The large, faint supernova remnant (SNR) G70.0-21.5 is believed to be the result of a Type Ia supernova some 90,000 yr ago at a distance of ∼1 kpc based on the Gaia proper motion and parallax of an ...unusual white dwarf. We have obtained narrow passband optical images and high-resolution spectroscopy to determine shock speeds of 70 to 110 km s−1. The shock itself is unusual in that the sharp H filaments arise from a very thin postshock zone where preshock neutral atoms are rapidly excited and ionized. Combining the shock speed with the remnant's estimated age, distance, and diameter, we investigate the SNR evolution in the post-Sedov phase. One-dimensional models that ignore such factors as magnetic fields, cosmic rays, and thermal conduction are marginally consistent with the observations.
Our view of the interstellar medium of the Milky Way and the universe beyond is affected by the structure of the local environment in the solar neighborhood. We present the discovery of a ...30-degree-long arc of ultraviolet emission with a thickness of only a few arcminutes: the Ursa Major arc. This consists of several arclets seen in the near- and far-ultraviolet bands of the GALEX satellite. A two degree section of the arc was first detected in the H
α
optical spectral line in 1997; additional sections were seen in the optical by the team of amateur astronomers included in this work. This direction of the sky is known for very low hydrogen column density and dust extinction; many deep fields for extragalactic and cosmological investigations lie in this direction. Diffuse ultraviolet and optical interstellar emission are often attributed to scattering of light by interstellar dust. The lack of correlation between the Ursa Major arc and thermal dust emission observed with the
Planck
satellite, however, suggests that other emission mechanisms must be at play. We discuss the origin of the Ursa Major arc as the result of an interstellar shock in the solar neighborhood.
ABSTRACT
We report the results of the stellar occultation by (UII) Umbriel on 2020 September 21. The shadow crossed the USA and Canada, and 19 positive chords were obtained. A limb parameter ...accounted for putative topographic features in the limb fittings. Ellipse fittings were not robust – only upper limits were derived for the true size/shape of a putative Umbriel ellipsoid. The adopted spherical solution gives radius = 582.4 ± 0.8 km, smaller/close to 584.7 ± 2.8 km from Voyager II. The apparent ellipse fit results in a true semi-major axis of 584.9 ± 3.8 km, semi-minor axis of 582.3 ± 0.6 km, and true oblateness of 0.004 ± 0.008 for a putative ellipsoid. The geometric albedo was pV = 0.26 ± 0.01. The density was ρ = 1.54 ± 0.04 g cm−3. The surface gravity was 0.251 ± 0.006 m s−2 and the escape velocity was 0.541 ± 0.006 km s−1. Upper limits of 13 and 72 nbar (at 1σ and 3σ levels, respectively) were obtained for the surface pressure of a putative isothermal CO2 atmosphere at T = 70 K. A milliarcsecond precision position was derived: α = 02h30m28${_{.}^{\rm s}}$84556 ± 0.1 mas, δ = 14o19′36″.5836 ± 0.2 mas. A large limb parameter of 4.2 km was obtained, in striking agreement with opposite Southern hemisphere measurements by Voyager II in 1986. Occultation and Voyager results indicate that the same strong topography variation in the surface of Umbriel is present on both hemispheres.
We developed a new robust reduction-responsive polymersome based on the amphiphilic block copolymer PEG-SS-PAChol. The stability and robustness were achieved by the smectic physical cross-linking of ...cholesterol-containing liquid crystal polymer PAChol in the hydrophobic layer. The reduction-sensitivity was introduced by the disulfide bridge (-S–S-) that links the hydrophilic PEG block and the hydrophobic PAChol block. We used a versatile synthetic strategy based on atom transfer radical polymerization (ATRP) to synthesize the reduction-responsive amphiphilic block copolymers. The reductive cleavage of the disulfide bridge in the block copolymers was first evidenced in organic solution. The partial destruction of PEG-SS-PAChol polymersomes in the presence of a reducing agent was then demonstrated by cryo-electron microscopy. Finally, the calcein release from PEG-SS-PAChol polymersomes triggered by glutathione (GSH) was observed both in PBS suspension and in vitro inside the macrophage cells. High GSH concentrations (≥35 mM in PBS or artificially enhanced in macrophage cells by GSH-OEt pretreatment) and long incubation time (in the order of hours) were, however, necessary to get significant calcein release. These polymersomes could be used as drug carriers with very long circulation profiles and slow release kinetics.
