Suicide is a devastating public health problem and very few biological treatments have been found to be effective for quickly reducing the intensity of suicidal ideation (SI). We have previously ...shown that a single dose of ketamine, a glutamate N-methyl-d-aspartate (NMDA) receptor antagonist, is associated with a rapid reduction in depressive symptom severity and SI in patients with treatment-resistant depression.
We conducted a randomized, controlled trial of ketamine in patients with mood and anxiety spectrum disorders who presented with clinically significant SI (n = 24). Patients received a single infusion of ketamine or midazolam (as an active placebo) in addition to standard of care. SI measured using the Beck Scale for Suicidal Ideation (BSI) 24 h post-treatment represented the primary outcome. Secondary outcomes included the Montgomery-Asberg Depression Rating Scale--Suicidal Ideation (MADRS-SI) score at 24 h and additional measures beyond the 24-h time-point.
The intervention was well tolerated and no dropouts occurred during the primary 7-day assessment period. BSI score was not different between the treatment groups at 24 h (p = 0.32); however, a significant difference emerged at 48 h (p = 0.047). MADRS-SI score was lower in the ketamine group compared to midazolam group at 24 h (p = 0.05). The treatment effect was no longer significant at the end of the 7-day assessment period.
The current findings provide initial support for the safety and tolerability of ketamine as an intervention for SI in patients who are at elevated risk for suicidal behavior. Larger, well-powered studies are warranted.
Abstract
Wide-field surveys for transiting planets are well suited to searching diverse stellar populations, enabling a better understanding of the link between the properties of planets and their ...parent stars. We report the discovery of HAT-P-69 b (TOI 625.01) and HAT-P-70 b (TOI 624.01), two new hot Jupiters around A stars from the Hungarian-made Automated Telescope Network (HATNet) survey that have also been observed by the
Transiting Exoplanet Survey Satellite
. HAT-P-69 b has a mass of
M
Jup
and a radius of
R
Jup
and resides in a prograde 4.79 day orbit. HAT-P-70 b has a radius of
R
Jup
and a mass constraint of
M
Jup
and resides in a retrograde 2.74 day orbit. We use the confirmation of these planets around relatively massive stars as an opportunity to explore the occurrence rate of hot Jupiters as a function of stellar mass. We define a sample of 47,126 main-sequence stars brighter than
T
mag
= 10 that yields 31 giant planet candidates, including 18 confirmed planets, 3 candidates, and 10 false positives. We find a net hot Jupiter occurrence rate of 0.41 ± 0.10% within this sample, consistent with the rate measured by
Kepler
for FGK stars. When divided into stellar mass bins, we find the occurrence rate to be 0.71 ± 0.31% for G stars, 0.43 ± 0.15% for F stars, and 0.26 ± 0.11% for A stars. Thus, at this point, we cannot discern any statistically significant trend in the occurrence of hot Jupiters with stellar mass.
We report the detection of a transiting Earth-size planet around GJ 357, a nearby M2.5 V star, using data from the Transiting Exoplanet Survey Satellite (TESS). GJ 357 b (TOI-562.01) is a transiting, ...hot, Earth-sized planet (Teq = 525 ± 11 K) with a radius of Rb = 1.217 ± 0.084 R⊕ and an orbital period of Pb = 3.93 d. Precise stellar radial velocities from CARMENES and PFS, as well as archival data from HIRES, UVES, and HARPS also display a 3.93-day periodicity, confirming the planetary nature and leading to a planetary mass of Mb = 1.84 ± 0.31 M⊕. In addition to the radial velocity signal for GJ 357 b, more periodicities are present in the data indicating the presence of two further planets in the system: GJ 357 c, with a minimum mass of Mc = 3.40 ± 0.46 M⊕ in a 9.12 d orbit, and GJ 357 d, with a minimum mass of Md = 6.1 ± 1.0 M⊕ in a 55.7 d orbit inside the habitable zone. The host is relatively inactive and exhibits a photometric rotation period of Prot = 78 ± 2 d. GJ 357 b isto date the second closest transiting planet to the Sun, making it a prime target for further investigations such as transmission spectroscopy. Therefore, GJ 357 b represents one of the best terrestrial planets suitable for atmospheric characterization with the upcoming JWST and ground-based ELTs.
Context. The NASA mission TESS is currently doing an all-sky survey from space to detect transiting planets around bright stars. As part of the validation process, the most promising planet ...candidates need to be confirmed and characterized using follow-up observations.
