In view of the current coal mine safety supervision problems of insufficient real-time and pertinence, relying on the basic data support of “comprehensive management and control platform” in the ...intelligent construction of coal mine, this paper proposes the supervision concept of using information technology to build coal mine safety production risk monitoring and early warning system. This paper analyzes three forms of existing coal mine safety risk data integration, takes the special topic of fire risk in coal mine goaf as an example, and explains the real-time supervision mode of major risk special topic with four risk indexes of blue, yellow, orange and red. Taking an eastern province as an example, the intelligent supervision mode based on coal mine safety production risk monitoring and early warning system is verified, which realizes the remote real-time supervision of some functions of mine end supervision and the drilling query of important safety index data, and greatly improves the real-time and per
The mine fire risk evaluation method has problems of single evaluation dimension, incomplete evaluation index and unreliable evaluation result. In order to solve the above problems, based on the ...analytic hierarchy process, a staged multi-index comprehensive evaluation method for fire risk of coal working face is put forward. In order to analyze the coal working face internal fire, the method selects spontaneous combustion tendency, spontaneous combustion period, million-ton ignition rate, coal seam thickness, coal seam dip angle, geological structure, coal seam gas grade, coal mine process, goaf treatment method, upper and lower traveling wind pressure difference of the coal working face, the effectiveness of fire prevention and extinguish measures, self-heating period stage and Graham index as evaluation indexes. The method calculates the evaluation index score by adopting an interpolation method and gives weight to each evaluation index. Then the fire risk scores of the three stages including incubation per
This paper establishes an integrated education model using hierarchical analysis to divide raw data into a number of sample data based on the magnitude of similarity of data attributes. The centroids ...of the mental health education model were added to the set, and then the set was updated and looped sequentially. Profile coefficients were used to evaluate the clustering results. The evaluation criteria were precision, which is the degree of accuracy in dividing data categories. The maximum value of the assignment profile of mental health education is 96.04, and the maximum score of mental health education popularization excellence is 71.7. It shows that the integrated education model can optimize the content of mental health education, strengthen the integration of innovative entrepreneurship education and mental health education, and achieve the development of the cultivation path of mental and physical health entrepreneurs.
Detection and analysis of circulating tumor cells (CTCs) have emerged as a promising way to diagnose cancer, study its cellular mechanism, and test or develop potential treatments. However, the ...rarity of CTCs among peripheral blood cells is a big challenge toward CTC detection. In addition, in cases where there is similar size range between certain types of CTCs (e.g. breast cancer cells) and white blood cells (WBCs), high‐resolution techniques are needed. In the present work, we propose a deterministic dielectrophoresis (DEP) method that combines the concept of deterministic lateral displacement (DLD) and insulator‐based dielectrophoresis (iDEP) techniques that rely on physical markers such as size and dielectric properties to differentiate different type of cells. The proposed deterministic DEP technology takes advantage of frequency‐controlled AC electric field for continuous separation of CTCs from peripheral blood cells. Utilizing numerical modeling, different aspects of coupled DLD‐DEP design such as the required applied voltages, velocities, and geometrical parameters of DLD arrays of microposts are investigated. Regarding the inevitable difference and uncertainty ranges for the reported crossover frequencies of cells, a comprehensive analysis is conducted on applied electric field frequency as design's determinant factor. Deterministic DEP design provides continuous sorting of CTCs from WBCs even with similar size and has the future potential for high throughput and efficiency.
The effect of storage temperature and time on lipid composition of Scenedesmus sp. was studied. When stored at 4°C or higher, the free fatty acid content in the wet biomass increased from a trace to ...62.0% by day 4. Using two-step catalytic conversion, algae oil with a high free fatty acid content was converted to biodiesel by pre-esterification and transesterification. The conversion rate of triacylglycerols reached 100% under the methanol to oil molar ratio of 12:1 during catalysis with 2% potassium hydroxide at 65°C for 30min. This process was scaled up to produce biodiesel from Scenedesmus sp. and Nannochloropsis sp. oil. The crude biodiesel was purified using bleaching earth. Except for moisture content, the biodiesel conformed to Chinese National Standards.
In 2006, Hubert, Mauduit and Sárközy extended the notion of binary sequences to
-dimensional binary lattices and introduced the measures of pseudorandomness of binary lattices. In 2011, Gyarmati, ...Mauduit and Sárközy extended the notions of family complexity, collision and avalanche effect from binary sequences to binary lattices. In this paper, we construct pseudorandom binary lattices by using cyclotomic classes in finite fields and study the pseudorandom measure of order
, family complexity, collision and avalanche effect. Results indicate that such binary lattices are “good,” and their families possess a nice structure in terms of family complexity, collision and avalanche effect.
