ABSTRACT
We investigated 12 unclassified Be stars or candidates, 8 from the Galaxy, 2 from the Large Magellanic Cloud (LMC), and 2 from the Small Magellanic Cloud (SMC). Based on the analysis of ...high-resolution spectroscopic (FEROS) and photometric data, we confirmed the presence of the Be phenomenon for all objects of our sample, except for one (IRAS 07455-3143). We derived their effective temperature, spectral type, luminosity class, interstellar extinction and, using the distances from Gaia DR2, we obtained their bolometric magnitude, luminosity, and radius. Modelling of the forbidden lines present in the FEROS spectra revealed information about the kinematics and geometry of the circumstellar medium of these objects. In addition, we analysed the light curves of four stars, finding their most probable periods. The evolutionary stage of 11 stars of our sample is suggested from their position on the HR diagram, taking into account evolutionary tracks of stars with solar, LMC, and SMC metallicities. As results, we identified B and Be supergiants, Be stars probably at the main sequence or close to its end, post-AGB and HAeBe candidates, and Ae stars in the main sequence or in the pre-main sequence. However, our most remarkable results are the identification of the third Ae supergiant (ARDB 54, the first one in the LMC), and of an ‘LBV impostor’ in the SMC (LHA 115-N82).
Andes Large-area PArticle detector for Cosmic-ray physics and Astronomy (ALPACA) is an international experiment that applies southern very-high-energy (VHE) gamma-ray astronomy to determine the ...origin of cosmic rays around the knee energy region (10
15
eV − 10
16
eV). The experiment consists of an air shower (AS) array with a surface of 83,000m
2
and an underground water Cherenkov muon detector (MD) array covering 5,400m
2
. The experimental site is at the Mt. Chacaltaya plateau in La Paz, Bolivia, with an altitude of 4,740m corresponding to 572g/cm
2
atmospheric thickness. As the prototype experiment of ALPACA, the ALPAQUITA experiment aims to begin data acquisition in late 2021. The ALPAQUITA array consists of a smaller AS array (18,450m
2
) and underground MD (900m
2
), which are now under construction. ALPAQUITA’s sensitivity to gamma-ray sources is evaluated with Monte Carlo simulations. The simulation finds that five gamma-ray sources observed by H.E.S.S. and HAWC experiments will be detected by ALPAQUITA beyond 10TeV and ne out of these five - HESS J1702-420A - above 300 TeV in one calendar year observation. The latter finding means that scientific discussions can be made on the emission mechanism of gamma rays beyond 100TeV from southern sources on the basis of the observational results of this prototype experiment.
Observation techniques of high-energy gamma rays using air showers have remarkably progressed via the Tibet AS
γ
, HAWC, and LHAASO experiments. These observations have significantly contributed to ...gamma-ray astronomy in the northern sky’s sub-PeV region. Moreover, in the southern sky, the ALPACA experiment is underway at 4,740 m altitude on the Chacaltaya plateau in Bolivia. This experiment estimates the gamma-ray flux from the difference between the number of on-source and off-source events by real data, utilizing the gamma-ray detection efficiency calculated through Monte Carlo simulations, which in turn depends on the hadronic interaction models. Even though the number of cosmic-ray background events can be experimentally estimated, this model dependence affects the estimation of gamma-ray detection efficiency. However, previous reports have assumed that the model dependence is negligible and have not included it in the error of gamma-ray flux estimation. Using ALPAQUITA, the prototype experiment of ALPACA, we quantitatively evaluated the model dependence on hadronic interaction models for the first time. We evaluate the model dependence on hadronic interactions as less than 3.6 % in the typical gamma-ray flux estimation performed by ALPAQUITA; this is negligible compared with other uncertainties such as energy scale uncertainty in the energy range from 6 to 300 TeV, which is dominated by the Monte Carlo statistics. This upper limit of 3.6 % model dependence is expected to apply to ALPACA.
