The effects of anticoagulation with citrate or hirudin on heparin effects on platelet aggregation was studied with whole blood aggregometry on blood from healthy volunteers. Platelet aggregation was ...initiated by collagen. The heparin effect was also studied with filtragometry where hirudin was used as the anticoagulant. In citrated blood, a mean collagen dose of 0.42 +/- 0.04 micrograms/ml resulted in an impedance change of 1.1 +/- 0.3 Ohm. Preincubation with heparin doses of 0.5, 2.5 and 5 IU/ml enhanced the impedance induced by the same dose of collagen by 2.9 +/- 1.4, 11.4 +/- 1.6 and 9.9 +/- 2.3 times, respectively (p less than 0.0001, ANOVA). In hirudinized blood a similar degree of change in impedance (1.5 +/- 0.2 Ohm) was achieved at significantly lower concentration of collagen (0.08 +/- 0.006 micrograms/ml, p less than 0.0001). Preincubation with heparin in doses of 0.5, 2.5 and 5 IU/ml increased impedance by 1.5 +/- 0.5, 3.9 +/- 1.6 and 1.3 +/- 0.5 times, respectively (p less than 0.0001, ANOVA). The dose-related increments were smaller in hirudinized blood as compared to citrated blood (p less than 0.04). With filtragometry, heparin dose-dependently shortened the aggregation time (p less than 0.0007). Compared to hirudin alone as anticoagulant, heparin in an equipotent dose in these experiments shortened aggregation time (p less than 0.05). In conclusion, heparin enhanced platelet aggregation both in calcium-chelated blood and in blood anticoagulated with hirudin. Heparin also dose-dependently increased platelet aggregation in filtragometry. Thus the heparin potentiating effect on platelet aggregation seems to be independent of extracellular ionized calcium and be operative at physiological calcium concentrations.
It is not easy to processing piston ring contour because of its complicating shape. From view of time-domain analysis, in order to trace the curve of piston ring, servo actuator must have high speed ...and acceleration to complete movement of back and forth. From view of frequency -domain analysis, the order of harmonic of the piston ring contour is very high, so the control system bandwidth also should be wide enough. It’s hard to satisfy these requirements for the traditional drive methods by using rotate serve and Lead screw. In this paper, a new method of direct drive by linear motor is provided, And achieve good results.
The littlest Higgs model is the most economical one among various little Higgs models. In the context of the littlest Higgs model, we study the process \(e^{+}e^{-}\to e^{+}e^{-}H\) at the ILC and ...calculate the correction of the littlest Higgs model to the cross section of this process. The results show that, in the favorable parameter spaces preferred by the electroweak precision data, the value of the relative correction is in the range from a few percent to tens percent. In most case, the correction is large enough to reach the measurement precision of the ILC. Therefore, the correction of the littlest Higgs model to the process \(e^{+}e^{-}\to e^{+}e^{-}H\) might be detected at the ILC which will give an ideal way to test the model.
The littlest Higgs model is the most economical little Higgs model. The observation of the new gauge bosons predicted by the littlest Higgs model could serve as a robust signature of the model. The ...ILC, with the high energy and luminosity, can open an ideal window to probe these new gauge bosons, specially, the lightest \(B_H\). In the framework of the littlest Higgs model, we study a gauge boson \(B_{H}\) production process \(\gamma\gamma\to W^{+}W^{-}B_H\). The study shows that the cross section of the process can vary in a wide range(\(10^{-1}-10^1\) fb) in most parameter spaces preferred by the electroweak precision data. The high c.m. energy(For example, \(\sqrt{s}=1500\) GeV) can obviously enhance the cross section to the level of tens fb. For the favorable parameter spaces, the sufficient typical events could be assumed at the ILC. Therefore, our study about the process \(\gamma\gamma\to W^{+}W^{-}B_H\) could provide a useful theoretical instruction for probing \(B_H\) experimentally at ILC. Furthermore, such process would offer a good chance to study the triple and quartic gauge couplings involving \(B_H\) and the SM gauge bosons which shed important light on the symmetry breaking features of the littlest Higgs model.
