporal onset of excitations versus quench speed as predicted from quantum extensions of the Kibble-Zurek mechanism. The satisfactory agreement of the measured scaling exponent with the analytical theory and numerical simulations provides experimental confirmation of the quantum Kibble-Zurek model.
According to the current understanding of cosmic structure formation, the precursors of the most massive structures in the Universe began to form shortly after the Big Bang, in regions corresponding ...to the largest fluctuations in the cosmic density field. Observing these structures during their period of active growth and assembly-the first few hundred million years of the Universe-is challenging because it requires surveys that are sensitive enough to detect the distant galaxies that act as signposts for these structures and wide enough to capture the rarest objects. As a result, very few such objects have been detected so far. Here we report observations of a far-infrared-luminous object at redshift 6.900 (less than 800 million years after the Big Bang) that was discovered in a wide-field survey. High-resolution imaging shows it to be a pair of extremely massive star-forming galaxies. The larger is forming stars at a rate of 2,900 solar masses per year, contains 270 billion solar masses of gas and 2.5 billion solar masses of dust, and is more massive than any other known object at a redshift of more than 6. Its rapid star formation is probably triggered by its companion galaxy at a projected separation of 8 kiloparsecs. This merging companion hosts 35 billion solar masses of stars and has a star-formation rate of 540 solar masses per year, but has an order of magnitude less gas and dust than its neighbour and physical conditions akin to those observed in lower-metallicity galaxies in the nearby Universe. These objects suggest the presence of a dark-matter halo with a mass of more than 100 billion solar masses, making it among the rarest dark-matter haloes that should exist in the Universe at this epoch.
We report the discovery and constrain the physical conditions of the interstellar medium of the highest-redshift millimeter-selected dusty star-forming galaxy to date, SPT-S J031132−5823.4 (hereafter ...SPT0311−58), at . SPT0311−58 was discovered via its 1.4 mm thermal dust continuum emission in the South Pole Telescope (SPT)-SZ survey. The spectroscopic redshift was determined through an Atacama Large Millimeter/submillimeter Array 3 mm frequency scan that detected CO(6-5), CO(7-6), and (2-1), and subsequently was confirmed by detections of CO(3-2) with the Australia Telescope Compact Array and with APEX. We constrain the properties of the ISM in SPT0311−58 with a radiative transfer analysis of the dust continuum photometry and the CO and line emission. This allows us to determine the gas content without ad hoc assumptions about gas mass scaling factors. SPT0311−58 is extremely massive, with an intrinsic gas mass of . Its large mass and intense star formation is very rare for a source well into the epoch of reionization.
We present C ii observations of 20 strongly lensed dusty star-forming galaxies at 2.1 < z < 5.7 using Atacama Pathfinder EXperiment and Herschel. The sources were selected on their 1.4 mm flux (S
1.4 ...mm > 20 mJy) from the South Pole Telescope (SPT) survey, with far-infrared (FIR) luminosities determined from extensive photometric data. The C ii line is robustly detected in 17 sources, all but one being spectrally resolved. 11 out of 20 sources observed in C ii also have low-J CO detections from Australia Telescope Compact Array. A comparison with mid- and high-J CO lines from Atacama Large Millimeter/submillimeter Array reveals consistent C ii and CO velocity profiles, suggesting that there is little differential lensing between these species. The C ii, low-J CO and FIR data allow us to constrain the properties of the interstellar medium. We find C ii to CO(1–0) luminosity ratios in the SPT sample of 5200 ± 1800, with significantly less scatter than in other samples. This line ratio can be best described by a medium of C ii and CO emitting gas with a higher C ii than CO excitation temperature, high CO optical depth τCO(1–0) ≫ 1, and low to moderate C ii optical depth
$\tau _{{\rm C\,\small {II}}}$
≲ 1. The geometric structure of photodissociation regions allows for such conditions.
ABSTRACT The South Pole Telescope has discovered 100 gravitationally lensed, high-redshift, dusty, star-forming galaxies (DSFGs). We present 0 5 resolution 870 Atacama Large Millimeter/submillimeter ...Array imaging of a sample of 47 DSFGs spanning , and construct gravitational lens models of these sources. Our visibility-based lens modeling incorporates several sources of residual interferometric calibration uncertainty, allowing us to properly account for noise in the observations. At least 70% of the sources are strongly lensed by foreground galaxies ( ), with a median magnification of , extending to . We compare the intrinsic size distribution of the strongly lensed sources to a similar number of unlensed DSFGs and find no significant differences in spite of a bias between the magnification and intrinsic source size. This may indicate that the true size distribution of DSFGs is relatively narrow. We use the source sizes to constrain the wavelength at which the dust optical depth is unity and find this wavelength to be correlated with the dust temperature. This correlation leads to discrepancies in dust mass estimates of a factor of two compared to estimates using a single value for this wavelength. We investigate the relationship between the C ii line and the far-infrared luminosity and find that the same correlation between the C ii/ ratio and found for low-redshift star-forming galaxies applies to high-redshift galaxies and extends at least two orders of magnitude higher in . This lends further credence to the claim that the compactness of the IR-emitting region is the controlling parameter in establishing the "C ii deficit."
