We set the first limits on the ultra-high energy (UHE) neutrino fluence at energies greater than 109 GeV from gamma-ray bursts (GRBs) based on data from the second flight of the Antarctic Impulsive ...Transient Antenna (ANITA). During the 31 day flight of ANITA-II, 26 GRBs were recorded by Swift or Fermi. Of these, we analyzed the 12 GRBs which occurred during quiet periods when the payload was away from anthropogenic activity. In a blind analysis, we observe 0 events on a total background of 0.0044 events in the combined prompt window for all 12 low-background bursts. We also observe 0 events from the remaining 14 bursts. We place a 90% confidence level limit on the E --4 prompt neutrino fluence between 108 GeV < E < 1012 GeV of E 4 Delta *Q = 2.5 X 1017 GeV3 cm--2 from GRB090107A. This is the first reported limit on the UHE neutrino fluence from GRBs above 109 GeV, and the strongest limit above 108 GeV.
The NASA supported High-Altitude Calibration (HiCal)-2 instrument flew as a companion balloon to the ANITA-4 experiment in December 2016. Based on a high-voltage (HV) discharge pulser producing ...radio-frequency (RF) calibration pulses, HiCal-2 comprised two payloads, which flew for a combined 18 days, covering 1.5 revolutions of the Antarctic continent. ANITA-4 captured over 10,000 pulses from HiCal-2, both direct and reflected from the surface, at distances varying from 100–700 km, providing a large dataset for surface reflectivity measurements. Herein we present details on the design, construction and performance of HiCal-2.
The Antarctic Impulsive Transient Antenna (ANITA) is a NASA long-duration balloon experiment with the primary goal of detecting ultra-high-energy (>1018eV) neutrinos via the Askaryan Effect. The ...fourth ANITA mission, ANITA-IV, recently flew from Dec 2 to Dec 29, 2016. For the first time, the Tunable Universal Filter Frontend (TUFF) boards were deployed for mitigation of narrow-band, anthropogenic noise with tunable, switchable notch filters. The TUFF boards also performed second-stage amplification by approximately 45 dB to boost the ∼μV-level radio frequency (RF) signals to ∼ mV-level for digitization, and supplied power via bias tees to the first-stage, antenna-mounted amplifiers. The other major change in signal processing in ANITA-IV is the resurrection of the 90° hybrids deployed previously in ANITA-I, in the trigger system, although in this paper we focus on the TUFF boards. During the ANITA-IV mission, the TUFF boards were successfully operated throughout the flight. They contributed to a factor of 2.8 higher total instrument livetime on average in ANITA-IV compared to ANITA-III due to reduction of narrow-band, anthropogenic noise before a trigger decision is made.
Changing practice paradigms: Negotiating your future Satiani, Bhagwan B., MD, MBA; Motew, Stephen J., MD; Darling, R. Clem, MD ...
Journal of vascular surgery,
04/2012, Letnik:
55, Številka:
4
Journal Article
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There are many recent and ongoing changes in the practice of medicine from a business standpoint as well as in overall practice management. Economic and lifestyle desires have pushed many physicians ...to a decision point of whether or not to join a large multispecialty group or to sell their practice and become an employee of a hospital system. There are advantages and disadvantages to both options; however, deciding on the most appropriate path for each individual can be a daunting task. At our recent breakfast session at the vascular annual meeting in Chicago, Illinois, in June 2011, we brought to light these topics to try and help enlighten physicians on which option may be right for them. There is no single answer/option that will fit every practice, but discussion for various practice management designs are outlined and critiqued. This article cannot fully discuss each view in the allotted space, but it is designed to encourage thought and discussion among the vascular surgical community as a whole.
Lunar lava tube radiation safety analysis De Angelis, Giovanni; Wilson, J. W.; Clowdsley, M. S. ...
Journal of radiation research,
12/2002, Letnik:
43 Suppl, Številka:
S
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For many years it has been suggested that lava tubes on the Moon could provide an ideal location for a manned lunar base, by providing shelter from various natural hazards, such as cosmic radiation, ...meteorites, micrometeoroids, and impact crater ejecta, and also providing a natural environmental control, with a nearly constant temperature, unlike that of the lunar surface showing extreme variation in its diurnal cycle. An analysis of radiation safety issues on lunar lava tubes has been performed by considering radiation from galactic cosmic rays (GCR) and Solar Particle Events (SPE) interacting with the lunar surface, modeled as a regolith layer and rock. The chemical composition has been chosen as typical of the lunar regions where the largest number of lava tube candidates are found. Particles have been transported all through the regolith and the rock, and received particles flux and doses have been calculated. The radiation safety of lunar lava tubes environments has been demonstrated.
Solar modulation affects the secondary cosmic rays responsible for in situ cosmogenic nuclide (CN) production the most at the high geomagnetic latitudes to which CN production rates are traditionally ...referenced. While this has long been recognized (e.g., D. Lal, B. Peters, Cosmic ray produced radioactivity on the Earth, in: K. Sitte (Ed.), Handbuch Der Physik XLVI/2, Springer-Verlag, Berlin, 1967, pp. 551–612 and D. Lal, Theoretically expected variations in the terrestrial cosmic ray production rates of isotopes, in: G.C. Castagnoli (Ed.), Proceedings of the Enrico Fermi International School of Physics 95, Italian Physical Society, Varenna 1988, pp. 216–233), these variations can lead to potentially significant scaling model uncertainties that have not been addressed in detail. These uncertainties include the long-term (millennial-scale) average solar modulation level to which secondary cosmic rays should be referenced, and short-term fluctuations in cosmic ray intensity measurements used to derive published secondary cosmic ray scaling models. We have developed new scaling models for spallogenic nucleons, slow-muon capture and fast-muon interactions that specifically address these uncertainties. Our spallogenic nucleon scaling model, which includes data from portions of 5 solar cycles, explicitly incorporates a measure of solar modulation (
S), and our fast- and slow-muon scaling models (based on more limited data) account for solar modulation effects through increased uncertainties. These models improve on previously published models by better sampling the observed variability in measured cosmic ray intensities as a function of geomagnetic latitude, altitude, and solar activity. Furthermore, placing the spallogenic nucleon data in a consistent time-space framework allows for a more realistic assessment of uncertainties in our model than in earlier ones.