Aims. In this article, our aim is to confirm the planetary nature of the transiting planet candidate TOI-674b using spectroscopic and photometric observations.
Methods. We use TESS, Spitzer, ground-based light curves, and HARPS spectrograph radial velocity measurements to establish the physical properties of the transiting exoplanet candidate TOI-674b. We perform a joint fit of the light curves and radial velocity time series to measure the mass, radius, and orbital parameters of the candidate.
Results. We confirm and characterize TOI-674b, a low-density super-Neptune transiting a nearby M dwarf. The host star (TIC 158588995, V = 14.2 mag, J = 10.3 mag) is characterized by its M2V spectral type with M⋆ = 0.420 ± 0.010 Mꙩ, R⋆ = 0.420 ± 0.013 Rꙩ, and T(eff) = 3514 ± 57 K; it is located at a distance d = 46.16 ± 0.03 pc. Combining the available transit light curves plus radial velocity measurements and jointly fitting a circular orbit model, we find an orbital period of 1.977143 ± 3 × 10^(−6) days, a planetary radius of 5.25 ± 0.17 Rꚛ, and a mass of 23.6 ± 3.3 Mꚛ implying a mean density of ρp =0.91 ± 0.15 g/cu. cm. A non-circular orbit model fit delivers similar planetary mass and radius values within the uncertainties. Given the measured planetary radius and mass, TOI-674b is one of the largest and most massive super-Neptune class planets discovered around an M-type star to date. It is found in the Neptunian desert, and is a promising candidate for atmospheric characterization using the James Webb Space Telescope.
We present the confirmation and characterisation of GJ 3473 b (G 50–16, TOI-488.01), a hot Earth-sized planet orbiting an M4 dwarf star, whose transiting signal (
P
= 1.1980035 ± 0.0000018 d) was ...first detected by the Transiting Exoplanet Survey Satellite (TESS). Through a joint modelling of follow-up radial velocity observations with CARMENES, IRD, and HARPS together with extensive ground-based photometric follow-up observations with LCOGT, MuSCAT, and MuSCAT2, we determined a precise planetary mass,
M
b
= 1.86 ± 0.30
M
⊕
, and radius,
R
b
= 1.264 ± 0.050
R
⊕
. Additionally, we report the discovery of a second, temperate, non-transiting planet in the system, GJ 3473 c, which has a minimum mass,
M
c
sin
i
= 7.41 ± 0.91
M
⊕
, and orbital period,
P
c
= 15.509 ± 0.033 d. The inner planet of the system, GJ 3473 b, is one of the hottest transiting Earth-sized planets known thus far, accompanied by a dynamical mass measurement, which makes it a particularly attractive target for thermal emission spectroscopy.
Dynamical histories of planetary systems, as well as the atmospheric evolution of highly irradiated planets, can be studied by characterizing the ultra-short-period planet population, which the TESS ...mission is particularly well suited to discover. Here, we report on the follow-up of a transit signal detected in the TESS sector 19 photometric time series of the M3.0 V star TOI-1685 (2MASS J04342248+4302148). We confirm the planetary nature of the transit signal, which has a period of
P
b
= 0.6691403
−0.0000021
+0.0000023
d, using precise radial velocity measurements taken with the CARMENES spectrograph. From the joint photometry and radial velocity analysis, we estimate the following parameters for TOI-1685 b: a mass of
M
b
= 3.78
−0.63
+0.63
M
⊕
, a radius of
R
b
= 1.70
−0.07
+0.07
R
⊕
, which together result in a bulk density of
ρ
b
= 4.21
−0.82
+0.95
g cm
−3
, and an equilibrium temperature of
T
eq
= 1069
−16
+16
K. TOI-1685 b is the least dense ultra-short-period planet around an M dwarf known to date. TOI-1685 b is also one of the hottest transiting super-Earth planets with accurate dynamical mass measurements, which makes it a particularly attractive target for thermal emission spectroscopy. Additionally, we report with moderate evidence an additional non-transiting planet candidate in the system, TOI-1685 c, which has an orbital period of
P
c
= 9.02
−0.12
+0.10
d.
Context.
We report the discovery of TOI-519 b (TIC 218795833), a transiting substellar object (
R
= 1.07
R
Jup
) orbiting a faint M dwarf (
V
= 17.35) on a 1.26 d orbit. Brown dwarfs and massive ...planets orbiting M dwarfs on short-period orbits are rare, but more have already been discovered than expected from planet formation models. TOI-519 is a valuable addition to this group of unlikely systems, and it adds towards our understanding of the boundaries of planet formation.
