Supercritical carbon dioxide dyeing (SDD) as a dyeing media not only provides a friendly dyeing environment but also significantly increases polymeric dyeing performances ascribed to strong azo dye ...affinity. Disperse azo dyes have shown to be highly efficient dyeing agents due to their facile coupling synthesis, side chains position, and length tunability to optimize absorption properties. Herein, we first synthesize two series of disperse red azo dyes via a coupling chemical route. Further, we investigate the position of the electron withdrawing group and alkyl chains length impact onto the absorption and color fastness properties. Upon synthesis,
H NMR and mass spectroscopy were used to characterize our newly synthesized series dye structure. Also, according to spectroscopic characterization, the functional group positions as well as the alkyl chains length have a major impact on the dye series maximum light absorption wavelength and performance. We have performed SDD dyeing of polyethylene terephthalate woven and determined each dye color fastness, we find that a reduced electron withdrawing effect and alkyl chains increase reduce color-fastness performances. Overall, our dyes exhibited a good resistance against detergent water, perspiration, abrasion, and friction.
Multifunctional flexible electronics present tremendous opportunities in the rapidly evolving digital age. One potential avenue to realize this goal is the integration of polyoxometalates (POMs) and ...ionic liquid‐based gels (ILGs), but the challenge of macrophase separation due to poor compatibility, especially caused by repulsion between like‐charged units, poses a significant hurdle. Herein, the possibilities of producing diverse and homogenous POMs‐containing ionohydrogels by nanoconfining POMs and ionic liquids (ILs) within an elastomer‐like polyzwitterionic hydrogel using a simple one‐step random copolymerization method, are expanded vastly. The incorporation of polyzwitterions provides a nanoconfined microenvironment and effectively modulates excessive electrostatic interactions in POMs/ILs/H2O blending system, facilitating a phase transition from macrophase separation to a submillimeter scale worm‐like microphase‐separation system. Moreover, combining POMs‐reinforced ionohydrogels with a developed integrated self‐powered sensing system utilizing strain sensors and Zn‐ion hybrid supercapacitors has enabled efficient energy storage and detection of external strain changes with high precision. This work not only provides guidelines for manipulating morphology within phase‐separation gelation systems, but also paves the way for developing versatile POMs‐based ionohydrogels for state‐of‐the‐art smart flexible electronics.
This work presents a universal approach for synthesizing polyoxometalates (POMs)‐reinforced ionic liquid‐based gels (ILGs) and builds up an efficient bridge between them. The potential of POMs and ILGs across numerous fields, combined with structure–property–performance elucidation, has led to the identification of superior POMs‐improved ILGs suitable for the fabrication of self‐powered sensing systems.
Adult neural stem cells (NSCs) are a group of multi‐potent, self‐renewing progenitor cells that contribute to the generation of new neurons and oligodendrocytes. Three subtypes of NSCs can be ...isolated based on the stages of the NSC lineage, including quiescent neural stem cells (qNSCs), activated neural stem cells (aNSCs) and neural progenitor cells (NPCs). Although it is widely accepted that these three groups of NSCs play different roles in the development of the nervous system, their molecular signatures are poorly understood. In this study, we applied the Monte‐Carlo Feature Selection (MCFS) method to identify the gene expression signatures, which can yield a Matthews correlation coefficient (MCC) value of 0.918 with a support vector machine evaluated by ten‐fold cross‐validation. In addition, some classification rules yielded by the MCFS program for distinguishing above three subtypes were reported. Our results not only demonstrate a high classification capacity and subtype‐specific gene expression patterns but also quantitatively reflect the pattern of the gene expression levels across the NSC lineage, providing insight into deciphering the molecular basis of NSC differentiation.
The program of MCFS method produced six IF‐THEN rules for identification of different subtypes of NSCs. The performance of these IF‐THEN rules is quite good and these rules provide a more clear picture for the classification of each NSC.
Aromatic essential oils (EO) are important plant extracts that have attracted great interest for their various biological activities and their potential to replace chemical preservatives in the field ...of food preservation. Moreover, the volatility of EOs has further expanded their applications in antibacterial packaging (AP) systems.