Two-dimensional (2D) transition metal dichalcogenides (TMDCs) and graphene compose a new family of crystalline materials with atomic thicknesses and exotic mechanical, electronic, and optical ...properties. Due to their inherent exceptional mechanical flexibility and strength, these 2D materials provide an ideal platform for strain engineering, enabling versatile modulation and significant enhancement of their optical properties. For instance, recent theoretical and experimental investigations have demonstrated flexible control over their electronic states via application of external strains, such as uniaxial strain and biaxial strain. Meanwhile, many nondestructive optical measurement methods, typically including absorption, reflectance, photoluminescence, and Raman spectroscopies, can be readily exploited to quantitatively determine strain-engineered optical properties. This review begins with an introduction to the macroscopic theory of crystal elasticity and microscopic effective low-energy Hamiltonians coupled with strain fields, and then summarizes recent advances in strain-induced optical responses of 2D TMDCs and graphene, followed by the strain engineering techniques. It concludes with exciting applications associated with strained 2D materials, discussions on existing open questions, and an outlook on this intriguing emerging field.
Circulating Tumor Cells (CTCs) play a prominent role in early cancer detection. Emerging label-free techniques can be promising to CTC detection due to advantages in preserving cell integrity and ...minimal sample consumption. Deterministic Lateral Displacement (DLD) is a size-based label-free technique employing laminar flow for continuous sorting of suspended cells. However, separation based solely on size is challenging as the size distributions of CTCs tend to overlap with blood cells. Moreover, the rarity of CTCs in blood requires high throughput processing of samples for clinical utility. In this work, a dielectrophoretic DLD technique is presented to segregate CTCs from blood. This technique utilizes the cell size and dielectric properties as well as particle movement caused by polarization effect to accomplish continuous separation at high flow rates. A numerical model is developed and validated to investigate the effects of various parameters related to the fluid flow, micro-post array, and electric field. It is demonstrated that the dielectrophoretic DLD with specific post arrangement can continuously separate A549 lung CTCs from WBCs by applying a field frequency close to the crossover frequency of CTCs. The analysis further indicates that such a device can perform well despite uncertainties of CTC crossover frequencies. Additionally, efficient separation with minimum clogging can be achieved by setting the electric field perpendicular to fluid flow. The presented platform offers distinct advantages and can be potentially combined with techniques such as antibody-based immune-binding methods for rapid detection of CTCs.
Various lab on a chip devices have been developed recently to detect and separate circulating tumour cells (CTCs) for early stage cancer detection. Because CTCs are extremely rare in the blood, next ...generation CTC microfilters aim at significant improvement in both efficiency and throughput. CTC microfilters based on cell deformability seem to be a promising direction. In the present research, we study a CTC passing event through a micro-filtering channel with various 3D geometries. The pressure signatures for different types of cells passing through different channels are characterized numerically. Specifically, five kinds of cross-sections, circular, square, triangular and two kinds of rectangular channels with aspect ratios of 2 and 5, are studied in this work. The total pressures for cells passing through the channels are calculated and reveal different behaviour from what is predicted by the static surface tension model. Among all five cross-sections studied, the circular cross-section features the highest critical pressure and thus is most suitable for high efficiency CTC separation. The square filtering channel provides the second largest critical pressure, and the triangular cross-section provides the least critical pressure among these three cross-sections. All these three cross-sections are better than the rectangular channels with aspect ratios of 2 and 5. For the rectangular channel, a high aspect ratio channel may lead to cell splitting at high speed, which will result in a periodic pressure signature. Our findings will provide valuable information for the design of next generation CTC microfilters.
The geometrical effects of filtering channels in a CTC microfilter have been studied. Pressure signatures and cell deformation have been characterized using numerical modeling.
The prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as ...to provide basis for treatment and management of patients.
A total of 335 patients with glioma were included in this study. These patients were admitted to the medical center between November 2015 and December 2018. The clinical data, including demographic data, tumor characteristics, treatment strategy, expression pattern of tumor markers, and survival data, were retrospectively reviewed. Survival data were analyzed using Kaplan-Meier curves with log-rank test, while multivariate analysis Cox regression model was used to investigate risk factors for mortality.
In this patient cohort, glioblastoma (40%), diffuse glioma (14.6%) and oligodendroglioma (9.6%) were the most common pathological types. The expression of Ki-67 was associated with several clinicopathological parameters (e.g. tumor type, grade, and number of lesions). In addition, Ki-67 correlated with the mortality within the first year of the post-treatment follow-up (P < 0.001). Kaplan-Maier analysis revealed that older patients (≥ 45 years) displayed worse prognosis than those aged under 45 years (P = 0.038). Dismal prognosis was also associated with clinical parameters, including high tumor grade, multiple lesions, and Karnofsky performance score (KPS). Multivariate analysis showed that low KPS (< 85) increased the risk of mortality by 2.3 folds with a 95% CI of 1.141 to 4.776 (P = 0.020). Low tumor grade (grade 1-2) oppositely reduced the mortality risk by 0.22 folds (95% CI, 0.065 to 0.763, P = 0.0168).
KPS and tumor grade were independent prognostic factors in patients with gliomas.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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