Monoamine oxidase plays a significant role in the control of intracellular concentration of monoaminergic neurotransmitters or neuromodulators and dietary amines. The rapid degradation of these ...molecules ensures the proper functioning of synaptic neurotransmission and is critically important for the regulation of emotional and other brain functions. The development of human MAO inhibitors led to important breakthroughs in the therapy of several neuropsychiatric disorders. Different families of heterocycles containing 2 or 4 nitrogen atoms have been used as scaffolds for synthesizing selective monoamine oxidase inhibitors, but the early period of the MAO-inhibitors started with hydrazine derivatives. Pyrazole, pyrazoline, and pyrazolidine derivatives can be considered as a cyclic hydrazine moiety. This scaffold also displayed promising antidepressant and anticonvulsant properties as demonstrated by different and established animal models. Diversely substituted pyrazoles, embedded with a variety of functional groups, are important biological agents and a significant amount of research activity has been directed towards this chemical class.
We present a model with
S
3
⊗
Z
2
model plus a sterile neutrino and its phenomenological expectations for the production of charged scalars at the compact linear collider. At tree level, our model ...predicts a total cross section in between 0.1 and
10
-
5
pb for the
e
-
e
+
→
H
+
H
-
process, considering all possible mass values for the charged scalar in the CLIC experiment. We also show that this prediction holds regardless of the masses of the other exotic particles and their couplings. We also show that an indirect detection from its effects in the
e
e
¯
→
e
e
¯
+ missing energy process is possible under specific conditions, or a direct detection under other circumstances. However, one cannot use this process to study the sterile neutrinos present in this model, given that they have a small influence in the total cross-section for the direct detection of the exotic scalar to be possible.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Galaxy rotation curves and nonextensive statistics Frigerio Martins, C.; Lima, J. A. S.; Chimenti, P.
Monthly notices of the Royal Astronomical Society,
06/2015, Letnik:
449, Številka:
4
Journal Article
Recenzirano
Odprti dostop
We investigate the influence of the nonextensive q-statistics and kinetic theory on galactic scales through the analysis of a devised sample of spiral rotation curves. Largely supported by recent ...developments on the foundations of statistical mechanics and a plethora of astrophysical applications, the theory also provides an alternative interpretation to the empirical cored dark matter profiles observed in galaxies. We show that the observations could well be fitted with reasonable values for the mass model parameters, encouraging further investigation into q-statistics on the distribution of dark matter from both observational and theoretical points of view.
Abstract
In 1956 Reines & Cowan discovered the neutrino using a liquid scintillator detector. The neutrinos interacted with the scintillator, producing light that propagated across transparent ...volumes to surrounding photo-sensors. This approach has remained one of the most widespread and successful neutrino detection technologies used since. This article introduces a concept that breaks with the conventional paradigm of transparency by confining and collecting light near its creation point with an opaque scintillator and a dense array of optical fibres. This technique, called LiquidO, can provide high-resolution imaging to enable efficient identification of individual particles event-by-event. A natural affinity for adding dopants at high concentrations is provided by the use of an opaque medium. With these and other capabilities, the potential of our detector concept to unlock opportunities in neutrino physics is presented here, alongside the results of the first experimental validation.
The Neutrinos Angra Experiment has completed a major step by finishing the commissioning of the detector and the data acquisition system at the experimental site located in the Angra dos Reis nuclear ...power plant. The experiment, consisting of a water-based detector and associated electronics, was designed with the goal of detecting the electron antineutrinos produced by the nuclear reactor. The detection is possible due to the Inverse Beta Decay, where the final products in the water are photons in the UV-to-visible range of the spectrum. The assembled detector comprises three active volumes filled with water: (i) a cubic detector (Target) for electron antineutrinos, covered by 32 8-inch photomultiplier tubes (PMTs), (ii) a lateral layer surrounding the Target (Lateral veto) equipped with 4 PMTs and (iii) a third volume covering the top of both (Top veto), also equipped with 4 PMTs. In the present document the main features of the detector assembly as well as the integration of the readout electronics on-site are reported. Finally, some operational characteristics are shown based on analysis of the first measurements performed with the fully working detector.
The ν-Angra experiment aims to estimate the flux of antineutrino particles coming out from the Angra II nuclear reactor. Such flux is proportional to the thermal power released in the fission process ...and therefore can be used to infer the quantity of fuel that has been burned during a certain period. To do so, the ν-Angra Collaboration has developed an antineutrino detector and a complete acquisition system to readout and store the signals generated by its sensors. The entire detection system has been installed inside a container laboratory placed beside the dome of the nuclear reactor, in a restricted zone of the Angra II site. The system is supposed to work standalone for a few years in order to collect enough data so that the experiment can be validated. The detector's readout electronics and its environmental conditions are crucial parts of the experiment and they should work autonomously and be controlled and monitored remotely. Additionally, threshold configuration is a central issue of the experiment since antineutrino particles produce low energy signals in the detector, being necessary to carefully adjust it for all the detector channels in order to make the system capable of detecting signals as low as those generated by single photons. To this end, an embedded system was developed and integrated to the detection apparatus installed in the container at the Angra II site and is now operational and accessible to the ν-Angra Collaboration. This article aims at describing the proposed embedded system and presenting the results obtained during its commissioning phase.
A simple and rapid analytical method was developed for the determination of phthalates, usually employed in nail cosmetic products. The method is based on an ultrasonic extraction of the sample with ...ethanol–water (90:10, v/v) followed by HPLC separation and quantitation. HPLC was carried out using a C18 column and spectrophotometric detection at 254
nm. A linear gradient elution was performed with ethanol–water starting from 50 to 95% ethanol in 30
min. Standard calibration curves were linear for all the analytes over the concentration range 5–200
μg
ml
−1 with LOD values of about 0.5
μg
ml
−1.
The proposed green analytical method has been successfully applied for the analysis of commercial samples in order to check the presence of phthalates and to determine their concentration.
The direct HPLC enantioseparation of five pairs of new chiral pyrazole derivatives on coated cellulose- and amylose-based chiral stationary phases (Chiralpak AD, Chiralcel OJ and Chiralcel OJ-RH) and ...new immobilised amylose-based Chiralpak IA CSP was performed. Very high enantioselectivity factor (
α) values were achieved in polar organic and reversed-phase conditions by using OJ-RH as CSP. Chiralpak IA exhibited an excellent chiral resolving ability in normal-phase mode and it allowed the enantioseparation of analytes investigated with resolution factors (Rs) >20. Due to its bonded nature, it was successfully employed at analytical and semipreparative scale in combination with normal-phase eluents containing “non-standards” solvents such as acetone.
The synthesis of a series of N1-substituted 3,5-diphenyl pyrazolines and their activity against
Helicobacter pylori is reported.
In order to develop new anti-
Helicobacter pylori agents, a series of ...N1-substituted 3,5-diphenyl pyrazolines
P1–
P13 was prepared and evaluated for their antibacterial activity. All synthesized compounds showed little or no activity against different species of Gram-positive and Gram-negative bacteria of clinical relevance and against various strains of pathogenic fungi. The same derivatives exhibited a significant degree of activity against a range of
H. pylori strains, including those resistant to the reference compound metronidazole. Among the prepared compounds those with an N1-acetyl group and a 4-methoxy substituent in the 5-phenyl ring showed the best activity against
H. pylori metronidazole resistant strains in the 1–4
μg/mL MIC range.
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