Physiologic and behavioral changes during pregnancy may alter HIV-1 susceptibility and infectiousness. Prospective studies exploring pregnancy and HIV-1 acquisition risk in women have found ...inconsistent results. No study has explored the effect of pregnancy on HIV-1 transmission risk from HIV-1-infected women to male partners.
In a prospective study of African HIV-1-serodiscordant couples, we evaluated the relationship between pregnancy and the risk of HIV-1 acquisition among women and HIV-1 transmission from women to men.
Three thousand three hundred and twenty-one HIV-1-serodiscordant couples were enrolled, 1085 (32.7%) with HIV-1 susceptible female partners and 2236 (67.3%) with susceptible male partners. HIV-1 incidence in women was 7.35 versus 3.01 per 100 person-years during pregnant and nonpregnant periods hazard ratio 2.34, 95% confidence interval (CI) 1.33-4.09. This effect was attenuated and not statistically significant after adjusting for sexual behavior and other confounding factors (adjusted hazard ratio 1.71, 95% CI 0.93-3.12). HIV-1 incidence in male partners of infected women was 3.46 versus 1.58 per 100 person-years when their partners were pregnant versus not pregnant (hazard ratio 2.31, 95% CI 1.22-4.39). This effect was not attenuated in adjusted analysis (adjusted hazard ratio 2.47, 95% CI 1.26-4.85).
HIV-1 risk increased two-fold during pregnancy. Elevated risk of HIV-1 acquisition in pregnant women appeared in part to be explained by behavioral and other factors. This is the first study to show that pregnancy increased the risk of female-to-male HIV-1 transmission, which may reflect biological changes of pregnancy that could increase HIV-1 infectiousness.
To study emissions of CO2 in the Baltimore, MD‐Washington, D.C. (Balt‐Wash) area, an aircraft campaign was conducted in February 2015, as part of the Fluxes of Atmospheric Greenhouse‐Gases in ...Maryland (FLAGG‐MD) project. During the campaign, elevated mole fractions of CO2 were observed downwind of the urban center and local power plants. Upwind flight data and Hybrid Single Particle Lagrangian Integrated Trajectory (HYSPLIT) model analyses help account for the impact of emissions outside the Balt‐Wash area. The accuracy, precision, and sensitivity of CO2 emissions estimates based on the mass balance approach were assessed for both power plants and cities. Our estimates of CO2 emissions from two local power plants agree well with their Continuous Emissions Monitoring Systems (CEMS) records. For the 16 power plant plumes captured by the aircraft, the mean percentage difference of CO2 emissions was −0.3%. For the Balt‐Wash area as a whole, the 1𝜎 CO2 emission rate uncertainty for any individual aircraft‐based mass balance approach experiment was ±38%. Treating the mass balance experiments, which were repeated seven times within 9 days, as individual quantifications of the Balt‐Wash CO2 emissions, the estimation uncertainty was ±16% (standard error of the mean at 95% CL). Our aircraft‐based estimate was compared to various bottom‐up fossil fuel CO2 (FFCO2) emission inventories. Based on the FLAGG‐MD aircraft observations, we estimate 1.9 ± 0.3 MtC of FFCO2 from the Balt‐Wash area during the month of February 2015. The mean estimate of FFCO2 from the four bottom‐up models was 2.2 ± 0.3 MtC.
Key Points
1.9 ± 0.3 MtC of fossil fuel CO2 was emitted in Baltimore‐Washington during February 2015 based on data collected during seven aircraft flights
Four bottom‐up inventories indicate 2.2 ± 0.3 MtC of fossil fuel CO2 was emitted, in good agreement with our top‐down estimate
The uncertainty from a single flight segment was ±38% (1𝜎); data from seven flights yielded a precision of 16% at the 95% confidence level
Context.
On 2020 November 29, the first widespread solar energetic particle (SEP) event of solar cycle 25 was observed at four widely separated locations in the inner (≲1 AU) heliosphere. ...Relativistic electrons as well as protons with energies > 50 MeV were observed by Solar Orbiter (SolO), Parker Solar Probe, the Solar Terrestrial Relations Observatory (STEREO)-A and multiple near-Earth spacecraft. The SEP event was associated with an M4.4 class X-ray flare and accompanied by a coronal mass ejection and an extreme ultraviolet (EUV) wave as well as a type II radio burst and multiple type III radio bursts.