When caring for mechanically ventilated adults with acute hypoxaemic respiratory failure (AHRF), clinicians are faced with an uncertain choice between ventilator modes allowing for spontaneous ...breaths or ventilation fully controlled by the ventilator. The preferences of clinicians managing such patients, and what motivates their choice of ventilator mode, are largely unknown. To better understand how clinicians' preferences may impact the choice of ventilatory support for patients with AHRF, we issued a survey to an international network of intensive care unit (ICU) researchers.
We distributed an online survey with 32 broadly similar and interlinked questions on how clinicians prioritise spontaneous or controlled ventilation in invasively ventilated patients with AHRF of different severity, and which factors determine their choice.
The survey was distributed to 1337 recipients in 12 countries. Of these, 415 (31%) completed the survey either fully (52%) or partially (48%). Most respondents were identified as medical specialists (87%) or physicians in training (11%). Modes allowing for spontaneous ventilation were considered preferable in mild AHRF, with controlled ventilation considered as progressively more important in moderate and severe AHRF. Among respondents there was strong support (90%) for a randomised clinical trial comparing spontaneous with controlled ventilation in patients with moderate AHRF.
The responses from this international survey suggest that there is clinical equipoise for the preferred ventilator mode in patients with AHRF of moderate severity. We found strong support for a randomised trial comparing modes of ventilation in patients with moderate AHRF.
A potato crop multimodel assessment was conducted to quantify variation among models and evaluate responses to climate change. Nine modeling groups simulated agronomic and climatic responses at ...low‐input (Chinoli, Bolivia and Gisozi, Burundi)‐ and high‐input (Jyndevad, Denmark and Washington, United States) management sites. Two calibration stages were explored, partial (P1), where experimental dry matter data were not provided, and full (P2). The median model ensemble response outperformed any single model in terms of replicating observed yield across all locations. Uncertainty in simulated yield decreased from 38% to 20% between P1 and P2. Model uncertainty increased with interannual variability, and predictions for all agronomic variables were significantly different from one model to another (P < 0.001). Uncertainty averaged 15% higher for low‐ vs. high‐input sites, with larger differences observed for evapotranspiration (ET), nitrogen uptake, and water use efficiency as compared to dry matter. A minimum of five partial, or three full, calibrated models was required for an ensemble approach to keep variability below that of common field variation. Model variation was not influenced by change in carbon dioxide (C), but increased as much as 41% and 23% for yield and ET, respectively, as temperature (T) or rainfall (W) moved away from historical levels. Increases in T accounted for the highest amount of uncertainty, suggesting that methods and parameters for T sensitivity represent a considerable unknown among models. Using median model ensemble values, yield increased on average 6% per 100‐ppm C, declined 4.6% per °C, and declined 2% for every 10% decrease in rainfall (for nonirrigated sites). Differences in predictions due to model representation of light utilization were significant (P < 0.01). These are the first reported results quantifying uncertainty for tuber/root crops and suggest modeling assessments of climate change impact on potato may be improved using an ensemble approach.
