Education for the first professional degree in dentistry is intended to produce graduates capable of offering a wide range of high quality dental services to the general public. More than that, it is ...expected that graduates will be firmly grounded in the scientific basis for their professional practices and be equipped to evaluate critically and integrate selectively new scientific findings that emerge during their professional lifetimes. In addition, they are expected to be able to work effectively with diverse patient populations and to conduct their practices with a high level of sensitivity to the ethical and psychosocial dimensions of patient care. Indiana University School of Dentistry has undergone a process of curriculum reform that has yielded a new first professional degree program. Its hallmarks are large, multidisciplinary courses (seven courses in the first two years) that are taught using a variety of strategies including problem-based learning in small groups as well as lectures. The biomedical sciences curriculum is concept-based. Students will demonstrate their understanding of science concepts and methods by applying them to the solution of research and health care problems. Biomedical sciences will be taught at a level that will provide a comprehensive understanding of the functioning of the human body in health and disease, allow students to assimilate the coming revolution in molecular medicine, and selectively use new diagnostics, preventives, and therapeutics that evolve as molecular biological technologies yield solutions to current medical and dental problems. Using the biomedical sciences curriculum as a vehicle, we will also achieve the goal of training dentists as critical thinkers, problem solvers, lifelong learners, and ethical practitioners, skillful in peer and self-evaluation, and cognizant of the psychosocial as well as biomedical perspective of health and disease.
Hypnotic analgesia has occupied a pivotal place in experimental and clinical hypnosis. It emerged early in the 19th century when effective clinical techniques for pain management had not yet ...developed, and the relief of pain and suffering had not even become a well-defined social goal. Its acceptance was further complicated by political struggles surrounding the humanitarian transformation of medicine during this era as well as a redefinition of the physician patient relationship that wrested control from the patient. The initial struggle for professional acceptance was won only when the debate became almost entirely localized within the professional community. Acceptance of hypnosis by professional organizations has been followed by alternating periods of interest and indifference. While the evidence for the powerful effects of suggestion and related variables has often been observed and reported in nonhypnotic contexts, their relationship to hypnotic phenomena has often not been appreciated. Since the mid-20th century, scientific information about hypnotic analgesia has grown substantially and has had significant influence on strategies for acute and chronic pain management. If recent calls for its wider application in pain management are to succeed, it will require additional data from clinical populations and a balanced and scientifically prudent approach by its advocates.
OBJECTIVE:Metabolic syndrome (MS) has become a health and financial burden worldwide. Susceptibility of genetically determined metabotype of MS has not yet been investigated. We aimed to identify a ...distinctive metabolic profile of blood serum which might correlates to the early detection of the development of MS associated to genetic polymorphism.
DESIGN AND METHOD:We applied high resolution NMR spectroscopy to profile blood serum from patients without MS (n = 945) or with (n = 291). Principal component analysis (PCA) and projection to latent structures for discriminant analysis (PLS-DA) were applied to NMR spectral datasets. Results were cross-validated using the Venetian Blinds approach. Additionally, five SNPs previously associated with MS were genotyped with SNPlex and tested for associations between the metabolic profiles and the genetic variants. Statistical analysis was performed using in-house MATLAB scripts and the PLS Toolbox statistical multivariate analysis library.
RESULTS:Our analysis provided a PLS-DA Metabolic Syndrome discrimination model based on NMR metabolic profile (AUC = 0.86) with 84% of sensitivity and 72% specificity. The model identified 11 metabolites differentially regulated in patients with MS. Among others, fatty acids, glucose, alanine, hydroxyisovalerate, acetone, trimethylamine, 2-phenylpropionate, isobutyrate and valine, significantly contributed to the model. The combined analysis of metabolomics and SNP data revealed an association between the metabolic profile of MS and genes polymorphism involved in the adiposity regulation and fatty acids metabolismrs2272903_TT (TFAP2B), rs3803_TT (GATA2), rs174589_CC (FADS2) and rs174577_AA (FADS2). In addition, individuals with the rs2272903-TT genotype seem to develop MS earlier than general population.
CONCLUSIONS:Our study provides new insights on the metabolic alterations associated with a MS high-risk genotype. These results could help in future development of risk assessment and predictive models for subclinical cardiovascular disease.
In this paper I examine the clinical use of hypnosis for pain management from a cognitive-behavioral perspective. This perspective emphasizes the multifaceted nature of hypnotic interventions and the ...importance of patients' attitudes, expectations, and beliefs in modulating the pain experience. Special attention is given to identifying ways of combining cognitive and contextual variables to maximize clinical outcomes. Since this approach does not pivot around the concept of a hypnotic trance state, we look elsewhere in our quest to understand the nature of pain modulation in the hypnotic context. Freedom from a theoretical commitment to the hypnotic trance state is seen as opening new avenues for the development of effective clinical interventions.
