Guiding the beta-emitting isotope lutetium-177 to prostate cancer lesions with the prostate-specific membrane antigen–targeted radioligand
177
Lu-PSMA-617 plus using standard care was compared with ...standard care in patients with metastatic castration-resistant prostate cancer. The radioligand therapy prolonged progression-free and overall survival. Adverse effects were more common, but quality of life was maintained.
Objective: To determine the prevalence of acquired hepatocerebral degeneration (AHD), its clinical and neuroimaging characteristics and response to treatments.
Background: Acquired hepatocerebral ...degeneration is a chronic encephalopathy with predominant motor signs in the context of severe liver disease. Its clinical picture is not well defined, and its prevalence and risk factors are not well known.
Methods: Review of a database of 1000 patients with cirrhosis to identify cases of AHD. Clinical and neuroimaging data, follow‐up and response to treatments, including liver transplantation, were recorded.
Results: Eight patients with AHD were identified. Its prevalence was 0.8% of patients with cirrhosis. The main risk factor for AHD was the presence of portosystemic shunts. Movement disorders, especially a combination of parkinsonism and cerebellar signs were observed in all patients. All AHD cases showed on MRI T1‐weighted images hyperintensities in the globus pallidus, and 75% had extrapallidal involvement as well. Antiparkisonian drugs and treatments to prevent acute encephalopathies were ineffective. Three patients who underwent liver transplantation did not experience neurological improvement. Persistence of portosystemic shunts was demonstrated in two cases.
Conclusions: Acquired hepatocerebral degeneration is a chronic encephalopathy which occurs in ∼1% of patients with liver cirrhosis and seems related to portosystemic shunts. Its is characterized by a combination of parkinsonism and cerebellar signs. MRI pallidal and extrapallidal lesions are seen in most patients, probably reflecting intracerebral deposits of manganese. Liver transplant did not improve the neurological signs in our patients, perhaps because of the persistence of portosystemic shunts.
Milky Way demographics with the VVV survey Alonso-García, Javier; Saito, Roberto K.; Hempel, Maren ...
Astronomy and astrophysics (Berlin),
11/2018, Letnik:
619
Journal Article
Recenzirano
Odprti dostop
Context
. The inner regions of the Galaxy are severely affected by extinction, which limits our capability to study the stellar populations present there. The Vista Variables in the Vía Láctea (VVV) ...ESO Public Survey has observed this zone at near-infrared wavelengths where reddening is highly diminished.
Aims
. By exploiting the high resolution and wide field-of-view of the VVV images we aim to produce a deep, homogeneous, and highly complete database of sources that cover the innermost regions of our Galaxy.
Methods
. To better deal with the high crowding in the surveyed areas, we have used point spread function (PSF)-fitting techniques to obtain a new photometry of the VVV images, in the
ZY JHK
s
near-infrared filters available.
Results
. Our final catalogs contain close to one billion sources, with precise photometry in up to five near-infrared filters, and they are already being used to provide an unprecedented view of the inner Galactic stellar populations. We make these catalogs publicly available to the community. Our catalogs allow us to build the VVV giga-CMD, a series of color-magnitude diagrams of the inner regions of the Milky Way presented as supplementary videos. We provide a qualitative analysis of some representative CMDs of the inner regions of the Galaxy, and briefly mention some of the studies we have developed with this new dataset so far.
Experimentally, we have found that among the "complicated" phases of potassium at intermediate pressures is one which has the same space group as the double hexagonal-close-packed structure, although ...its atomic coordination is completely different. Calculations on this P6(3)/mmc (hP4) structure as a function of pressure show three isostructural transitions and three distinctive types of chemical bonding: free electron, ionic, and metallic. Interestingly, relationships between localized metallic structures and ionic compounds are found.