Aims.
We present multi-spacecraft particle observations and place them in context with source observations from remote sensing instruments and discuss how such observations may further our understanding of particle acceleration and transport in this widespread event.
Methods.
Velocity dispersion analysis (VDA) and time shift analysis (TSA) were used to infer the particle release times at the Sun. Solar wind plasma and magnetic field measurements were examined to identify structures that influence the properties of the energetic particles such as their intensity. Pitch angle distributions and first-order anisotropies were analyzed in order to characterize the particle propagation in the interplanetary medium.
Results.
We find that during the 2020 November 29 SEP event, particles spread over more than 230° in longitude close to 1 AU. The particle onset delays observed at the different spacecraft are larger as the flare–footpoint angle increases and are consistent with those from previous STEREO observations. Comparing the timing when the EUV wave intersects the estimated magnetic footpoints of each spacecraft with particle release times from TSA and VDA, we conclude that a simple scenario where the particle release is only determined by the EUV wave propagation is unlikely for this event. Observations of anisotropic particle distributions at SolO, Wind, and STEREO-A do not rule out that particles are injected over a wide longitudinal range close to the Sun. However, the low values of the first-order anisotropy observed by near-Earth spacecraft suggest that diffusive propagation processes are likely involved.
ABSTRACT
fink is a broker designed to enable science with large time-domain alert streams such as the one from the upcoming Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST). It ...exhibits traditional astronomy broker features such as automatized ingestion, annotation, selection, and redistribution of promising alerts for transient science. It is also designed to go beyond traditional broker features by providing real-time transient classification that is continuously improved by using state-of-the-art deep learning and adaptive learning techniques. These evolving added values will enable more accurate scientific output from LSST photometric data for diverse science cases while also leading to a higher incidence of new discoveries which shall accompany the evolution of the survey. In this paper, we introduce fink, its science motivation, architecture, and current status including first science verification cases using the Zwicky Transient Facility alert stream.
Neutrinos exist in one of three types or 'flavours'-electron, muon and tau neutrinos-and oscillate from one flavour to another when propagating through space. This phenomena is one of the few that ...cannot be described using the standard model of particle physics (reviewed in ref.
), and so its experimental study can provide new insight into the nature of our Universe (reviewed in ref.
). Neutrinos oscillate as a function of their propagation distance (L) divided by their energy (E). Therefore, experiments extract oscillation parameters by measuring their energy distribution at different locations. As accelerator-based oscillation experiments cannot directly measure E, the interpretation of these experiments relies heavily on phenomenological models of neutrino-nucleus interactions to infer E. Here we exploit the similarity of electron-nucleus and neutrino-nucleus interactions, and use electron scattering data with known beam energies to test energy reconstruction methods and interaction models. We find that even in simple interactions where no pions are detected, only a small fraction of events reconstruct to the correct incident energy. More importantly, widely used interaction models reproduce the reconstructed energy distribution only qualitatively and the quality of the reproduction varies strongly with beam energy. This shows both the need and the pathway to improve current models to meet the requirements of next-generation, high-precision experiments such as Hyper-Kamiokande (Japan)
and DUNE (USA)
.
Genetic variants of inosine triphosphatase (ITPA) that confer reduced ITPase activity are associated with protection against ribavirin(RBV)-induced hemolytic anemia in peginterferon(IFN)/RBV-based ...treatment of hepatitis C virus (HCV). Patients with reduced ITPase activity showed improved treatment efficacy when treated with IFN/RBV. In addition, a genetic polymorphism near the IL28B gene is associated with an improved response to IFN/RBV treatment. RBV has been an important component of IFN-containing regimens, and is currently recommended in combination with several IFN-free regimens for treatment of harder to cure HCV infections.
To evaluate whether genetic variations that reduce ITPase activity impact RBV-induced anemia in IFN-free/RBV regimens.