This review focuses on the contributions of EOs to food packaging by (1) introducing the antibacterial activity of EOs; (2) summarizing the implementation of EO-APs; (3) analyzing the applications of EO-APs in food preservation; and (4) assessing the safety of EOs.
Understanding the different combinations of EOs and food packaging will help improve the effectiveness of EO-APs in food preservation and better target their use, which will promote their application in food systems. By combining them with packaging materials, the adverse flavor of EOs can be reduced and their action time prolonged, which will greatly improve their effective utilization rate in food preservation.
•Essential oils can be used as ingredients of active food packaging.•Introduced the main active ingredients and antibacterial effects of EOs commonly used in food preservation.•Focused on summarizing the implementation of EOs-AP.•Analyzed the application of EOs-AP in food preservation.
Epstein–Barr virus (EBV) is a tumor virus that is associated with a variety of neoplasms, including EBV-associated gastric carcinoma (EBVaGC). Recently, EBV was reported to generate various circular ...RNAs (circRNAs). CircRNAs are important regulators of tumorigenesis by modulating the malignant behaviors of tumor cells. However, to date, the functions of ebv-circRNAs in EBVaGC remain poorly understood. In the present study, we observed high ebv-circRPMS1 expression in EBVaGC and showed that ebv-circRPMS1 promoted the proliferation, migration, and invasion and inhibited the apoptosis of EBVaGC cells. In addition, METTL3 was upregulated in GC cells overexpressing ebv-circRPMS1. Mechanistically, ebv-circRPMS1 bound to Sam68 to facilitate its physical interaction with the METTL3 promotor, resulting in the transactivation of METTL3 and cancer progression. In clinical EBVaGC samples, ebv-circRPMS1 was associated with distant metastasis and a poor prognosis. Based on these findings, ebv-circRPMS1 contributed to EBVaGC progression by recruiting Sam68 to the METTL3 promoter to induce METTL3 expression. ebv-circRPMS1, Sam68, and METTL3 might serve as therapeutic targets for EBVaGC.
•ebv-circRPMS1 promoted the proliferation, migration, invasion, and anti-apoptosis abilities of EBVaGC cells.•ebv-circRPMS1 performed its effects by recruiting the Sam68 to the promoter of METTL3 and enhancing its transcription.•In clinical EBVaGC samples, ebv-circRPMS1 was associated with distant metastasis and poor prognosis.
A series of nonpharmaceutical interventions (NPIs) was launched in Beijing, China, on January 24, 2020, to control coronavirus disease 2019. To reveal the roles of NPIs on the respiratory syncytial ...virus (RSV), respiratory specimens collected from children with acute respiratory tract infection between July 2017 and Dec 2021 in Beijing were screened by capillary electrophoresis‐based multiplex PCR (CEMP) assay. Specimens positive for RSV were subjected to a polymerase chain reaction (PCR) and genotyped by G gene sequencing and phylogenetic analysis using iqtree v1.6.12. The parallel and fixed (paraFix) mutations were analyzed with the R package sitePath. Clinical data were compared using SPSS 22.0 software. Before NPIs launched, each RSV endemic season started from October/November to February/March of the next year in Beijing. After that, the RSV positive rate abruptly dropped from 31.93% in January to 4.39% in February 2020; then, a dormant state with RSV positive rates ≤1% from March to September, a nearly dormant state in October (2.85%) and November (2.98%) and a delayed endemic season in 2020, and abnormal RSV positive rates remaining at approximately 10% in summer until September 2021 were detected. Finally, an endemic RSV season returned in October 2021. There was a game between Subtypes A and B, and RSV‐A replaced RSV‐B in July 2021 to become the dominant subtype. Six RSV‐A and eight RSV‐B paraFix mutations were identified on G. The percentage of severe pneumonia patients decreased to 40.51% after NPIs launched. NPIs launched in Beijing seriously interfered with the endemic season of RSV.
•A novel open type I-CAES with hydraulic machine and spray cooling is proposed.•A transient thermodynamic model including air-water heat transfer is presented.•OI-CAES enables continuous energy ...storage and near isothermal compression.•Indicated efficiency of 98% and roundtrip efficiency of 76% are achieved.•Compression and expansion time ratio of 99% and 96% are obtained.