Triatomine vectors transmit Trypanosoma cruzi, the etiological agent of Chagas disease in humans. Transmission to humans typically occurs when contaminated triatomine feces come in contact with the ...bite site or mucosal membranes. In the Southern Cone of South America, where the highest burden of disease exists, Triatoma infestans is the principal vector for T. cruzi. Recent studies of other vector-borne illnesses have shown that arthropod microbiota influences the ability of infectious agents to colonize the insect vector and transmit to the human host. This has garnered attention as a potential control strategy against T. cruzi, as vector control is the main tool of Chagas disease prevention. Here we characterized the microbiota in T. infestans feces of both wild-caught and laboratory-reared insects and examined the relationship between microbial composition and T. cruzi infection using highly sensitive high-throughput sequencing technology to sequence the V3-V4 region of the 16S ribosomal RNA gene on the MiSeq Illumina platform. We collected 59 wild (9 with T. cruzi infection) and 10 lab-reared T. infestans (4 with T. cruzi infection) from the endemic area of Arequipa, Perú. Wild T. infestans had greater hindgut bacterial diversity than laboratory-reared bugs. Microbiota of lab insects comprised a subset of those identified in their wild counterparts, with 96 of the total 124 genera also observed in laboratory-reared insects. Among wild insects, variation in bacterial composition was observed, but time and location of collection and development stage did not explain this variation. T. cruzi infection in lab insects did not affect α- or β-diversity; however, we did find that the β-diversity of wild insects differed if they were infected with T. cruzi and identified 10 specific taxa that had significantly different relative abundances in infected vs. uninfected wild T. infestans (Bosea, Mesorhizobium, Dietzia, and Cupriavidus were underrepresented in infected bugs; Sporosarcina, an unclassified genus of Porphyromonadaceae, Nestenrenkonia, Alkalibacterium, Peptoniphilus, Marinilactibacillus were overrepresented in infected bugs). Our findings suggest that T. cruzi infection is associated with the microbiota of T. infestans and that inferring the microbiota of wild T. infestans may not be possible through sampling of T. infestans reared in the insectary.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Field biology is an area of research that involves working directly with living organisms in situ through a practice known as “fieldwork.” Conducting fieldwork often requires complex logistical ...planning within multiregional or multinational teams, interacting with local communities at field sites, and collaborative research led by one or a few of the core team members. However, existing power imbalances stemming from geopolitical history, discrimination, and professional position, among other factors, perpetuate inequities when conducting these research endeavors. After reflecting on our own research programs, we propose four general principles to guide equitable, inclusive, ethical, and safe practices in field biology: be collaborative, be respectful, be legal, and be safe. Although many biologists already structure their field programs around these principles or similar values, executing equitable research practices can prove challenging and requires careful consideration, especially by those in positions with relatively greater privilege. Based on experiences and input from a diverse group of global collaborators, we provide suggestions for action-oriented approaches to make field biology more equitable, with particular attention to how those with greater privilege can contribute. While we acknowledge that not all suggestions will be applicable to every institution or program, we hope that they will generate discussions and provide a baseline for training in proactive, equitable fieldwork practices.
Eight infants with SCID-X1 had multilineage immune reconstitution after autologous hematopoietic stem-cell transplantation of marrow stem cells transfected with a lentiviral vector containing
IL2RG
...cDNA after busulfan conditioning. Previous infections cleared and functional T cells developed in all eight infants, IgM levels normalized in seven, and three had a response to vaccines.
•These results demonstrate that this approach is “more likely to be applicable in a wider array of situations”.•Results also indicate that the degenerative changes in the RDT is not dependent upon ...ancestral filiation or sex in any given age category.•This procedure not require intensive training or specialized technologies to obtain satisfactory results which include high repeatability and replicability.•The model proposed here may be generalizable across all humans.•Establishment of standards for the knowledge of levels of accuracy and precision on both global and local scale.
Estimation of the age-at-death in adults is essential when the identification of deceased persons with unknown identity is required in both humanitarian and judicial contexts. However, the methodologies and the results obtained can be questioned. Various efforts have been developed to adjust procedures to specific populations, always seeking the precision and accuracy of the methodologies. It is known that the estimation of the age-at-death in adults coexists with wide margins of error, due to several reasons, including but not limited to statistical problems, the size of the sample or the physiological process of aging.
This research focuses on a degenerative indicator of the dentin (Root Dentin Translucency) and its combination with Periodontal Height (PH) following the Lamendin’s technique for estimation of the age-at-death in adults. The main objective of this research was to demonstrate the applicability of a Bayesian model based on a Forensic International Dental Database (FIDB) that include Root Translucency Height (RTH) and PH as a method to age-at-death in adults. The conclusion of this research was that the combined both indicators become a generalizable age-at-death in adults model for all human populations, where the Bayesian method would offer optimal results in any population. In this way, those populations that do not have had the possibility of validating a specific procedure, now have the opportunity to apply a valid method for estimating age-at-death in adults to global scope.
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