We study the three-boson bound-state mass and wave functions for ground and excited states within the three-body relativistic framework with Kamada and Gl\"ocke boosted potentials in the limit of a ...zero-range interaction. We adopt a nonrelativistic short-range separable potential, with Yamaguchi and Gaussian form factors, and drive them towards the zero-range limit by letting the form factors' momentum scales go to large values while keeping the two-body binding fixed. We show that the three-boson relativistic masses and wave functions are model-independent towards the zero-range limit, and the Thomas collapse is avoided, while the nonrelativistic limit kept the Efimov effect. Furthermore, the stability in the zero-range limit is a result of the reduction of boosted potential with the increase of the virtual pair center of mass momentum within the three-boson system. Finally, we compare the present results with Light-Front and Euclidean calculations.
Numerous formal specification methods for reactive systems have been proposed in the literature. Because the significant differences between the methods are hard to determine, choosing the best ...method for a particular application can be difficult. We have applied several different methods, including Modechart, VFSM, ESTEREL, Basic LOTOS, Z, SDL, and C, to an application problem encountered in the design of software for AT&T's 5ESS telephone switching system. We have developed a set of criteria for evaluating and comparing the different specification methods. We argue that the evaluation of a method must take into account not only academic concerns, but also the maturity of the method, its compatibility with the existing software development process and system execution environment, and its suitability for the chosen application domain.
ABSTRACT This case report aims to show the anatomical and functional results of a patient diagnosed as having cancer-associated retinopathy treated with a controlled-release dexamethasone implant ...(Ozurdex). Anatomical outcomes were assessed using spectral domain optical coherence tomography; and functional outcomes, by measuring visual acuity, microperimetry, and mutifocal electroretinography. The follow-up period was 1 year.
La ética de los monstruos Chaves Gil, Jose Ignacio
Mediaciones sociales (Madrid, España ),
07/2020, Letnik:
19
Journal Article
Recenzirano
Odprti dostop
Las representaciones alrededor de personalidades complejas, tal vez físicamente deformes, psicológicamente desviadas o de comportamientos “crueles”, han contribuido a la construcción de ciertos ...imaginarios sobre esos “monstruos” para intentar mantenernos al margen de sus actos y pensamientos, para no “contagiarnos”. Como si los demás no fuéramos también, de alguna manera, “monstruos”.
El temor a lo extraño, a lo diferente, a lo que se sale de la “normalidad” impuesta, nos hace comportarnos también como monstruos frente a las personas distintas, ya lo sean por su físico, su religión, su ideología, sus opciones sexuales o cualquier otro atributo que los haga disímiles.
We present the list of amphibians for the El Silencio de Los Ángeles Cloud Forest (Villa Blanca Hotel and Reserve) in San Ramón de Alajuela, Costa Rica, Central America. We performed nocturnal visual ...and acoustic surveys in the trail system, mainly from 2013 to 2014. We also received data from the local guides up to 2019. We compared the similarity of amphibian richness of our site against other premontane reserves in Costa Rica with a cluster analysis (Jaccard index, single linkage). We recorded 26 species distributed in 16 genera, eight families and two orders. Notrotiton gamezi was the only threatened species detected. The El Silencio de los Ángeles Cloud Forest site is around 80 % similar to San Lorencito River Station and 55% to Nectandra Reserve. Containing 12% of the Costa Rica’s amphibian richness, this premontane woodland should be considered among the most important clouded forest in Central Costa Rica for amphibian conservation.
Presentamos la lista de anfibios para el Bosque Nuboso de El Silencio de Los Ángeles (Hotel y Reserva Villa Blanca) en San Ramón de Alajuela, Costa Rica, Centro América. Realizamos estudios nocturnos visuales y acústicos en el sistema de senderos, principalmente de 2013 a 2014. También recibimos datos de los guías locales hasta 2019. Comparamos la similitud de la riqueza de anfibios de nuestro sitio contra otros sitios premontanos en Costa Rica con un Análisis Clúster (índice de Jaccard, enlace único). Registramos 26 especies distribuidas en 16 géneros, ocho familias y dos órdenes. Notrotiton gamezi fue la única especie amenazada detectada. El sitio del Bosque Nuboso de El Silencio de los Ángeles presenta una similitud de alrededor del 80% a la Estación del Río San Lorencito y 55% a la Reserva Nectandra. Con un 12% de la riqueza de anfibios de Costa Rica, este bosque premontano debe considerarse entre los bosques nublados más importantes del centro de Costa Rica para la conservación de los anfibios.
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