Aim. Russian multicenter register of familial hypercholesterolemia (FH) was transformed into Register of patients with FH and very high cardiovascular risk with insufficient effect of hypolipidemic ...therapy (RENESSANS Registry) in 2017 The aim of RENESSANS was maximal inclusion of patients not only with FH, but also those with atherosclerotic cardiovascular diseases (CVD), who did not achieve targeted level of low density lipoprotein cholesterol (LDL-C) using hypolipidemic drug therapy.Material and methods. The RENESSANS Registry is an open, national, observing study that includes patients with definite and probable (according to Dutch lipid clinic network and Simon Broome Registry criteria) heterozygous and homozygous FH, as well as patients of very high cardiovascular risk. There were designed two register forms: for patients with FH and for very high cardiovascular risk patients. Doctors filled out forms in paper and electronic variants. They took into consideration the risk factors of atherosclerosis and anamnesis of CVD, adherence to diet and hypolipidemic therapy. Concentrations of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) were measured in blood serum in all centers. LDL-C level was defined according to Friedewald formula: LDL-C=TC-HDL-C-TG/2,2 (mmol/l).Results. The Registry consisted of 1208 FH patients and 497 patients with very high risk (average age 54±13 and 61±8, respectively, 37% men). Baseline levels of lipids were 9,4±2,3 and 6,9±1,5 mmol/l for TC, 6,6±2,1 and 4,5±1,3 mmol/l for LDL-C, respectively. The frequency of hypolipidemic therapy in both groups is 70%, while targeted level of LDL-C was achieved extremely rarely.Conclusion. The results show insufficient adherence and low effectiveness of standard hypolipidemic therapy both in patients with FH and very high cardiovascular risk. PCSK9 inhibitors are recommended for resistant hypercholesterolemia treatment. The RENESSANS Registry allows to improve FH diagnostics, to assess treatment effectiveness and choose patients who need treatment with PCSK9 inhibitors.
The atmospheric plasma jet system was investigated for deposition of oxide layers on polymer (kapton) substrates. The plasma in the system was excited by an RF power source working in pulse modulated ...mode. This modulation allowed exciting high density plasma in the active part of the duty cycle and simultaneously keeping the neutral gas in the plasma jets at the substrate sufficiently cold, thus protecting the kapton substrate from thermal damage. The atmospheric plasma jet system was tested in two configurations: as single jet system and as linear multi‐jet system with four equivalent jets. The plasma in the system was investigated by means of impedance measurements. A calibrated capacitive voltage probe and a Rogowski current coil were used for direct measurement of voltage and current RF waveforms, respectively. From these data the power deposited in the discharge and the plasma column impedance were estimated. The real part of plasma impedance was used for electron concentration ne estimation. It was found that the electron concentration in the plasma jet was about 2 × 1013 cm−3. The atmospheric plasma jet source was used for low temperature deposition of conductive oxide (ZnO) thin films on kapton, silicon and quartz glass substrates. As growth precursors for ZnO films, Zn‐acetylacetonate vapors were used. Deposited ZnO films on both kapton and quartz glass contained hexagonal crystalline phase. They were optically transparent and had an electrical conductivity σ ≈ 10−1–100 S · cm−1.
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