Over the years b-blocker metoprolol is one of the commonly prescribed drugs for the treatment of various cardiovascular pathologies . The following review article discusses the classification of ...b-blockers , and pharmacokinetics of two metoprolol forms available on the market today: metoprolol tartrate (Vasocardin, Corvitolum, Egilok ) and metoprolol succinate (Betaloc ZOK). The role of metoprolol in the treatment of hypertension, coronary artery disease and heart failure is described here as well.
The TD-DFT/B97-D/6-311G
**
method is used to calculate the electronic absorption spectra of
А
⋯
Х
⋯
А
supramolecules with intermolecular hydrogen bonds (HBs), where
А
is 4-
n
-propoxycinnamic acid,
Х
...is a nonmesogen molecule with bifunctional HB acceptors. Nonmesogens
Х
(
B
,
C
,
D
,
E
) consist of two pyridyl fragments connected by bridging groups of different natures: 4,4′-bipyridine (
В
), 1,2-bis(4-pyridyl)ethane (
С
), 1,2-bis(4-pyridyl)ethylene (
D
), 4,4′-azopyridine (
Е
). It is shown that the introduction of bridging groups (–CН
2
–CН
2
–, –CН=СН–, –N=N
–
) significantly affects the energy of frontier orbitals and electronic absorption spectra (EAS) of nonmesogens
Х
in the near-UV region. The EAS of two structural units
A
⋯
В
⋯
A
,
A
⋯
A
, which may be formed due to the self-assembly in two-component mesogen
А
–nonmesogen
В
systems, are compared. Due to hydrogen bonds (O–H⋯N and O–H⋯O), having different types and strengths in these complexes, the high-intensity band shifts to shorter wavelengths in complex
А
⋯
В
⋯
А
and to longer wavelengths in complex
А
⋯
А
with respect to the λ = 333 nm band of monomer
А
. It is shown that EAS of hydrogen-bonded complexes
А
⋯
Х
⋯
А
are not superpositions of EAS of individual components. The spectra show electronic transitions related to charge transfer between the components of the complexes. Using nonmesogens
Х
of different nature in supramolecules
А
⋯
Х
⋯
А
will allow one to change purposefully their electro-optical properties and to achieve intense absorption in particular regions of UV spectra.
Complicated systemic inflammatory response syndrome in patients undergone open-heart surgery is an important issue of cardiac surgery. The conditions and trigger mechanisms leading to such a ...complication remain unclear.We studied the impact of mechanincal myocardial injury products released into blood during open-heart surgery, lipopolysaccharides and their combination on isolated monocytes.It was found that mechanically injured myocardial tissue can be a source of intracellular heat shock protein 70 (Hsp70). The content of Hsp70 in the cytosolic cardiomyocyte fraction responsible for mechanical myocardial injury modeling corresponds to the level of proinflammatory cytokine production by monocytes and the density of TLR4 surface expression. The study results confirm the synergy and potentiation of the combined impact of mechanical myocardial injury products and lipopolysaccharides on the levels of cytokine production by monocytes.
Paper show methodic of determine of place of single-phase ground fault with intermittent arc on the overhead power line. The informative signs of single-phase ground fault place are determine by ...values of voltage of the «resonance» frequencies of zero sequence with measuringby sensors install on the overhead power line and by values of voltage of direct and inverse sequences measuring by sensors install on 0.4 kV side of consumers substations. Place of fault can be calculate by determined values of the voltages of the "resonant" harmonics, measured on consumers substations. Calculation accuracy is limited by parts of power line between consumers substations.
Time dynamics of CD14 and СD16 antigen expression on the surface of peripheral blood monocytes and serum cytokine contents was evaluated at different terms after surgical intervention in patients ...undergoing on-pump coronary artery bypass graft surgery. An association has been shown between severity of organ dysfunctions, as assessed by SOFA scores, and concentrations of IL-6 and IL-10 during early postoperative terms. On day +1 after surgery, the monocyte subpopulation profile was changed, due to relative decrease in CD14hiCD16– and increase in CD14hiCD16+. Expression of CD14 on the surface of CD14hiCD16–is reduced, along with increased expression of CD16 receptor. The observed association between relative CD14hiCD16– contents, CD16 expression level on CD14hiCD16+ monocyte subpopulation, and SOFA scores suggest a significant contribution of above-mentioned subpopulations to clinical course at early terms after surgical intervention.
