Artificial intelligence technology has advanced rapidly in recent years and has the potential to improve healthcare outcomes. However, technology uptake will be largely driven by clinicians, and ...there is a paucity of data regarding the attitude that clinicians have to this new technology. In June-August 2019 we conducted an online survey of fellows and trainees of three specialty colleges (ophthalmology, radiology/radiation oncology, dermatology) in Australia and New Zealand on artificial intelligence. There were 632 complete responses (n = 305, 230, and 97, respectively), equating to a response rate of 20.4%, 5.1%, and 13.2% for the above colleges, respectively. The majority (n = 449, 71.0%) believed artificial intelligence would improve their field of medicine, and that medical workforce needs would be impacted by the technology within the next decade (n = 542, 85.8%). Improved disease screening and streamlining of monotonous tasks were identified as key benefits of artificial intelligence. The divestment of healthcare to technology companies and medical liability implications were the greatest concerns. Education was identified as a priority to prepare clinicians for the implementation of artificial intelligence in healthcare. This survey highlights parallels between the perceptions of different clinician groups in Australia and New Zealand about artificial intelligence in medicine. Artificial intelligence was recognized as valuable technology that will have wide-ranging impacts on healthcare.
Matrix-matched calibration by natural zircon standards and analysis of natural materials as a reference are the principle methods for achieving accurate results in microbeam U–Pb dating and Hf ...isotopic analysis. We describe a new potential zircon reference material for laser ablation ICP-MS that was extracted from a potassic granulite facies rock collected in the southern part of the Bohemian Massif (Plešovice, Czech Republic).
Data from different techniques (ID-TIMS, SIMS and LA ICP-MS) and several laboratories suggest that this zircon has a concordant U–Pb age with a weighted mean
206Pb/
238U date of 337.13
±
0.37 Ma (ID-TIMS, 95% confidence limits, including tracer calibration uncertainty) and U–Pb age homogeneity on the scale used in LA ICP-MS dating. Inhomogeneities in trace element composition due to primary growth zoning prevent its use as a calibration standard for trace element analysis. The content of U varies from 465 ppm in pristine parts of the grains to ~
3000 ppm in actinide-rich sectors that correspond to pyramidal faces with a high degree of metamictization (present in ca. 30% of the grains). These domains are easily recognized from high intensities on BSE images and should be avoided during the analysis. Hf isotopic composition of the Plešovice zircon (>
0.9 wt.% Hf) is homogenous within and between the grains with a mean
176Hf/
177Hf value of 0.282482
±
0.000013 (2SD). The age and Hf isotopic homogeneity of the Plešovice zircon together with its relatively high U and Pb contents make it an ideal calibration and reference material for laser ablation ICP-MS measurements, especially when using low laser energies and/or small diameters of laser beam required for improved spatial resolution.
The Megamaser Cosmology Project (MCP) seeks to measure the Hubble Constant (H 0) in order to improve the extragalactic distance scale and constrain the nature of dark energy. We are searching for ...sources of H2O maser emission from active galactic nuclei with sub-pc accretion disks, as in NGC 4258, and following up these discoveries with very long baseline interferometric (VLBI) imaging and spectral monitoring. Here we present a VLBI map of the H2O masers toward UGC 3789, a galaxy well into the Hubble Flow. We have observed masers moving at rotational speeds up to 800 km s-1 at radii as small as 0.08 pc. Our map reveals masers in a nearly edge-on disk in Keplerian rotation about a 107 M supermassive black hole. When combined with centripetal accelerations, obtained by observing spectral drifts of maser features (to be presented in Paper II), the UGC 3789 masers may provide an accurate determination of H 0, independent of luminosities and metallicity and extinction corrections.
