Recent rapid thinning of West Antarctic ice shelves are believed to be caused by intrusions of warm deep water that induce basal melting and seaward meltwater export. This study uses data from three ...bottom-mounted mooring arrays to show seasonal variability and local forcing for the currents moving into and out of the Dotson ice shelf cavity. A southward flow of warm, salty water had maximum current velocities along the eastern channel slope, while northward outflows of freshened ice shelf meltwater spread at intermediate depth above the western slope. The inflow correlated with the local ocean surface stress curl. At the western slope, meltwater outflows followed the warm influx along the eastern slope with a ~2-3 month delay. Ocean circulation near Dotson Ice Shelf, affected by sea ice distribution and wind, appears to significantly control the inflow of warm water and subsequent ice shelf melting on seasonal time-scales.
ABSTRACT We explore the similarity and difference of the quasi-periodic pulsations (QPPs) observed in the decay phase of solar and stellar flares at X-rays. We identified 42 solar flares with ...pronounced QPPs, observed with RHESSI, and 36 stellar flares with QPPs, observed with XMM-Newton. The empirical mode decomposition (EMD) method and least-squares fit by a damped sine function were applied to obtain the periods (P) and damping times (τ) of the QPPs. We found that (1) the periods and damping times of the stellar QPPs are 16.21 15.86 minutes and 27.21 28.73 minutes, while those of the solar QPPs are 0.90 0.56 and 1.53 1.10 minutes, respectively; (2) the ratios of the damping times to the periods ( ) observed in the stellar QPPs (1.69 0.56) are statistically identical to those of solar QPPs (1.74 0.77); and (3) the scalings of the QPP damping time with the period are well described by the power law in both solar and stellar cases. The power indices of the solar and stellar QPPs are 0.96 0.10 and , respectively. This scaling is consistent with the scalings found for standing slow magnetoacoustic and kink modes in solar coronal loops. Thus, we propose that the underlying mechanism responsible for the stellar QPPs is the natural magnetohydrodynamic oscillation in the flaring or adjacent coronal loops, as in the case of solar flares.
Background and purpose
High blood pressure (BP) at presentation is associated with poor outcomes in acute ischaemic stroke, but serial BP measurements may better delineate the clinical implications ...of BP. The aim was to investigate the association between various BP parameters and functional outcomes in acute ischaemic stroke patients treated with endovascular thrombectomy (EVT).
Methods
This study reports a retrospective analysis of a prospective registry of a comprehensive stroke centre. Patients treated with EVT due to large vessel occlusion in the anterior circulation were enrolled. BP was measured hourly during the first 24 h after admission. Associations of various BP parameters, including BP variability, with functional outcomes at 3 months, including good outcomes (modified Rankin Scale score of 0–2), were analysed.
Results
Of the 378 enrolled patients (mean age 70 ± 11 years, male 54.2%), 313 (82.8%) achieved successful reperfusion after EVT, and 149 (39.4%) had good outcomes at 3 months. Higher mean systolic BP each 10 mmHg increase, odds ratio 0.82 (0.69–0.97) and higher systolic successive variation (SV) each 10% increase, odds ratio 0.37 (0.18–0.76) were associated with a reduced likelihood of achieving good outcomes. In addition, reperfusion status after EVT moderated the influence of higher systolic SV on good outcomes (Pint = 0.05).
Conclusion
The results showed that a higher mean systolic BP and systolic SV during the first 24 h of EVT reduced the likelihood of good outcomes at 3 months. The effects of these parameters on outcomes are more substantial amongst patients with successful reperfusion after EVT, suggesting that different BP control strategies should be employed according to reperfusion status.
