The Central and Eastern Anatolian plateaus are integral parts of the world's third largest orogenic plateau. In the past decade, geophysical surveys have provided insights into the crust, ...lithosphere, and mantle beneath Eastern Anatolia. These observations are now accompanied by recent surveys in Central Anatolia and new data constraining the timing and magnitude of uplift along its northern and southern margins. Together with predictions from geodynamic models on the effects of various processes on surface deformation and uplift, the observations can be integrated to identify probable mechanisms of Anatolian Plateau growth.
A changeover from shortening to extension along the southern margin of Central Anatolia that is coeval with the start of uplift can be most easily associated with oceanic slab break-off and tearing. This interpretation is supported by tomography, deep seismicity (or lack thereof), and gravity data. Based on the timing of uplift, geophysical and geochemical observations, and model predictions, slab break-off likely occurred first beneath Eastern Anatolia in middle to late Miocene time, and propagated westward toward Cyprus by the latest Miocene. Alternatively, the break-off near Cyprus could have occurred in late Pliocene to early Pleistocene time, in association with collision of the Eratosthenes Seamount (continental fragment) with the subduction zone. Uplift at the northern margin of Central Anatolia appears to result from crustal shortening starting in the late Miocene or early Pliocene, which has been linked to the broad restraining bend of the North Anatolian Fault. The uplift history of the interior of Central Anatolia since the late Miocene is unclear, although shortening there appears to have ended by the late Miocene, followed by NE–SW extension. This change in the deformation style broadly coincides with faster retreat of the Hellenic trench as well as uplift of the northern and southern margins of Central Anatolia.
These different events throughout the plateau may be linked, as faster retreat of the Hellenic trench has been predicted to occur after slab break-off, which could have induced extension of Central Anatolia and helped to form the North Anatolian Fault through accelerated westward movement of Anatolia relative to Eurasia. Correlative geochronologic evidence that we summarize here supports the hypothesis that the geodynamic activity throughout the Aegean–Anatolian domain starting in latest Miocene to early Pliocene time defines a series of events that may all be linked to slab break-off.
ABSTRACT
This paper reports on the detailed characterization of the K2-111 planetary system with K2, WASP, and ASAS-SN photometry, as well as high-resolution spectroscopic data from HARPS-N and ...ESPRESSO. The host, K2-111, is confirmed to be a mildly evolved (log g = 4.17), iron-poor (Fe/H = −0.46), but alpha-enhanced (α/Fe=0.27), chromospherically quiet, very old thick disc G2 star. A global fit, performed by using PyORBIT, shows that the transiting planet, K2-111 b, orbits with a period Pb = 5.3518 ± 0.0004 d and has a planet radius of $1.82^{+0.11}_{-0.09}$ R⊕ and a mass of $5.29^{+0.76}_{-0.77}$ M⊕, resulting in a bulk density slightly lower than that of the Earth. The stellar chemical composition and the planet properties are consistent with K2-111 b being a terrestrial planet with an iron core mass fraction lower than the Earth. We announce the existence of a second signal in the radial velocity data that we attribute to a non-transiting planet, K2-111 c, with an orbital period of 15.6785 ± 0.0064 d, orbiting in near-3:1 mean motion resonance with the transiting planet, and a minimum planet mass of 11.3 ± 1.1 M⊕. Both planet signals are independently detected in the HARPS-N and ESPRESSO data when fitted separately. There are potentially more planets in this resonant system, but more well-sampled data are required to confirm their presence and physical parameters.
Abstract Background There are limited data comparing ultrafiltration with standard medical therapy as first-line treatment in patients with severe congestive heart failure (HF). We compared ...ultrafiltration and conventional therapy in patients hospitalized for HF and overt fluid overload. Methods and Results Fifty-six patients with congestive HF were randomized to receive standard medical therapy (control group; n = 29) or ultrafiltration (ultrafiltration group; n = 27). The primary end point of the study was rehospitalizations for congestive HF during a 1-year follow-up. Despite similar body weight reduction at hospital discharge in the 2 groups (7.5 ± 5.5 and 7.9 ± 9.0 kg, respectively; P = .75), a lower incidence of rehospitalizations for HF was observed in the ultrafiltration-treated patients during the following year (hazard ratio 0.14, 95% confidence interval 0.04–0.48; P = .002). Ultrafiltration-induced benefit was associated with a more stable renal function, unchanged furosemide dose, and lower B-type natriuretic peptide levels. At 1 year, 7 deaths (30%) occurred in the ultrafiltration group and 11 (44%) in the control group ( P = .33). Conclusions In HF patients with severe fluid overload, first-line treatment with ultrafiltration is associated with a prolonged clinical stabilization and a greater freedom from rehospitalization for congestive HF.
