A 32-year-old woman developed acute monocytic leukemia within a year of treatment for Hodgkin's disease with chemotherapy and radiation. Residual leukemia was present in the bone marrow after two ...induction courses of high-dose Ara-C. She received a bone marrow transplant from an HLA- and DR-identical sister and remains in complete remission more than 2 years after transplantation. Only one other instance of a remission greater than 2 years after transplantation for secondary acute leukemia could be found in the literature. Although bone marrow transplantation may be carried out successfully in these patients, it is possible that they may be more vulnerable to transplant-related complications because of their previous exposure to chemotherapy and radiation. Only further study can clarify this matter and determine the best time for the procedure and which regimen should be used.
Are sitosterols atherogenic? Lawn, Bernard; Portman, Oscar W.; Stare, Fredrick J.
Clinical pharmacology and therapeutics,
November 1962, Letnik:
3, Številka:
6
Journal Article
Recenzirano
In the editorial which appeared in the July‐August, 1962, issue of this journal, the untoward effects and possible danger of various cholesterol‐lowering agents were discussed, and only dietary ...modifications were considered a safe approach. In the discussion of sitosterols, the authors of the editorial stated that no toxic effects had as yet been reported. However, they made reference to a report by Curran and Costello in 1956 and stated: “There is evidence that sitosterols can induce atherosclerosis in experimental animals.” The implication that this may also be the case in man is apparent from the leitmotiv of the editorial.
CEBAF energy recovery experiment Bogacz, A.; Beard, K.; Bengtsson, J. ...
Proceedings of the 2003 Particle Accelerator Conference,
2003, Letnik:
1
Conference Proceeding
Odprti dostop
A successful GeV scale energy recovery demonstration with high ratio of accelerated-to-recovered energies (50:1) was recently carried out on the CEBAF recirculating linear accelerator. Future high ...energy (multi-GeV), high current (hundreds of milli-Amperes) beams would require gigaWatt-class RF systems in conventional linacs - a prohibitively expensive proposition. However, invoking energy recovery alleviates extreme RF power demands; required RF power becomes nearly independent of beam current, which improves linac efficiency and increases cost effectiveness. Furthermore, energy recovering linacs promise efficiencies of storage rings, while maintaining beam quality of linacs: superior emittance and energy spread and short bunches (sub-pico sec.). Finally, energy recovery alleviates shielding, if the beam is dumped below the neutron production threshold. Jefferson Lab has demonstrated its expertise in the field of Energy Recovery Linacs (ERLs) with the successful operation of the Infrared FEL, where 5 mA of average beam current have been accelerated up to 50 MeV and the energy stored in the beam was recovered via deceleration and given back to the RF power source. To date this has been the largest scale demonstration of energy recovery.
