The development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new ...approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening, detection and mechanistic study of drugs. This review highlights the latest (2010–2018) microfluidic technology for drug analysis and discusses the potential future development in this field.
In this article, a new extended (2+1)-dimensional Boussinesq equation which can be used to describe the propagation of shallow water waves, was investigated. By using the bilinear bell polynomial ...theorem, the Hirota bilinear form of this considered equation can be obtained. Then, on the basis of the Hirota bilinear form, some new exact solutions through the extended homoclinic test approach with an arbitrary constant solution u0 were yielded. These exact solutions show the evolution of periodic characteristics as can be seen from the three-dimensional figures. The results shown new mechanical structures and reveal different characteristics for this evolution equation.
•Used the bilinear Bell polynomials approach to derive the Hirota bilinear form to the new extended (2+1)-dimensional Boussinesq equation which can be applied to describe the propagation of shallow water waves.•We obtained some new exact solutions through the extended homoclinic test approach with an arbitrary constant solution u0, and the evolution of periodic characteristics as can be seen from the 3D-plot.
Narrative review of ferroptosis in obesity He, Lian‐Ping; Zhou, Zi‐Xuan; Li, Cui‐Ping
Journal of cellular and molecular medicine,
April 2023, Letnik:
27, Številka:
7
Journal Article
Recenzirano
Odprti dostop
Obesity is widely recognized as a major global health problem caused by a chronic energy imbalance resulting from a combination of excess caloric intake and insufficient energy expenditure. Excessive ...energy intake and physical inactivity are traditional risk factors for obesity. Obesity is a risk factor for many diseases, including hypertension, diabetes and tumours. Recent studies have found a strong link between ferroptosis and obesity. Ferroptosis is an iron‐dependent regulated cell death caused by iron overload and reactive oxygen species‐dependent excessive accumulation of lipid peroxidation. Ferroptosis is involved in many biological processes, such as amino acid metabolism, iron metabolism and lipid metabolism. Some potential strategies to reduce the adverse effects of ferroptosis on obesity are suggested and future research priorities are highlighted.
Propolis is a honeybee product with broad clinical applications. Current literature describes that propolis is collected from plant resins. From a systematic database search, 241 compounds were ...identified in propolis for the first time between 2000 and 2012; and they belong to such diverse chemical classes as flavonoids, phenylpropanoids, terpenenes, stilbenes, lignans, coumarins, and their prenylated derivatives, showing a pattern consistent with around 300 previously reported compounds. The chemical characteristics of propolis are linked to the diversity of geographical location, plant sources and bee species.
Ferroptosis is a novel form of regulated cell death typically characterized by non‐apoptotic, iron‐dependent, and reactive accumulation of oxygen species. Recent studies have found that ferroptosis ...plays an important role in the pathophysiology of pre‐eclampsia (PE). In order to find potential therapeutic targets for ferroptosis intervention and better prevent the occurrence and progression of PE, the signalling pathways that regulate ferroptosis need to be identified. In this article, we review the role of vitamin D in PE and the role of ferroptosis in PE. Based on recent literature, we propose the scientific hypothesis that vitamin D can alleviate preeclampsia by modulating the ferroptosis signalling pathway. The aim of this review is to understand the regulatory pathways of ferroptosis in PE and to identify potential therapeutic targets.
A Ni/Co co‐catalyzed reductive hydrocyanation of various alkynes was developed for the production of saturated nitriles. Hydrocyanic acid is generated in situ from safe and readily available ...formamide. Formamide played multiple roles as a cyano source, dehydrant, and reductant for the NiII pre‐catalyst and vinyl nitriles, along with acting as the co‐solvent in this reaction. Detailed mechanistic investigation supported a pathway via hydrocyanation of C≡C bond and the subsequent reduction of C=C bond. Wide substrate scope, the employment of a cheap and stable nickel salt as pre‐catalyst, a safe cyano source and convenient experimental operation render this hydrocyanation practical for the laboratory synthesis of saturated nitriles.
The functions and regulation of Smurfs in cancers Fu, Lin; Cui, Chun-Ping; Zhang, Xueli ...
Seminars in cancer biology,
December 2020, 2020-12-00, 20201201, Letnik:
67, Številka:
Pt 2
Journal Article
Recenzirano
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Smad ubiquitination regulatory factor 1 (Smurf1) and Smurf2 are HECT-type E3 ubiquitin ligases, and both Smurfs were initially identified to regulate Smad protein stability in the TGF-β/BMP signaling ...pathway. In recent years, Smurfs have exhibited E3 ligase-dependent and -independent activities in various kinds of cells. Smurfs act as either potent tumor promoters or tumor suppressors in different tumors by regulating biological processes, including metastasis, apoptosis, cell cycle, senescence and genomic stability. The regulation of Smurfs activity and expression has therefore emerged as a hot spot in tumor biology research. Further, the Smurf1- or Smurf2-deficient mice provide more in vivo clues for the functional study of Smurfs in tumorigenesis and development. In this review, we summarize these milestone findings and, in turn, reveal new avenues for the prevention and treatment of cancer by regulating Smurfs.
Recent genome-wide association studies (GWAS) have identified multiple risk loci that show strong associations with schizophrenia. However, pinpointing the potential causal genes at the reported loci ...remains a major challenge. Here we identify candidate causal genes for schizophrenia using an integrative genomic approach. Sherlock integrative analysis shows that ALMS1, GLT8D1, and CSNK2B are schizophrenia risk genes, which are validated using independent brain expression quantitative trait loci (eQTL) data and integrative analysis method (SMR). Consistently, gene expression analysis in schizophrenia cases and controls further supports the potential role of these three genes in the pathogenesis of schizophrenia. Finally, we show that GLT8D1 and CSNK2B knockdown promote the proliferation and inhibit the differentiation abilities of neural stem cells, and alter morphology and synaptic transmission of neurons. These convergent lines of evidence suggest that the ALMS1, CSNK2B, and GLT8D1 genes may be involved in pathophysiology of schizophrenia.
During nearly 25 years of water injection development in Gaotaizi reservoir of LHP oilfield, due to poor reservoir physical properties, poor adaptability of well pattern and difficulty in ...establishing effective displacement between oil and water Wells, linear water injection, infill adjustment and refracturing tests have been carried out successively. Although certain effects have been seen, the effects are short and unsatisfactory. In this paper, the microscopic pore structure, sensitivity and seepage characteristics of ultra-low permeability high platform reservoir are studied through core laboratory experiments. New technology of nonlinear test and low permeable physical simulation experiment, the research on the rules of the nonlinear characteristics of the reservoir fluid and the characteristics of movable oil through research has been clear about the dragon bubble oilfield high effective displacement distance platform layer, and the new fracturing technology and the development of the technology to adjust the organic combination, the displacement between well and well past into displacement between Wells and joint network, explore the ultra-low permeability reservoir to improve the single well production, new ways to improve the development effect, with the types of low permeability oilfield development effectively.
Expectations can profoundly modulate pain experience, during which the periaqueductal gray (PAG) plays a pivotal role. In this article, we focus on motivationally evoked neural activations in ...cortical and brainstem regions both before and during stimulus administration, as has been demonstrated by experimental studies on pain-modulatory effects of expectations, in the hope of unraveling how the PAG is involved in descending and ascending nociceptive processes. This motivational perspective on expectancy effects on the perception of noxious stimuli sheds new light on psychological and neuronal substrates of pain and its modulation, thus having important research and clinical implications.
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