The production cross sections of D0 and Λ+c hadrons originating from beauty-hadron decays (i.e., nonprompt) were measured for the first time at midrapidity (|y|<0.5) by the ALICE Collaboration in ...proton-proton collisions at a center-of-mass energy √s=13 TeV. They are described within uncertainties by perturbative QCD calculations employing the fragmentation fractions of beauty quarks to baryons measured at forward rapidity by the LHCb Collaboration. The b¯b production cross section per unit of rapidity at midrapidity, estimated from these measurements, is dσb¯b/dy||y|<0.5=83.1±3.5(stat)±5.4(syst)+12.3−3.2(extrap) μb. The baryon-to-meson ratios are computed to investigate the hadronization mechanism of beauty quarks. The nonprompt Λ+c/D0 production ratio has a similar trend to the one measured for the promptly produced charmed particles and to the p/π+ and Λ/K0S ratios, suggesting a similar baryon-formation mechanism among light, strange, charm, and beauty hadrons. The pT -integrated nonprompt Λ+c/D0 ratio is found to be significantly higher than the one measured in e+e− collisions.
Midrapidity production of π±, K±, and (¯p)p measured by the ALICE experiment at the CERN Large Hadron Collider, in Pb-Pb and inelastic pp collisions at √sNN=5.02 TeV, is presented. The invariant ...yields are measured over a wide transverse momentum (pT) range from hundreds of MeV/c up to 20 GeV/c. The results in Pb-Pb collisions are presented as a function of the collision centrality, in the range 0–90%. The comparison of the pT-integrated particle ratios, i.e., proton-to-pion (p/π) and kaon-to-pion (K/π) ratios, with similar measurements in Pb-Pb collisions at √sNN=2.76 TeV show no significant energy dependence. Blast-wave fits of the pT spectra indicate that in the most central collisions radial flow is slightly larger at 5.02 TeV with respect to 2.76 TeV. Particle ratios (p/π, K/π) as a function of pT show pronounced maxima at pT≈3GeV/c in central Pb-Pb collisions. At high pT, particle ratios at 5.02 TeV are similar to those measured in pp collisions at the same energy and in Pb-Pb collisions at √sNN=2.76 TeV. Using the pp reference spectra measured at the same collision energy of 5.02 TeV, the nuclear modification factors for the different particle species are derived. Within uncertainties, the nuclear modification factor is particle species independent for high pT and compatible with measurements at √sNN=2.76 TeV. The results are compared to state-of-the-art model calculations, which are found to describe the observed trends satisfactorily.
Across Europe, more than one third of patients are diagnosed with HIV infection late. Late presentation for care has been associated with higher risk of clinical progression and mortality. In the ...present study, we evaluated the prevalence, epidemiological characteristics and survival probability of patients with late and very late presentation, newly diagnosed with HIV infection in Catania, Italy, from 1985 to 2010.
According to the European Consensus definition, Late Presenters (LP) were defined as subjects presenting for care with a CD4+ T-cell count below 350 cells/µl or with an AIDS-defining event, regardless of CD4+ T-cell count; patients with advanced HIV disease (Very Late Presenters) (VLP) were those presenting with a CD4+ T-cell count below 200 cells/µl or with an AIDS-defining event, regardless of CD4+ T-cell count.
620 patients were included in the study. 345 (55.6%) subjects were LP, 35% of them were asymptomatic; 246 (39.7%) were VLP. In univariate analysis, late presentation was related to age (p < 0.001), to heterosexual exposure to HIV infection (70% of heterosexual subjects were LP) (p < 0.005) and to being diagnosed during the calendar period from 1991 to 2000 (p < 0.001). Very late presentation was related to age (p < 0.001), male sex (p < 0.01), heterosexual risk (p < 0.001) and to being diagnosed during the calendar period from 1991 to 2000 (p < 0.001). In multivariate analysis, age (p < 0.0001), being older than 50 years old (p = 0.02), years of diagnosis 1991-1995 (p < 0.005) and 1996-2000 (p < 0.05) in the subgroup of late presenters and age (p < 0.0001), being older than 50 years old (p < 0.005), male sex (p < 0.0001), years of diagnosis 1991-1995 (p < 0.05) and 1996-2000 (p < 0.005) in the subgroup of very late presenters maintained statistical significance. The survival probability within LP and VLP group was statistically lower than no LP/VLP (log rank test p < 0.0005 and p < 0.0001, respectively). For both LP (p < 0.002) and VLP (p < 0.0001), survival probability was significantly lower in the pre-HAART era, in comparison with the period of mono/dual therapy and the HAART era.
More than fifty percent of patients in our setting were diagnosed late with HIV infection and, consequently, treated late. Late and very late presentation were associated with lower survival probability. The implementation of strategies focused on targeted prevention efforts and HIV testing programs appears fundamental to diagnose and treat HIV infection as early as possible.
