The population of Milky Way (MW) satellites contains the faintest known galaxies and thus provides essential insight into galaxy formation and dark matter microphysics. Here we combine a model of the ...galaxy-halo connection with newly derived observational selection functions based on searches for satellites in photometric surveys over nearly the entire high Galactic latitude sky. In particular, we use cosmological zoom-in simulations of MW-like halos that include realistic Large Magellanic Cloud (LMC) analogs to fit the position-dependent MW satellite luminosity function. We report decisive evidence for the statistical impact of the LMC on the MW satellite population due to an estimated 6 2 observed LMC-associated satellites, consistent with the number of LMC satellites inferred from Gaia proper-motion measurements, confirming the predictions of cold dark matter models for the existence of satellites within satellite halos. Moreover, we infer that the LMC fell into the MW within the last 2 Gyr at high confidence. Based on our detailed full-sky modeling, we find that the faintest observed satellites inhabit halos with peak virial masses below at 95% confidence, and we place the first robust constraints on the fraction of halos that host galaxies in this regime. We predict that the faintest detectable satellites occupy halos with peak virial masses above , highlighting the potential for powerful galaxy formation and dark matter constraints from future dwarf galaxy searches.
TMPS identified the first homozygous c.783delC in GDF9 gene in 1 patient with POF.
Targeted massively parallel sequencing (TMPS) has been used in genetic diagnosis for Mendelian disorders. In the ...past few years, the TMPS has identified new and already described genes associated with primary ovarian insufficiency (POI) phenotype. Here, we performed a targeted gene sequencing to find a genetic diagnosis in idiopathic cases of Brazilian POI cohort. A custom SureSelectXT DNA target enrichment panel was designed and the sequencing was performed on Illumina NextSeq sequencer. We identified 1 homozygous 1‐bp deletion variant (c.783delC) in the GDF9 gene in 1 patient with POI. The variant was confirmed and segregated using Sanger sequencing. The c.783delC GDF9 variant changed an amino acid creating a premature termination codon (p.Ser262Hisfs*2). This variant was not present in all public databases (ExAC/gnomAD, NHLBI/EVS and 1000Genomes). Moreover, it was absent in 400 alleles from fertile Brazilian women screened by Sanger sequencing. The patient's mother and her unaffected sister carried the c.783delC variant in a heterozygous state, as expected for an autosomal recessive inheritance. Here, the TMPS identified the first homozygous 1‐bp deletion variant in GDF9. This finding reveals a novel inheritance pattern of pathogenic variant in GDF9 associated with POI, thus improving the genetic diagnosis of this disorder.
•A novel feature selection algorithm based on Bat Algorithm and Optimum-Path Forest.•A comparison against different transfer functions for agent’s positioning.•Several datasets have been employed to ...the experimental section.
Besides optimizing classifier predictive performance and addressing the curse of the dimensionality problem, feature selection techniques support a classification model as simple as possible. In this paper, we present a wrapper feature selection approach based on Bat Algorithm (BA) and Optimum-Path Forest (OPF), in which we model the problem of feature selection as an binary-based optimization technique, guided by BA using the OPF accuracy over a validating set as the fitness function to be maximized. Moreover, we present a methodology to better estimate the quality of the reduced feature set. Experiments conducted over six public datasets demonstrated that the proposed approach provides statistically significant more compact sets and, in some cases, it can indeed improve the classification effectiveness.
Abstract
We present
Magellan
/IMACS spectroscopy of the recently discovered Milky Way satellite Eridanus II (Eri II). We identify 28 member stars in Eri II, from which we measure a systemic radial ...velocity of
and a velocity dispersion of
. Assuming that Eri II is a dispersion-supported system in dynamical equilibrium, we derive a mass within the half-light radius of
, indicating a mass-to-light ratio of
/
and confirming that it is a dark matter-dominated dwarf galaxy. From the equivalent width measurements of the Ca triplet lines of 16 red giant member stars, we derive a mean metallicity of Fe/H = −2.38 ± 0.13 and a metallicity dispersion of
. The velocity of Eri II in the Galactic standard of rest frame is
v
GSR
= −66.6
, indicating that either Eri II is falling into the Milky Way potential for the first time or that it has passed the apocenter of its orbit on a subsequent passage. At a Galactocentric distance of ∼370 kpc, Eri II is one of the Milky Way’s most distant satellites known. Additionally, we show that the bright blue stars previously suggested to be a young stellar population are not associated with Eri II. The lack of gas and recent star formation in Eri II is surprising given its mass and distance from the Milky Way, and may place constraints on models of quenching in dwarf galaxies and on the distribution of hot gas in the Milky Way halo. Furthermore, the large velocity dispersion of Eri II can be combined with the existence of a central star cluster to constrain massive compact halo object dark matter with mass ≳10
.
