Abstract
This report presents a concept of constructing a detector
dedicated for detection of muons observed during measurements
carried out at the MPD (Multi-Purpose Detector) detector that is
...currently under construction at the NICA facility, Russia, Dubna. It
has been proposed to design and build an additional detector that
will complement the current MPD set and increase its measurement
capabilities. The main goal of this project is to provide
information from cosmic muons that pass the MPD detector in both
in-beam and off-beam experiments. Hence, the detector is called the
MPD COsmic Ray Detector (MCORD).The conceptual design of MCORD is
proposed by a Polish consortium NICA-PL comprising several Polish
scientific institutions.
The data from cosmic ray muons could be used as a trigger for
calibration of other detection systems comprising the MPD
detector. Large surface covered by the MCORD offers also possibility
for efficient registration of muons generated in expanding
atmospheric showers induced by distant sources. Moreover, beyond
some energy threshold, observation of muons originating from decays
of collision products will also be possible. In this report examples
of the MCORD functionality as a part of the MPD detector are
presented.
The MCORD is designed as a universal, fast triggering system built
as a modular reconfigurable construction. The detection system will
be based on plastic scintillators equipped with wavelength shifting
fibers, and silicon photomultipliers (SiPM) will be used for
scintillation readout. The online analysis of received signals will
be performed using digital FPGA modules. Due to the modular design,
the same system (its small part) can be used for both laboratory
testing of other MPD sub-detectors, and the calibration of these
detectors after placing them inside the MPD in off-beam mode. The
full detector will support these systems as an additional trigger,
calibrator, and muon identifier during the normal operation of the
MPD detector with the beam. Thanks to its unique construction, it
will expand the possibilities of collecting scientific data of the
MPD detector with astrophysical observations.
The publication will show the assumptions of the mechanical
structure and electronic systems of the planned detector. The
installation site of the detector as part of the MPD detector will
be described in detail. In the following, the results of simulations
made in preparation for this project will be presented. In
particular, simulations with the CORSIKA code present angular
distributions of particles in cosmic showers in the Dubna city
region. Since muons dominate the cosmic ray showers, the MPD
detector response to expected cosmic muon flux was also
simulated. The results provide information about the muon cut-off
thresholds depending on the MPD detector composition during the
installation campaign. Simulations of muon events that could be used
for MPD subsystems calibration were also performed. The results
shown for various configuration of MCORD detector modules will
enable the estimation of the time necessary to perform such tests in
the future.
Simulations with UrQMD model shows the muon abundances due to
beam-beam collisions. Approximately 90% of muons are created from
pions, whereas the number of muons that reach the MCORD detector is
10 times greater than the number of pions. The MPD detector response
was also simulated under the influence of a stream of various
particles, especially muons. It shows energy dependence of muon
transmission coefficient for MPD with and without ECal
assembled. Assuming requirement for muon transmission above 95%,
the muon cut-off thresholds are 1.6 GeV and 2.0 GeV, respectively.
MCORD detector performance evaluation is also reported. In the case
when we used scintillators with one fiber with a diameter of 1 mm,
the time resolution of about 1.0 ns was recorded, which corresponds
to the positional accuracy (σ
x
) of 7.1 cm. The results of
laboratory tests show that application of a 2 mm diameter WLS fiber
instead of the previously used 1 mm diameter fiber improves the
time resolution to 0.80 ns.
Summary
Background
Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas.
Objectives
To evaluate the clinicopathological features of ...95 cases of vulvar melanoma.
Methods
p53, CD117, Ki‐67, neurofibromin, brafv600e and nrasq61r immunostains, and molecular analyses by either targeted next‐generation or direct sequencing, were performed on available archival materials.
Results
Molecular testing detected mutations in KIT (44%), BRAF (25%), NF1 (22%), TP53 (17%), NRAS (9%) and TERT promoter (9%). Co‐mutation of KIT and NF1 and of KIT and NRAS were identified in two and one cases, respectively. KIT mutations were significantly associated with better progression‐free survival in univariate analyses. In multivariate analyses CD117 expression was significantly associated with better progression‐free survival. Tumour thickness was significantly associated with worse progression‐free and overall survival, and perineural invasion significantly correlated with reduced melanoma‐specific survival and reduced overall survival. Cases were from multiple centres and only a subset of samples was available for molecular testing.
Conclusions
KIT mutations and CD117 overexpression are markers of better progression‐free survival. In addition to its prognostic value, molecular testing may identify cases that might respond to targeted agents or immunotherapeutic approaches.
What's already known about this topic?
Vulvar melanomas are rare, with poorer prognoses than conventional cutaneous melanomas.
To date, few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas.
What does this study add?