We demonstrate here that our models reasonably account for the effects of solar modulation on measured secondary cosmic ray intensities, within the uncertainties of our combined source datasets. We also estimate solar modulation variations over the last 11.4 ka from a recent physics-based sunspot number reconstruction derived from tree-ring
14C data. This approximation suggests that spallogenic nucleon scaling factors in our model for sea level and high geomagnetic latitudes can differ by up to ∼
10%, depending on the time step over which the model sunspot numbers are averaged. The potential magnitude of this difference supports our contention that incorporating long-term solar modulation into secondary cosmic ray scaling is important. Although millennial-scale solar modulation clearly requires further study, we believe it is reasonable at present to use our
S value record for scaling spallogenic nucleons during the last 11.4 ka, and the weighted mean
S value for that period of 0.950 for longer exposure times. By accounting for solar modulation effects on the global variations in nucleon and muon fluxes, these models thus provide a useful framework on which to base CN production rate scaling functions.
Although human c-IAP1 and c-IAP2 have been reported to possess antiapoptotic activity against a variety of stimuli in several mammalian cell types, we observed that full-length c-IAP1 and c-IAP2 ...failed to protect cells from apoptosis induced by Bax overexpression, tumor necrosis factor α treatment or Sindbis virus infection. However, deletion of the C-terminal RING domains of c-IAP1 and c-IAP2 restored antiapoptotic activity, indicating that this region negatively regulates the antiapoptotic function of the N-terminal BIR domain. This finding is consistent with the observation by others that the spacer region and RING domain of c-IAP1 functions as an E3 ligase, promoting autoubiquitination and degradation of c-IAP1. In addition, we found that c-IAP1 is cleaved during apoptosis to 52- and 35-kDa fragments. Both fragments contain the C-terminal end of c-IAP1 including the RING finger. In vitro cleavage of c-IAP1 with apoptotic cell extracts or with purified recombinant caspase-3 produced similar fragments. Furthermore, transfection of cells with the spacer-RING domain alone suppressed the antiapoptotic function of the N-terminal BIR domain of c-IAP1 and induced apoptosis. Optimal death-inducing activity of the spacer-RING required both the spacer region and the zinc-binding RING domain of c-IAP1 but did not require the caspase recruitment domain located within the spacer region. To the contrary, deletion of the caspase recruitment domain increased proapoptotic activity, apparently by stabilizing the C-terminal fragment.
Two types of catfish alloantigen-dependent cytotoxic T cells were cloned from PBL from a fish immunized in vivo and stimulated in vitro with the allogeneic B cell line 3B11. Because these are the ...first clonal cytotoxic T cell lines derived from an ectothermic vertebrate, studies were undertaken to characterize their recognition and cytotoxic mechanisms. The first type of CTL (group I) shows strict alloantigen specificity, i.e., they specifically kill and proliferate only in response to 3B11 cells. The second type (group II) shows broad allogeneic specificity, i.e., they kill and proliferate in response to several different allogeneic cells in addition to 3B11. "Cold" target-inhibition studies suggest that group II CTL recognize their targets via a single receptor, because the killing of one allotarget can be inhibited by a different allotarget. Both types of catfish CTL form conjugates with and kill targets by apoptosis. Killing by Ag-specific cytotoxic T cells (group I) was completely inhibited by treatment with EGTA or concanamycin A, and this killing is sensitive to PMSF inhibition, suggesting that killing was mediated exclusively by the secretory perforin/granzyme mechanism. In contrast, killing by the broadly specific T cytotoxic cells (group II) was only partially inhibited by either EGTA or concanamycin A, suggesting that these cells use a cytotoxic mechanism in addition to that involving perforin/granzyme. Consistent with the presumed use of a secretory pathway, both groups of CTL possess putative lytic granules. These results suggest that catfish CTL show heterogeneity with respect to target recognition and cytotoxic mechanisms.
An extensive grazing study was conducted between 1988 and 2001 in a Heteropogon contortus (black speargrass) pasture in central Queensland. The study was designed to measure the effects of stocking ...rate on native pasture, native pasture with legume oversown, and native pasture with animal diet supplement/spring burning on pasture and animal production. Summer rainfall throughout the study was below the long-term mean. Mean annual pasture utilisation ranged from 13% at 8ha/steer up to 61% at 2ha/steer. Increasing stocking rate treatments reduced total pasture yields while total yields in legume oversown treatments were similar to those in native pasture at the same stocking rate. When spring burning was possible, total yields were reduced in the subsequent autumn. Increasing stocking rate in native pasture tended to reduce H. contortus and Bothriochloa bladhii, increased the composition of intermediate species, such as B. decipiens and Chloris divaricata, and also changed the frequencies of a range of minor species. Oversowing legumes resulted in Stylosanthes scabra cv. Seca increasing from <1% of pasture composition in 1988 to 50% in 2000 and was associated with a reduction in H. contortus and changes in the frequencies of some minor species. Stocking rates heavier than 4ha/steer resulted in annual pasture utilisation greater than 30% and were unsustainable because they reduced total yield and resulted in undesirable changes in species composition. It was concluded that pasture production was sustainable when stocking rates were maintained at 4ha/steer, which equates to 30% annual pasture utilisation, and through the judicious use of spring burning.
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