A measurement of dielectron production in proton-proton (pp) collisions at √s = 13 TeV recorded with the ALICE detector at the CERN LHC, is presented in this Letter. The data set was recorded with a ...reduced magnetic solenoid field. This enables the investigation of a kinematic domain at low dielectron (ee) invariant mass mee and pair transverse momentum pT,ee that was previously inaccessible at the LHC. The cross section for dielectron production is studied as a function of mee, pT,ee, and event multiplicity dNch/dη. The expected dielectron rate from hadron decays, called hadronic cocktail, utilizes a parametrization of the measured η/π0 ratio in pp and proton-nucleus collisions, assuming that this ratio shows no strong dependence on collision energy at low transverse momentum. Comparison of the measured dielectron yield to the hadronic cocktail at 0.15 < mee < 0.6 GeV / c2 and for pT,ee < 0.4 GeV/c indicates an enhancement of soft dielectrons, reminiscent of the "anomalous" soft-photon and soft-dilepton excess in hadron-hadron collisions reported by several experiments under different experimental conditions. The enhancement factor over the hadronic cocktail amounts to 1.61 ± 0.13 ( stat ) ± 0.17 (syst, data) ± 0.34 (syst, cocktail) in the ALICE acceptance. Acceptance-corrected excess spectra in m ee and pT,ee are extracted and compared with calculations of dielectron production from hadronic bremsstrahlung and thermal radiation within a hadronic many-body approach.
Sr isotope records from marginal marine basins track the mixing between seawater and local continental runoff, potentially recording the effects of sea level, tectonic, and climate forcing in marine ...fossils and sediments. Our 110 new 87Sr/86Sr analyses on oyster and foraminifera samples from six late Miocene stratigraphic sections in southern Turkey, Crete, and Sicily show that 87Sr/86Sr fell below global seawater values in the basins several million years before the Messinian Salinity Crisis, coinciding with tectonic uplift and basin shallowing. 87Sr/86Sr from more centrally located basins (away from the Mediterranean coast) drop below global seawater values only during the Messinian Salinity Crisis. In addition to this general trend, 55 new 87Sr/86Sr analyses from the astronomically tuned Lower Evaporites in the central Apennines (Italy) allow us to explore the effect of glacio‐eustatic sea level and precipitation changes on 87Sr/86Sr. Most variation in our data can be explained by changes in sea level, with greatest negative excursions from global seawater values occurring during relative sea level lowstands, which generally coincided with arid conditions in the Mediterranean realm. We suggest that this greater sensitivity to lowered sea level compared with higher runoff could relate to the inverse relationship between Sr concentration and river discharge. Variations in the residence time of groundwater within the karst terrain of the circum‐Mediterranean region during arid and wet phases may help to explain the single (robust) occurrence of a negative excursion during a sea level highstand, but this explanation remains speculative without more detailed paleoclimatic data for the region.
Key Points
Negative Sr isotope excursions in Miocene Mediterranean marine sediments
Sr isotope excursions primarily correspond to sea level fall or basin uplift
Groundwater effects on river and basin water geochemistry are likely important
Cyclic adenosine 3'5' monophosphate (cAMP) and protein kinase A (PKA) cooperate with phosphatidylinositol 3' kinase (PI3K) signals in the control of growth and survival. To determine the molecular ...mechanism(s) involved, we identified and mutagenized a specific serine (residue 83) in p85alpha(PI3K), which is phosphorylated in vivo and in vitro by PKA. Expression of p85alpha(PI3K) mutants (alanine or aspartic substitutions) significantly altered the biological responses of the cells to cAMP. cAMP protection from anoikis was reduced in cells expressing the alanine version p85alpha(PI3K). These cells did not arrest in G1 in the presence of cAMP, whereas cells expressing the aspartic mutant p85D accumulated in G1 even in the absence of cAMP. S phase was still efficiently inhibited by cAMP in cells expressing both mutants. The binding of PI3K to Ras p21 was greatly reduced in cells expressing p85A in the presence or absence of cAMP. Conversely, expression of the aspartic mutant stimulated robustly the binding of PI3K to p21 Ras in the presence of cAMP. Mutation in the Ser 83 inhibited cAMP, but not PDGF stimulation of PI3K. Conversely, the p85D aspartic mutant amplified cAMP stimulation of PI3K activity. Phosphorylation of Ser 83 by cAMP-PKA in p85alpha(PI3K) was also necessary for estrogen signaling as expression of p85A or p85D mutants inhibited or amplified, respectively, the binding of estrogen receptor to p85alpha and AKT phosphorylation induced by estrogens. The data presented indicate that: (1) phosphorylation of Ser 83 in p85alpha(PI3K) is critical for cAMP-PKA induced G1 arrest and survival in mouse 3T3 fibroblasts; (2) this site is necessary for amplification of estrogen signals by cAMP-PKA and related receptors. Finally, these data suggest a general mechanism of PI3K regulation by cAMP, operating in various cell types and under different conditions.
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