Abstract
We present a study of the influence of magnetic field strength and morphology in Type Ia supernovae and their late-time light curves and spectra. In order to both capture self-consistent ...magnetic field topologies and evolve our models to late times, a two-stage approach is taken. We study the early deflagration phase (∼1 s) using a variety of magnetic field strengths and find that the topology of the field is set by the burning, independent of the initial strength. We study late-time (∼1000 days) light curves and spectra with a variety of magnetic field topologies and infer magnetic field strengths from observed supernovae. Lower limits are found to be 10
6
G. This is determined by the escape, or lack thereof, of positrons that are tied to the magnetic field. The first stage employs 3D MHD and a local burning approximation and uses the code Enzo. The second stage employs a hybrid approach, with 3D radiation and positron transport and spherical hydrodynamics. The second stage uses the code HYDRA. In our models, magnetic field amplification remains small during the early deflagration phase. Late-time spectra bear the imprint of both magnetic field strength and morphology. Implications for alternative explosion scenarios are discussed.
The most non-trivial of the established microscopic theories of physics is quantum chromodynamics, QCD, the theory of the strong interaction. A critical link between theory and experiment is provided ...by the methods of perturbative QCD, notably the well-known factorization theorems. Giving an accurate account of the concepts, theorems and their justification, this book is a systematic treatment of perturbative QCD. As well as giving a mathematical treatment, the book relates the concepts to experimental data, giving strong motivations for the methods. It also examines in detail transverse-momentum-dependent parton densities, an increasingly important subject not normally treated in other books. Ideal for graduate students starting their work in high-energy physics, it will also interest experienced researchers wanting a clear account of the subject.
Traditional cosmological hydrodynamics simulations fail to spatially resolve the circumgalactic medium (CGM), the reservoir of tenuous gas surrounding a galaxy and extending to its virial radius. We ...introduce the technique of Enhanced Halo Resolution (EHR), enabling more realistic physical modeling of the simulated CGM by consistently forcing gas refinement to smaller scales throughout the virial halo of a simulated galaxy. We investigate the effects of EHR in the tempest simulations, a suite of enzo-based cosmological zoom simulations following the evolution of an L* galaxy, resolving spatial scales of 500 comoving pc out to 100 comoving kpc in galactocentric radius. Among its many effects, EHR (1) changes the thermal balance of the CGM, increasing its cool gas content and decreasing its warm/hot gas content; (2) preserves cool gas structures for longer periods; and (3) enables these cool clouds to exist at progressively smaller size scales. Observationally, this results in a boost in "low ions" like H i and a drop in "high ions" like O vi throughout the CGM. These effects of EHR do not converge in the tempest simulations, but extrapolating these trends suggests that the CGM is actually a mist consisting of ubiquitous, small, long-lived, cool clouds suspended in a medium at the halo virial temperature. We find that EHR produces the above effects by (1) better sampling the distribution of CGM phases, enabling runaway cooling in the dense, cool tail of the phase distribution; and (2) preventing cool gas clouds from artificially mixing with the ambient hot halo and evaporating.
Effective strategies are required to reduce the prevalence of overweight and obesity; however, the effectiveness of current weight loss programmes is variable. One contributing factor may be the ...difference in weight loss success between men and women. A systematic review was conducted to determine whether the effectiveness of weight loss interventions differs between men and women. Randomized controlled trials published up until March 2014 were included. Effect sizes (Hedges' g) were used to examine the difference in weight outcomes between men and women. A total of 58 studies met the eligibility criteria with 49 studies of higher quality included in the final data synthesis. Eleven studies that directly compared weight loss in men and women reported a significant sex difference. Ten of these reported that men lost more weight than women; however, women also lost a significant amount of weight. Analysis of effect sizes found small differences in weight loss favouring men for both diet (g = 0.489) and diet plus exercise (g = 0.240) interventions. There is little evidence from this review to indicate that men and women should adopt different weight loss strategies. Current evidence supports moderate energy restriction in combination with exercise for weight loss in both men and women.
Mortgages loans are vital for the acquisition of housing property and mortgage lending rates play an important role in mortgage market trends, borrowers, and lenders’ decisions. Objective: the aim of ...this paper is to evaluate the combined effect of current and previous mortgage rates on mortgage refinancing. Prior work: the paper inclines on the ontology of a single reality of the interaction between mortgage rates and mortgage refinancing with attendant epistemology that their interaction is measurable. Method: the paper adopts the positivist paradigm and a quantitative technique. It used data on the U.S. Mortgage Bankers Association (MBA) retrieved from the economic and financial database of Fusion Media. Data were analysed using the OLS technique. Novel Findings show that current-actual and previous mortgage rates have a significant positive effect on mortgage refinancing at p=0.05 and p=0.04 respectively. Significance: the findings have implication for mortgage lending and refinancing decisions for mortgage bankers (lenders), mortgage borrowers and policy makers. It also provides current academic study material for university business schools and for future researchers to apply the model used in this research for related expanded research. Value: The paper contributes a new model with two genres of mortgage rate (current mortgage rate and previous mortgage rate) and how these two types of mortgage rates influence mortgage refinancing.
