Late‐onset cytomegalovirus (CMV) disease commonly occurs after discontinuation of antiviral prophylaxis. We determined the utility of testing CD8+ T‐cell response against CMV as a predictor of ...late‐onset CMV disease after a standard course of antiviral prophylaxis. Transplant patients at high‐risk for CMV disease were enrolled. CD8+ T‐cell‐mediated immunity (CMI) was tested using the QuantiFERON‐CMV assay at baseline, 1, 2 and 3 months posttransplant by measurement of interferon‐γ response to whole blood stimulation with a 21‐peptide pool. The primary outcome was the ability of CMI testing to predict CMV disease in the first 6 months posttransplant. There were 108 evaluable patients (D+/R+ n = 39; D‐/R+ n = 34; D+/R‐ n = 35) of whom 18 (16.7%) developed symptomatic CMV disease. At the end of prophylaxis, CMI was detectable in 38/108 (35.2%) patients (cutoff 0.1 IU/mL interferon‐γ). CMV disease occurred in 2/38 (5.3%) patients with a detectable interferon‐γ response versus 16/70 (22.9%) patients with a negative response; p = 0.038. In the subgroup of D+/R‐ patients, CMV disease occurred in 1/10 (10.0%) patients with a detectable interferon‐γ response (cutoff 0.1 IU/mL) versus 10/25 (40.0%) patients with a negative CMI, p = 0.12. Monitoring of CMI may be useful for predicting late‐onset CMV disease.
The measurement of CMV‐specific cell mediated immunity may be useful for predicting CMV disease occurring after prophylaxis. See editorial by Danziger‐Isakov and Heeger on page 987.
The mathematical model of hot-rolled coil rolling at the Steckel mill (Ferriera Valsider SpA) has been thoroughly investigated in the paper. There has been made a verification of the developed model ...to use it for the rolling technology design. The influence of the stand stiffness has also been taken into account. When simulating rolling temperature conditions, an average error was within the range from 8.27 to 9.11% at the mill 3170 and from 0.003% to-0.92% at the mill 1780. When simulating rolling force, an average error was within the range from 0.5% to 5.7% at the mill 3170 and from-4.89 to 6.59% at the mill 1780. The equation has been obtained, and the comparison of calculated stands stiffness has been made at the mill 3170 and 1780.There has been determined influence on the actual measurement of the pre-treatment temperature for the feed processing by descaler, which results in significant errors compared to the calculation results.
A method for preparing 1-tosyl-3
H
-naphtho1,2,3-
de
quinoline-2,7-diones by the reaction of
N
-(9,10-anthraquinon-1-yl)chloroacetamide with sodium
p
-toluenesulfinate has been developed. ...Nucleophilic substitution of the tosyl group by nitrogen and oxygen nucleophiles has been found to proceed under mild conditions. The corresponding 1-substituted 3
H
-naphtho1,2,3-
de
quinoline-2,7-diones have been obtained by the reaction of these compounds with amines, phenol, sodium hydroxide, and sodium azide.
The SiO
2
, Gd
2
O
3
–SiO
2
and Eu
2
O
3
–SiO
2
were synthesized by two ways: using the silicon oxide isolated from kaolin and using the silicon oxide obtained by hydrolysis of tetraethoxysilane. ...Agar-agar (polysaccharide) was added as a structure-forming agent and the freeze-drying was used for obtaining powders. DSC and TG up to 700°С revealed endothermic effects corresponding to the loss of free moisture, the decomposition of metal hydroxide and hydroxogroups (≡Si–OH) from the silica surface. The powders calcined at 700°С are X-ray amorphous. The morphology of the samples was studied using transmission electron microscopy (TEM) and dynamic light scattering (DLS). The hydrodynamic size of the particles synthesized from kaolin, determined using DLS method, exceeds the particle size established by TEM. The hydrodynamic size of the nanoparticles obtained from tetraethoxysilane is within the particle size determined by TEM. The agglomerates formed by particles synthesized from tetraethoxysilane are less strong than those obtained from kaolin. In the Eu
2
O
3
–SiO
2
system obtained using tetraethoxysilane, nanocrystallinity with a particle size of 8–40 nm was detected. The luminescence excitation spectra for the Eu
2
O
3
–SiO
2
samples synthesized by both ways differ in the ratio of the supersensitive
5
D
0
–
7
F
2
and magnetodipole
5
D
0
–
7
F
1
transition bands. For the Gd
2
O
3
–SiO
2
nanopowder obtained from tetraethoxysilane, an increase in the
5
D
0
–
7
F
2
intensity, as well as the appearance of a second
5
D
0
–
7
F
1
peak were observed.
The "wing nut" is a widespread transport and ship fixture designed to locking of hatches, covers and portholes. A more advanced closed die forging for the "wing nut" forgings of transport fittings ...was proposed with preforming by new method of bulk buckling of billet with upsetting ratio (height to diameter ratio) of 4.2...4.4. The billet and process calculation were performed based on results of researched and a new die forging was tested on a screw friction press. The results of experimental studies conducted on model lead billets at room temperature, and steel billets heated to 1180 °C, confirmed the increase in the accuracy rate of the billet material utilization ratio (one forging mass to one billet mass ratio) from 0.519 to 0.734 and metal savings up to 41% in comparison with the basic die forging without preforming of billet. It is shown that the introduction of a preforming by bulk buckling operation improves the forgings macrostructure (grainflow) even for cases the initial billets are buckled to folding defect formation, because with the further finishing die forging of semi-finished work-pieces the folding defect is displacing (or extruding) into flash. The improved die forging process and recommendations are accepted for implementation in the industry and the direction of reducing the cost of repair work for transport is noted.