In this study, genetic analyses were conducted in the PEARL-IV trial to investigate the effect of activity-reducing ITPA variants as well as IL28B polymorphism on anemia, platelet (PLT) counts, and virologic response in HCV genotype1a-infected patients treated with the direct-acting antiviral (DAA) regimen of ombitasvir/paritaprevir/ritonavir and dasabuvir±RBV.
Reduction in ITPase activity and homozygosity for the IL28Brs12979860 CC genotype protected against RBV-induced anemia. In patients receiving RBV, reduced ITPase activity was associated with reduced plasma RBV concentration and higher PLT counts. ITPase activity had no impact on response to DAA treatment, viral kinetics, or baseline IP-10 levels.
Our study demonstrates that genetics of ITPA and IL28B may help identify patients protected from RBV-induced anemia when treated with IFN-free regimens. Our work demonstrates for the first time that IL28B genetics may also have an impact on RBV-induced anemia. This may be of particular significance in patients with difficult-to-cure HCV infections, such as patients with decompensated cirrhosis where RBV-containing regimens likely will continue to be recommended.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A 90° bend curved light-guide for TOF scintillating detectors Olivenboim, M.; Cohen, E.O.; Burshtein, L. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
12/2021, Letnik:
1018, Številka:
C
Journal Article
Recenzirano
We report here a bench study of TOF resolution using a 90° bend curved solid light-guide (LG) used to transport the light from a plastic scintillator counter to a photomultiplier (PMT). The 90° LG ...allows the rotation of the PMT axis to be vertical to the detector axis, in an environment featured by a strong magnetic field along the detector surface, or other geometrical constrains. We show that with a TOF counter of 2000×100×60 mm3 and light read-out by PMTs at its two 100 × 60 mm2 sides, when 90° LG benders are used between the scintillating bar and the PMTs on both sides, the TOF resolution is worsen, by 5–10%.
Abstract In the management of ISS auxological, biochemical, psychosocial and ethical elements have to be considered. In boys with constitutional delay of growth and puberty androgens are effective in ...increasing height and sexual characteristics, but adult height is unchanged. GH therapy is efficacious in increasing height velocity and adult height, but the inter-individual variation is considerable. The effect on psychosocial status is uncertain. Factors affecting final height gain include GH dose, height deficit in comparison to midparental height, age and first year height velocity. In case of a low predicted adult height at the onset of puberty, addition of a GnRH analogue can be considered. Although GH therapy appears safe, long-term monitoring is recommended.
We present the first measurements of the double ratio of the polarization-transfer components (Px′/Pz′)p/(Px′/Pz′)s for knock-out protons from the s and p shells in C12 measured by the C12(e→,e′p→) ...reaction in quasi-elastic kinematics. The data are compared to theoretical predictions in the relativistic distorted-wave impulse approximation. Our results show that the differences between s- and p-shell protons, observed when compared at the same initial momentum (missing momentum), largely disappear when the comparison is done at the same proton virtuality. We observe no difference in medium modifications between protons from the s and p shells with the same virtuality in spite of the large differences in the respective nuclear densities.
We report on the first measurement of flux-integrated single differential cross sections for charged-current (CC) muon neutrino (νμ) scattering on argon with a muon and a proton in the final state, ...Ar40 (νμ,μp)X. The measurement was carried out using the Booster Neutrino Beam at Fermi National Accelerator Laboratory and the MicroBooNE liquid argon time projection chamber detector with an exposure of 4.59×1019 protons on target. Events are selected to enhance the contribution of CC quasielastic (CCQE) interactions. The data are reported in terms of a total cross section as well as single differential cross sections in final state muon and proton kinematics. We measure the integrated per-nucleus CCQE-like cross section (i.e., for interactions leading to a muon, one proton, and no pions above detection threshold) of (4.93±0.76stat±1.29sys)×10−38 cm2, in good agreement with theoretical calculations. The single differential cross sections are also in overall good agreement with theoretical predictions, except at very forward muon scattering angles that correspond to low-momentum-transfer events.
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