Larval mosquitoes are aquatic omnivorous scavengers which scrape food from submerged surfaces and collect suspended food particles with their mouth brushes. The composition of diets that have been ...used in insectaries varies widely though necessarily provides sufficient nutrition to allow colonies to be maintained. Issues such as cost, availability and experience influence which diet is selected. One component of larval diets, essential fatty acids, appears to be necessary for normal flight though deficiencies may not be evident in laboratory cages and are likely more important when mosquitoes are reared for release into the field in e.g. mark-release-recapture and genetic control activities. In this study, four diets were compared for rearing Anopheles gambiae and Aedes aegypti, all of which provide these essential fatty acids. Two diets were custom formulations specifically designed for mosquitoes (Damiens) and two were commercially available fish foods: Doctors Foster and Smith Koi Staple Diet and TetraMin Plus Flakes. Development rate, survival, dry weight and adult longevity of mosquitoes reared with these four diets were measured. The method of presentation of one diet, Koi pellets, was additionally fed in two forms, pellets or a slurry, to determine any effect of food presentation on survival and development rate. While various criteria might be selected to choose 'the best' food, the readily-available Koi pellets resulted in development rates and adult longevity equal to the other diets, high survival to the adult stage and, additionally, this is available at low cost.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•Bacterial pathogens rewire host proteomes to enable their replication and spread.•Identifying host-pathogen protein interactions elucidates pathogenic rewiring.•Protein interaction studies are ...shifting towards quantitative and unbiased approaches.•Bacterial-host interaction studies require endogenous experimental systems.•Linking interspecies interaction studies to functional assays can measure their phenotypic impacts.
Infectious diseases are the result of molecular cross-talks between hosts and their pathogens. These cross-talks are in part mediated by host–pathogen protein–protein interactions (HP-PPI). HP-PPI play crucial roles in infections, as they may tilt the balance either in favor of the pathogens’ spread or their clearance. The identification of host proteins targeted by viral or bacterial pathogenic proteins necessary for the infection can provide insights into their underlying molecular mechanisms of pathogenicity, and potentially even single out pharmacological intervention targets. Here, we review the available methods to study HP-PPI, with a focus on recent mass spectrometry based methods to decipher bacterial–human infectious diseases and examine their relevance in uncovering host cell rewiring by pathogens.
In this Perspective, we discuss developments in mass-spectrometry-based proteomic technology over the past decade from the viewpoint of our laboratory. We also reflect on existing challenges and ...limitations, and explore the current and future roles of quantitative proteomics in molecular systems biology, clinical research and personalized medicine.
Targeted proteomics by selected/multiple reaction monitoring (S/MRM) or, on a larger scale, by SWATH (sequential window acquisition of all theoretical spectra) MS (mass spectrometry) typically relies ...on spectral reference libraries for peptide identification. Quality and coverage of these libraries are therefore of crucial importance for the performance of the methods. Here we present a detailed protocol that has been successfully used to build high-quality, extensive reference libraries supporting targeted proteomics by SWATH MS. We describe each step of the process, including data acquisition by discovery proteomics, assertion of peptide-spectrum matches (PSMs), generation of consensus spectra and compilation of MS coordinates that uniquely define each targeted peptide. Crucial steps such as false discovery rate (FDR) control, retention time normalization and handling of post-translationally modified peptides are detailed. Finally, we show how to use the library to extract SWATH data with the open-source software Skyline. The protocol takes 2-3 d to complete, depending on the extent of the library and the computational resources available.
There is high demand and a growing expectation for predictions of environmental conditions that go beyond 0–14-day weather forecasts with outlooks extending to one or more seasons and beyond. This is ...driven by the needs of the energy, water management, and agriculture sectors, to name a few. There is an increasing realization that, unlike weather forecasts, prediction skill on longer time scales can leverage specific climate phenomena or conditions for a predictable signal above the weather noise. Currently, it is understood that these conditions are intermittent in time and have spatially heterogeneous impacts on skill, hence providing strategic windows of opportunity for skillful forecasts. Research points to such windows of opportunity, including El Niño or La Niña events, active periods of the Madden–Julian oscillation, disruptions of the stratospheric polar vortex, when certain large-scale atmospheric regimes are in place, or when persistent anomalies occur in the ocean or land surface. Gains could be obtained by increasingly developing prediction tools and metrics that strategically target these specific windows of opportunity. Across the globe, reevaluating forecasts in this manner could find value in forecasts previously discarded as not skillful. Users’ expectations for prediction skill could be more adequately met, as they are better aware of when and where to expect skill and if the prediction is actionable. Given that there is still untapped potential, in terms of process understanding and prediction methodologies, it is safe to expect that in the future forecast opportunities will expand. Process research and the development of innovative methodologies will aid such progress.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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