The clinical significance of Mycobacterium abscessus infection in the lung transplant population is not well understood.
An international survey was performed to determine the incidence and clinical ...outcomes of M abscessus infections before and after lung transplantation.
Thirty-one (50%) of the 62 transplant centers affiliated with the International Society of Heart and Lung Transplantation responded to the survey. Of 5,200 transplants performed, 17 patients (0.33%) (M/F, 12:5) were identified with M abscessus after transplantation. Two patients had respiratory colonization before lung transplantation. Post-transplantation M abscessus infections occurred in the pulmonary allograft in 12, in skin/soft tissue in 3, or both in 2. Median time to diagnosis after transplantation was 18.5 months (range, 1-111 months). Therapies included multiple antibiotics in 16, surgical débridement in 2, interferon-gamma in 1, or no therapy owing to presumed colonization in 1. Eleven (73%) of 16 treated patients had a radiologic or microbiologic response to treatment. Concurrent infections were common, with Aspergillus (n = 8) and Pseudomonas aeruginosa (n = 5) most frequently seen. Death in 2 patients was attributed to M abscessus. Ten of 17 patients are alive and considered cured.
M abscessus infection in the lung transplant recipient is uncommon and challenging; however, successful treatment can occur. Prolonged combination anti-microbial therapy is required for pulmonary involvement, and surgical débridement is recommended for cutaneous lesions. Concurrent infections are common and may contribute to mortality in this immunosuppressed population.
MPD TPC status Averyanov, A.; Bazhazhin, A.; Chepurnov, V.F. ...
Journal of instrumentation,
07/2020, Letnik:
15, Številka:
7
Journal Article
Recenzirano
In the frame of the JINR scientific program on study of hot and dense baryonic matter a new accelerator complex Ion Collider fAcility (NICA) based on the Nuclotron-M is under realization. Two ...interaction points are foreseen at NICA for two detectors. One of these detectors, the Multi-Purpose Detector (MPD), is optimized for investigations of heavy-ion collisionsat a luminosity up to 1027 cm−2 s−1 for ions up to Au79+. The Time-Projection Chamber (TPC) is the main tracking detector of the MPD central barrel. It is a well-known detector for 3-dimensional tracking and particle identification for high multiplicity events. The conceptual layout of MPD, TPC design and it's parameters, the current status of the readout based on multiwire proportional chamber (MWPC) and readout electronics based on SAMPA chip as well as the status of TPC subsystems are presented.
In the article it was suggested to simulate the process of super-plastic deformation on optically transparent materials, created on diene and vinyl-aromatic carbohydrates, polar softener and ...achromatic stabilizer. It was shown that the index of rate hardening of such materials could change from 0.2 to 1.0 within the rate intervals of super-plastic deformation. The authors are convinced that prior to this article the alloy Sn-38%Pb was the best material for simulation of the processes of super-plastic deformation. Advantages and disadvantages of tin-lead alloy for simulation of super-plastic deformation were mentioned in the article. The article contains examples of chemical composition of new materials: the foundation (component content - 100 weight parts) - butadienesterene, isoprenesterene, butadiene-α- metylsterene; stabilizer (component content - 0.5 weight parts) - 2,6-ditretbutyl-4-metylphenol; polar softener (component content - 5-40 weight parts) - dibutylphtalate, dibutylsebacate. It was shown that introduction of polar softener reduces the effort of material flow. An unsufficient alternation of softeners content allowed modifying either behaviour of an alloy with different super-plastic structure or various temperature conditions of deforming.
The immunogenicity of influenza vaccine is suboptimal in lung transplant recipients. Use of a booster dose and vaccine delivery by the intradermal rather than intramuscular route may improve ...response. We prospectively evaluated the immunogenicity and safety of a 2‐dose boosting strategy of influenza vaccine. Sixty lung transplant recipients received a standard intramuscular injection of the 2006–2007 inactivated influenza vaccine, followed 4 weeks later by an intradermal booster of the same vaccine. Immunogenicity was assessed by measurement of geometric mean titer of antibodies after both the intramuscular injection and the intradermal booster. Vaccine response was defined as 4‐fold or higher increase of antibody titers to at least one vaccine antigen. Thirty‐eight out of 60 patients (63%) had a response after intramuscular vaccination. Geometric mean titers increased for all three vaccine antigens following the first dose (p < 0.001). However, no significant increases in titer were observed after the booster dose for all three antigens. Among nonresponders, 3/22 (13.6%) additional patients responded after the intradermal booster (p = 0.14). The use of basiliximab was associated with a positive response (p = 0.024). After a single standard dose of influenza vaccine, a booster dose given by intradermal injection did not significantly improve vaccine immunogenicity in lung transplant recipients.
In a cohort of 60 lung transplant recipients, a booster dose of seasonal influenza vaccine delivered intradermally does not significantly boost the immunogenicity of the standard intramuscular dose.
In a frame of the JINR scientific program on study of hot and dense baryonic matter a new accelerator complex Ion Collider fAcility (NICA) based on the Nuclotron-M is under realization. It will ...operate at luminosity up to 1027 cm−2s−1 for Au79+ ions. Two interaction points are foreseen at NICA for two detectors which will operate simultaneously. One of these detectors, the Multi-Purpose Detector (MPD), is optimized for investigations of heavy-ion collisions. The Time-Projection Chamber (TPC) is the main tracking detector of the MPD central barrel. It is a well-known detector for 3-dimensional tracking and particle identification for high multiplicity events. The conceptual layout of MPD and detailed description of the design and main working parameters of TPC, the readout system based on MWPC and readout electronics as well as the TPC subsystems and tooling for assembling and integration TPC into MPD are presented.
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