It has been suggested that genes other than CFTR could modulate the severity of lung disease in cystic fibrosis (CF). Neutrophil Fcgamma receptor II (FcgammaRII) is involved in host defense against ...microorganisms and in inflammatory response. We evaluated the association between genetic variability of this gene and both airway infection with Pseudomonas aeruginosa and severity of lung disease in patients with CF. We studied 167 Italian unrelated patients with CF and 50 control subjects. The distribution of FcgammaRIIA genotypes in CF patients was compared with that in control subjects and the different genotypes were related with the presence or absence of P. aeruginosa infection and markers of disease severity in CF patients. The distribution of FcgammaRIIA genotypes was not significantly different between CF patients and controls. We observed that in CF patients with the same CFTR genotype (DeltaF508/DeltaF508), those carrying the R allele of FcgammaRIIA had an increased risk of acquiring chronic P. aeruginosa infection (P=0.042, R.R.: 4.38; 95% CI: 1.17/22.4). Moreover, the frequency of R/R genotype in patients with chronic P. aeruginosa infection seems to be higher than that of control subjects and patients without chronic infection. The observation that CF patients carrying the R allele of FcgammaRIIA are at higher risk of acquiring chronic P. aeruginosa infection suggests that the FcgammaRII loci genetic variation is contributing to this infection susceptibility.
Questioni di inizio vita Alarcón Sevilla, Verónica; Antonietta La Torre, Maria; Antonio Cobacho Gómez, José ...
Mimesis Edizioni,
2015
Book
Odprti dostop
Il C.I.R.B. (Centro Interuniversitario di Ricerca Bioetica), cui aderiscono tutte le Università campane, è un organismo di ricerca nel quale - con metodo rigorosamente scientifico, grazie al concorso ...di qualificati cultori delle varie discipline interessate e in un clima di costante e costruttivo dialogo con i rappresentanti delle diverse posizioni culturali - è possibile delineare le trame di una serena e ponderata riflessione comune su tematiche che coinvolgono l’identità stessa della persona umana e il destino delle generazioni future.
En diciembre de 2019, se produjo un nuevo brote de enfermedad por coronavirus (COVID-19) en Wuhan, China. El síndrome respiratorio agudo severo-coronavirus-2 (SARS-CoV-2), que es el séptimo ...coronavirus conocido que infecta a los humanos, es altamente infeccioso y se ha expandido rápidamente en todo el mundo desde su descubrimiento. El diagnóstico de la infección por SARS-CoV-2 se basa en la detección del genoma viral (ARN) a través de técnicas de biología molecular. Con este fin, se extrae el ARN total para su posterior detección mediante PCR cuantitativa en tiempo real (RT-qPCR). Las pruebas cuantitativas de ácidos nucleicos se han convertido en el “estándar de oro” para el diagnóstico y guía en la toma de decisiones clínicas. Sin embargo, los ensayos de RT-qPCR dirigidos al SARS-CoV-2 tienen varios desafíos, especialmente en términos de diseño de cebadores / sondas y de desarrollo de metodologías que permitan estimar la carga viral en pacientes con diagnóstico de COVID-19.
Adaptive Riesz basis decomposition for image search Capodiferro, Licia; Carli, Marco; Costantini, Luca ...
2009 17th European Signal Processing Conference,
2009-Aug., 20090801
Conference Proceeding, Journal Article
A novel technique via Quadtree Gauss-Laguerre Transform (LGT) for a complete localization of a complex image in an multimedia database is presented. This technique is based on an iterative Maximum ...Likelihood procedure that allows to compare a region of interest (ROI) of an image with a content of a database, independently from location, rotation and scale. At this aim the ROI is expanded in terms of a Riesz basis, consisting of a set Circular Harmonic Gauss Laguerre functions, selected in order to make a trade off between accuracy and computational complexity. Numerical results obtained by a Monte Carlo simulation illustrate the performance of the method.
![Fc[gamma] receptor IIA geno...](http://api.summon.serialssolutions.com/2.0.0/image/issn/XR4PS5YY4K/1018-4813/small "Fc[gamma] receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis")
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