CuxS thin films were grown onto soda-lime glass substrates by pulsed laser deposition at two different wavelengths: 1064 and 532 nm. X-ray diffraction, Raman and UV-vis spectroscopies were used to ...characterize the CuxS films. Results are presented as a function of laser fluence. XRD patterns indicate that covellite and chalcocite phases were obtained. Raman spectra showed that chalcocite is the predominant phase in the crystalline samples. Optical band gap values are between 2.29 and 2.74 eV for ablation with 1064 nm wavelength; meanwhile, for 532 nm band gap values varied from 2.24 to 2.66 eV; which are in the range of expected values for CuxS films. At 1064 nm and 4.4 J cm−2 sample presented the highest optical absorbance in the visible range, which corresponds to the highest thickness. These are the best growth parameters for CuxS films in order to be used as absorber films for solar cells applications.
The first measurement of lepton-jet momentum imbalance and azimuthal correlation in lepton-proton scattering at high momentum transfer is presented. These data, taken with the H1 detector at HERA, ...are corrected for detector effects using an unbinned machine learning algorithm (multifold), which considers eight observables simultaneously in this first application. The unfolded cross sections are compared with calculations performed within the context of collinear or transverse-momentum-dependent factorization in quantum chromodynamics as well as Monte Carlo event generators.
The calyx of Held synapse of the medial nucleus of the trapezoid body functions as a relay synapse in the auditory brainstem. In vivo recordings have shown that this synapse displays low release ...probability and that the average size of synaptic potentials does not depend on recent history. We used a ventral approach to make in vivo extracellular recordings from the calyx of Held synapse in rats aged postnatal day 4 (P4) to P29 to study the developmental changes that allow this synapse to function as a relay. Between P4 and P8, we observed evidence for the presence of large short-term depression, which was counteracted by short-term facilitation at short intervals. Major changes occurred in the last few days before the onset of hearing for air-borne sounds, which happened at P13. The bursting pattern changed into a primary-like pattern, the amount of depression and facilitation decreased strongly, and the decay of facilitation became much faster. Whereas short-term plasticity was the most important cause of variability in the size of the synaptic potentials in immature animals, its role became minor around hearing onset and afterward. Similar developmental changes were observed during stimulation experiments both in brain slices and in vivo following cochlear ablation. Our data suggest that the strong reduction in release probability and the speedup of the decay of synaptic facilitation that happen just before hearing onset are important events in the transformation of the calyx of Held synapse into an auditory relay synapse.
The story-line of the activities that have produced the first group of scientists in Mexico working on particle accelerator science and technology is briefly presented.
•For the thiophene hydrogenation, the Ni(0.5)–Pt/HMOR catalyst is the most active.•Ni(X)–Pt/HMOR samples exhibit thio-resistance and thio-tolerance on thiophene HYD.•Ni(X)–Pt/HMOR catalysts show ...hydrogenation activity in the presence of 500ppm S.•Ni(X)–Pt/HMOR catalysts is less prone to deactivation.•Hydrogen spillover plays a key role in keeping HYD activity in the presence of sulfur.
A series of Ni(X)–Pt/HMOR catalysts (X=0, 0.5, 1.0, 1.5 and 2.0wt% of Ni and a fixed quantity of Pt=1wt%) were prepared and tested in the hydrogenation (HYD) of naphthalene with and without thiophene and also in the hydroconversion of thiophene. The catalysts were characterized using N2 physisorption, X-ray diffraction (XRD), temperature-programmed reduction (TPR), transmission electron microscopy (TEM) and TEM-EDS elemental analysis. The TPR and TEM results indicate that Pt is mainly located inside the pore system of the mordenite, whereas Ni is located on both the external surface and inside the pore system of the mordenite zeolite. Naphthalene hydrogenation exhibited a high conversion for all the catalysts. In the presence of a sulfur compound and for naphthalene hydrogenation, all the tested catalysts present a fast deactivation. Ni/HMOR catalyst was less active and presents complete deactivation. However, the Ni(0.5)–Pt/HMOR and Pt/HMOR catalysts are able to convert thiophene and produce mainly tetrahydrothiophene. This hydrogenation activity was stable, at least for 12h, showing that the catalytic system can preserve some of the hydrogenating capability. The values of thiophene hydroconversion and the selectivity to tetrahydrothiophene are much higher than the reported for similar systems. The hydrogenation activity is most likely due to the hydrogen spillover.
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