Searches for dark matter with liquid xenon time projection chamber experiments have traditionally focused on the region of the parameter space that is characteristic of weakly interacting massive ...particles, ranging from a few GeV / c 2 to a few TeV / c 2 . Models of dark matter with a mass much heavier than this are well motivated by early production mechanisms different from the standard thermal freeze-out, but they have generally been less explored experimentally. In this work, we present a reanalysis of the first science run of the LZ experiment, with an exposure of 0.9 tonne × yr , to search for ultraheavy particle dark matter. The signal topology consists of multiple energy deposits in the active region of the detector forming a straight line, from which the velocity of the incoming particle can be reconstructed on an event-by-event basis. Zero events with this topology were observed after applying the data selection calibrated on a simulated sample of signal-like events. New experimental constraints are derived, which rule out previously unexplored regions of the dark matter parameter space of spin-independent interactions beyond a mass of 10 17 GeV / c 2 . Published by the American Physical Society 2024
We estimate the amount of Ar37 produced in natural xenon via cosmic-ray-induced spallation, an inevitable consequence of the transportation and storage of xenon on the Earth’s surface. We then ...calculate the resulting Ar37 concentration in a 10-tonne payload (similar to that of the LUX-ZEPLIN experiment) assuming a representative schedule of xenon purification, storage, and delivery to the underground facility. Using the spallation model by Silberberg and Tsao, the sea-level production rate of Ar37 in natural xenon is estimated to be 0.024 atoms/kg/day. Assuming the xenon is successively purified to remove radioactive contaminants in 1-tonne batches at a rate of 1 tonne/month, the average Ar37 activity after 10 tons are purified and transported underground is 0.058-0.090 μBq/kg, depending on the degree of argon removal during above-ground purification. Such cosmogenic Ar37 will appear as a noticeable background in the early science data, while decaying with a 35-day half-life. This newly noticed production mechanism of Ar37 should be considered when planning for future liquid-xenon-based experiments.
Novel regimens combining bedaquiline and pretomanid with either linezolid (BPaL regimen) or moxifloxacin and pyrazinamide (BPaMZ regimen) shorten the treatment duration needed to cure tuberculosis ...(TB) in BALB/c mice compared to that of the first-line regimen and have yielded promising results in initial clinical trials. However, the independent contribution of the investigational new drug pretomanid to the efficacy of BPaMZ has not been examined, and its contribution to BPaL has been examined only over the first 2 months of treatment. In the present study, the addition of pretomanid to BL increased bactericidal activity, prevented emergence of bedaquiline resistance, and shortened the duration needed to prevent relapse with drug-susceptible isolates by at least 2 months in BALB/c mice. Addition of pretomanid to bedaquiline, moxifloxacin, and pyrazinamide (BMZ) resulted in a 1-log
greater CFU reduction after 1 month of treatment and/or reduced the number of mice relapsing in each of 2 experiments in BALB/c mice and in immunocompromised nude mice. Bedaquiline-resistant isolates were found at relapse in only one BMZ-treated nude mouse. Treatment of infection with a pyrazinamide-resistant mutant in BALB/c mice with BPaMZ prevented selection of bedaquiline-resistant mutants and reduced the proportion of mice relapsing compared to that for BMZ treatment alone. Among severely ill C3HeB/FeJ mice with caseous pneumonia and cavitation, BPaMZ increased median survival (≥60 versus 21 days) and reduced median lung CFU by 2.4 log
at 1 month compared to the level for BMZ. In conclusion, in 3 different mouse models, pretomanid contributed significantly to the efficacy of the BPaMZ and BPaL regimens, including restricting the selection of bedaquiline-resistant mutants.
In this paper, results of different models are compared for calculating effective, cold-circuit (beam-free) phase velocities and interaction impedances of folded waveguide (FW) slow wave circuits for ...use in millimeter-wave traveling wave tubes (TWT). These parameters are needed for one-dimensional (1-D) parametric model simulations of FW traveling wave tubes (FWTWTs). The models investigated include approximate analytic expressions, equivalent circuit, three-dimensional (3-D) finite difference, and 3-D finite element. The phase velocity predictions are compared with experimental measurements of a representative FW circuit. The various model results are incorporated into the CHRISTINE1D code to obtain predictions of small signal gain in a 40-55 GHz FWTWT. Comparing simulated and measured frequency-dependent gain provides a sensitive, confirming assessment of the accuracy of the simulation tools. It is determined that the use of parametric 1-D TWT models for accurate, full band predictions of small signal gain in FWTWTs requires knowledge of phase velocity and impedance functions that are accurate to <0.5% and <10%, respectively. Saturated gain predictions, being approximately half as sensitive to these parameters, appear to require correct specification of phase velocity and interaction impedance to within /spl sim/1% and 20%, respectively. Although all models generate sufficiently accurate predictions of the interaction impedance, not all generate sufficiently accurate predictions of the effective axial phase velocity.
Objectives/Hypothesis The wound healing characteristics of incisions made with the short pulsed CO2 laser tuned to 9.55 μm versus the traditional 10.6 μm were investigated. Previous studies have ...shown that at 9.55 μm, collagen is targeted more selectively than at 10.6 μm, which results in decreased acute thermal injury patterns. This study investigates the difference in wound healing over time between lasers and compares laser incisions with cold knife techniques .
Study Design Randomized controlled trial using a porcine model.
Methods Tissue from 10.6‐μm and 9.55‐μm incisions of 10 piglets was evaluated with histological analysis and tensiometry at 3, 7, 14, and 21 days postoperatively. A Bonferroni‐Dunn corrected analysis of variance analysis at a 95% significance level was used to compare the effect of wavelength.
Results The results demonstrate that although knife incisions are consistently stronger than laser incisions, the 9.55‐μm CO2 laser incisions are no stronger than incisions made with the conventional 10.6‐μm laser. Furthermore, histological analysis shows no difference in lateral thermal damage between lasers at 3, 7, 14, and 21 days postoperatively. The progression of collagen formation and inflammation does not differ over time.
Conclusion This study of wound healing using a porcine model demonstrates that the 9.55‐μm CO2 laser does not demonstrate an improvement in wound healing over the traditional 10.6‐μm CO2 laser. These results may be secondary to the common explosive vaporization mechanism produced by both lasers in the infrared spectrum.
The Many Hosts of Mycobacteria (MHM) meeting series brings together basic scientists, clinicians and veterinarians to promote robust discussion and dissemination of recent advances in our knowledge ...of numerous mycobacterial diseases, including human and bovine tuberculosis (TB), nontuberculous mycobacteria (NTM) infection, Hansen's disease (leprosy), Buruli ulcer and Johne's disease. The 9th MHM conference (MHM9) was held in July 2022 at The Ohio State University (OSU) and centered around the theme of “Confounders of Mycobacterial Disease.” Confounders can and often do drive the transmission of mycobacterial diseases, as well as impact surveillance and treatment outcomes. Various confounders were presented and discussed at MHM9 including those that originate from the host (comorbidities and coinfections) as well as those arising from the environment (e.g., zoonotic exposures), economic inequality (e.g. healthcare disparities), stigma (a confounder of leprosy and TB for millennia), and historical neglect (a confounder in Native American Nations). This conference report summarizes select talks given at MHM9 highlighting recent research advances, as well as talks regarding the historic and ongoing impact of TB and other infectious diseases on Native American Nations, including those in Southwestern Alaska where the regional TB incidence rate is among the highest in the Western hemisphere.
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