The authors describe a rare case of inflammatory pseudotumor involving the clivus, where a soft tissue mass lesion, with extension into the prevertebral retropharyngeal space and the cavernous ...sinuses, was detected by CT and MRI. The mass resembled a malignant tumor or aggressive infectious lesion, and the final diagnosis of inflammatory pseudotumor was a diagnosis of exclusion, decided after histopathological examination.
AIM To determine adiponectin expression in colonic tissue of murine colitis and systemic cytokine expression after melatonin treatments and sleep deprivation.METHODS The following five groups of ...C57BL/6 mice were used in this study:(1) group Ⅰ,control;(2) group Ⅱ,2% DSS induced colitis for 7 d;(3) group Ⅲ,2% DSS induced colitis and melatonin treatment;(4) group Ⅳ,2% DSS induced colitis with sleep deprivation(SD) using specially designed and modified multiple platform water baths; and(5) group V,2% DSS induced colitis with SD and melatonin treatment. Melatonin(10 mg/kg) or saline was intraperitoneally injected daily to mice for 4 d. The body weight was monitored daily. The degree of colitis was evaluated histologically after sacrificing the mice. Immunohistochemical staining and Western blot analysis was performed using anti-adiponectin antibody. After sampling by intracardiac punctures,levels of serum cytokines were measured by ELISA. RESULTS Sleep deprivation in water bath exacerbated DSS induced colitis and worsened weight loss. Melatonin injection not only alleviated the severity of mucosal injury,but also helped survival during stressful condition. The expression level of adiponectin in mucosa was decreased in colitis,with the lowest level observed in colitis combined with sleep deprivation. Melatonin injection significantly(P < 0.05) recovered the expression of adiponectin. The expression levels of IL-6 and IL-17 were increased in the serum of mice with DSS colitis but decreased after melatonin injection. CONCLUSION This study suggested that melatonin modulated adiponectin expression in colonic tissue and melatonin and adiponectin synergistically potentiated antiinflammatory effects on colitis with sleep deprivation.
Pulmonary choriocarcinoma is a very rare tumor in men. Herrein, the case of a pulmonary choriocarcinoma in 39-year-old man, and whether it had a primary nature, is reported. He denied any prior ...medical illness, but was admitted to our hospital with a history of a cough, and progressive dyspnea and hemoptysis 2 and 1 week duration, respectively. Chest radiographs on admission revealed a huge lung mass, 10 cm in diameter, in the left upper lung field, with left pleural effusion. Although biopsies using several diagnostic methods for the pathological confirmation were attempted, the pathology was not confirmed. Finally, the patient died after 2 months of regression. An autopsy of the lung was then performed. 저자들은 39세 남자 환자에서 부검을 통해 폐의 융모상피암종을 확인하였으나 고환과 같은 생식선 또는 성선 이외(extragonad) 부위에서의 암종 존재 유무를 확인하지 못하여 원발성인지 혹은 전이성인지를 구분하지 못한 폐의 융모상피암 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.