This study, involving 10 clinical institutions from the U.S.A., Spain and Poland, shows that KIT mutations and CD117 overexpression are markers of better progression‐free survival for vulvar melanoma.
What is the translational message?
CD117 immunostaining and KIT mutational analysis can potentially serve as prognostic markers of vulvar melanoma.
Targeted inhibitors may have a therapeutic role in cases harbouring actionable mutations.
Respond to this article
PANDA Phase One Liu, Z.; Liu, B.; Shen, X. ...
The European physical journal. A, Hadrons and nuclei,
06/2021, Letnik:
57, Številka:
6
Journal Article
Recenzirano
Odprti dostop
The Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany, provides unique possibilities for a new generation of hadron-, nuclear- and atomic physics experiments. The future ...antiProton ANnihilations at DArmstadt (PANDA or
P
¯
ANDA) experiment at FAIR will offer a broad physics programme, covering different aspects of the strong interaction. Understanding the latter in the non-perturbative regime remains one of the greatest challenges in contemporary physics. The antiproton–nucleon interaction studied with PANDA provides crucial tests in this area. Furthermore, the high-intensity, low-energy domain of PANDA allows for searches for physics beyond the Standard Model,
e.g.
through high precision symmetry tests. This paper takes into account a staged approach for the detector setup and for the delivered luminosity from the accelerator. The available detector setup at the time of the delivery of the first antiproton beams in the HESR storage ring is referred to as the
Phase One
setup. The physics programme that is achievable during Phase One is outlined in this paper.
The Nuclotron-based Ion Collider fAcility (NICA) is under construction at the Joint Institute for Nuclear Research (JINR), with commissioning of the facility expected in late 2022. The Multi-Purpose ...Detector (MPD) has been designed to operate at NICA and its components are currently in production. The detector is expected to be ready for data taking with the first beams from NICA. This document provides an overview of the landscape of the investigation of the QCD phase diagram in the region of maximum baryonic density, where NICA and MPD will be able to provide significant and unique input. It also provides a detailed description of the MPD set-up, including its various subsystems as well as its support and computing infrastructures. Selected performance studies for particular physics measurements at MPD are presented and discussed in the context of existing data and theoretical expectations.
Decays of b hadrons into final states containing a D0 meson and a muon are used to measure the bb¯ production cross-section in proton–proton collisions at a centre-of-mass energy of 7 TeV at the LHC. ...In the pseudorapidity interval 2<η<6 and integrated over all transverse momenta we find that the average cross-section to produce b-flavoured or b¯-flavoured hadrons is (75.3±5.4±13.0) μb.
The exclusive charmonium production process in p¯p annihilation with an associated π0 meson p¯p→J/ψπ0 is studied in the framework of QCD collinear factorization. The feasibility of measuring this ...reaction through the J/ψ→e+e− decay channel with the AntiProton ANnihilation at DArmstadt (P¯ANDA) experiment is investigated. Simulations on signal reconstruction efficiency as well as the background rejection from various sources including the p¯p→π+π−π0 and p¯p→J/ψπ0π0 reactions are performed with PandaRoot, the simulation and analysis software framework of the P¯ANDA experiment. It is shown that the measurement can be done at P¯ANDA with significant constraining power under the assumption of an integrated luminosity attainable in four to five months of data taking at the maximum design luminosity.
MCORD - MPD Cosmic Ray Detector a new features Bielewicz, M.; Milewicz-Zalewska, M.; Grodzicka-Kobylka, M. ...
EPJ Web of Conferences,
2019, Letnik:
204
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
The main detector system at the Nuclotron-based Ion Collider fAcility (NICA) located in Dubna, Russia is the Multi-Purpose Detector (MPD). For better calibration reason, the MPD needs an additional ...trigger system for an off-beam calibration of MPD sub-detectors and for rejection (veto) of cosmic muons. The system should also be useful for practical astrophysics observations of cosmic showers. The consortium NICA-PL group defines goals and basic assumptions for the MPD Cosmic Ray Detector (MCORD). This article describes the conceptual design and simulation plans of the MCORD detector based on plastic scintillators with SiPM photodetectors and electronic digital system based on the MicroTCA crate.
.
This paper summarises a comprehensive Monte Carlo simulation study for precision resonance energy scan measurements. Apart from the proof of principle for natural width and line shape measurements ...of very narrow resonances with PANDA, the achievable sensitivities are quantified for the concrete example of the charmonium-like
X
(3872) state discussed to be exotic, and for a larger parameter space of various assumed signal cross-sections, input widths and luminosity combinations. PANDA is the only experiment that will be able to perform precision resonance energy scans of such narrow states with quantum numbers of spin and parities that differ from
J
P
C
=
1
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.
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