Summary
There are relevant clinical overlaps between some of the painful temporomandibular disorders (TMD) and headache conditions that may hamper the diagnostic process and treatment. A ...non‐systematic search for studies on the relationship between TMD and headaches was carried out in the following databases: PubMed, Cochrane Library and Embase. Important pain mechanisms contributing to the close association and complex relationship between TMD and headache disorders are as follows: processes of peripheral and central sensitisation which take place in similar anatomical areas, the possible impairment of the descending modulatory pain pathways and the processes of referred pain. In addition, the clinical examination does not always provide distinguishing information to differentiate between headaches and TMD. So, considering the pathophysiology and the clinical presentation of some types of headache and myofascial TMD, such overlap can be considered not only a matter of comorbid relationship, but rather a question of disorders where the distinction lines are sometimes hard to identify. These concerns are certainly reflected in the current classification systems of both TMD and headache where the clinical consequences of diagnosis such as headache attributed to or associated with TMD are uncertain. There are several similarities in terms of therapeutic strategies used to manage myofascial TMD and headaches. Considering all these possible levels of interaction, we reinforce the recommendation for multidisciplinary approaches, by a team of oro‐facial pain specialists and a neurologist (headache specialist), to attain the most precise differential diagnosis and initiate the best and most efficient treatment.
In this paper we present an approach to music genre classification which converts an audio signal into spectrograms and extracts texture features from these time-frequency images which are then used ...for modeling music genres in a classification system. The texture features are based on Local Binary Pattern, a structural texture operator that has been successful in recent image classification research. Experiments are performed with two well-known datasets: the Latin Music Database (LMD), and the ISMIR 2004 dataset. The proposed approach takes into account some different zoning mechanisms to perform local feature extraction. Results obtained with and without local feature extraction are compared. We compare the performance of texture features with that of commonly used audio content based features (i.e. from the MARSYAS framework), and show that texture features always outperforms the audio content based features. We also compare our results with results from the literature. On the LMD, the performance of our approach reaches about 82.33%, above the best result obtained in the MIREX 2010 competition on that dataset. On the ISMIR 2004 database, the best result obtained is about 80.65%, i.e. below the best result on that dataset found in the literature.
► Music genre classification using LBP texture descriptors extracted from spectrograms. ► Evaluate performance with local feature extraction and with global feature extraction. ► Compare results with state of the art in Latin Music Database and in ISMIR 2004 database.
Abstract
We present Magellan/IMACS spectroscopy of the recently discovered Milky Way satellite Tucana III (Tuc III). We identify 26 member stars in Tuc III from which we measure a mean radial ...velocity of
v
hel
= −102.3 ± 0.4 (stat.) ± 2.0 (sys.)
, a velocity dispersion of
, and a mean metallicity of
. The upper limit on the velocity dispersion is
σ
< 1.5
at 95.5% confidence, and the corresponding upper limit on the mass within the half-light radius of Tuc III is 9.0 × 10
4
M
⊙
. We cannot rule out mass-to-light ratios as large as 240
M
⊙
/
L
⊙
for Tuc III, but much lower mass-to-light ratios that would leave the system baryon-dominated are also allowed. We measure an upper limit on the metallicity spread of the stars in Tuc III of 0.19 dex at 95.5% confidence. Tuc III has a smaller metallicity dispersion and likely a smaller velocity dispersion than any known dwarf galaxy, but a larger size and lower surface brightness than any known globular cluster. Its metallicity is also much lower than those of the clusters with similar luminosity. We therefore tentatively suggest that Tuc III is the tidally stripped remnant of a dark matter-dominated dwarf galaxy, but additional precise velocity and metallicity measurements will be necessary for a definitive classification. If Tuc III is indeed a dwarf galaxy, it is one of the closest external galaxies to the Sun. Because of its proximity, the most luminous stars in Tuc III are quite bright, including one star at
V
= 15.7 that is the brightest known member star of an ultra-faint satellite.