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With the rapid advancement of laser scanning and photogrammetry technologies, frequent geometric data collection at construction sites by contractors has been increased for the purpose of improving ...constructability, productivity, and onsite safety. However, the conventional static laser scanning method suffers from operational limitations due to the presence of many occlusions commonly found in a typical construction site. Obtaining a complete scan of a construction site without information loss requires that laser scans are obtained from multiple scanning locations around the site, which also necessitates extra work for registering each scanned point cloud. As an alternate solution to this problem, this paper introduces an autonomous mobile robot which navigates a scan site based on a continuously updated point cloud map. This mobile robot system utilizes the 2D Hector Simultaneous Localization and Mapping (SLAM) technique to estimate real-time positions and orientations of the robot in the x-y plane. Then, the 2D localization information is used to create 3D point clouds of unknown environments in real time to determine its navigation paths as a pre-scanning process. The advantage of this framework is the ability to determine the optimal scan position and scan angle to reduce the scanning time and effort for gathering high resolution point cloud data in real-time. The mobile robot system is able to capture survey-quality RGB-mapped point cloud data, and automatically register the scans for geometric reconstruction of the site. The performance of the overall system was tested in an indoor environment and validated with promising results.
•A SLAM-driven automatic point cloud registration framework is proposed.•The framework is based on combination of dynamic and static scans.•The static scan performs better in efficiency and accuracy than the dynamic scan.•The framework works with small overlap areas and without common targets or features.
We have studied the self-assembly of amphiphilic dendrons extended with linear polyethylene oxide (PEO) chains and their ion complexes. Keeping the dendron core and linear PEO chain compatible allows ...for the combination of dendritic core-shell and conventional block copolymer characteristics for complex mesophase behavior. An unexpected sequence of crystalline lamellar, cubic micellar (Pm3̄n), hexagonal columnar, continuous cubic (Ia3̄d), and lamellar mesophases is observed. Multiple phase behavior within single compounds allows for the study of charge transport and mechanical property correlations as a function of structure. The results suggest an advanced molecular design concept for the next generation of nanostructured materials in applications involving charge transport.
AbstractConstruction sites need to be monitored continuously to detect unsafe conditions and protect workers from potential injuries and fatal accidents. In current practices, construction-safety ...monitoring relies heavily on manual observation, which is labor-intensive and error-prone. Due to the complex environment of construction sites, it is extremely challenging for safety inspectors to continuously monitor and manually identify all incidents that may expose workers to safety risks. There exist many research efforts applying sensing technologies to construction sites to reduce the manual efforts associated with construction-safety monitoring. However, several bottlenecks are identified in applying these technologies to the onsite safety monitoring process, including (1) recognition and registration of potential hazards, (2) real-time detection of unsafe incidents, and (3) reporting and sharing of the detected incidents with relevant participants in a timely manner. The objective of this study was to create and evaluate a low-cost automated safety monitoring system to assist in the construction-safety monitoring process. This paper presents a framework for this safety monitoring system as a cloud-based real time on-site application. The system integrates Bluetooth low-energy (BLE)-based location detection technology, building information model (BIM)-based hazard identification, and a cloud-based communication platform. Potential unsafe areas are defined automatically or manually in a BIM model. Real-time worker locations are acquired to detect incidents where workers are exposed to predefined risks. Then, the safety monitoring results are instantly communicated over the cloud for effective safety management. Through a real-world construction site case study, the system successfully demonstrated the capability to detect unsafe conditions and collect and analyze the trajectories of workers with respect to potential safety hazards. The results indicate that the proposed approach can assist in the construction site monitoring process and potentially improve site safety.