We used the Karl G. Jansky Very Large Array to image one primary beam area at 3 GHz with 8" FWHM resolution and 1.0 mu Jy beam super(-1) rms noise near the pointing center. The P(D) distribution from ...the central 10 arcmin of this confusion-limited image constrains the count of discrete sources in the 1 < S( mu Jy) < 10 range. At this level, the brightness-weighted differential count S super(2)n(S) is converging rapidly, as predicted by evolutionary models in which the faintest radio sources are star-forming galaxies; and asymptotically =96% of the background originating in galaxies has been resolved into discrete sources. About 63% of the radio background is produced by active galactic nuclei (AGNs), and the remaining 37% comes from star-forming galaxies that obey the far-infrared (FIR)/radio correlation and account for most of the FIR background at lambda asymptotically = 160 mu m. Our new data confirm that radio sources powered by AGNs and star formation evolve at about the same rate, a result consistent with AGN feedback and the rough correlation of black hole and stellar masses. The confusion at centimeter wavelengths is low enough that neither the planned Square Kilometre Array nor its pathfinder ASKAP EMU survey should be confusion limited, and the ultimate source detection limit imposed by "natural" confusion is < or =, slant0.01 mu Jy at nu = 1.4 GHz. If discrete sources dominate the bright extragalactic background reported by ARCADE 2 at 3.3 GHz, they cannot be located in or near galaxies and most are < or =, slant0.03 mu Jy at 1.4 GHz.
ABSTRACT As part of the Megamaser Cosmology Project, we present VLBI maps of nuclear water masers toward five galaxies. The masers originate in sub-parsec circumnuclear disks. For three of the ...galaxies, we fit Keplerian rotation curves to estimate their supermassive black hole (SMBH) masses, and determine (2.9 0.3) × 106 M for J0437+2456, (1.7 0.1) × 107 M for ESO 558-G009, and (1.1 0.2) × 107 M for NGC 5495. In the other two galaxies, Mrk 1029 and NGC 1320, the geometry and dynamics are more complicated and preclude robust black hole mass estimates. Including our new results, we compiled a list of 15 VLBI-confirmed disk maser galaxies with robust SMBH mass measurements. With this sample, we confirm the empirical relation of Rout ∝ 0.3MSMBH reported in Wardle & Yusef-Zadeh. We also find a tentative correlation between maser disk outer radii and Wide-Field Infrared Survey Explorer luminosity. We find no correlations of maser disk size with X-ray 2-10 keV luminosity or O iii luminosity.
The mechanistic target of rapamycin (mTOR) signaling pathway coordinates environmental and intracellular cues to control eukaryotic cell growth. As a pivot point between anabolic and catabolic ...processes, mTOR complex 1 (mTORC1) signaling has established roles in regulating metabolism, translation and autophagy. Hyperactivity of the mTOR pathway is associated with numerous human diseases, including diabetes, cancer and epilepsy. Pharmacological inhibition of the mTOR pathway can extend lifespan in a variety of model organisms. Given its broad control of essential cellular processes and clear relevance to human health, there is extensive interest in elucidating how upstream inputs regulate mTORC1 activation. In this Cell Science at a Glance article and accompanying poster, we summarize our understanding of how extracellular and intracellular signals feed into the mTOR pathway, how the lysosome acts as an mTOR signaling hub, and how downstream signaling controls autophagy and lysosome biogenesis.