The KLOE-2 Inner Tracker: Detector commissioning and operation Balla, A.; Bencivenni, G.; Branchini, P. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
02/2017, Letnik:
845
Journal Article
Recenzirano
Odprti dostop
The KLOE-2 experiment started its data taking campaign in November 2014 with an upgraded tracking system including an Inner Tracker built with the cylindrical GEM technology, to operate together with ...the Drift Chamber improving the apparatus tracking performance. The Inner Tracker is composed of four cylindrical triple-GEM, each provided with an X–V strips-pads stereo readout and equipped with the GASTONE ASIC developed inside the KLOE-2 collaboration. Although GEM detectors are already used in high energy physics experiment, this device is considered a frontier detector due to its cylindrical geometry: KLOE-2 is the first experiment to use this novel solution. The results of the detector commissioning, detection efficiency evaluation, calibration studies and alignment, both with dedicated cosmic-ray muon and Bhabha scattering events, will be reported.
Thermoresponsive behavior of different kinds of polymersomes was studied using small angle neutron scattering (SANS), transmission electron microscopy (TEM), and proton nuclear magnetic resonance (1H ...NMR). The polymersomes were made of block copolymers containing a 2000 Da polyethylene glycol (PEG) as a hydrophilic block and either a liquidlike polymer (e.g., PBA: polybutylacrylate), a solidlike polymer (PS: polystyrene), or a liquid crystalline (LC) polymer as a hydrophobic block. Structural changes in polymersomes are driven in all cases by the critical dehydration temperature of PEG corona, which is closely related to the chemical structure and chain mobility of the hydrophobic block. No structural changes occur upon heating from 25 to 75 °C in the liquidlike polymersomes where the critical dehydration temperature of PEG should be higher than 75 °C. In contrast, glassy PEG-b-PS polymersomes and LC polymersomes show structural changes around 55 °C, which corresponds to the critical dehydration temperature of PEG in those block copolymers. Furthermore, the structural changes depend on the properties of the hydrophobic layer. Glassy PEG-b-PS polymersomes aggregate together above 55 °C, but the bilayer membrane is robust enough to remain intact. This aggregation is reversible, and rather separate polymersomes are recovered upon cooling. However, LC polymersomes display drastic and irreversible structural changes when heated above ∼55 °C. These changes are dependent on the LC structures of the hydrophobic layer. Nematic LC polymersomes turn into thick-walled capsules, whereas smectic LC polymersomes collapse into dense aggregates. As these drastic and irreversible changes decrease or remove the inner compartment volume of the vesicle, LC polymersomes can be used for thermal-responsive controlled release, as shown by a study of calcein release. Finally, toxicity studies proved that LC polymersomes were noncytotoxic and had no effect on cell morphology.
Agenesis of paranasal sinuses has only been described in case reports of patients with primary ciliary dyskinesia (PCD). As agenesis of paranasal sinuses may contribute to low nasal nitric oxide ...levels, a common finding in PCD, we speculated that this condition might frequently occur in PCD patients. Patients referred for PCD evaluation were consecutively recruited for 30 months. In addition to standard diagnostic testing for PCD, a computed tomography (CT) scan of paranasal sinuses was performed in all subjects. 86 patients (46 children aged 8-17 yrs) were studied. PCD was diagnosed in 41 subjects and secondary ciliary dyskinesia (SCD) was diagnosed in the remaining 45 subjects. Frontal and/or sphenoidal sinuses were either aplastic or hypoplastic on CT scans in 30 (73%) out of 41 PCD patients, but in only 17 (38%) out of 45 with SCD (p = 0.002). There was a significant inverse correlation between the score for aplasia/hypoplasia of each paranasal sinus and nasal NO values in the PCD patients (p = 0.008, r = -0.432) but not in SCD (p = 0.07, r = -0.271). The findings of aplasia/hypoplasia of the frontal and or sphenoidal sinuses may be part of the spectrum of PCD and this finding should prompt exclusion of this condition.
Budding yeast Rad9, like its orthologs, controls two aspects of the cellular response to DNA double strand breaks (DSBs) - signalling of the DNA damage checkpoint and DNA end resection. Rad9 binds to ...damaged chromatin via modified nucleosomes independently of the cell cycle phase. Additionally, Rad9 engages in a cell cycle-regulated interaction with Dpb11 and the 9-1-1 clamp, generating a second pathway that recruits Rad9 to DNA damage sites. Binding to Dpb11 depends on specific S/TP phosphorylation sites of Rad9, which are modified by cyclin-dependent kinase (CDK). Here, we show that these sites additionally become phosphorylated upon DNA damage. We define the requirements for DNA damage-induced S/TP phosphorylation of Rad9 and show that it is independent of the cell cycle or CDK activity but requires prior recruitment of Rad9 to damaged chromatin, indicating that it is catalysed by a chromatin-bound kinase. The checkpoint kinases Mec1 and Tel1 are required for Rad9 S/TP phosphorylation, but their influence is likely indirect and involves phosphorylation of Rad9 at S/TQ sites. Notably, DNA damage-induced S/TP phosphorylation triggers Dpb11 binding to Rad9, but the DNA damage-induced Rad9-Dpb11 interaction is dispensable for recruitment to DNA damage sites, indicating that the Rad9-Dpb11 interaction functions beyond Rad9 recruitment.
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