The molecular basis of a spontaneous mutation causing beta-thalassaemia in a boy of north European descent was characterised. The codon at the beta 39 position had mutated from CAG (glutamine) to the ...stop codon TAG. This nonsense mutation occurs commonly in a hereditary form of beta-thalassaemia in the Mediterranean area; its production by a spontaneous mutation suggests that this region of the beta-globin gene is a mutational hot spot.
In this paper, we investigate three i/sub DDT/-based test methodologies, Double Threshold i/sub DDT/, Delta i/sub DDT/, and Delayed i/sub DDT/, and we compare their effectiveness in the detection of ...defects in very deep sub-micron random logic circuits. The target defects are resistive opens and resistive bridges. We present preliminary simulation results of 49 defects to study the defect sensitivity of each of the three test methods. This paper reports our preliminary results on these three test methods using a relatively small transistor-level sample circuit, and is not intended to imply any feasibility in a production environment. The test methods presented herein are the subject of a current invention disclosure.
A 2.2-kilobase clone comprising a major portion of the coding sequence of the Na super(+),K super(+)-ATPase alpha subunit was cloned from human placenta and its sequence was identical to that ...encoding the alpha subunit of human kidney and HeLa cells. Transfer blot analysis of the mRNA products of the Na super(+),K super(+)-ATPase gene from various human tissues and cell lines revealed only one band ( approximately equals 4.7 kilobases) under low and high stringency washing conditions. DNA analysis revealed a polymorphic EcoRI band and chromosome localization by flow sorting and in situ hybridization showed that the alpha subunit is on the short arm (band p11-p13) of chromosome 1.
In this paper we introduce a new PIC method based on an adaptive multi-resolution scheme for solving the one dimensional Vlasov–Poisson equation. Our approach is based on a description of the ...solution by particles of unit weight and on a reconstruction of the density at each time step of the numerical scheme by an adaptive wavelet technique: the density is firstly estimated in a proper wavelet basis as a distribution function from the current empirical data and then “de-noised” by a thresholding procedure. The so-called Landau damping problem is considered for validating our method. The numerical results agree with those obtained by the classical PIC scheme, suggesting that this multi-resolution procedure could be extended with success to plasma dynamics in higher dimensions.