The Huqf Supergroup, Sultanate of Oman, contains an important record of Neoproterozoic history, including evidence for two glaciations, a massive reorganization of the global carbon cycle, and the ...Ediacaran-Cambrian transition. New U-Pb geochronologic data provide precise constraints on the age of several key stratigraphic levels in the Neoproterozoic Huqf Supergroup and its subjacent crystalline basement rocks. The basement ages constrain an interval of felsic magmatism to have occurred from at least 840 Ma to approximately 810 Ma. Detrital zircons from several stratigraphic levels within the Huqf Supergroup yield ages in excess of 2.5 Ga, suggesting proximity of Archean crust during the Neoproterozoic evolution of the eastern Arabian Peninsula. Volcanic ash beds intercalated within the Huqf Supergroup were dated in the Oman Mountains, and in several subsurface wells (South Oman Salt Basin). Glacial deposits of the Abu Mahara Group in the Oman Mountains (Ghubrah Formation) contain volcaniclastic rocks that are approximately 713 Ma; overlying syn-glacial turbiditic sandstones of the Fiq Formation yield a suite of detrital zircon dates ranging from 920 to 664 Ma so that deposition of at least the upper Fiq must have post-dated 664 Ma. In the South Oman Salt Basin, volcaniclastic deposits intercalated within glaciogenic strata of the Fiq Formation yielded zircons, the youngest of which is about 645 Ma. These data indicate two distinct episodes of glaciation at approximately 713 and <645 Ma. The uppermost Ara Group of the Huqf Supergoup contains multiple ash beds within its carbonate strata, where an age of roughly 547 Ma is reported for rocks that occur above strata marked by a pronounced negative (-12per thousand) to positive (+4per thousand) excursion in carbon isotope composition. Higher in the Ara sequence, three distinct ash beds dated at about 543 Ma, 542 Ma, and 541 Ma closely approximate the Ediacaran-Cambrian boundary in Oman. The dramatic carbon isotope excursion of ∼16 permil in the Shuram Formation (middle Nafun Group) has a firm maximum age of approximately 620 Ma as provided by detrital zircon ages from the base of the formation. Interpolation and downward extrapolation from the Ma Group ages, coupled with correlation to other global strata, suggests the base of the Shuram C-isotope excursion to be on the order of 560 Ma, with an estimated duration of approximately 5 to 11 m.y. This excursion is inferred to post-date the last well-documented Neoproterozoic glaciation (about 582 Ma) and is broadly coincident with the appearance of complex organisms in the fossil record.
We present a measurement of the Hubble constant made using geometric distance measurements to megamaser-hosting galaxies. We have applied an improved approach for fitting maser data and obtained ...better distance estimates for four galaxies previously published by the Megamaser Cosmology Project: UGC 3789, NGC 6264, NGC 6323, and NGC 5765b. Combining these updated distance measurements with those for the maser galaxies CGCG 074-064 and NGC 4258, and assuming a fixed velocity uncertainty of 250 km s−1 associated with peculiar motions, we constrain the Hubble constant to be H0 = 73.9 3.0 km s−1 Mpc−1 independent of distance ladders and the cosmic microwave background. This best value relies solely on maser-based distance and velocity measurements, and it does not use any peculiar velocity corrections. Different approaches for correcting peculiar velocities do not modify H0 by more than 1 , with the full range of best-fit Hubble constant values spanning 71.8-76.9 km s−1 Mpc−1. We corroborate prior indications that the local value of H0 exceeds the early-universe value, with a confidence level varying from 95% to 99% for different treatments of the peculiar velocities.
In Papers I and II from the Megamaser Cosmology Project, we reported initial observations of H sub(2)O masers in an accretion disk of a supermassive black hole at the center of the galaxy UGC 3789, ...which gave an angular-diameter distance to the galaxy and an estimate of H sub(0) with 16% uncertainty. We have since conducted more very long baseline interferometric observations of the spatial-velocity structure of these H sub(2)O masers, as well as continued monitoring of its spectrum to better measure maser accelerations. These more extensive observations, combined with improved modeling of the masers in the accretion disk of the central supermassive black hole, confirm our previous results, but with significantly improved accuracy. We find H sub(0) = 68.9 + or - 7.1 km s super(-1) Mpc super(-1); this estimate of H sub(0) is independent of other methods and is accurate to + or -10%, including sources of systematic error. This places UGC 3789 at an angular-diameter distance of 49.6 + or -5.1 Mpc, with a central supermassive black hole of (1.16 + or - 0.12) x 10 super(7) M sub(middot in circle).
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