Biological effects of exposure to red light (lambda = 660 +/- 10 nm) on the viability and morphophysiological characteristics of Drosophila melanogaster have been studied. The ability of this ...physical agent to modify these features is shown. The degree of expression and impact of biological effects depend on the dose, functional and genetic status of the organism. The study of the life expectancy of the exposed to EHF and white light D. melanogaster has revealed that expression of the features depends on the radiation doses, genotype, sex, the nature of the position of wings and lighting conditions. It has been found that the dark mode (24 h-night) is more favorable than the artificial lighting. Individuals with the left wing at the top are more sensitive to the external factors.
Recently, there has been an increased interest in aluminosilicates of natural origin, both in connection with the application in water and soil treatment systems, and as a matrix for the creation of ...biologically active composites. Glauconite is an aluminosilicate widely distributed in nature, which is promising for the development of effective enterosorbents and detoxification methods. New bactericidal composites based on glauconite from the Beloozersky deposit in the Saratov region are proposed. The method of scanning electron microscopy was used to study the morphological characteristics of individual glauconite and its composites. And the trace element composition was determined by energy dispersive X-ray spectroscopy. It was also established that the nitrogen adsorption-desorption isotherms for the studied glauconite sample are of type IV according to the classification of Deming and Teller (BET classification), and the sample is characterized by the presence of mesopores from 2 to 50 nm in size. The specific surface area of enriched glauconite by BET was 22.78 m2/g, and the total pore volume (P/Po = 0.98) - 0.044 cm3/g. Composites with methylene blue, cetyl priridinium chloride and their mixture were obtained on the basis of the enriched fraction of glauconite by sorption immobilization. The sorption capacity of glauconite in relation to the above biologically active substances is determined. An increase in the antibacterial effect of the obtained composites on standard strains of Staphylococcus aureus ATCC 6538 P and Escherichia coli ATCC 25922 relative to individual substances was revealed. Thus, the work shows that glauconite and composites based on it is a promising object for creating new types of enterosorbents for subsequent use in medicine and veterinary medicine.
Blood pressure (BP) control in hypertensive patients remains poor worldwide, particularly in high-risk patients with hypertension and diabetes. Guidelines recommend that such patients receive prompt ...pharmacological therapy at maximal doses to rapidly control BP. We aimed to evaluate efficacy and safety of single-pill combination (SPC) perindopril/indapamide (PER/IND) at full dose (10/2.5 mg) in hypertensive patients, including diabetics, with BP uncontrolled by previous medication.
Twelve-week prospective, observational study in patients with uncontrolled hypertension (≥160-200 mmHg systolic BP SBP and <110 mmHg diastolic BP DBP) on a previous SPC or free-dose combination of renin-angiotensin system blocker plus thiazide diuretic, substituted with PER/IND 10/2.5 mg. Office BP, quality of life, and blood parameters were evaluated in the whole cohort and patients with type 2 diabetes mellitus.
2120 ambulatory hypertensive patients were enrolled, including 307 with type 2 diabetes. Two weeks after substitution, SBP significantly decreased from 171.0 ± 13.3 to 148.6 ± 13.4 mmHg, and DBP from 98.6 ± 8.3 to 88.8 ± 7.9 mmHg (both p < 0.00001). A similar rapid decrease was noted in the diabetes subgroup. After 12 weeks, BP had reduced by 42/19 mmHg in the whole cohort (diabetes subgroup: 41/18 mmHg). Most (84%; diabetes subgroup: 77%) patients reached BP target (<140/90 mmHg). Laboratory tests and quality of life improved in the whole cohort and the diabetic subgroup.
Switching to PER/IND at full dose (10/2.5 mg) was well tolerated, leading to fast BP reduction and control in the majority of patients with uncontrolled hypertension, including difficult-to-treat patients with diabetes.
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