Recent advances in strategies for synthesizing nanoparticles-such as semiconductor quantum dots, magnets and noble-metal clusters-have enabled the precise control of composition, size, shape, crystal ...structure, and surface chemistry. The distinct properties of the resulting nanometre-scale building blocks can be harnessed in assemblies with new collective properties, which can be further engineered by controlling interparticle spacing and by material processing. Our study is motivated by the emerging concept of metamaterials-materials with properties arising from the controlled interaction of the different nanocrystals in an assembly. Previous multi-component nanocrystal assemblies have usually resulted in amorphous or short-range-ordered materials because of non-directional forces or insufficient mobility during assembly. Here we report the self-assembly of PbSe semiconductor quantum dots and Fe2O3 magnetic nanocrystals into precisely ordered three-dimensional superlattices. The use of specific size ratios directs the assembly of the magnetic and semiconducting nanoparticles into AB13 or AB2 superlattices with potentially tunable optical and magnetic properties. This synthesis concept could ultimately enable the fine-tuning of material responses to magnetic, electrical, optical and mechanical stimuli.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Tramadol is a unique analgesic medication, available in variety of formulations, with both monoaminergic reuptake inhibitory and opioid receptor agonist activity increasingly prescribed worldwide as ...an alternative for high-affinity opioid medication in the treatment of acute and chronic pain. It is a prodrug that is metabolized by cytochrome P450 (CYP) enzymes CYP2D6 and CYP3A4 to its more potent opioid analgesic metabolites, particularly the O-demethylation product M1. The opioid analgesic potency of a given dose of tramadol is influenced by an individual’s CYP genetics, with poor metabolizers experiencing little conversion to the active M1 opioid metabolite and individuals with a high metabolic profile, or ultra-metabolizers, experiencing the greatest opioid analgesic effects. The importance of the CYP metabolism has led to the adoption of computer clinical decision support with pharmacogenomics tools guiding tramadol treatment in major medical centers. Tramadol’s simultaneous opioid agonist action and serotonin (5-HT) and norepinephrine reuptake inhibitory effects result in a unique side effect profile and important drug interactions that must be considered. Abrupt cessation of tramadol increases the risk for both opioid and serotonin–norepinephrine reuptake inhibitor withdrawal syndromes. This review provides updated important information on the pharmacology, pharmacokinetics, CYP genetic polymorphisms, drug interactions, toxicity, withdrawal, and illicit use of tramadol.
Abstract
The interplay of charge, spin, orbital and lattice degrees of freedom has recently received great interest due to its potential to improve the magnetocaloric effect (MCE) for the purpose of ...magnetic cooling applications. Here, a new mechanism for a large entropy change with low magnetic fields in rare-earth tetraborides, especially for Ho
1-
x
Dy
x
B
4
(
x
= 0.0, 0.5, and 1.0), is proposed. For
x
= 0.0, 0.5, and 1.0, the maximum entropy changes of the giant inverse MCE are found to be 22.7 J/kgK, 19.6 J/kgK, and 19.0 J/kgK with critical fields of 25 kOe, 40 kOe, and 50 kOe, respectively. For all compounds, systematic study on how the entropy changes as a function of the field and temperature is performed to investigate their correlation with consecutive double transitions, i.e., the magnetic dipolar order at
T
=
T
N
and the quadrupolar order at
T
=
T
Q
(
T
Q
<
T
N
). Based on Landau theory, it is found that this behaviour is attributed to the strong coupling between magnetic dipoles and quadrupoles in the presence of strong spin-orbit coupling and geometric frustration. Our work offers new insights into both academic and industrial interests in the discovery of giant MCE with various applications for magnetic cooling systems.
Organisms must learn new strategies to adapt to changing environments. Activity in different neurons often exhibits synchronization that can dynamically enhance their communication and might create ...flexible brain states that facilitate changes in behavior. We studied the role of gamma-frequency (~40 Hz) synchrony between prefrontal parvalbumin (PV) interneurons in mice learning multiple new cue-reward associations. Voltage indicators revealed cell-type-specific increases of cross-hemispheric gamma synchrony between PV interneurons when mice received feedback that previously learned associations were no longer valid. Disrupting this synchronization by delivering out-of-phase optogenetic stimulation caused mice to perseverate on outdated associations, an effect not reproduced by in-phase stimulation or out-of-phase stimulation at other frequencies. Gamma synchrony was specifically required when new associations used familiar cues that were previously irrelevant to behavioral outcomes, not when associations involved new cues or for reversing previously learned associations. Thus, gamma synchrony is indispensable for reappraising the behavioral salience of external cues.
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