Isothermal compressed air energy storage (I-CAES) is a high efficient emission-free technology to facilitate the integration of fluctuating renewable energy into the power grid. However, in conventional closed type I-CAES (CI-CAES), the volumetric energy storage density is very low since two working mediums exist (water and air) and the water storage tank doubles the system volume. Thus, an open type I-CAES (OI-CAES) is proposed to solve this problem. Based on reversible hydraulic pump/turbine, the proposed system could achieve continuous energy storage/release and increase the compression/expansion time ratio, thus increasing the volumetric energy storage density. Combined with spray cooling, OI-CAES system could achieve near isothermal compression/expansion and improve the energy storage efficiency. A transient mathematical model is established based on thermodynamic laws and heat transfer theory. Thermodynamic analyses including a single cycle analysis and a continuous cycle analysis are carried out. A comprehensive performance assessment of the proposed systems is conducted and the effect of spray flow rate is analyzed. The results show that the compression time ratio during energy storage and the expansion time ratio during energy release are increased to 99.2% and 95.6% respectively. The energy storage density is doubled compared to CI-CAES at the same working pressure. The nearly isothermal compression/expansion is achieved with air temperature change as low as 5 °C. The indicated efficiency and roundtrip efficiency are as high as 0.98 and 0.76 respectively.
Mechanisms through which tissues are formed and maintained remain unknown but are fundamental aspects in biology. Tissue‐specific gene expression is a valuable tool to study such mechanisms. But in ...many biomedical studies, cell lines, rather than human body tissues, are used to investigate biological mechanisms Whether or not cell lines maintain their tissue‐specific characteristics after they are isolated and cultured outside the human body remains to be explored. In this study, we applied a novel computational method to identify core genes that contribute to the differentiation of cell lines from various tissues. Several advanced computational techniques, such as Monte Carlo feature selection method, incremental feature selection method, and support vector machine (SVM) algorithm, were incorporated in the proposed method, which extensively analyzed the gene expression profiles of cell lines from different tissues. As a result, we extracted a group of functional genes that can indicate the differences of cell lines in different tissues and built an optimal SVM classifier for identifying cell lines in different tissues. In addition, a set of rules for classifying cell lines were also reported, which can give a clearer picture of cell lines in different issues although its performance was not better than the optimal SVM classifier. Finally, we compared such genes with the tissue‐specific genes identified by the Genotype‐tissue Expression project. Results showed that most expression patterns between tissues remained in the derived cell lines despite some uniqueness that some genes show tissue specificity.
We used several advanced computational methods to analyze the gene expression profiles of cell lines from different tissues. Several biomarker genes and interpretable classification rules were identified and an optimal classifier was constructed.
•Experimental investigation was conducted on shear behavior of SSG in PC decks.•The interface shear force -slip non-linear relations of the specimens were obtained.•The effect of different parameters ...on behavior of specimens was investigated.•The failure modes, ductility, bearing capacity of test specimens were analyzed.•The existing design formulas may be utilized to calculate shear capacity of SSG.
In order to study the shear behavior of a group of shear studs placed on a composite beam, a total of 16 pushout tests were conducted, including 4 specimens with cast-in-place (CIP) concrete decks and 12 specimens with precast concrete (PC) decks. The primary parameters considered include reserved hole shape, loading path, and deck casting method. Through the experiment, the interface shear force-slip curves and the failure modes of shear stud groups (SSGs) in both CIP and PC decks under monotonic and repetitive loads were obtained. The results show that the shear behavior of the SSGs in square reserved holes is more favorable than that in circular reserved holes, the shear strength of SSGs in PC decks is smaller than that in CIP decks under monotonic loads. The general failure modes for a SSG are the cutoff of stud shanks and the damage of root welds at studs. While the shear strength of a SSGs in PC decks is similar to that in CIP decks under repetitive loads, ensuring the ductile failure mode of stud fracture and the shear capacity not smaller than that stipulated in the design code for reinforced concrete (RC) structures, even without using any rebar in a reserved hole. The peak interface shear force and the trend of interface shear force-slip curves under repetitive loads are also similar to that under monotonic loads, although the interface slip corresponding to peak force under monotonic loads is smaller than that under repetitive loads. The study results indicate that the SSG in a PC deck can be fully utilized and the existing design formulas almost may be utilized to calculate shear capacity of shear stud groups.