Summary
The impression of increased muscle hardness in painful muscles is commonly reported in the clinical practice but may be difficult to assess. Therefore, the aim of this review was to present ...and discuss relevant aspects regarding the assessment of muscle hardness and its association with myofascial temporomandibular disorder (TMD) pain. A non‐systematic search for studies of muscle hardness assessment in patients with pain‐related TMDs was carried out in PubMed, Cochrane Library, Embase and Google Scholar. Mechanical devices and ultrasound imaging (strain and shear wave elastography) have been consistently used to measure masticatory muscle hardness, although an undisputable reference standard is yet to be determined. Strain elastography has identified greater masseter hardness of the symptomatic side in patients with unilateral myofascial TMD pain when compared to the contralateral side and healthy controls (HC). Likewise, shear wave elastography has shown greater masseter elasticity modulus in patients with myofascial TMD pain when compared to HC, which may be an indication of muscle hardness. Although assessment bias could partly explain these preliminary findings, future randomised controlled trials are encouraged to investigate this relationship. This qualitative review indicates that the muscle hardness of masticatory muscles is still a rather unexplored field of investigation with a good potential to improve the assessment and potentially also the management of myofascial TMD pain. Nonetheless, the current evidence in favour of increased hardness in masticatory muscles in patients with myofascial TMD pain is weak, and the pathophysiological importance and clinical usefulness of such information remain unclear.
What is the prevalence of malignant testicular germ cell tumors (TGCT) and its precursors, (pre-) germ cell neoplasia in situ (GCNIS), in late teenagers and adults who have androgen insensitivity ...syndrome (AIS) and the impact of an individual's genetic susceptibility to development of TGCT?
No GCNIS or TGCT was diagnosed, but pre-GCNIS was identified in 14 and 10% of complete and partial AIS patients, respectively, and was associated with a higher genetic susceptibility score (GSS), with special attention for KITLG (rs995030) and ATFZIP (rs2900333).
Many adult women with AIS decline prophylactic gonadectomy, while data regarding the incidence, pathophysiology and outcomes of TGCT in postpubertal individuals with AIS are lacking. The relevance of genetic factors, such as single nucleotide polymorphisms (SNPs), in predisposing AIS individuals to TGCT is unknown.
This multicenter collaborative study on prophylactically removed gonadal tissue was conducted in a pathology lab specialized in germ cell tumor biology.
Material from 52 postpubertal individuals with molecularly confirmed AIS (97 gonadal samples) was included; the median age at surgery was 17.5 (14-54) years. Immunohistochemical studies and high-throughput profiling of 14 TGCT-associated SNPs were performed. The main outcome measures were the prevalence of pre-GCNIS, GCNIS and TGCT, and its correlation with a GSS, developed based on the results of recent genome-wide association studies.
The earliest recognizable change preceding GCNIS, referred to as pre-GCNIS, was present in 14% of individuals with complete and 10% of those with partial AIS at a median age of 16 years. No GCNIS or invasive TGCT were found. The median GSS was significantly greater for those with, compared to those without, pre-GCNIS (P = 0.01), with an overlap between groups. Our data suggest important roles for risk alleles G at KITLG (rs995030) and C at ATFZIP (rs2900333), among the 14 studied TGCT-associated SNPs.
N/A.
A limited number of cases were included.
Our data suggest that the prevalence of pre-GCNIS in individuals with AIS beyond puberty is around 15%. Genetic susceptibility likely contributes to pre-GCNIS development in AIS but factors related to malignant progression remain unclear. Although data in older patients remain scarce, malignant progression appears to be a rare event, although the natural history of the premalignant lesion remains unknown. Therefore, the practice of routine prophylactic gonadectomy in adults with AIS appears questionable and the patient's preference, after having been fully informed, should be decisive in this matter.
This study was supported by research grants from the Research Foundation Flanders (FWO) (to M.C.), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq G0D6713N) (to B.B.M. and M.C.) and the European Society for Pediatric Endocrinology (ESPE), granted by Novo Nordisk AB (to J.K.). There are no competing interests.
The aim of the present work is to identify an environmentally clean coating process that will present lower influence in the Ti–6Al–4V fatigue strength. Axial fatigue tests of Ti–6Al–4V alloy TiN, ...CrN and WC:H (tungsten containing diamond-like carbon) Physical Vapor Deposition (PVD) coated was evaluated. Decrease in fatigue life was observed for coated specimens in comparison to base metal. Scanning Electron Microscopy technique was used to observe crack origin sites and coating thickness. DLC coating provides higher Ti–6Al–4V alloy PVD coated fatigue strength due to lower defects presence and the chromium interlayer, which acts as a barrier to fatigue crack propagation.
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