Purpose : The incidence of neonatal hyperbilirubinemia is twice as high in East Asians as in Caucasians. However, its metabolic basis has not been clearly explained. The UDP-glucuronosyltransferase ...gene(UGT1A1) mutation was found to be a risk factor of neonatal hyperbilirubinemia. We studied whether neonatal hyperbilirubinemia is associated with the 1828G>A(rs 10929303) polymorphism of the UGT1A1 gene, which encodes for a key enzyme of bilirubin metabolism. Methods : The genomic DNA was isolated from 80 Korean full term neonates who had greater than a 12 mg/dL level of serum bilirubin with no obvious cause, and the genomic DNA was also isolated from 164 Korean neonates of the control population. We studied a single nucleotide polymorphism (SNP) of 1828G>A in the untranslated region of the UGT1A1 gene by direct sequencing. Results : Three of the 80 neonates with a serum bilirubin level above 12 mg/dL had homozygous mutations and 10 of the 80 neonates with a serum bilirubin level above 12 mg/dL had heterozygous mutations. Thirteen of the 164 neonates of the control group had homozygous mutations and 16 neonates of the control group had heterozygous mutations. The allele frequency of 1828G>A polymorphism of UGT1A1 in the hyperbilirubinemia group was 10.0 percent, which was not significantly different from the allele frequency of 12.8 percent in the control group. Conclusion : In this study, the 1828G>A polymorphism of the UGT1A1 gene was detected in the Korean neonates with neonatal hyperbilirubinemia. Our results indicated that this SNP is not associated with the prevalence of hyperbilirubinemia in Koreans. 목 적 : 신생아 황달은 중국, 일본, 한국인 등 동양인에서 서양인에 비해 많이 발생하여 유전적인 요인이 있을 것으로 생각되며 빌리루빈 대사의 주된 효소인 Uridine diphosphate glucuronosyl transferase 유전자의 다형성이 관여한다고 보고되고 있다. 저자들은 빌리루빈 대사의 핵심 효소인 UGT1A1 유전자의 다형성이 한국인 신생아 황달과 어떤 연관성이 있는지 알아 보고자 본 연구를 시행하였다. 방 법 : 혈중 빌리루빈 수치가 12 mg/dL 이상의 건강하고, 위험인자가 없는 만삭아 중 신생아 황달 환아 80명과, 대조군 164명으로부터 혈액을 0.5 cc를 채취하여 DNA을 분리하였다. UGT1A1 유전자를 PCR로 증폭하여, 염기서열 분석 방법을 통해 UGT1A1 유전자 untranslated region의 1828G>A(rs 10929303) 단일염기다형성을 확인하였다. 결 과 : UGT1A1 유전자 3' untranslated region의 guanine에서 adenine으로의 1828G>A 단일염기다형성이 신생아 고빌리루빈군 중 총 혈청 빌리루빈이 12 mg/dL 이상인 80명 중 67명(83.8%)이 GG 유전형을 보였고 10명(12.5%)이 GA 이종접합, 3명(3.7%)이 AA 유전형을 나타냈다. 대조군 164명에서는 135명(82.3%)이 GG 유전형을 보였고, GA 이종접합은 16명(9.8%), AA 유전형은 13명(7.9%)으로 나타났다. 변이형 대립유전자 빈도는 고빌리루빈혈증군에서 10.0%로 대조군 12.8%와 비슷하였다(P=0.3687). 결 론 : 한국인 신생아 황달에서 UGT1A1 유전자의 1828G>A 다형성을 확인하였으나, 이는 고빌리루빈혈증군에서 대조군에서와 비슷한 빈도로 관찰되어 한국인 신생아 황달의 발생과 연관이 없을 것으로 생각된다.
Antioxidative activities againt 1,1-dipheny1-2-picrylhydrazy1 (DPPH) radical were evaluated for ten diarylheptanoids, ...1,7-bis-(3,4-dihydroxypheny1)-heptane-3-O-¥â-D-glucopyranosy(1¡æ3)-¥â-D-xylopyranoside(1), 1,7-bis-(3,4-dihydroxypheny1)-heptane-3-O-¥â-D-apiofuranosy1(1¡æ6)-¥â-D-glucopyranoside(2), 1,7-bis-(3,4-dihydroxypheny1)-heptane-5-O-¥â-D-glucopyranoside (3), 1,7-bis-(3,4-dihydroxypheny1)-5-hydroxyheptane(4), 1,7-bis-(3,4-dihydroxypheny1)-heptane-3-one-5-O-¥â-D-glucopyranoside(5), oregonin(6), hirautaonlo(7), hirsutenone(8), 1,7-bis-(3,4-dihydroxypheny1)-5-hydroxyheptane-3-O-¥â-D-xylopyranoside(9) and playphylloside(10), which were isolated from Alnus japonica, aglycones (4,7 and 8) and mono goycosides (3, 6 and 9) showed more strong antioxidative activities than diglycosides (1 and 2) against the DPPH radical. Especially, hirstutenone(8) showed superior activity among the diarylheptaoid.
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