Clearing of the dormant liver stage (the hypnozoite) of
P. vivax
malaria is important to prevent the relapse of infection. In this randomized clinical trial, a single dose of tafenoquine is shown to ...have significant activity against the hypnozoite form of
P. vivax
.
Malaria remains a global health burden. Elimination of the hypnozoite is required in patients infected with
P. vivax
to prevent relapse. In this report, the safety of a single dose of tafenoquine was ...similar to that of a 14-day course of primaquine in patients with normal G6PD activity.
Objective: To assess patterns of self-treatment and its effects on the duration of sexually transmitted disease (STD) symptoms before medical care. Methods: A cross-sectional interview survey in ...public STD clinics (7 U.S. cities). Patients, seeking treatment for STD symptoms or having a known infected sexual contact, reported selftreatment behaviors and symptom duration. Additional data were abstracted from medical charts. Results: Self-treatment, primarily over-the-counter topical medications (54.8%), was reported by 21.8% of 2,508 symptomatic patients. Self-treaters were significantly more likely to be African-American (odds ratio OR = 1.8), female (OR = 1.7), over age 30 (OR = 1.3), report >1 symptom (OR = 1.4), and report a genital lesion (OR = 2.1). Symptom duration was 2 days longer among self-treaters (p < 0.01). African-Americans (OR = 1.5), men (OR = 1.2), and self-treaters of symptoms other than genital lesions (OR = 1.4) had a significantly longer time from symptom onset to receiving medical care. Conclusions: Self-treatment is common among patients with STDs. Self-treatment of a genital lesion, unlike certain demographic factors and self-treatment of other STD symptoms, did not prolong the time to medical treatment.
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