Abstract
We present Atacama Large Millimeter Array C i(1 − 0) (rest frequency 492 GHz) observations for a sample of 13 strongly lensed dusty star-forming galaxies (DSFGs) originally discovered at ...1.4 mm in a blank-field survey by the South Pole Telescope (SPT). We compare these new data with available C i observations from the literature, allowing a study of the interstellar medium (ISM) properties of ∼30 extreme DSFGs spanning a redshift range 2 < z < 5. Using the C i line as a tracer of the molecular ISM, we find a mean molecular gas mass for SPT-DSFGs of 6.6 × 1010 M⊙. This is in tension with gas masses derived via low-J
12CO and dust masses; bringing the estimates into accordance requires either (a) an elevated CO-to-H2 conversion factor for our sample of αCO ∼ 2.5 and a gas-to-dust ratio ∼200, or (b) an high carbon abundance
$X_{\rm C\,\small {I}} \sim 7\times 10^{-5}$
. Using observations of a range of additional atomic and molecular lines (including C i, C iiand multiple transitions of CO), we use a modern photodissociation region code (3d-pdr) to assess the physical conditions (including the density, UV radiation field strength and gas temperature) within the ISM of the DSFGs in our sample. We find that the ISM within our DSFGs is characterized by dense gas permeated by strong UV fields. We note that previous efforts to characterize photodissociation region regions in DSFGs may have significantly under-estimated the density of the ISM. Combined, our analysis suggests that the ISM of extreme dusty starbursts at high redshift consists of dense, carbon-rich gas not directly comparable to the ISM of starbursts in the local Universe.
Adeno-associated virus (AAV) vectors are currently the leading candidates for virus-based gene therapies because of their broad tissue tropism, non-pathogenic nature and low immunogenicity. They have ...been successfully used in clinical trials to treat hereditary diseases such as haemophilia B (ref. 2), and have been approved for treatment of lipoprotein lipase deficiency in Europe. Considerable efforts have been made to engineer AAV variants with novel and biomedically valuable cell tropisms to allow efficacious systemic administration, yet basic aspects of AAV cellular entry are still poorly understood. In particular, the protein receptor(s) required for AAV entry after cell attachment remains unknown. Here we use an unbiased genetic screen to identify proteins essential for AAV serotype 2 (AAV2) infection in a haploid human cell line. The most significantly enriched gene of the screen encodes a previously uncharacterized type I transmembrane protein, KIAA0319L (denoted hereafter as AAV receptor (AAVR)). We characterize AAVR as a protein capable of rapid endocytosis from the plasma membrane and trafficking to the trans-Golgi network. We show that AAVR directly binds to AAV2 particles, and that anti-AAVR antibodies efficiently block AAV2 infection. Moreover, genetic ablation of AAVR renders a wide range of mammalian cell types highly resistant to AAV2 infection. Notably, AAVR serves as a critical host factor for all tested AAV serotypes. The importance of AAVR for in vivo gene delivery is further highlighted by the robust resistance of Aavr(-/-) (also known as Au040320(-/-) and Kiaa0319l(-/-)) mice to AAV infection. Collectively, our data indicate that AAVR is a universal receptor involved in AAV infection.
We present the results from a survey of 12CO emission in 40 luminous sub-millimetre galaxies (SMGs), with 850-μm fluxes of S
850 μm = 4-20 mJy, conducted with the Plateau de Bure Interferometer. We ...detect 12CO emission in 32 SMGs at z ∼ 1.2-4.1, including 16 SMGs not previously published. Using multiple 12CO line (J
up = 2-7) observations, we derive a median spectral line energy distribution for luminous SMGs. We report the discovery of a fundamental relationship between 12CO FWHM and 12CO line luminosity in high-redshift starbursts, which we interpret as a natural consequence of the baryon-dominated dynamics within the regions probed by our observations. We use far-infrared luminosities to assess the star formation efficiency in our SMGs, finding that the slope of the L′CO-L
FIR relation is close to linear. We derive molecular gas masses, finding a mean gas mass of (5.3 ± 1.0) × 1010 M. Combining these with dynamical masses, we determine the redshift evolution of the gas content of SMGs, finding that they do not appear to be significantly more gas rich than less vigorously star-forming galaxies at high redshifts. Finally, we collate X-ray observations, and study the interdependence of gas and dynamical properties of SMGs with their AGN activity and supermassive black hole masses (M
BH), finding that SMGs lie significantly below the local M
BH-σ relation.
The standard quantum limit of measurement uncertainty can be surpassed using squeezed states, which minimize the uncertainty product in Heisenberg's relation by reducing the uncertainty of one ...property at the expense of another1. Collisions in ultracold atomic gases have been used to induce quadrature spin squeezing in two-component Bose condensates 2, 3, for which the complementary properties are the components of the total spin vector. Here, we generalize this finding to a higher-dimensional spin space by measuring squeezing in a spin-1 Bose condensate. Following a quench through a quantum phase transition, we demonstrate that spin-nematic quadrature squeezing improves on the standard quantum limit by up to 8-10 dB--a significant increase on previous measurements. This squeezing is associated with negligible occupation of the squeezed modes, and is analogous to optical two-mode vacuum squeezing. The observation has implications for continuous variable quantum information and quantum-enhanced magnetometry. PUBLICATION ABSTRACT
The entatic state denotes a distorted coordination geometry of a complex from its typical arrangement that generates an improvement to its function. The entatic-state principle has been observed to ...apply to copper electron-transfer proteins and it results in a lowering of the reorganization energy of the electron-transfer process. It is thus crucial for a multitude of biochemical processes, but its importance to photoactive complexes is unexplored. Here we study a copper complex-with a specifically designed constraining ligand geometry-that exhibits metal-to-ligand charge-transfer state lifetimes that are very short. The guanidine-quinoline ligand used here acts on the bis(chelated) copper(I) centre, allowing only small structural changes after photoexcitation that result in very fast structural dynamics. The data were collected using a multimethod approach that featured time-resolved ultraviolet-visible, infrared and X-ray absorption and optical emission spectroscopy. Through supporting density functional calculations, we deliver a detailed picture of the structural dynamics in the picosecond-to-nanosecond time range.
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![The nature of the [C ii] em...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/0035-8711_1365-8711_1365-2966/small "The nature of the [C ii] emission in dusty star-forming galaxies from the SPT survey")