Aims.
We set out to determine the nature of the Transiting Exoplanet Survey Satellite (TESS) object of interest TOI-519 b.
Methods.
Our analysis uses a SPOC-pipeline TESS light curve from Sector 7, multicolour transit photometry observed with MuSCAT2 and MuSCAT, and transit photometry observed with the LCOGT telescopes. We estimated the radius of the transiting object using multicolour transit modelling, and we set upper limits for its mass, effective temperature, and Bond albedo using a phase curve model that includes Doppler boosting, ellipsoidal variations, thermal emission, and reflected light components.
Results.
TOI-519 b is a substellar object with a radius posterior median of 1.07
R
Jup
and 5th and 95th percentiles of 0.66 and 1.20
R
Jup
, respectively, where most of the uncertainty comes from the uncertainty in the stellar radius. The phase curve analysis sets an upper effective temperature limit of 1800 K, an upper Bond albedo limit of 0.49, and a companion mass upper limit of 14
M
Jup
. The companion radius estimate combined with the
T
eff
and mass limits suggests that the companion is more likely a planet than a brown dwarf, but a brown-dwarf scenario is a priori more likely given the lack of known massive planets in ≈ 1 day orbits around M dwarfs with
T
eff
< 3800 K, and given the existence of some (but few) brown dwarfs.
Context.
We report the discovery of TOI 263.01 (TIC 120916706), a transiting substellar object (
R
= 0.87
R
Jup
) orbiting a faint M3.5 V dwarf (
V
= 18.97) on a 0.56 d orbit.
Aims.
We setout to ...determine the nature of the Transiting Exoplanet Survey Satellite (TESS) planet candidate TOI 263.01 using ground-based multicolour transit photometry. The host star is faint, which makes radial-velocity confirmation challenging, but the large transit depth makes the candidate suitable for validation through multicolour photometry.
Methods.
Our analysis combines three transits observed simultaneously in
r
′,
i
′, and
z
s
bands usingthe MuSCAT2 multicolour imager, three LCOGT-observed transit light curves in
g
′,
r
′, and
i
′ bands, a TESS light curve from Sector 3, and a low-resolution spectrum for stellar characterisation observed with the ALFOSC spectrograph. We modelled the light curves with P
Y
T
RANSIT
using a transit model that includes a physics-based light contamination component, allowing us to estimate the contamination from unresolved sources from the multicolour photometry. Using this information we were able to derive the true planet–star radius ratio marginalised over the contamination allowed by the photometry.Combining this with the stellar radius, we were able to make a reliable estimate of the absolute radius of the object.
Results.
The ground-based photometry strongly excludes contamination from unresolved sources with a significant colour difference to TOI 263. Furthermore, contamination from sources of the same stellar type as the host is constrained to levels where the true radius ratio posterior has a median of 0.217 and a 99 percentile of0.286. The median and maximum radius ratios correspond to absolute planet radii of 0.87 and 1.41
R
Jup
, respectively,which confirms the substellar nature of the planet candidate. The object is either a giant planetor a brown dwarf (BD) located deep inside the so-called “brown dwarf desert”. Both possibilities offer a challenge to current planet/BD formation models and make TOI 263.01 an object that merits in-depth follow-up studies.
Spectroscopy of transiting exoplanets can be used to investigate their atmospheric properties
and habitability. Combining radial velocity (RV) and transit data provides additional information
on ...exoplanet physical properties. We detect a transiting rocky planet with an orbital period
of 1.467 days around the nearby red dwarf star Gliese 486. The planet Gliese 486 b is
2.81 Earth masses and 1.31 Earth radii, with uncertainties of 5%, as determined from RV data
and photometric light curves. The host star is at a distance of ~8.1 parsecs, has a J-band magnitude of ~7.2, and is observable from both hemispheres of Earth. On the basis of these properties and the planet’s short orbital period and high equilibrium temperature, we show that this terrestrial planet is suitable for emission and transit spectroscopy.
Citrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC), which are two ...clinically important human gastrointestinal pathogens. Thus, C. rodentium has long been used as a model to understand the molecular basis of EPEC and EHEC infection in vivo. In this Review, we discuss recent studies in which C. rodentium has been used to study mucosal immunology, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens. These insights should help to elucidate the roles of mucosal inflammatory responses and the microbiota in the virulence of enteric pathogens.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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