OBJECTIVE: To profile the liver cancer specific long noncoding RNAs(lnc RNAs) and competing endogenous RNA(ce RNA) networks of Hepatitis B virus(HBV)-associated hepatocarcinogensis(HCG) and to ...examine the effect of compound K on the expression of identified ce RNA networks.METHODS: Based on lnc RNA and messenger RNA(m RNA) microarray data of HBV-associated liver cancer, the current study profiles the cancer specific lnc RNAs and ce RNA networks of HBV-associated HCG through comprehensive application of Reg RNA 2, mi RTar Base and Pearson correlation coefficient analysis. Compound K-treated liver cancer cells were harvested for analysis of transcriptional levels of both enoyl-Co A hydratase and 3-hydroxyacyl Co A dehydrogenase(EHHADH)-AS1 and ENTPD5.RESULTS: The results revealed that 11 Encyclopedia of DNA Elements annotated lnc RNAs were differentially expressed in the process of HBV-associated HCG. Among these lnc RNAs, 95 potential ce RNA networks with highly positively correlated expression profiles between the interacting lnc RNAs and m RNAs(Pearson correlation coefficient ≥ 0.7) were constructed. Of note, two HBV-associated ce RNA networks, EHHADH-AS1-hsa-mi R-4459-ectonucleoside triphosphate diphosphohydrolase 5 and LINC01018-hsa-mi RNA-574-5p-glucose-6-phosphatase catalytic subunit, with Pearson correlation coefficient ≥ 0.9, may play a critical role in hepatocellular carcinoma development, which was supported by experimental evidence. Interestingly, compound K, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin, which has been proven to promote apoptosis of human hepatocellular carcinoma cells, was found to impede the down-regulation of EHHADH-AS1 in several liver cancer cell lines including Hep G3 B, Huh-7 and plc/prf/5 cells.CONCLUSION: Comprehensive application of co-expression network analysis and prediction of RNA interaction may be a feasible strategy to unravel the potential ce RNA networks involved in the process of human diseases.
Purpose/Significance National Social Science Fund reflects the trend and direction of research, the knowledge mapping analysis of NSFC in the field of library, information and documentation science ...can reveal its theme structure, track research hotspots and summarize the evolution paths. Method/Process Taking the National Social Science Fund Programs in library, information and documentation science from 2009 to 2018 as the sample, text mining and knowledge mapping analysis of data are carried out by using CiteSpace software. Results/Conclusions There are mainly six major knowledge domains: library science, documentation science, information science, archives science, enterprise competitive intelligence and western projects. The overall knowledge evolution has gradually transformed from traditional research topics to emerging topics and cross-disciplinary research. The research themes are characterized by obvious technology leading effect and policy guidance effect. This study expands the application da
Spurious reflections from shiny surfaces are one of the main problems in machine vision inspection systems based on triangulation of structured light This paper presents a practical way to solve this ...problem using reference points developed off-line and stored in a Look Up Table (LUT). First, a non-contact real-time 3D machine vision inspection system is described. Its accuracy is +/-2 /spl mu/m using a structured laser light sheet imaged by a machine vision camera. Based on the triangulation method, the system uses a single image and a fixed sheet of light combined with known position of the object being inspected The inspection locations on the object's surfaces are created off-line. To increase the inspection speed and eliminate the influence of spurious reflections from shiny surfaces, inspection of subsequent objects checks only those previously found locations. The system's repeatability depends on improving the laser centroid algorithm and avoiding reflections from shiny surfaces, A new algorithm is presented which calculates the center of the diffusely reflected laser line using a machine vision camera. The system verifies that this algorithm is more robust and accurate than traditional ones, To avoid spurious reflections from shiny surfaces, the object is first scanned off-line, finding as many points as possible where the laser line crosses the object Then the 3-space locations of these points are found using the standard triangulation algorithm. Next the object's surfaces are reconstructed using the scanned 3D points, breaking the object into various simple surface primitives such as planes, cylinders, cones, spheres and splined surfaces. The influence of the spurious reflections from shiny surfaces is eliminated by deleting those points which do not fall on the constructed surfaces. Based on the reconstructed surfaces, the system creates the object's inspection locations which is used later for fast and accurate on-line inspection,.
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